Efektivitas Pelayanan Pengurusan Paspor di Kantor Imigrasi Kelas I Makassar

Hasil penelitian ini menunjukkan bahwa terdapat 5 faktor yang menyebabkan tidak efektifnya pelayanan pengurusan paspor di Kantor Imigrasi Kelas I Makassar, yaitu: pelayanan security yang kurang baik, pelayanan berbasis online kurang di mengerti oleh masyarakat, sistem pelayanan yang bergantung sepenuhnya kepada sistem jaringan, sistem kuota memberikan kerancuan dalam menentukan pengurusan paspor dihari berikutnya yang dimaksud jika kuota pada hari tersebut tidak menggunakan target pelayanan yang kemudian hanya bergantung pada kata semampunya, serta kurangnya sosialisasi yang bersentuhan langsung kepada masyarakat berdampak pada kurangnya informasi tentang tata cara pengurusan paspor. Faktor pendorong pelayanan pengurusan paspor di kantor imigrasi kelas I Makassar: bukti langsung (Tangible), kehandalan (Reliability), daya tanggap (Responsiveness), jaminan (Assurance)

Costos por procesos de producción del orito (baby banana) de la finca Carmita del Cantón La Maná, provincia de Cotopaxi, año 2020

The general objective that was established to develop this research project is to create a cost system for the orito “baby banana” production process, at the Carmita Farm in La Maná Canton, Cotopaxi Province, Year 2020. The methodology that was used for the development of this research were field research that allowed access to the information in order to collect it and issue the results that the researcher expects, the descriptive research that was commissioned. To describe the situation of why this study is carried out, the applied research serves to know the research problem and give it the respective solutions, the research methods, inductive method, deductive method and analytical-synthetic method were also applied, which help to know aspects about the work of the “baby banana” orito, to develop cost accounting, research techniques such as observation allowed the identification of the production process, the interview served to ask a series of questions and in this way address the owner of the farm to obtain clear information and thus execute effectively this investigative work, the survey that was carried out to the workers to find out if they receive any type of social benefit and to obtain more information about the production process of the “baby banana” and establish the analyzes, and finally the questionnaires that contained a series of questions to get reliable data. The population is located according to the area to be studied, which is why the population was made up of all the farm staff who provided information to be able to carry out this research and the sample that is represented by administrative and field workers, due to this, statistical formulas were not needed. The results that were achieved with the execution of this project were productive because the owner knew the accounting process of his farm and the costs incurred in each of the processes in order to make the farm grow. With the structure of this process cost model, it was known that it would help the owner to have a correct management in each of these phases in order to achieve a favorable profit which allows him to make coherent decisions and be a solvent agricultural company and thus continue to contribute to the sustainability of the canton and country in general.El objetivo general que se estableció para desarrollar este proyecto de investigación versa en establecer un sistema de costos para el proceso de producción de orito “baby banana”, en la Finca Carmita del Cantón La Maná, Provincia de Cotopaxi, Año 2020. La metodología que se utilizó para el desarrollo de esta investigación fueron algunos tipos de investigación entre ellas la investigación de campo que permitió acceder a la información para de esta manera recopilar la información y emitir los resultados que el investigador espera, la investigación descriptiva que se encargó de describir la situación de porque se realiza este estudio, la investigación aplicada sirve para conocer el problema de la investigación y darle las respectivas soluciones, también se aplicaron los métodos de investigación, método inductivo, método deductivo y método analítico – sintético los cuales ayudan a conocer aspectos sobre el trabajo del orito “baby banana”, para desarrollar la contabilidad de los costos, las técnicas de investigación como la observación permitió la identificación del proceso productivo, la entrevista sirvió para realizar un serie de preguntas y de esta manera dirigirnos al dueño de la finca para obtener información clara y así ejecutar eficazmente este trabajo investigativo, la encuesta que fue realizada a los trabajadores para conocer si reciben algún tipo de beneficio social y conseguir más información sobre el proceso de producción del orito y establecer los respectivos análisis, y por último los cuestionarios que contenían una serie de preguntas para conseguir datos confiables. La población se trata de ubicar según al área que se vaya a estudiar por lo cual la población se conformó con todo el personal de la finca que proporcionaron de información para poder ejecutar esta investigación y la muestra que está representada por los trabajadores administrativos y de campo, debido a esto no se necesitó de fórmulas estadísticas. Los resultados que se consiguieron con la ejecución de este proyecto fueron fructíferos debido a que el propietario conoció el proceso contable de su finca y los costos incurridos en cada uno de los procesos con la finalidad de hacer crecer a la finca. Con la estructura de este modelo de costos por procesos se conoció que le ayudara al señor propietario a tener un manejo correcto en cada una de estas fases con la finalidad de conseguir una utilidad favorable la cual le permita tomar decisiones coherentes y ser una empresa agraria solvente y así seguir aportando a la sostenibilidad del Cantón y País en general

A GWAS in Latin Americans identifies novel face shape loci, implicating VPS13B and a Denisovan introgressed region in facial variation

To characterize the genetic basis of facial features in Latin Americans, we performed a genome-wide association study (GWAS) of more than 6000 individuals using 59 landmark-based measurements from two-dimensional profile photographs and ~9,000,000 genotyped or imputed single-nucleotide polymorphisms. We detected significant association of 32 traits with at least 1 (and up to 6) of 32 different genomic regions, more than doubling the number of robustly associated face morphology loci reported until now (from 11 to 23). These GWAS hits are strongly enriched in regulatory sequences active specifically during craniofacial development. The associated region in 1p12 includes a tract of archaic adaptive introgression, with a Denisovan haplotype common in Native Americans affecting particularly lip thickness. Among the nine previously unidentified face morphology loci we identified is the VPS13B gene region, and we show that variants in this region also affect midfacial morphology in mice

Phenotypic prediction from genotype data : applications to pigmentation in forensics, anthropology and genetic mapping

La pigmentation humaine est étudiée dans un contexte médico-légal, anthropologique et clinique. La prédiction de la pigmentation a été principalement limitée aux cohortes d'ascendance européenne. Dans cette thèse, mes principaux objectifs sont (1) de prédire les phénotypes de pigmentation dans une population génétiquement éloignée des études précédentes et de fournir une ligne directrice pour d'autres études, (2) de prédire la pigmentation d’échantillons d'ADN ancien du monde entier, et (3) d’investiguer données transcriptomiques pour l’ensemble des gènes associés à la pigmentation. Sur base de la cohorte CANDELA (>7000 individus métissés d’Amérique Latine), j’ai généré de nouveaux sets de SNPs aptes à prédire la pigmentation (quantitative) de la peau et celle (catégorique) des yeux et des cheveux d’une population métisse d’une meilleure façon que les sets existants. Deuxièmement, j'ai adapté ces sets de SNPs prédisant la couleur de la peau et des yeux pour prendre en compte deux spécificités de l'ADN ancien : la faible couverture et la pseudo-haploïdie, et j'ai amélioré les modèles de prédiction pour prendre en compte l'ascendance mal représentée dans la cohorte CANDELA. J’ai validé la méthode sur des données publiques contemporaines et l’ai ensuite appliquée à ~3600 échantillons d’ADN ancien disponibles publiquement (base de données AADR). Troisièmement, j'ai exploré l'expression des gènes de pigmentation à partir de l'ensemble de données GTEx et réalisé des tests d'association phénotype-transcriptome à l'aide des méthodes S-MultiXcan, ce qui a permis d’identifier une nouvelle association entre CACNA2D2 et l'indice de mélanine.Human pigmentation is studied in a forensic, anthropological and clinical context. Pigmentation prediction has been primarily limited to cohorts of European ancestry. In thisthesis, my main objectives are (1) to predict pigmentation phenotypes in a population genetically distant from previous studies and provide a guideline for further studies, ( thesis, my main objectives are (1) to predict pigmentation phenotypes in a population genetically distant from previous studies and provide a guideline for further studies, ( 2) to predict pigmentation in ancient DNA samples from around the world, and (3) to investigate transcriptomic data for the set of genes associated with pigmentation. Based on the CANDELA cohort cohort (>7000 admixed Latin American), I generated new sets of SNPs that can predict skin (quantitative) and eye/hair (categorical) pigmentation in a mestizo population better than the population in a better way than the existing sets. Second, I adapted these sets of SNPs predicting skin and eye color to take into account two specificities of ancient DNA: low-coverage and pseudo-haploidy, and I improved the prediction models to take into account the poorly represented ancestry in the CANDELA cohort. I validated the method on co ntemporary data and then applied it to ~3600 publicly available ancient DNA samples (AADR database). Third, I explored the expression of pigmentation genes from the GTEx and AADR datasets. mble of GTEx data and performed phenotype-transcriptome association tests using S-MultiXcan methods, which identified a novel association between CACNA2D2 and melanin index

Functional Noble Metal Nanoparticle for Biomedical Application

The work presented in this thesis entitled “Functional Noble Metal Nanoparticle for Biomedical Application” was initiated by the author in January, 2011 in Centre for «Seenced Materials, Indian Association for the Cultivation of Science, Kolkata, under ee sepervision of Dr. Nikhil Ranjan Jana. Noble metal nanoparticles have versatile application potential in biomedical field == they are highly biocompatible, posses plasmon-based strong optical properties suitable Se detection/imaging and their synthetic method and surface chemistry are well eS-enced. Thus they have been successfully applied in cell labeling/subcellular targeting, eme-specific drug/gene delivery, photothermal therapy, selective and sensitive detection sf Geomolecules and extended to in vivo clinical studies. In recent years, fluorescent gold qumoctesters have gained increased research focus particularly in biolabeling and sensing ggpiacation duc to their low cytotoxicity, small hydrodynamic diameter and superior Siomestability. These attracted features make them promising cellular imaging probes and cepiecement of toxic semiconductor nanocrystals. Currently researchers are concentrating on nanotechnology based solution of geumodicgenerative disease. Nanoparticles have the potential to influence the amyloid Sieiliatiom process and they could possibly cross blood-brain barrier to reach the amyloid Giees plague. Thus many efforts have been made on the development of nanoparticle Sesed anti-amyloid therapeutic probes for prevention and treatment of neurological Gender As for example, gold nanoparticle based functional probes are used for effective execmme of amyloid aggregation and photothermal dissolution of preformed amyloid 7 vilro. Although extensive amount of researches have been performed in developing high guiiity fanctional fluorescent gold clusters, their synthesis and surface functionalization oe stil challenging to the scientific community. Major problems involve poor synthetic the formation of larger proportion of nanoparticle side product that lowers Gee senthetic yield as well as fluorescence quantum yield of clusters.The research was conducted under the supervision of Prof. N R Jana under SMS [School of Materials Science]The research was carried out under CSIR fellowship

Breast cancer survival prognosis using the graph convolutional network with Choquet fuzzy integral

Abstract Breast cancer is the most prevalent kind of cancer among women and there is a need for a reliable algorithm to predict its prognosis. Previous studies focused on using gene expression data to build predictive models. However, recent advancements have made multi-omics cancer data sets (gene expression, copy number alteration, etc.) accessible. This has acted as the motivation for the creation of a novel model that utilizes a graph convolutional network (GCN) and Choquet fuzzy ensemble, incorporating multi-omics and clinical data retrieved from the publicly available METABRIC Database. In this study, graphs have been used to extract structural information, and a Choquet Fuzzy Ensemble with Logistic Regression, Random Forest, and Support Vector Machine as base classifiers has been employed to classify breast cancer patients as short-term or long-term survivors. The model has been run using all possible combinations of gene expression, copy number alteration, and clinical modality, and the results have been reported. Furthermore, a comparison has been made between the obtained results and different baseline models and state-of-the-art to demonstrate the efficacy of the proposed model in terms of different metrics. The results of this model based on Accuracy, Matthews correlation coefficient, Precision, Sensitivity, Specificity, Balanced Accuracy, and F1-Measure are 0.820, 0.528, 0.630, 0.666, 0.871, 0.769, and 0.647, respectively

DC Capacitor-Less Two-Terminal Unified Active Capacitor and Inductor

Flexible characteristics, tunable parameters, and improved power density are the desired attributes that have led to widespread research on active capacitors and inductors (ACI) in power conversion systems. However, the two-terminal realisation of ACI is challenging due to different trade-offs between power density, device stress, and reliability of the added components. Moreover, the requirement of handling second-harmonic ripple makes bulk electrolytic capacitors nearly indispensable in two-terminal ACIs. Thus, the scope of power density improvement becomes constrained. Hence, active capacitors requiring minimum or no bulk dc-link capacitance are seen as an attractive technology in recent literatures. However, they can mimic either inductive or capacitive behaviour with a single converter unit, restricting their adaptability across different applications. This limitation is addressed in this work with the proposed unified active capacitor and inductor (UACI), realised without any bulk dc capacitor. It emulates variable capacitance and inductance while offering a smooth transition from one characteristic to another. High effective impedance due to a small susceptance at transition duty prevents undesirable current overshoot during the transition. A laboratory-scale prototype of the proposed ACI is fabricated, and the hardware is verified up to +/-450 VAR.</p