Assessing Urban Density: A Multidimensional Model

Compact urban development is today widely pursued on sustainability, cost-effectiveness, equity, health, and place-making grounds. Starting with an examination of the different benefits related to urban density, this thesis investigates the complexity and multidimensionality of the densification process. Establishing that improperly planned, compaction creates undesirable urban environments and undermine residents' quality of life, the research identifies five necessary conditions to successful densification. Suitable compact development is accompanied by a mix of uses, a provision of public transit, a social inclusiveness, and an access to open space, along with the increase of residential density. Based on this conclusion, five performance indicators of suitable density are selected and aggregated into a composite index aiming to assess density holistically. This work is concluded by applying the created index to two particularly relevant density case studies: Portland (OR) Downtown Waterfront Urban Renewal Area and Amsterdam IJburg

Charles Perrault : memoirs of my life

Includes bibliographical references and index.It is impossible to know whether Perrault intended the Memoirs to be published. There are early references to "your uncles," identifying Perrault's children as his immediate audience; however, he offered nothing about his own parents, and very little of the anecdotal information about his upbringing or childhood experiences that would be natural to include in a family history. Instead, Perrault focused upon his career, offering observations on the various situations he had encountered and the Individuals with whom he had dealt. In this sense, the Memoirs are more of a selfapology; they offer Perrault's side of the story, in defense against how he had been depicted by his enemies, and finally giving release to many of the thoughts that diplomacy had prevented him from expressing at the time of the actual events .A note on the text -- The early years -- Colbert and the academies -- The Louvre -- Art, patronage, and power -- Public service, private struggle.Digitized at the University of Missouri--Columbia MU Libraries Digitization Lab in 2012. Digitized at 600 dpi with Zeutschel, OS 15000 scanner. Access copy, available in MOspace, is 400 dpi, grayscale

Biocompatible polymer-assisted dispersion of multi walled carbon nanotubes in water, application to the investigation of their ecotoxicity using Xenopus laevis amphibian larvae

Carbon nanotubes (CNTs) tend to readily agglomerate and settle down in water, while the adsorption of compounds present in natural aquatic media could enhance their dispersion and stabilization in the water column. We designed a new exposure protocol to compare the biological responses of Xenopus laevis larvae exposed in semi-static conditions to size-reduced agglomerates of multi-walled carbon nanotubes (MWCNTs) in suspension in the water column and/or to larger agglomerates. Suspensions were prepared using a combination of a non-covalent functionalization with a non-toxic polymer (either carboxymethylcellulose, CMC, or gum arabic, GA) and mechanical dispersion methods (mainly ultrasonication). The ingestion of agglomerates which have settled down was incriminated in the disruption of the intestinal transit and the assimilation of nutrients, leading to acute and chronic toxicities at the highest tested concentrations. Rise in mortality, decrease in the growth rate and induction of genotoxicity from low concentrations (1 mg/L in the presence of CMC) were evidenced in presence of suspended MWCNTs in the water column. The biological responses seemed to be modulated when GA, a potential antioxidant, was used. We hypothesized that MWCNTs should interfere mainly at the surface of the gills, acting as a potential respiratory toxicant and generally inducing indirect effects

Plasma proteomics of green turtles (\u3cem\u3eChelonia mydas\u3c/em\u3e) reveals pathway shifts and potential biomarker candidates associated with health and disease

Evaluating sea turtle health can be challenging due to an incomplete understanding of pathophysiologic responses in these species. Proteome characterization of clinical plasma samples can provide insights into disease progression and prospective biomarker targets. A TMT-10-plex-LC–MS/MS platform was used to characterize the plasma proteome of five, juvenile, green turtles (Chelonia mydas) and compare qualitative and quantitative protein changes during moribund and recovered states. The 10 plasma samples yielded a total of 670 unique proteins. Using ≥1.2-fold change in protein abundance as a benchmark for physiologic upregulation or downregulation, 233 (34.8%) were differentially regulated in at least one turtle between moribund and recovered states. Forty-six proteins (6.9%) were differentially regulated in all five turtles with two proteins (0.3%) demonstrating a statistically significant change. A principle component analysis showed protein abundance loosely clustered between moribund samples or recovered samples and for turtles that presented with trauma (n = 3) or as intestinal floaters (n = 2). Gene Ontology terms demonstrated that moribund samples were represented by a higher number of proteins associated with blood coagulation, adaptive immune responses and acute phase response, while recovered turtle samples included a relatively higher number of proteins associated with metabolic processes and response to nutrients. Abundance levels of 48 proteins (7.2%) in moribund samples significantly correlated with total protein, albumin and/or globulin levels quantified by biochemical analysis. Differentially regulated proteins identified with immunologic and physiologic functions are discussed for their possible role in the green turtle pathophysiologic response and for their potential use as diagnostic biomarkers. These findings enhance our ability to interpret sea turtle health and further progress conservation, research and rehabilitation programs for these ecologically important species

La Cenerentola

De cada obra s'ha digitalitzat un programa sencer. De la resta s'han digitalitzat les parts que són diferents.Empresa: Juan A. PamiasOrquestra del Gran Teatre del Liceu dirigida per Franco FerrarisÒpera de Gioachino Rossini i llibret de Jacopo Ferretti sobre un conte de Perraul

Cultivating epizoic diatoms provides insights into the evolution and ecology of both epibionts and hosts

11 pages, 3 figures, 1 table, supplementary information https://doi.org/10.1038/s41598-022-19064-0.-- Data availability: DNA sequence data generated for this study are published on the NCBI GenBank online sequence depository under the accession numbers listed in Table S1. Additional micrographs and cleaned voucher material from the sequenced cultures are available from lead author MPAOur understanding of the importance of microbiomes on large aquatic animals—such as whales, sea turtles and manatees—has advanced considerably in recent years. The latest observations indicate that epibiotic diatom communities constitute diverse, polyphyletic, and compositionally stable assemblages that include both putatively obligate epizoic and generalist species. Here, we outline a successful approach to culture putatively obligate epizoic diatoms without their hosts. That some taxa can be cultured independently from their epizoic habitat raises several questions about the nature of the interaction between these animals and their epibionts. This insight allows us to propose further applications and research avenues in this growing area of study. Analyzing the DNA sequences of these cultured strains, we found that several unique diatom taxa have evolved independently to occupy epibiotic habitats. We created a library of reference sequence data for use in metabarcoding surveys of sea turtle and manatee microbiomes that will further facilitate the use of environmental DNA for studying host specificity in epizoic diatoms and the utility of diatoms as indicators of host ecology and health. We encourage the interdisciplinary community working with marine megafauna to consider including diatom sampling and diatom analysis into their routine practicesFinancial support for sequencing and SEM comes from the Jane and the Roland Blumberg Centennial Professorship in Molecular Evolution at UT Austin and the US Department of Defense (grant number W911NF-17-2-0091). Sampling in South Africa was done with partial financial support from The Systematics Association (UK) through the Systematics Research Fund Award granted to RM (2017 and 2020). Work in the Adriatic Sea was supported by Croatian Science Foundation, project UIP-05-2017-5635 (TurtleBIOME). KF has been fully supported by the “Young researchers' career development project – training of doctoral students” of the CSF funded by the EU from the European Social Fund. NJR was funded by the Spanish government (AEI) through the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000928-S)Peer reviewe

Os retratos de Maria Isabel e Maria Francisca de Bragança, de Nicolas-Antoine Taunay

Nicolas-Antoine Taunay, French landscape painter, produced also several portraits during his stay at the Rio de Janeiro Court. In this city, in 1816, he paints the queen Carlota Joaquina and all her daughters. In this group, two portraits have a very special way: the paintings still today catalogued as Maria Francisca and Maria Teresa, but probably being Maria Isabel and Maria Francisca de Assis - princesses that, in this year, left Brazil to marry the Spanish King Fernando VII, and his brother Carlos Maria Isidro de Bourbon. In this article, beyond to describe these portraits (and analyse the identities of the portrayed princesses), I analyse their functions in the Court society and the mains artists of this gender in Europe. I will discuss, as well, the hypothesis about the Taunay choices. In this sense, I will analyse the possible circulation of the typologies of portrait between Italy, Portugal, Spain and France, understanding these productions by Taunay and the functions occupied by these portraits in the political relations between Brazil and Europe.Nicolas-Antoine Taunay, pintor de paisagens francês, também realizou alguns retratos durante sua estadia na corte do Rio de Janeiro. Nessa cidade, em 1816, ele pinta a rainha Carlota Joaquina e todas as suas filhas. Nesse conjunto, dois retratos sobressaem-se de modo especial: os hoje ainda inventariados como de Maria Francisca e de Maria Teresa, mas que provavelmente são o de Maria Isabel e o de Maria Francisca de Assis - princesas que, nesse ano, deixavam o Brasil para casar-se, respectivamente, com Fernando VII, o rei espanhol, e com seu irmão Carlos Isidro de Bourbon. Neste artigo, além de descrevermos os retratos (e analisarmos a questão da identidade das princesas retratadas), abordamos suas funções na sociedade das cortes e os principais artistas do gênero na Europa. Discutimos, também, as hipóteses que permeiam as escolhas de Taunay para sua execução. Nesse sentido, tratamos da possível circulação de tipologias entre Itália, Portugal, Espanha e França, buscando entender a forma como Taunay os realizou e as funções que doravante tais retratos ocupariam nas relações entre o Brasil e a Europa.Universidade Federal de São Paulo (UNIFESP)UNIFESPSciEL

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Cuentos de hadas y otras narraciones

Contén: Griselda, p. 35-61 ; Piel de Asno, p. 63-78 ; Los deseos ridículos, p.79-86 ; La bella durmiente del bosque, p. 93-106 ; Capurecita Encarnada, p. 107-112 ; Barba Azul, p. 113-122 ; Maese Gato o El gato de cristal, p. 123-130 ; Las Hadas, p. 131-136 ; Cenicienta o El zapatito de cristal, p. 137-146 ; Riquete el del Copete, p. 147-156 ; Pulgarcito, p. 157-170 ; La sagaz Princesa o Las aventuras de Picarilla, p. 171-19