Surgical repair of post-infarction ventricular free-wall rupture in the Netherlands: data from a nationwide registry

Background: Ventricular free-wall rupture (VFWR) is an infrequent but catastrophic complication of acute myocardial infarction (AMI). Most reports about outcome after surgical treatment are single-center experiences. We examined the early and mid-term outcomes after surgical repair of post-AMI VFWR using the Netherlands Heart Registration (NHR) database. Methods: We included data from NHR patients (>18 years old) who underwent surgery for post-AMI VFWR between 2014 and 2019. The primary end-point was in-hospital mortality. Secondary outcomes included postoperative complications and mid-term survival. Results: The study included 148 patients (54.7% male, mean age 66.5±11.1 years). Critical preoperative status was found in 62.6% of subjects. In-hospital mortality was 31.1% (46 of 148). Multivariable analysis identified female sex [odds ratio (OR), 5.49; 95% confidence interval (CI): 2.24–13.46] and critical preoperative status (OR, 4.06; 95% CI: 1.36–12.13) as independent predictors of in-hospital mortality. The overall median postoperative follow-up was 2.2 (interquartile range, 0.7–3.8) years. Overall survival rates at three and five years were 58.9% and 55.7%, respectively. Among hospital survivors, only 15 (14.7%) patients died during follow-up, with a five-year survival rate of 80.8%. Conclusions: In-hospital mortality after surgical repair of post-AMI VFWR is considerable. Female sex and preoperative critical status are independent predictors of early postoperative (in-hospital) death. Logistic EuroSCORE I can reliably predict in-hospital mortality (optimal cut-off >33%). Mid-term follow-up of patients surviving in-hospital course shows excellent results

Neutron star matter equation of state and gravitational wave emission

The EOS of strongly interacting matter at densities ten to fifteen orders of magnitude larger than the typical density of terrestrial macroscopic objects determines a number of neutron star properties, including the pattern of gravitational waves emitted following the excitation of nonradial oscillation modes. This paper reviews some of the approaches employed to model neutron star matter, as well as the prospects for obtaining new insights from the experimental study of gravitational waves emitted by neutron stars.Comment: 15 pages, 8 figures. To be published as a Brief Review in Modern Physics Letters

The nonmesonic weak decay of the hypertriton

The nonmesonic decay of the hypertriton is calculated based on a hypertriton wavefunction and 3N scattering states, which are rigorous solutions of 3-body Faddeev equations using realistic NN and hyperon-nucleon interactions. The pion-exchange together with heavier meson exchanges for the $\Lambda N \to N N$ transition is considered. The total nonmesonic decay rate is found to be 0.5% of the free $\Lambda$ decay rate. Integrated as well as differential decay rates are given. The p- and n- induced decays are discussed thoroughly and it is shown that the corresponding total rates cannot be measured individually.Comment: 27 pages, 20 figures, revtex, submitted to Phys. Rev.

Hyperon-hyperon interactions and properties of neutron matter

We present results from Brueckner-Hartree-Fock calculatons for beta stable neutron star matter with nucleonic and hyperonic degress degrees of freedom, employing the most recent parametrizations of the baryon-baryon interaction of the Nijmegen group. It is found that the only strange baryons emergin in beta stable matter up to total barionic densities of 1.2 fm^-3 are $\Sigma^-$ and $\Lambda$. The corresponding equations of state are then used to compute properties of neutron stars such as masses and radii.Comment: 27 pages, LateX, includes 8 PostScript figures, (submitted to PRC

Associated strangeness production at threshold

The associated strangeness dissociation at threshold has been studied at the COSY-11 facility measuring the hyperon - and the K+K- meson pair production. Measurements of the near threshold Lambda and Sigma0 production via the pp -> pK+ Lambda / Sigma0 reaction at COSY-11 have shown that the Lambda / Sigma0 cross section ratio exceeds the value at high excess energies (Q >= 300 MeV) by an order of magnitude. For a better understanding additional data have been taken between 13 MeV and 60 MeV excess energy. The near threshold production of the charged kaon-antikaon pair is related to the discussion about the nature of the scalar states in the 1 GeV/c^2 mass range, i.e. the f0(980) and a0(980). The interpretation as a K anti-K molecule is strongly dependent on the K anti-K interaction which can be studied via the production channel. A first total cross section value on the reaction pp -> ppK+K- at an excess energy of 17 MeV i.e. below the phi production threshold was measured.Comment: 3 pages, 2 figures, Presented at Conference on Quarks and Nuclear Physics (QNP 2002), Julich, Germany, 9-14 Jun 200

Impact of lifelong exercise training on endothelial ischemia-reperfusion and ischemic preconditioning in humans.

Reperfusion is essential for ischemic tissue survival, but causes additional damage to the endothelium (i.e. ischemia-reperfusion [IR] injury). Ischemic preconditioning (IPC) refers to short repetitive episodes of ischemia that can protect against IR. However, IPC efficacy attenuates with older age. Whether physical inactivity contributes to the attenuated efficacy of IPC to protect against IR injury in older humans is unclear. We tested the hypotheses that lifelong exercise training relates to 1) attenuated endothelial IR and 2) maintained IPC efficacy that protects veteran athletes against endothelial IR. In 18 sedentary male individuals (SED, 20 years, 63±7 years) and 20 veteran male athletes (ATH, >5 exercise hours/week for >20 years, 63±6 years), we measured brachial artery endothelial function with flow-mediated dilation (FMD) before and after IR. We induced IR by 20-minutes of ischemia followed by 20-minutes of reperfusion. Randomized over 2 days, participants underwent either 35-minute rest or IPC (3 cycles of 5-minutes cuff inflation to 220 mmHg with 5-minutes of rest) before IR. In SED, FMD decreased after IR (median [interquartile range]): (3.0% [2.0-4.7] to 2.1% [1.5-3.9], P=0.046) and IPC did not prevent this decline (4.1% [2.6-5.2] to 2.8% [2.2-3.6],P=0.012). In ATH, FMD was preserved after IR (3.0% [1.7-5.4] to 3.0% [1.9-4.1], P=0.82) and when IPC preceded IR (3.2% [1.9-4.2] to 2.8% [1.4-4.6],P=0.18). These findings indicate that lifelong exercise training is associated with increased tolerance against endothelial IR. These protective, preconditioning effects of lifelong exercise against endothelial ischemia-reperfusion may contribute to the cardio-protective effects of exercise training

Strangeness Production in Proton-Proton Collisions Close to Threshold

Exclusive data on the reactions pp -> ppK+K- and pp -> pK+ Lambda/Sigma0 have been taken at the cooler synchrotron COSY close to threshold. At equal excess energies, an enhancement of the Lambda/Sigma0 ratio by one order of magnitude has been observed compared to data at higher excess energies. New results obtained at the COSY-11 facility explore the transition region between this low-energy Sigma0 suppression and excess energies of 60 MeV. A first total cross section for elementary antikaon production below the phi threshold has been determined, two orders of magnitude smaller compared to kaon production at the same excess energy.Comment: 4 pages, 2 figures, Talk given by P. Moskal at 16th International Conference on Particles and Nuclei (PANIC 02), Osaka, Japan, 30 Sep - 4 Oct 200

A Realistic Description of Nucleon-Nucleon and Hyperon-Nucleon Interactions in the SU_6 Quark Model

We upgrade a SU_6 quark-model description for the nucleon-nucleon and hyperon-nucleon interactions by improving the effective meson-exchange potentials acting between quarks. For the scalar- and vector-meson exchanges, the momentum-dependent higher-order term is incorporated to reduce the attractive effect of the central interaction at higher energies. The single-particle potentials of the nucleon and Lambda, predicted by the G-matrix calculation, now have proper repulsive behavior in the momentum region q_1=5 - 20 fm^-1. A moderate contribution of the spin-orbit interaction from the scalar-meson exchange is also included. As to the vector mesons, a dominant contribution is the quadratic spin-orbit force generated from the rho-meson exchange. The nucleon-nucleon phase shifts at the non-relativistic energies up to T_lab=350 MeV are greatly improved especially for the 3E states. The low-energy observables of the nucleon-nucleon and the hyperon-nucleon interactions are also reexamined. The isospin symmetry breaking and the Coulomb effect are properly incorporated in the particle basis. The essential feature of the Lambda N - Sigma N coupling is qualitatively similar to that obtained from the previous models. The nuclear saturation properties and the single-particle potentials of the nucleon, Lambda and Sigma are reexamined through the G-matrix calculation. The single-particle potential of the Sigma hyperon is weakly repulsive in symmetric nuclear matter. The single-particle spin-orbit strength for the Lambda particle is very small, in comparison with that of the nucleons, due to the strong antisymmetric spin-orbit force generated from the Fermi-Breit interaction.Comment: Revtex v2.09, 69 pages with 25 figure

The hadron-quark phase transition in dense matter and neutron stars

We study the hadron-quark phase transition in the interior of neutron stars (NS's). We calculate the equation of state (EOS) of hadronic matter using the Brueckner-Bethe-Goldstone formalism with realistic two-body and three-body forces, as well as a relativistic mean field model. For quark matter we employ the MIT bag model constraining the bag constant by using the indications coming from the recent experimental results obtained at the CERN SPS on the formation of a quark-gluon plasma. We find necessary to introduce a density dependent bag parameter, and the corresponding consistent thermodynamical formalism. We calculate the structure of NS interiors with the EOS comprising both phases, and we find that the NS maximum masses fall in a relatively narrow interval, $1.4 M_\odot \leq M_{\rm max} \leq 1.7 M_\odot$. The precise value of the maximum mass turns out to be only weakly correlated with the value of the energy density at the assumed transition point in nearly symmetric nuclear matter.Comment: 25 pages, Revtex4, 16 figures included as postscrip