Les quartiers sensibles en Franche-Comté

Le laboratoire ThéMA (UMR 6049, CNRS-Université de Franche-Comté) a mené une recherche sur les quartiers sensibles de Franche-Comté, entre 2003 et 2006 à la demande des services de l'État. Elle fait suite à une étude du même type réalisée par l'IRADES (UPRESA 6049) entre 1991 et 1998 (cf. Images de Franche-Comté n°15)

5. De la couleur des prépositions dans leurs emplois fonctionnels

Jean-Jacques Franckel & Denis Paillard proposent de la préposition une approche innovante par rapport aux travaux actuels qui privilégient – au nom en particulier de la grammaticalisation – un point de départ spatial, ne rendant pas compte de bon nombre de phénomènes courants, tels la différence instaurée par la commutation d’apparence synonymique : choisir (entre + parmi) des candidats, comparer un chat (à + avec) un tigre, ou, à l’inverse, une sélection entre les distributions sans qu’un rapport clair soit établi intuitivement entre elles (par exemple entre tirer sur /Ø un lapin, tirer sur un lapin / sa cigarette / la couverture...). L’article établit les bases théoriques et méthodologiques permettant de remédier aux insuffisances constatées ailleurs

URANSE simulation of an active variable-pitch cross-flow Darrieus tidal turbine: Sinusoidal pitch function investigation

This article describes a 2D CFD simulation implementation of a crossflow tidal turbine, the blades of which have their pitch modified during revolution. Unsteady flow around the turbine is computed with an URANSE method, using the solver ANSYS-CFX. Spatial and temporal discretizations have been studied. The pitch motion of the blades is obtained through mesh deformation, and the main rotation is implemented through sliding boundaries, with general grid interface model. The turbulence model used is kx SST. Langtry Menter transition model was tried but showed high discrepancies with experimental results. Five experimental cases were used to assess the accuracy of the simulation. It provided accurate computed forces for a wide range of tip speed ratios, and proved to be suitable for exploratory simulations. Harmonic pitch control was thus implemented for a tip speed ratio of 5, close to an operational value for a crossflow turbine. First, second and third harmonics pitch function were tested. It was shown that an improvement of more than 50% could be achieved with the second harmonics, with a large reduction in thrust. The flow inside the turbine and close to the blade was examined so that the case of performance improvement due to pitch control could be clearly understood. It was observed that turbine efficiency improvement requires a very slight recirculation and an angle of attack decrease on the upstream part of the turbine, and an angle of attack increase on the downstream part. The flow deceleration through the turbine was found to be a primary factor in pitch function as well. Moreover the hydrodynamic torque and thus the energy required to control the pitch were found to be insignificant

Changes in training load, running performance, lower body power and biochemical characteristics of back players throughout a professional Rugby Union season

The aim of this study was to observe and quantify changes in training load (TL), running performance, lower body power and biochemical characteristics of professional rugby union back players over an entire season. Eight professional players (age: 25.8 ± 4.6 y) participated in this study. Session-RPE (S-RPE) and microtechnologies (GPS) were used for assessing training load (TL). During the season, running performance was monitored using the YoYo Recovery Test Level-2 (YYRT2) and lower body power performance using the drop jump (DJ) test. Changes in hematological, endocrine and muscle damage parameters were examined through 3 blood samples taken at separate times throughout the season. TL progressively and significantly (p < 0.001) decreased throughout the season particularly due to the decrease in the training volume. The last blood sample of the season revealed a significant (p < 0.001) increase in hematological parameters and a significant increase (p < 0.01) in cortisol blood concentration without change in the testosterone/cortisol ratio. No significant change in YYRT2 performance was observed over the season, while DJ test performance was significantly lower during the first 2 blocks of the season compared to other blocks. The training volume showed a significant negative correlation with DJ-test performances (TD: r = -0.49 and S-RPE: r = -0.40, p < 0.001). Although there was a decrease in training volume throughout the season, there was no significant changes in running performance. Furthermore, lower body power production showed a significant increase in particular during the last part of the season

Atrial natriuretic factor during atrial fibrillation and supraventricular tachycardia

Plasma immunoreactive atrial natriuretic factor was measured in 10 patients with chronic atrial fibrillation before and after cardioversion to sinus rhythm, and in 14 patients during electrophysiologic evaluation of paroxysmal supraventricular tachycardia. The mean plasma concentration of atrial natriuretic factor in atrial fibrillation was 138 ± 48 pg/ml and decreased to 116 ± 45 pg/ml 1 hour after cardioversion to sinus rhythm (p < 0.005). The mean plasma concentration of atrial natriuretic factor increased from 117 ± 53 pg/ml in sinus rhythm to 251 ± 137 pg/ml during laboratory-induced supraventricular tachycardia (p < 0.005). Right atrial pressures were recorded in 12 patients; the baseline atrial pressure was 4.3 ± 1.9 mm Hg and increased to 7.4 ± 3.6 mm Hg during supraventricular tachycardia (p < 0.005). A modest but significant linear relation was noted between the changes in plasma atrial natriuretic factor and right atrial pressure measurements during induced supraventricular tachycardia (r = 0.60, p < 0.05).In conclusion, changes in atrial rhythm and pressure may be an important factor modulating the release of atrial natriuretic factor in the circulation and raised levels of this hormone may be a contributing factor for the polyuria and the hypotension associated with paroxysmal supraventricular tachyarrhythmias

From farm, landscape and territory analysis to scenario exercise: an educational programme on participatory integrated analysis

Tools and methodologies have been developed to enable integrated analysis (IA) of complex issues like agro‐ecosystems and natural resources management. They are based on interdisciplinary and often on participatory approaches combining, interpreting and communicating knowledge from diverse scientific disciplines and from stakeholders. In this paper we present the original educational programme built to enable students in agronomy to implement participatory IA methods in order to deal with sustainability issues in rural territory. In this educational programme students take a professional project management situation on a given case study. One of the originality of the course programme lies in its twofold objectives: building student capacities for carrying out integrated multi‐scale analysis of complex systems and providing researchers with an operational research device which facilitates the integrated analysis of new study territories. The educational programme articulates trips in the case study region and formation modules on project management, farming systems sustainability assessment, landscape multifunctionality analysis, stakeholder analysis and interviews, territorial diagnosis and narrative scenario construction. The main objectives and methods used in these modules are presented and discussed in the light of the outcomes of the implementation of this educational programme. Discussion is focused on the main educational and research issues of this programme

Classification of and risk factors for hematologic complications in a French national cohort of 102 patients with Shwachman-Diamond syndrome.

International audienceBACKGROUND: Patients with the Shwachman-Diamond syndrome often develop hematologic complications. No risk factors for these complications have so far been identified. The aim of this study was to classify the hematologic complications occurring in patients with Shwachman-Diamond syndrome and to investigate the risk factors for these complications. DESIGN AND METHODS: One hundred and two patients with Shwachman-Diamond syndrome, with a median follow-up of 11.6 years, were studied. Major hematologic complications were considered in the case of definitive severe cytopenia (i.e. anemia <7 g/dL or thrombocytopenia <20 × 10(9)/L), classified as malignant (myelodysplasia/leukemia) according to the 2008 World Health Organization classification or as non-malignant. RESULTS: Severe cytopenia was observed in 21 patients and classified as malignant severe cytopenia (n=9), non-malignant severe cytopenia (n=9) and malignant severe cytopenia preceded by non-malignant severe cytopenia (n=3). The 20-year cumulative risk of severe cytopenia was 24.3% (95% confidence interval: 15.3%-38.5%). Young age at first symptoms (<3 months) and low hematologic parameters both at diagnosis of the disease and during the follow-up were associated with severe hematologic complications (P<0.001). Fifteen novel SBDS mutations were identified. Genotype analysis showed no discernible prognostic value. CONCLUSIONS Patients with Shwachman-Diamond syndrome with very early symptoms or cytopenia at diagnosis (even mild anemia or thrombocytopenia) should be considered at a high risk of severe hematologic complications, malignant or non-malignant. Transient severe cytopenia or an indolent cytogenetic clone had no deleterious value

3D reconstruction and comparison of shapes of DNA minicircles observed by cryo-electron microscopy

We use cryo-electron microscopy to compare 3D shapes of 158 bp long DNA minicircles that differ only in the sequence within an 18 bp block containing either a TATA box or a catabolite activator protein binding site. We present a sorting algorithm that correlates the reconstructed shapes and groups them into distinct categories. We conclude that the presence of the TATA box sequence, which is believed to be easily bent, does not significantly affect the observed shapes

En ville, sans ma voiture ! Evaluation du 22 septembre 2000 : résultats et analyses

A partir des enquêtes, des observations et des entretiens réalisés dans une douzaine de villes françaises et plusieurs villes étrangères, les principaux enseignements de la journée sont les suivants :- l'opinion publique locale est toujours très favorable à ce type d'opération (plus de 80 %), à l'exception des commerçants ; ce niveau de satisfaction est élevé dans tous les pays d’Europe, même s’il l’est un peu moins en Allemagne (autour de 70 %).- la fréquentation du centre ville est d’un niveau équivalent à un jour ordinaire, avec quelques disparités dans certaines villes selon les types de commerces ou de services, et les grandes surfaces périphériques n’ont pas plus de clients qu’un jour ordinaire;- l’usage de la bicyclette et de la marche s’accroît ainsi que la fréquentation des transports collectifs ;- en matière d’environnement, la baisse du niveau de bruit et surtout le changement d’ambiance sonore est apprécié par les citadins. On constate une baisse de pollution dans les périmètres réservés. Par contre, cette journée a peu d’influence sur les niveaux de pollution de fond

Familial hypercholesterolaemia in children and adolescents from 48 countries: a cross-sectional study

Background: Approximately 450 000 children are born with familial hypercholesterolaemia worldwide every year, yet only 2·1% of adults with familial hypercholesterolaemia were diagnosed before age 18 years via current diagnostic approaches, which are derived from observations in adults. We aimed to characterise children and adolescents with heterozygous familial hypercholesterolaemia (HeFH) and understand current approaches to the identification and management of familial hypercholesterolaemia to inform future public health strategies. Methods: For this cross-sectional study, we assessed children and adolescents younger than 18 years with a clinical or genetic diagnosis of HeFH at the time of entry into the Familial Hypercholesterolaemia Studies Collaboration (FHSC) registry between Oct 1, 2015, and Jan 31, 2021. Data in the registry were collected from 55 regional or national registries in 48 countries. Diagnoses relying on self-reported history of familial hypercholesterolaemia and suspected secondary hypercholesterolaemia were excluded from the registry; people with untreated LDL cholesterol (LDL-C) of at least 13·0 mmol/L were excluded from this study. Data were assessed overall and by WHO region, World Bank country income status, age, diagnostic criteria, and index-case status. The main outcome of this study was to assess current identification and management of children and adolescents with familial hypercholesterolaemia. Findings: Of 63 093 individuals in the FHSC registry, 11 848 (18·8%) were children or adolescents younger than 18 years with HeFH and were included in this study; 5756 (50·2%) of 11 476 included individuals were female and 5720 (49·8%) were male. Sex data were missing for 372 (3·1%) of 11 848 individuals. Median age at registry entry was 9·6 years (IQR 5·8-13·2). 10 099 (89·9%) of 11 235 included individuals had a final genetically confirmed diagnosis of familial hypercholesterolaemia and 1136 (10·1%) had a clinical diagnosis. Genetically confirmed diagnosis data or clinical diagnosis data were missing for 613 (5·2%) of 11 848 individuals. Genetic diagnosis was more common in children and adolescents from high-income countries (9427 [92·4%] of 10 202) than in children and adolescents from non-high-income countries (199 [48·0%] of 415). 3414 (31·6%) of 10 804 children or adolescents were index cases. Familial-hypercholesterolaemia-related physical signs, cardiovascular risk factors, and cardiovascular disease were uncommon, but were more common in non-high-income countries. 7557 (72·4%) of 10 428 included children or adolescents were not taking lipid-lowering medication (LLM) and had a median LDL-C of 5·00 mmol/L (IQR 4·05-6·08). Compared with genetic diagnosis, the use of unadapted clinical criteria intended for use in adults and reliant on more extreme phenotypes could result in 50-75% of children and adolescents with familial hypercholesterolaemia not being identified. Interpretation: Clinical characteristics observed in adults with familial hypercholesterolaemia are uncommon in children and adolescents with familial hypercholesterolaemia, hence detection in this age group relies on measurement of LDL-C and genetic confirmation. Where genetic testing is unavailable, increased availability and use of LDL-C measurements in the first few years of life could help reduce the current gap between prevalence and detection, enabling increased use of combination LLM to reach recommended LDL-C targets early in life