TRANSDERMIC TRANSPORT BY PORTABLE DEVICES: ANOTHER WAY TO APPLY COSMETICS

ABSTRACT: The skin is an important route of drug application. The outermost layer of skin, the stratum cornea is the first protective portion that hinders the permeability of substances. Physical methods such as ultrasonic peeling, ionization and electroporation can facilitate the entry of substance in the skin. The aim of the study was observe the ultrasonic peeling, the ionization and electroporation effects associated with Nano Gold fluid and Anti-winkle Serum in the skin. METHODS: Six Wistar animals were used and divided randomly into 3 groups of 2 animals each (a control group, a treated group with ultrasonic peeling plus Nano Gold fluid and another group treated with Dermoroller plus Anti-wrinkle Serum). The treatment lasted 10 days consecutive. RESULTS: The Histological analyzes showed a reduced in the cornea stratum and an increase of the epidermis in the group treated with ultrasonic peeling plus ionization and Nano Gold fluid. CONCLUSION: Furthermore, it was observed an increase in the fibroblasts with neoformation of collagen in the treated group with the Dermaroller plus serum anti-wrinkle

CORRELACIÓN ENTRE CONTROL DE TRONCO Y NÚMERO DE CAÍDAS EN ADULTOS MAYORES INSTITUCIONALIZADOS CON ACCIDENTE CEREBROVASCULAR

Objetivo: Identificar y analizar el valor predictivo del control de tronco en la mayor predisposición a sufrir una caída en un grupo de adultos mayores (AM) institucionalizados con accidente cerebrovascular (ACV), e incorporar la “Escala de evaluación postural para pacientes con ACV” (test PASS) como nuevo test predictor de caídas en AM que han sobrevivido a un ACV. Materiales y métodos: Un total de 20 AM con ACV de la Fundación Villa Padre Hurtado, participaron en el estudio prospectivo y recibieron evaluaciones iniciales de referencia de su control de tronco mediante el test PASS,  su estabilidad y riesgo de caída según el test Timed up and go (TUG), el nivel de funcionalidad y dependencia mediante el test Evaluación funcional del AM (EFAM) y por último, el nivel cognitivo con el test Minimental (MMSE). El número de caídas fue registrado por el personal de salud de la institución durante 5 meses, 1 de Agosto al 31 de Diciembre del año 2011. Resultados: Se observaron resultados estadísticamente significativos  (P<0,05) en la correlación entre el control de tronco y el riesgo a caer en pacientes institucionalizados con ACV. Discusión y Conclusión: Este estudio proporciona un importante valor predictivo al test PASS para el riesgo de caer en AM institucionalizados con ACV. Los resultados sugieren evaluaciones confiables y destaca el uso de intervenciones tempranas y tardías  en el control de tronco.Palabras clave: Caídas; adulto mayor; accidente cerebrovascula

Effects of the extracorporeal shock wave therapy on the skin : an experimental study

Extracorporeal shock wave therapy (ESWT) has been extensively studied for its multiple biological properties, and although it is widely applied in esthetical procedures, little is known about its effects on the epidermis and dermis. In this study, a histological and immunohistochemical study of the effects of ESWT was performed on rat skin. Forty-five female rats were treated with one or two sessions of ESWT and sacrificed on days 1, 7, 14, and 21 after treatment. The samples were histologically processed and then morphometric analyses were performed to assess the epidermis, dermis, and subcutaneous fat tissue thickness. Immunohistochemical reactions were also performed against the antibodies: basic fibroblastic growth factor (FGF2), its receptor (FGFR1), and alpha-smooth muscle actin. Slides were scanned and digitally assessed, to determine the microvessel density (MVD) and digital scoring of the immunohistochemical staining. The results showed that ESWT produced a significantly higher collagen content, MVD, and epidermis and dermis thickness than the control, non-treated group. Both in epidermis and dermis, FGF2 was overexpressed in the ESWT-treated groups, whereas FGFR1 was increased only in the group treated with two ESWT sessions at 21-days post-treatment. The ESWT-treated groups have also shown diminished thickness of subcutaneous fat tissue. In conclusion, ESWT induces neocollagenesis and neoangiogenesis, and upregulates the FGF2 expression, particularly in the groups treated with two sessions. Furthermore, it was demonstrated that overexpression of FGF2 on skins treated with ESWT seems to be a key role on its mechanism of action342389396CNPQ - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPESP – Fundação de Amparo à Pesquisa Do Estado De São Paulo145722/2013-9; 101367/2014-7; 117277/2014-22015/25905-