Scaling up a learning technology strategy: Supporting student/faculty teams in learner‐centred design

Many post‐secondary institutions are experiencing the challenge of scaling up their learning technology initiatives without a matching increase in staff resources. This mismatch is particularly acute at the design stage of projects, where both domain knowledge and instructional design expertise are needed. To address this, we are developing structures and tools for a small cadre of instructional design experts to support a growing number of learning technology projects developed by student/faculty teams. One of these tools, the Learner‐Centred Design Idea Kit, is an interactive WWW‐based resource now in a fourth iteration of use in an undergraduate course, Designing Learning Activities with Interactive Multimedia. The course and the LCD Idea Kit which supports it are part of a larger institutional strategy to introduce technology‐enabled change in the learning process, working ‘bottom‐up’ with individual faculty and using the LCD Idea Kit to scale up the course across multiple university departments. In this paper, we describe the course and the Kit in detail and provide and overview of our current status and lessons learned

Evidencias Psicométricas de la Escala de Autoestima Corporal en adolescentes

La presente investigación tuvo como objetivo validar la Escala de Autoestima Corporal (EAC) de Peris, Maganto y Garaigordobil (2016) en estudiantes de tercero a quinto grado de secundaria de Lima Metropolitana. Este estudio se realizó con un enfoque cuantitativo de tipo instrumental con una muestra de 692 estudiantes (45.66% mujeres y 54.34% varones) de 13 a 17 años de edad pertenecientes a instituciones educativas particulares y públicas. La validez convergente se comprobó con la Escala de Autoestima de Rosenberg (EAR), en la versión peruana de Ventura-León, Caycho-Rodríguez y Barboza-Palomino (2018). Los resultados del análisis factorial exploratorio validaron la existencia de 5 subescalas que se relacionan entre sí, estás son: satisfacción corporal (ω=.90), atractivo corporal (ω =.88), cara (ω =.63), torso inferior (ω =.86) y torso superior (ω=.76). En relación a los resultados del análisis factorial confirmatorio, el modelo 3 revela mejores índices de ajuste en comparación con los otros modelos. Los resultados del M3 fueron: chi cuadrado (x2 = 698.76), grados de libertad (gl= 214), índices comparativos (CFI= .97), el índice Tucker-Lewis (TLI= .97), la raíz residual estandarizada cuadrática media (SRMR= .04) y el error cuadrático medio de aproximación (RMSEA = .08). En conclusión, la EAC cuenta con evidencia empírica basada en el contenido, en la estructura interna, en relación con otra variable y fiabilidad, la cual puede ser aplicada a adolescentes como una prueba de screening para detectar el riesgo de problemas de autoestima corporal, tanto en el aspecto cognitivo como en el aspecto emocional.The objective of this research was to validate the Body Self-Esteem Scale (BSS) of Peris, Maganto and Garaigordobil (2016) in students from third to fifth grade of secondary schools in Metropolitan Lima. This study was carried out with a quantitative approach of instrumental type with a sample of 692 students (45.66% females and 54.34% males) from 13 to 17 years of age belonging to private and public educational institutions. Convergent validity was tested with the Rosenberg Self-Esteem Scale (RSS), in the Peruvian version of Ventura-León, Caycho-Rodríguez and Barboza-Palomino (2018). The results of the exploratory factor analysis validated the existence of five subscales that are related to each other, these are: body satisfaction (ω=.90), body attractiveness (ω =.88), face (ω =.63), lower torso (ω =.86) and upper torso (ω=.76). In relation to the results of the confirmatory factor analysis, model 3 reveals better adjustment rates compared to the other models. The results of M3 were: chi-square (x2 = 698.76), degrees of freedom (gl= 214), comparative indices (CFI= .97), the Tucker-Lewis index (TLI= .97), the residual standardized root mean square (SRMR= .04) and the approximation mean square error (RMSEA = .08). In conclusion, the CAD has empirical evidence based on content, internal structure, in relation to other variable and reliability, which can be applied to adolescents as a screening test to detect the risk of body self-esteem problems, both in the cognitive and emotional aspect.Tesi

Expectativas laborales y potencial directivo en estudiantes de Licenciatura en Turismo

El propósito del estudio fue diagnosticar las expectativas, prioridades laborales y potencial directivo de un grupo de estudiantes de primer año de la  carrera de Licenciatura en Turismo de la Universidad de Camagüey Ignacio Agramonte Loynaz, Cuba. Además, se establecieron grupos focales de desarrollo. Fueron aplicados dos cuestionarios y analizados los datos con el paquete estadístico Statgraphics Centurion VXI y sus técnicas de análisis descriptivo. Fue posible identificar que en todos los estudiantes las expectativas laborales son inferiores al potencial directivo. Los principales aspectos en los que debe influirse son: las habilidades comunicativas, la profesionalidad, la vocación de directivo, el interés y dinamismo, la autoactualización, las relaciones con personas y la creatividad laboral. Son propuestos tres grupos de trabajo con 24; 21 y 5 individuos de acuerdo a las características expresadas en los tests. A partir de herramientas gráficas se muestran las posiciones relativas de los grupos y los individuos, lo que junto a la información que les da origen será relevante para plantear una futura etapa de investigación donde se diseñen y evalúen programas complementarios a la formación de pregrado

Differences in the signaling pathways of α1A- and α1B-adrenoceptors are related to different endosomal targeting

Aims: To compare the constitutive and agonist-dependent endosomal trafficking of α1A- and α1B-adrenoceptors (ARs) and to establish if the internalization pattern determines the signaling pathways of each subtype. Methods: Using CypHer5 technology and VSV-G epitope tagged α1A- and α1B-ARs stably and transiently expressed in HEK 293 cells, we analyzed by confocal microscopy the constitutive and agonist-induced internalization of each subtype, and the temporal relationship between agonist induced internalization and the increase in intracellular calcium (determined by FLUO-3 flouorescence), or the phosphorylation of ERK1/2 and p38 MAP kinases (determined by Western blot). Results and Conclusions: Constitutive as well as agonist-induced trafficking of α1A and α1B ARs maintain two different endosomal pools of receptors: one located close to the plasma membrane and the other deeper into the cytosol. Each subtype exhibited specific characteristics of internalization and distribution between these pools that determines their signaling pathways: α1A-ARs, when located in the plasma membrane, signal through calcium and ERK1/2 pathways but, when translocated to deeper endosomes, through a mechanism sensitive to β-arrestin and concanavalin A, continue signaling through ERK1/2 and also activate the p38 pathway. α1B-ARs signal through calcium and ERK1/2 only when located in the membrane and the signals disappear after endocytosis and by disruption of the membrane lipid rafts by methyl-β-cyclodextrin

Feasibility study of the National Autistic Society EarlyBird parent support programme

The EarlyBird programme is a group-based psychoeducation intervention for parents of young children with autism. Although it is widely used in the United Kingdom, the evidence base for the programme is very limited. Using a mixed method, non-randomised research design, we aimed to test (1) the acceptability of the research procedures (recruitment, retention, suitability of measures), (2) the parental acceptability of EarlyBird (attendance, views of the programme, perceived changes) and (3) the facilitator acceptability of EarlyBird (fidelity, views of the programme, perceived changes). Seventeen families with a 2- to 5-year-old autistic child and 10 EarlyBird facilitators took part. Pre- and post-intervention assessment included measures of the child’s autism characteristics, cognitive ability, adaptive behaviour, emotional and behavioural problems and parent-reported autism knowledge, parenting competence, stress and wellbeing. Semi-structured interviews were completed at post-intervention with parents and facilitators. For those involved in the study, the research procedures were generally acceptable, retention rates were high and the research protocol was administered as planned. Generally, positive views of the intervention were expressed by parents and facilitators. Although the uncontrolled, within-participant design does not allow us to test for efficacy, change in several outcome measures from pre- to post-intervention was in the expected direction. Difficulties were encountered with recruitment (opt-in to the groups was ~56% and opt-in to the research was 63%), and strategies to enhance recruitment need to be built into any future trial. These findings should be used to inform protocols for pragmatic, controlled trials of EarlyBird and other group-based interventions for parents with young autistic children

Multi-timescale morphological modelling of a dune-fronted sandy beach

© 2018 The Authors Medium/long term trends (annual to decadal scale) of beach change are mostly used to make coastal management decisions. However, short term, extreme episodic events (short term) can erode the beach to exceed sustainable erosion thresholds thereby impacting long term trends of coastal change. Therefore, understanding coastal change at short and medium-long term (years to decades) timescales is essential to provide sustainable solutions to beach erosion. In this paper, we investigate and simulate the change of a beach-dune system for a megatidal coastline in the UK at storm timescale and at medium-long term timescale corresponding to sea level rise, in order to assess their significance in terms of beach management. The field site of choice is the Sefton coast, located in Liverpool Bay, United Kingdom. The approach used here involves process based modelling to determine storm-induced beach erosion and the application of modified Bruun Rule (Dean and Houston, 2016) to determine medium-long term evolution associated with climate change impacts. The application of the process-based model, XBeach, reveals that storm-induced short term beach erosion can be in the same scale or may surpass average medium/long term erosion thresholds and therefore, should be taken in to account when managing coastlines. Despite the complexities of the megatidal Sefton coast, the modified Bruun Rule proved to be capable of capturing long term beach profile change and assures that it can be confidently used to determine medium-long term beach-dune change due to sea level rise, once reliable estimates of longshore transport and sediment sources/sinks are made

Improve in-depth immunological risk assessment to optimize genetic-compatibility and clinical outcomes in child and adolescent recipients of parental donor kidney transplants: protocol for the INCEPTION study.

BACKGROUND: Parental donor kidney transplantation is the most common treatment option for children and adolescents with kidney failure. Emerging data from observational studies have reported improved short- and medium-term allograft outcomes in recipients of paternal compared to maternal donors. The INCEPTION study aims to identify potential differences in immunological compatibility between maternal and paternal donor kidneys and ascertain how this affects kidney allograft outcomes in children and adolescents with kidney failure. METHODS: This longitudinal observational study will recruit kidney transplant recipients aged ≤18 years who have received a parental donor kidney transplant across 4 countries (Australia, New Zealand, United Kingdom and the Netherlands) between 1990 and 2020. High resolution human leukocyte antigen (HLA) typing of both recipients and corresponding parental donors will be undertaken, to provide an in-depth assessment of immunological compatibility. The primary outcome is a composite of de novo donor-specific anti-HLA antibody (DSA), biopsy-proven acute rejection or allograft loss up to 60-months post-transplantation. Secondary outcomes are de novo DSA, biopsy-proven acute rejection, acute or chronic antibody mediated rejection or Chronic Allograft Damage Index (CADI) score of > 1 on allograft biopsy post-transplant, allograft function, proteinuria and allograft loss. Using principal component analysis and Cox proportional hazards regression modelling, we will determine the associations between defined sets of immunological and clinical parameters that may identify risk stratification for the primary and secondary outcome measures among young people accepting a parental donor kidney for transplantation. This study design will allow us to specifically investigate the relative importance of accepting a maternal compared to paternal donor, for families deciding on the best option for donation. DISCUSSION: The INCEPTION study findings will explore potentially differential immunological risks of maternal and paternal donor kidneys for transplantation among children and adolescents. Our study will provide the evidence base underpinning the selection of parental donor in order to achieve the best projected long-term kidney transplant and overall health outcomes for children and adolescents, a recognized vulnerable population. TRIAL REGISTRATION: The INCEPTION study has been registered with the Australian New Zealand Clinical Trials Registry, with the trial registration number of ACTRN12620000911998 (14th September 2020)

POT1 mutations predispose to familial melanoma

Deleterious germline variants in CDKN2A account for around 40% of familial melanoma cases, and rare variants in CDK4, BRCA2, BAP1 and the promoter of TERT have also been linked to the disease. Here we set out to identify new high-penetrance susceptibility genes by sequencing 184 melanoma cases from 105 pedigrees recruited in the UK, The Netherlands and Australia that were negative for variants in known predisposition genes. We identified families where melanoma cosegregates with loss-of-function variants in the protection of telomeres 1 gene (POT1), with a proportion of family members presenting with an early age of onset and multiple primary tumors. We show that these variants either affect POT1 mRNA splicing or alter key residues in the highly conserved oligonucleotide/oligosaccharide-binding (OB) domains of POT1, disrupting protein-telomere binding and leading to increased telomere length. These findings suggest that POT1 variants predispose to melanoma formation via a direct effect on telomeres.D.J.A., C.D.R.-E., Z.D., J.Z.L., J.C.T., M.P. and T.M.K. were supported by Cancer Research UK and the Wellcome Trust (WT098051). C.D.R.-E. was also supported by the Consejo Nacional de Ciencia y Tecnología of Mexico. K.A.P. and A.M.D. were supported by Cancer Research UK (grants C1287/A9540 and C8197/A10123) and by the Isaac Newton Trust. N.K.H. was supported by a fellowship from the National Health and Medical Research Council of Australia (NHMRC). L.G.A. was supported by an Australia and New Zealand Banking Group Limited Trustees PhD scholarship. A.L.P. is supported by Cure Cancer Australia. The work was funded in part by the NHMRC and Cancer Council Queensland. The work of N.A.G. was in part supported by the Dutch Cancer Society (UL 2012-5489). M.H., J.A.N.-B. and D.T.B. were supported by Cancer Research UK (programme awards C588/A4994 and C588/A10589 and the Genomics Initiative). C.L.-O., A.J.R. and V.Q. are funded by the Spanish Ministry of Economy and Competitiveness through the Instituto de Salud Carlos III (ISCIII), the Red Temática de Investigación del Cáncer (RTICC) del ISCIII and the Consolider-Ingenio RNAREG Consortium. C.L.-O. is an investigator with the Botín Foundation.This is the author accepted manuscript. The final version is available from NPG via http://dx.doi.org/10.1038/ng.294

Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours

Uveal melanoma (UM) is the most common intraocular tumour in adults and despite surgical or radiation treatment of primary tumours, ~50% of patients progress to metastatic disease. Therapeutic options for metastatic UM are limited, with clinical trials having little impact. Here we perform whole-genome sequencing (WGS) of 103 UM from all sites of the uveal tract (choroid, ciliary body, iris). While most UM have low tumour mutation burden (TMB), two subsets with high TMB are seen; one driven by germline MBD4 mutation, and another by ultraviolet radiation (UVR) exposure, which is restricted to iris UM. All but one tumour have a known UM driver gene mutation (GNAQ, GNA11, BAP1, PLCB4, CYSLTR2, SF3B1, EIF1AX). We identify three other significantly mutated genes (TP53, RPL5 and CENPE)

Il sito web dell'Osservatorio Vesuviano

L'Osservatorio Vesuviano ha di recente realizzato una radicale ristrutturazione del proprio sito Web, attivo dalla seconda metà del 1997, al fine di adeguarlo alla sua nuova configurazione giuridica. Infatti, dal 10 gennaio 2001 è entrato a far parte dell'Istituto Nazionale di Geofisica e Vulcanologia (INGV), un ente nazionale di nuova formazione in cui sono confluiti i maggiori enti ed istituzioni di ricerca operanti nel campo della geofisica e della vulcanologia in Italia. Con la nascita dell'INGV si è posta un'esigenza di coordinamento tra i siti web di dette istituzioni, che si configurano attualmente come sezioni del nuovo ente nazionale. Inoltre, è sorta la necessità di creare delle pagine comuni, relative all'ente nella sua totalità, che introducessero i visitatori alle pagine delle singole sezioni ed eventualmente a specifici tematismi riguardanti le attività dell'ente. A tal fine, è stato istituito un gruppo di Coordinamento Nazionale per il Web che comprende personale afferente alle diverse sezioni. Parallelamente sono stati istituiti gruppi di lavoro locali per la ristrutturazione dei siti delle sezioni. Nell'ambito di questa riorganizzazione, presso l'Osservatorio Vesuviano, con Decreto Direttoriale N. 6, del 30 gennaio 2002, è stato istituito un gruppo di lavoro con il compito di curare la progettazione e lo sviluppo del nuovo sito web della sezione. Nello svolgimento di questa attività il gruppo di lavoro si è posto come obbiettivi prioritari l'usabilità e l'accessibilità del sito, in ottemperanza alle indicazioni espresse dalla più recente normativa apparsa in materia. Per perseguire a pieno questi obbiettivi e garantire la massima fruibilità delle informazioni è stata prevista, fin dalla fase progettuale, la realizzazione del sito anche in versione inglese, che attualmente è in allestimento. Il nuovo sito web dell'Osservatorio Vesuviano è stato messo in linea il 22 maggio 2002 ed è visitabile all'indirizzo http://www.ov.ingv.it. Nel seguito del presente rapporto sono introdotte sinteticamente le finalità istituzionali e le principali attività dell'Osservatorio Vesuviano e sono descritte le fasi di progettazione e sviluppo del sito, con particolare dettaglio sulla strutturazione dei contenuti, definita nell'ambito delle linee dettate dal decreto di istituzione del gruppo di lavoro, e sulle scelte tecnologiche adottate