Effects of the reactive moiety of phenolipids on their antioxidant efficiency in model emulsified systems

Our previous research was focused on the effects of hydrophobicity on the antioxidant (AO) efficiency of series of homologous antioxidants with the same reactive moieties. In this work we evaluate the antioxidant efficiency of hydrophobic phenolipids in 4:6 olive oil-in-water emulsions, with different phenolic moieties (derived from caffeic, 4-hydroxycinnamic, dihydrocaffeic acids, tyrosol and hydroxytyrosol), with alkyl chains of 8 and 16 carbons, and compare the antioxidant efficiency with that of the parent compounds. All catecholic phenolipids, in particular the C8 derivatives, have proven to be better antioxidants for the oxidative protection of emulsions than their parental compounds with octyl dihydrocafffeate being the most efficient (16-fold increase in relation to the control). To understand the importance of some factors on the antioxidant efficiency of compounds in emulsions, Pearson’s correlation analysis was carried out between antioxidant activity and the first anodic potential (Epa), reducing capacity (FRAP value), DPPH radical scavenging activity (EC50) and the concentration of antioxidants in each region of the emulsified system. Results confirm the importance of the effective concentration of AOs in the interfacial region (AOI) (ρ = 0.820) and of the Epa (ρ = −0.677) in predicting their antioxidant efficiency in olive oil-in-water emulsions.Research was funded by FCT/MCTES (UIDB/QUI/50006/2020; PTDC/OCE-ETA/32492/ 2017–POCI-01-0145-FEDER-032492; doctoral grant SFRH/BD/100889/2014), FCT and REQUIMTELAQV for a post-doc fellowship (PTDC/OCE- ETA/32492/2017), Xunta de Galicia (10TAL314003PR), the University of Vigo (postdoctoral grant-Talent Recruitment Program 2018) and the IACOBUS 2019 program. The manuscript was prepared during a sabbatical leave of C. B.-D., supported by the University of Vigo

A FEMINILIDADE E SEXUALIDADE DA MULHER COM CÂNCER DE MAMA

O câncer de mama é um dos principais tumores que acometem as mulheres, sendo que afetam principalmente as mulheres de aproximadamente acima de 35 anos de idade. Essa patologia é muito temida pelas mulheres, pois está acontecendo com alta freqüência. Os efeitos que essa doença promove, não se resumem apenas em fisiológicos, mas também, psicológicos. Pois já que em sua grande maioria, a medida tomada como tratamento é a retirada da mama da paciente, processo este que altera e se tem uma grande interferência na feminilidade, na sexualidade e, principalmente na auto-imagem e auto-estima da mulher. Faz-se necessário uma equipe multidisciplinar para atender e tratar de forma mais integral possível, buscando sempre uma melhor qualidade de vida. Este artigo tem como base um delineamento do tipo bibliográfico, com base em pesquisas bibliográficas, revistas e livros de uma universidade, restrita no período de publicação, artigos científicos do Portal Scielo, do Google Acadêmico, Bireme, Lilacs, Cochrane, BVS, PubMed, Cinahl, Scopus

RECURSOS FISIOTERAPÊUTICOS NA PARALISIA CEREBRAL PEDIÁTRICA

A paralisia cerebral (PC) é também conhecida como encefalopatia crônica não progressiva da infância. O termo PC é um grupo de distúrbios cerebrais crônicos não progressivos do movimento ou da postura com inicio precoce prematuro. Este artigo tem como base um delineamento do tipo bibliográfico, com base em pesquisas bibliográficas, revistas e livros de uma Universidade, restrita no período de publicação, artigos científicos do Portal Scielo, do Google Acadêmico, Bireme, Lilacs, Cochrane, BVS, PubMed, Cinahl, Scopus. A pesquisa teve como principais autores citados no decorre do texto são: Tecklin, Sthepherd, Jakaitis, entre outros. Durante o levantamento bibliográfico foi observado que a fisioterapia disponibiliza de diversos recursos no tratamento da PC, onde os mesmos vão atuar buscando respostas positivas e a promovendo uma melhor qualidade de vida do paciente. Esses recursos são: hidroterapia, equoterapia, cinesioterapia e ressaltando que se tratando de crianças deve-se conciliar o tratamento com atividades lúdicas, ou seja, músicas e brinquedos. O tratamento fisioterapêutico na PC irá evitar e corrigir diversas alterações no organismo do paciente, então o profissional deve está ciente que, várias crianças podem ter o mesmo tipo de PC, porém, cada uma poderá reagir de forma diferente, com isso o tratamento deve ser individualizado e integral, promovendo assim um tratamento eficaz

TRANSTORNO OBSESSIVO-COMPULSIVO (TOC) E NEUROIMAGEM

Advanced neuroimaging techniques have played a key role in elucidating brain alterations in obsessive-compulsive disorder (OCD). These discoveries not only broaden our understanding of the pathophysiology of OCD, but also pave the way for the development of more effective and personalized therapeutic interventions. As neuroimaging skills are improved, an increasingly refined understanding of the neurobiological basis of psychiatric disorders such as OCD can be expected, offering hope and opportunities for a better quality of life for those suffering from these conditions. This study aimed to investigate the brain alterations associated with OCD using advanced neuroimaging techniques. A systematic literature review was carried out using the Scielo, Lilacs and Medline databases. After a qualitative analysis of the results, it was concluded that advanced neuroimaging techniques provide objective evidence of the brain alterations associated with Obsessive-Compulsive Disorder (OCD), contributing to a deeper understanding of the neural bases of the disorder and highlighting the crucial role of these techniques in research and the development of diagnostic and treatment strategies.As técnicas avançadas de neuroimagem têm desempenhado um papel fundamental na elucidação das alterações cerebrais no Transtorno obsessivo-compulsivo (TOC). Essas descobertas não só ampliam a compreensão da fisiopatologia do TOC, mas abrem caminho para o desenvolvimento de intervenções terapêuticas mais eficazes e personalizadas. À medida que são aprimoradas as habilidades em neuroimagem, pode-se esperar uma compreensão cada vez mais refinada das bases neurobiológicas dos transtornos psiquiátricos, como o TOC, oferecendo esperança e oportunidades para uma melhor qualidade de vida para aqueles que sofrem com essas condições. Este estudo teve como objetivo investigar as alterações cerebrais associadas ao TOC usando técnicas avançadas de neuroimagem. Diante disso, realizou-se uma revisão sistemática da literatura, utilizando as bases de dados Scielo, Lilacs e Medline. Após análise qualitativa dos resultados, concluiu-se que as técnicas avançadas de neuroimagem fornecem evidências objetivas das alterações cerebrais associadas ao Transtorno Obsessivo-Compulsivo (TOC), contribuindo para uma compreensão mais profunda das bases neurais do transtorno e destacando o papel crucial dessas técnicas na investigação e desenvolvimento de estratégias de diagnóstico e tratamento

Global assessment of marine plastic exposure risk for oceanic birds

Plastic pollution is distributed patchily around the world’s oceans. Likewise, marine organisms that are vulnerable to plastic ingestion or entanglement have uneven distributions. Understanding where wildlife encounters plastic is crucial for targeting research and mitigation. Oceanic seabirds, particularly petrels, frequently ingest plastic, are highly threatened, and cover vast distances during foraging and migration. However, the spatial overlap between petrels and plastics is poorly understood. Here we combine marine plastic density estimates with individual movement data for 7137 birds of 77 petrel species to estimate relative exposure risk. We identify high exposure risk areas in the Mediterranean and Black seas, and the northeast Pacific, northwest Pacific, South Atlantic and southwest Indian oceans. Plastic exposure risk varies greatly among species and populations, and between breeding and non-breeding seasons. Exposure risk is disproportionately high for Threatened species. Outside the Mediterranean and Black seas, exposure risk is highest in the high seas and Exclusive Economic Zones (EEZs) of the USA, Japan, and the UK. Birds generally had higher plastic exposure risk outside the EEZ of the country where they breed. We identify conservation and research priorities, and highlight that international collaboration is key to addressing the impacts of marine plastic on wide-ranging species

Global assessment of marine plastic exposure risk for oceanic birds

Plastic pollution is distributed patchily around the world’s oceans. Likewise, marine organisms that are vulnerable to plastic ingestion or entanglement have uneven distributions. Understanding where wildlife encounters plastic is crucial for targeting research and mitigation. Oceanic seabirds, particularly petrels, frequently ingest plastic, are highly threatened, and cover vast distances during foraging and migration. However, the spatial overlap between petrels and plastics is poorly understood. Here we combine marine plastic density estimates with individual movement data for 7137 birds of 77 petrel species to estimate relative exposure risk. We identify high exposure risk areas in the Mediterranean and Black seas, and the northeast Pacific, northwest Pacific, South Atlantic and southwest Indian oceans. Plastic exposure risk varies greatly among species and populations, and between breeding and non-breeding seasons. Exposure risk is disproportionately high for Threatened species. Outside the Mediterranean and Black seas, exposure risk is highest in the high seas and Exclusive Economic Zones (EEZs) of the USA, Japan, and the UK. Birds generally had higher plastic exposure risk outside the EEZ of the country where they breed. We identify conservation and research priorities, and highlight that international collaboration is key to addressing the impacts of marine plastic on wide-ranging species

Global assessment of marine plastic exposure risk for oceanic birds

Plastic pollution is distributed patchily around the world's oceans. Likewise, marine organisms that are vulnerable to plastic ingestion or entanglement have uneven distributions. Understanding where wildlife encounters plastic is crucial for targeting research and mitigation. Oceanic seabirds, particularly petrels, frequently ingest plastic, are highly threatened, and cover vast distances during foraging and migration. However, the spatial overlap between petrels and plastics is poorly understood. Here we combine marine plastic density estimates with individual movement data for 7137 birds of 77 petrel species to estimate relative exposure risk. We identify high exposure risk areas in the Mediterranean and Black seas, and the northeast Pacific, northwest Pacific, South Atlantic and southwest Indian oceans. Plastic exposure risk varies greatly among species and populations, and between breeding and non-breeding seasons. Exposure risk is disproportionately high for Threatened species. Outside the Mediterranean and Black seas, exposure risk is highest in the high seas and Exclusive Economic Zones (EEZs) of the USA, Japan, and the UK. Birds generally had higher plastic exposure risk outside the EEZ of the country where they breed. We identify conservation and research priorities, and highlight that international collaboration is key to addressing the impacts of marine plastic on wide-ranging species.B.L.C., C.H., and A.M. were funded by the Cambridge Conservation Initiative’s Collaborative Fund sponsored by the Prince Albert II of Monaco Foundation. E.J.P. was supported by the Natural Environment Research Council C-CLEAR doctoral training programme (Grant no. NE/S007164/1). We are grateful to all those who assisted with the collection and curation of tracking data. Further details are provided in the Supplementary Acknowledgements. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the U.S. Government.Peer reviewe

CONSIDERAÇÕES SOBRE FATORES EXTRÍNSECOS EM QUEDAS DE IDOSOS / CONSIDERATIONS ABOUT EXTRINSIC FACTORS IN FALLS OF SENIOR

Estima-se que no ano de 2025 a população idosa mundial será composta por 1,2 bilhões, já no de 2050, de 2 bilhões. Isso acarretará mudanças não somente fisiológicas, mas econômicas e sócias. Este estudo caracteriza como uma revisão de literatura, o qual coletou-se estudos nas bases de dados SCIELO e LILACS, refinando-os por abrangência temporal entre os anos de 2010 e 2014, textos em idiomas português. Os descritores de referência foram: acidentes por queda em idosos, fatores de risco de quedas em idosos. Utilizou-se 12 artigos, descartando-se os duplicados e os que não se estreitavam com o tema. As maiores prevalências de quedas são do sexo feminino e as condições de riscos acarretam nos idosos podem ser multifatoriais. Os fatores de risco de quedas podem ser divididos em intrínsecos que são relacionados às características do indivíduo e às mudanças de acordo com a idade, enquanto os extrínsecos são relacionados ao ambiente, principalmente o ambiente doméstico

Variants in <i>KMT2A</i> in Three Individuals with Previous Suspicion of 22q11.2 Deletion Syndrome

The condition known as 22q11.2 deletion syndrome (MIM #188400) is a rare disease with a highly variable clinical presentation including more than 180 features; specific guidelines for screening individuals have been used to support clinical suspicion before confirmatory tests by Brazil’s Craniofacial Project. Of the 2568 patients listed in the Brazilian Database on Craniofacial Anomalies, 43 individuals negative for the 22q11.2 deletion syndrome were further investigated through whole-exome sequencing. Three patients (6.7%) presented with heterozygous pathogenic variants in the KMT2A gene, including a novel variant (c.6158+1del) and two that had been previously reported (c.173dup and c.3241C>T); reverse phenotyping concluded that all three patients presented features of Wiedemann–Steiner syndrome, such as neurodevelopmental disorders and dysmorphic facial features (n = 3), hyperactivity and anxiety (n = 2), thick eyebrows and lower-limb hypertrichosis (n = 2), congenital heart disease (n = 1), short stature (n = 1), and velopharyngeal insufficiency (n = 2). Overlapping features between 22q11.2 deletion syndrome and Wiedemann–Steiner syndrome comprised neuropsychiatric disorders and dysmorphic characteristics involving the eyes and nose region; velopharyngeal insufficiency was seen in two patients and is an unreported finding in WDSTS. Therefore, we suggest that both conditions should be included in each other’s differential diagnoses

Image_1_A New Flow Cytometry-Based Single Platform for Universal and Differential Serodiagnosis of HTLV-1/2 Infection.tif

In the present work, we developed and evaluated the performance of a new flow cytometry-based single platform, referred to as “FC-Duplex IgG1 (HTLV-1/2)”, for universal and differential serodiagnosis of HTLV-1/2 infection. The proposed technology employs a system for detection of IgG1 antibodies in a single competitive immunofluorescence platform by flow cytometry using fluorescently labeled MT-2/MoT cell line mix coupled to a highly sensitive development system (Biotin/Streptavidin/Phycoerythrin). The stability of fluorescent labeling and the antigenicity of MT-2 and MoT cell lines were confirmed upon storage at −20°C for 2, 6, and 12 months. The anti-HTLV-1/2 IgG1 reactivity, expressed as percentage of positive fluorescent cells (PPFC), was evaluated for each target antigen along the titration curve of test serum samples (1:32 to 1:4,096). Upon selection of target cell line and serum dilutions with higher segregation score between groups, the performance of “FIX” and “FIX & PERM” protocols was evaluated. The “FIX” protocol presented excellent performance indices (Se = 92%/Sp = 94%/AUC = 0.96; Se = 96%/Sp = 100%/AUC = 0.99) for the universal (HTLV-1/2 vs. NI) and differential (HTLV-1 vs. HTLV-2) diagnosis of HTLV-1 infection, respectively. Optimization of the “FIX” protocol using the principle of synchronous and asynchronous pairwise analysis further improved the performance of “FC-Duplex IgG1 (HTLV-1/2)”, using the “FIX” protocol for differential diagnosis of HTLV-1 and HTLV-2 infections (Se = 100%/Sp = 100%/AUC = 1.00). In conclusion, the “FC-Duplex IgG1 (HTLV-1/2)” method represents an innovation in the biotechnology segment with the potential to compose a serological kit for differential diagnosis of HTLV-1/2 infection for reference laboratories and blood centers.</p