Caracterización Macroscópica De Morteros Romanos De Tipo Industrial En Villamanta (Madrid). Primeros Datos

The objective of this article is to show the results obtained from the physical and macroscopic characterization of the mortars sampled by Isabel Marqués and Alejandro Bermúdez, archaeological directors of the intervention carried out in El Tejar settlement, in the municipality of Villamanta (Madrid, Spain). The results of this work have determined a relevant typological classification among the samples, highlighting the presence of siliceous aggregates, ceramics in some mortars, a very varied grading and a distribution of the components that have conditioned the conservation. Of the four samples taken -VMT1 to VMT4- one of them has an aqueous pigmentation, belonging to an inside plaster, while the others correspond to lime mortars with aggregates from hydraulic surfaces. The archaeological investigation of the deposit of Villamanta is complemented by an implementation check of lime mortars, being one of the most important Roman context of Madrid. This research add a sequence of new results around the Roman mortars and implements a methodology in the study of the historical mortars

LA BIOGRAFÍA ARQUITECTÓNICA: UNA ALTERNATIVA PARA CARACTERIZAR LOS ASENTAMIENTOS ILERGETES DURANTE LA ÉPOCA DE CONQUISTA

Resumen: La conquista de  la Península Ibérica, originó en el nordeste peninsular la hibridación cultural entre dos etnias bien diferenciadas, conocidas como los pueblos ibéricos y los romanos, cuya plasmación más impresionante se dio en los cambios arquitectónicos de los asentamientos indígenas a partir de época republicana.El objetivo de este trabajo ha sido analizar dichas alteraciones en las planimetrías originales, tomando como muestra cinco poblados ilergetes de las zonas de interior, repartidos entre tres comarcas actuales diferenciadas geográficamente.Sometiendo a examen   dichas estructuras se ha pretendido no sólo analizar los cambios funcionales y estructurales, sino también establecer una categorización mediante un eje cronológico y geográfico, ofreciendo una imagen lo más completa posible de las variaciones en los patrones de poblamiento desde  el siglo III a.C. hasta el cambio de Era, amén de los cambios coyunturales que acompañaron a este proceso

Reseña de 'Ciencias sociales y educación infantil (3-6). Cuando despertó el mundo estaba allí'

El libro que se reseña pretende ser una aportación que ayude a los maestros y maestras en activo, y también a los que se encuentran en su etapa de formación, a trabajar las Ciencias Sociales en el aula desde una perspectiva científica y global. Esta obra aborda diversas cuestiones relacionadas con el reto de una enseñanza-aprendizaje de las Ciencias Sociales de nuestro tiempo para nuestro tiempo. Los niños y las niñas de educación infantil están en una etapa de desarrollo en la que necesitan construir su identidad, conocerse a ellos mismos y la realidad social que les rodea, y en este libro se da respuesta a ello desde las Ciencias Sociales. La educación infantil coherente debe asentar firmemente los cimientos que permitan el desarrollo de toda la posterior trayectoria educativa. Como comentan los autores, el asentamiento de unas buenas bases "pueden ayudar a prevenir problemas posteriores, en momentos en los que intervenir se convierte en una tarea más compleja". (p. 8)

Perfil lipídico y contenido en cla en carne de potros de razas hispano-bretón y burguete

Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria RZ2004-00023-00-0

Molecular detection of Tritrichomonas foetus in bovine samples: a novel real-time polymerase chain reaction (PCR) assay targeting EF1-alpha-Tf1 and a comparative study of published PCR techniques

The parasite T. foetus causes trichomonosis in cattle but is generally asymptomatic in males. Thus, many bulls carrying the disease go unnoticed, making the detection of T. foetus in bulls an important aspect for its control. Due to drawbacks posed by its cultivation, PCR is a preferred option for diagnostic laboratories. Most published PCR protocols target the genomic region compring the 18S, 5.8S, and 28S rRNA genes and internal transcribed spacers 1 and 2 (rRNA-ITS region), homologous to that of other Tritrichomonas species. There is minimal information on alternative genetic targets and no comparative studies have been published. We compared a protocol based on the microsatellite TfRE (called H94) and five protocols based on the rRNA-ITS region (called M06, M15, G02, G05, and N02). We also designed and evaluated a novel PCR-based assay on the EF1-alpha-Tf1 gene (called V21). The analytical sensitivity and specificity assays for the PCR protocols were performed according to the World Organisation for Animal Health (OIE) directives and the comparative study was performed with a widely used PCR (M06) on clinical samples from 466 breeding bulls. V21 showed a high degree of agreement with our reference M06 (kappa = 0.967), as well as M15 (kappa = 0.958), G05 (kappa = 0.948), and H94 (kappa = 0.986). Protocols H94 and V21 appear to be good approaches for confirming clinical cases in preputial bull samples when genomic regions alternative to rRNA-ITS are required. By contrast, N02 gave false negatives and G02 false positives

Broadening the antibacterial spectrum of histidine kinase autophosphorylation inhibitors via the use of epsilon-poly-L-lysine capped mesoporous silica-based nanoparticles

[EN] Two-component systems (TCS) regulate diverse processes such as virulence, stress responses, metabolism and antibiotic resistance in bacteria but are absent in humans, making them promising targets for novel antibacterials. By incorporating recently described TCS histidine kinase autophosphorylation inhibitors (HKAIs) into epsilon-poly-L-lysine capped nanoparticles (NPs) we could overcome the Gram negative (Gr(-)) permeability barrier for the HKAIs. The observed bactericidal activity against Gr(-) bacteria was shown to be due to the enhanced delivery and internalization of the HKAIs and not an inhibitory or synergistic effect of the NPs. The NPs had no adverse effects on mammalian cell viability or the immune function of macrophages in vitro and showed no signs of toxicity to zebrafish larvae in vivo. These results show that HKAIs are promising antibacterials for both Gr(-) and Gr + pathogens and that NPs are a safe drug delivery technology that can enhance the selectivity and efficacy of HKAIs against bacteria. (C) 2016 Elsevier Inc. All rights reserved.This work was funded by FP7 ITN STARS-Scientific Training in Antimicrobial Research Strategies (Contract No. PITN-GA-2009-238490, J.M.W., A.M.), H2020 MSCA IF (AND-659121, N.V.), grant BIO2013-42619-P from the Ministerio de Economia y Competitividad (A.M.), grant from the Spanish Government (Project MAT2015-64139-C4-1-R,N. M., J.R.M, R.M.M.), and a grant from Generalitat Valenciana (Project PROMETEOII/2014/047, N.M.). and Prometeo II/2014/029, A.M.).Velikova, N.; Mas Font, N.; Miguel-Romero, L.; Polo, L.; Stolte, E.; Zaccaria, E.; Cao, R.... (2017). Broadening the antibacterial spectrum of histidine kinase autophosphorylation inhibitors via the use of epsilon-poly-L-lysine capped mesoporous silica-based nanoparticles. Nanomedicine Nanotechnology Biology and Medicine. 13(2):569-581. https://doi.org/10.1016/j.nano.2016.09.011S56958113