La Batalla de Madrid (1936-39). Excavaciones en las defensas de la capital

Con motivo de diferentes intervenciones arqueológicas en la Comunidad de Madrid motivadas por el impacto de diversas infraestructuras al Patrimonio Arqueológico (desarrollos urbanísticos, carreteras y líneas de alta velocidad) se ha tenido ocasión de excavar y documentar distintos tipos de restos pertenecientes a este período de nuestra historia reciente, correspondientes a varias posiciones de combate de la Guerra Civil Española (1936-1939), en el transcurso de la batalla de Madrid.The impact originated by several public infrastructures (urban development, roads and high-speed train) on the archaeological heritage of the Community of Madrid motivated a considerable number of archaeological interventions. This allowed us to excavate and document different kinds of remains related to this period of our recent history, particularly several fighting positions of the Battle of Madrid, which took place during the Spanish Civil War (1936-1939)

Simulations of Alfvénic modes in TJ-II Stellarator

Alfvénic modes are one of the subclass of instabilities prevalent in burning plasmas due to interaction of energetic particles with background plasma. In this paper we investigate the properties of these modes with 3D simulations using modeling tools STELLGAP [1] and AE3D [2] of Neutral Beam Injection (NBI) heated H-plasmas in TJ-II low-magnetic-shear flexible heliac (B0 = 0.95 T, = 1.5 m, = 0.22 m). These simulations focus on modelling the experimental observations [3] for prominent modes in TJ-II plasmas. Our simulations show consistency in frequency and radial location with the measured Alfvén Eigenmodes [3]. These simulations are performed for chirping and steady modes in TJ-II discharge # 29839 at t = 1150 and 1160ms respectively

Uses of digital platforms in Higher Education from the perspectives of the educational research

[EN] The University is currently a complex and a key system for the development of the scientific knowledge and the training of future professional workers. It is happening a global digital inclusion, specifically in the university context. This digital transformation is defined in different types of resources. The use of digital platforms is one of the clearest mainstreaming. The digital innovation at universities points out a challenge to their community. The challenge at the institutions consists of transforming the face-to-face training model into a flexible model, even a mixed model combining face-to-face with online training. In fact, it is necessary to talk about a change of paradigm when we conceptualise the university training towards new approaches in order to search for a sustainable teaching. This contribution aims to show the newest aspects from the educational research about the changes in the Spanish university teaching. From the different reviewed reports, it is added some data about the implementation of virtual or digital platforms into the Spanish university system. This review affirms the generalised use of this type of resource. There are other analysed aspects about the impact of this technological tool to the teaching. Some proposals are added to consider in future lines of research, such us the emerging technologies which start to be used in educational contexts. We talk about learning analytics, makerspaces, active learning or adaptative learning. In short, it is affirmed the technological transformation towards the improvement of a more scalable and sustainable system.[ES] La universidad constituye un sistema complejo, que resulta clave para el desarrollo del conocimiento científico y la formación de profesionales. La integración digital que se está implantando a nivel global también se está produciendo en las instituciones universitarias. Esta transformación digital se viene concretando en diferentes desarrollos, siendo el del uso de plataformas digitales uno de los más evidentes. La innovación digital de las universidades plantea el reto a sus responsables de reconvertir a estas organizaciones, caracterizadas por un modelo formativo basado en la presencialidad, por otro más flexible o mixto en el que coexisten la actividad presencial y en línea (a distancia). De hecho, cabe hablar de un cambio de paradigma en la concepción de la formación universitaria, que se reorienta hacia nuevos enfoques, buscando una enseñanza más sostenible. Este texto plantea una puesta al día sobre lo que la investigación educativa nos aporta sobre estos cambios en la docencia universitaria española. A partir de diferentes informes consultados, se aportan una serie de datos sobre la implantación de las plataformas digitales o virtuales en el sistema universitario español, confirmando su uso generalizado. También se analizan algunos aspectos sobre el impacto que estas tecnologías aportan a la docencia. Además, se hacen algunas consideraciones de carácter prospectivo, y en esta línea se identifican algunas tecnologías emergentes que comienzan a ser empleadas en entornos educativos tales como: Learning Analytics, Makerspaces, Active Learning o Adaptative Learning. En síntesis, se constata una transformación tecnológica orientada a favorecer un aprendizaje más escalable y sostenible.De Pablos, J.; Colás, M.; López Gracia, A.; García-Lázaro, I. (2019). Los usos de las plataformas digitales en la enseñanza universitaria. Perspectivas desde la investigación educativa. REDU. Revista de Docencia Universitaria. 17(1):59-72. https://doi.org/10.4995/redu.2019.11177SWORD597217

Photopolymerization of ionic liquids in flexible microporous aramids for ion conductive solid polyelectrolytes

This work presents the preparation of novel solid polymer electrolytes based on flexible microporous aramids filled with photopolymerized ionic liquids and lithium salt. The materials combined a high ionic conductivity with the mechanical and thermal characteristics of the aramids, including also good flexibility and handleability. First, a simple casting process was followed to obtain microporous aramids with an interconnected channel morphology. In a second step, this channel structure was filled with a solution of non-commercial photopolymerizable ionic liquid, commercial ionic liquids and the lithium salt, followed by UV irradiation to obtain the conducting aramids. Ionic conductivity of the materials was studied at 25 °C, and also in the temperature range between −50 to 90 °C, together with SEM analyses of the filled porous structure and thermal properties, to fully characterize the photopolymerization process of the ionic liquids inside the porous structure. The materials showed high ionic conductivity values together with excellent thermal and mechanical properties, indicating their viability as flexible and thermally stable solid electrolytes.FEDER (Fondo Europeo de Desarrollo Regional) and both the Spanish Ministerio de Economía, Industria y Competitividad (MAT2017-84501-R and MAT2017-88923-P), the Consejería de Educacion-Junta ´ de Castilla y Leon ´ (BU306P18) and the Spanish Ministerio de Ciencia e Innovacion ´ (PID2019-108583RJ-I00/AEI/10.13039/501100011033)

A Model to Define an eHealth Technological Ecosystem for Caregivers

The ageing of world population has a direct impact on the health and care systems, as it means an increase in the number of people needing care which leads to higher care costs and the need for more resources. In this context, informal caregivers play an important role as they enable dependent persons to stay at home and thus reduce care costs. However, long-term continuous care provision has also an impact in the physical and mental health of the caregivers. Moreover, geographical barriers make it difficult for caregivers to accessing psychoeducation as a way to alleviate their problems. To support caregivers in their needs and provide specialized training, technology plays a fundamental role. The present work provides the theoretical basis for the development of a technological ecosystem focused on learning and knowledge management processes to develop and enhance the caregiving competences of formal and informal caregivers, both at home and in care environments. In particular, a platform-specific model to support the definition of the ecosystem based on Open Source software components is presented, along with a Business Model Canvas to define the business structure as part of the human elements of the technological ecosystem

Porous aromatic polyamides the easy and green way

We prepared microporous aramid films through a simple, inexpensive and green way, using ionic liquids (IL) as porosity promoters. Commercial poly(m-phenylene isophthalamide) (MPIA) films with different IL proportions were prepared, and then microporous films were obtained by removing the IL in distilled water. Microporous films presented density values between 0.34 and 0.71 g⋅cm−3 (around five times lower to commercial MPIA), with a homogeneous and controlled cellular morphology dependent on the proportion of the IL, showing cell sizes in the microcellular range (radii between 1 and 8 µm). Thermal, mechanical and electrical properties (specifically ionic conductivity) of the aramid films were analyzed to evaluate the influence of the IL proportion. Finally, it was observed that the MPIA/IL system presented a reversible thermally induced phase-separation process around 60 °C, which was characterized through AFM-Raman images and spectra, together with the variation of the ionic conductivity.FEDER (Fondo Europeo de Desarrollo Regional) and both the Spanish Agencia Estatal de Investigación (MAT2017-84501-R) and the Consejería de Educación-Junta de Castilla y León (BU306P18

The Koskobilo (Olazti, Navarre, Northern Iberian Peninsula) paleontological collection: New insights for the Middle and Late Pleistocene in Western Pyrenees

The destroyed site(s) of Koskobilo (Olazti, Navarre, Northern Iberian Peninsula) have yielded unique archaeo-paleontological evidence in the Western Pyrenees region. The quarry uncovered a karstic site with faunal remains in 1940, and fossils were recovered both in situ and from the quarry dump. Ten years later, while the quarry was still working, a new visit to the dump yielded a large lithic assemblage and additional fossil remains with a different taphonomic pattern, which has been interpreted as the remains coming from a different site or zone within the same karst system. Here we re-study the paleontological evidence and provide new dating on a speleothem covering a Stephanorhinus hemitoechus tooth, which has yielded a minimum date of c. 220 ka for part of the assemblage. In total, the fossil assemblage comprises 38 mammal and six avian taxa and three fish remains. The faunal evidence indicates that in 1940 a mix of taxa from both the Middle and Upper Pleistocene were recovered, and it is difficult to assign most of them to a concrete period. However, based on biochronological criteria some of the identified taxa (e.g., Ursus thibetanus, Ursus cf. deningeri, Cuon cf. priscus, Macaca sylvanus, cf. Megaceroides) could be roughly contemporaneous with the dated rhino tooth, which would provide a new window to the Middle Pleistocene of the region, with deposits from MIS 7d and/or older. Despite the difficulties in studying this collection, recovered without stratigraphic context and in a salvage operation, Koskobilo has yielded an important paleontological assemblage which helps to understand the paleoecology of the Middle Pleistocene human occupations in the Western Pyrenees

New data on the Quaternary of Navarre: the paleontological collection from Koskobilo (Olazti/Olazagutía)

Libro de resúmenes disponible para su descarga gratuita en el enlace: http://www.aranzadi.eus/catalogo/xv-reunion-nacional-cuaternario-libro-de-resumenesThe archaeopaleontological collection from Koskobilo is composed of hundreds of fossil and thousands of lithic remains, mostly recovered during the middle part of the 20th century. Here we present the complete paleontological study of the collection, which includes 36 mammal taxa, 6 avian taxa and a small fish vertebral collection. Additionally we have performed direct dating of a speleothem crust covering one of the rhinoceros teeth, which provides a minimum of 219 ka for part of the collection, the rest being from the Upper Pleistocene, mixed with some Holocene/recent elements. The paleontological collection from Koskobilo is one of the most important in the Western Pyrenees due to the scarcity of the local Middle Pleistocene fossil record and the rarity of some of the taxa represented, such as Ursus thibetanus, Macaca sylvanus and cf. Megaceroides.La presente investigación ha contado con el apoyo del grupo de investigación IT1044-16 de Eusko Jaurlaritza-Gobierno Vasco, del Grupo PPG17/05 de la Universidad del País Vasco-Euskal Herriko Unibertsitatea y del Ministerio de Ciencia, Innovación y Universidades (proyecto PGC2018-093925-B-C33)

The Absence of Caspase-8 in the Dopaminergic System Leads to Mild Autism-like Behavior

In the last decade, new non-apoptotic roles have been ascribed to apoptotic caspases. This family of proteins plays an important role in the sculpting of the brain in the early stages of development by eliminating excessive and nonfunctional synapses and extra cells. Consequently, impairments in this process can underlie many neurological and mental illnesses. This view is particularly relevant to dopamine because it plays a pleiotropic role in motor control, motivation, and reward processing. In this study, we analyze the effects of the elimination of caspase-8 (CASP8) on the development of catecholaminergic neurons using neurochemical, ultrastructural, and behavioral tests. To do this, we selectively delete the CASP8 gene in cells that express tyrosine hydroxylase with the help of recombination through the Cre-loxP system. Our results show that the number of dopaminergic neurons increases in the substantia nigra. In the striatum, the basal extracellular level of dopamine and potassium-evoked dopamine release decreased significantly in mice lacking CASP8, clearly showing the low dopamine functioning in tissues innervated by this neurotransmitter. This view is supported by electron microscopy analysis of striatal synapses. Interestingly, behavioral analysis demonstrates that mice lacking CASP8 show changes reminiscent of autism spectrum disorders (ASD). Our research reactivates the possible role of dopamine transmission in the pathogenesis of ASD and provides a mild model of autism.Ministerio de Economía y Competitividad RTI2018-098645-B-I00, PID2019-109569GB-I00, RTI2018-099778-B-I00Junta de Andalucía P18-RT-1372, US-1264806, PI-0080-2017, PI-0009-2017, PI-0134-2018, PEMP-0008-2020, P20_00958, CTS-510Instituto de Salud Carlos III PI18/01691Instituto de Investigación e Innovación en Ciencias Biomédicas de Cádiz-INiBICA LI19/06IN-CO22, IN-C09European Union 95568

The C-terminal region of Trypanosoma cruzi MASPs is antigenic and secreted via exovesicles.

Trypanosoma cruzi is the etiological agent of Chagas disease, a neglected and emerging tropical disease, endemic to South America and present in non-endemic regions due to human migration. The MASP multigene family is specific to T. cruzi, accounting for 6% of the parasite's genome and plays a key role in immune evasion. A common feature of MASPs is the presence of two conserved regions: an N-terminal region codifying for signal peptide and a C-terminal (C-term) region, which potentially acts as GPI-addition signal peptide. Our aim was the analysis of the presence of an immune response against the MASP C-term region. We found that this region is highly conserved, released via exovesicles (EVs) and has an associated immune response as revealed by epitope affinity mapping, IFA and inhibition of the complement lysis assays. We also demonstrate the presence of a fast IgM response in Balb/c mice infected with T. cruzi. Our results reveal the presence of non-canonical secreted peptides in EVs, which can subsequently be exposed to the immune system with a potential role in evading immune system targets in the parasite