Bone Regeneration with Wharton's Jelly-Bioceramic-Bioglass Composite

The aim of this development is to optimize a bone substitute (BS) for use in tissue engineering. This is achieved through the combination of three phases in a biocomposite (BCO), in which each is reabsorbed in the site of implantation and replaced by autologous bone (patient´s own). The inorganic phases are composed of irregular particles (150-300 microns) obtained by milling and sieving of a biphasic bioceramic (BC) of hydroxyapatite (HA of bovine origin) with 40% (wt.) β-tricalcium phosphate (β- TCP, obtained by chemical synthesis) and Bioglass type 45S5 (45SiO2 -24,5CaO - 24,5Na2O - 6P2O5, in % wt.). Instead, the organic phase consists of collagen extracted from Wharton´s jelly (part of the human embryonic tissue) from physical and chemical self-developed process. The BC is produced by mixture of HA and β-TCP (Bone Regeneration with Wharton´s Jelly-Bioceramic-Bioglass Composite. Available from: Fil: Fernández, C.A.. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Química; ArgentinaFil: Martínez, C.A.. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Química; Argentina. Universidad Nacional de Cuyo. Facultad de Odontologia; ArgentinaFil: Prado, Miguel Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Comision Nacional de Energia Atomica. Gerencia de Area de Aplicaciones de la Tecnología Nuclear. Gerencia de Investigación Aplicada. Grupo de Materiales Nucleares; ArgentinaFil: Olmedo, Daniel Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaFil: Ozols, Andres. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentin

Estado Da Arte Da Literatura Científica Sobre Hancornia Speciosa: Tendências E Lacunas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)The economic and scientific interest in Hancornia speciosa (mangabeira) has been growing in recent years, mainly due to the marketing of fruit and extraction of natural compounds with high pharmacological potential. In this study, a scientometric survey about mangabeira was carried out in order to promote and direct future studies on the species. As a result, low scientific productivity associated with this species was found, with only 131 articles published in the last 69 years. In addition, this study identified some trends in bibliographic production on mangabeira, among them: the increasing number of articles over the years; scientific dissemination in nationwide journals; the main focus of this study is associated with agronomic studies; the experimental approach is more frequent and usually associated with populations of restricted geographical distribution; and the scientific production is mainly from education institutions. Furthermore, this study also allowed the identification of some gaps in knowledge about mangabeira, among them the difficulty in describing and characterizing botanical lines; lack of analysis of the genetic diversity of widely distributed populations; lack of management and conservation projects for the species; lack of description of cultivation, collection and preservation techniques of fruits; and lack of identification of natural compounds responsible for its pharmacological activity. It is expected that the data generated in this study will serve to direct future studies on H. speciosa. © 2016, Sociedade Brasileira de Fruticultura. All rights reserved.384CAPES, Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorCNPq, Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEG, Fundação de Amparo à Pesquisa do Estado de GoiásFINEP, Financiadora de Estudos e ProjetosCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

The Fluorescence Detector of the Pierre Auger Observatory

The Pierre Auger Observatory is a hybrid detector for ultra-high energy cosmic rays. It combines a surface array to measure secondary particles at ground level together with a fluorescence detector to measure the development of air showers in the atmosphere above the array. The fluorescence detector comprises 24 large telescopes specialized for measuring the nitrogen fluorescence caused by charged particles of cosmic ray air showers. In this paper we describe the components of the fluorescence detector including its optical system, the design of the camera, the electronics, and the systems for relative and absolute calibration. We also discuss the operation and the monitoring of the detector. Finally, we evaluate the detector performance and precision of shower reconstructions.Comment: 53 pages. Submitted to Nuclear Instruments and Methods in Physics Research Section

Update on the correlation of the highest energy cosmic rays with nearby extragalactic matter

Data collected by the Pierre Auger Observatory through 31 August 2007 showed evidence for anisotropy in the arrival directions of cosmic rays above the Greisen-Zatsepin-Kuz'min energy threshold, \nobreak{$6\times 10^{19}$eV}. The anisotropy was measured by the fraction of arrival directions that are less than $3.1^\circ$ from the position of an active galactic nucleus within 75 Mpc (using the V\'eron-Cetty and V\'eron $12^{\rm th}$ catalog). An updated measurement of this fraction is reported here using the arrival directions of cosmic rays recorded above the same energy threshold through 31 December 2009. The number of arrival directions has increased from 27 to 69, allowing a more precise measurement. The correlating fraction is $(38^{+7}_{-6})$, compared with $21$ expected for isotropic cosmic rays. This is down from the early estimate of $(69^{+11}_{-13})$. The enlarged set of arrival directions is examined also in relation to other populations of nearby extragalactic objects: galaxies in the 2 Microns All Sky Survey and active galactic nuclei detected in hard X-rays by the Swift Burst Alert Telescope. A celestial region around the position of the radiogalaxy Cen A has the largest excess of arrival directions relative to isotropic expectations. The 2-point autocorrelation function is shown for the enlarged set of arrival directions and compared to the isotropic expectation.Comment: Accepted for publication in Astroparticle Physics on 31 August 201