100 research outputs found
Comparison of left bundle branch block and right ventricular apical pacing in dilated cardiomyopathy with radionuclide angiography
Petrophysics of Chicxulub Impact Crater's Peak Ring
A new set of physical property measurements was undertaken on 29 peak-ring samples from the IODP-ICDP Expedition 364. Among the studied lithologies, the dominant one recovered in the peak ring consists of shocked granitoid rocks (19 samples). Porosity measurements with two independent methods (triple weight and C-14-PMMA porosity mapping) concur and bring new observations on the intensity and distribution of fracturing and porosity in these shocked target rocks. Characterization of the porous network is taken a step further with two other independent methods (electrical and permeability measurements). Electrical properties such as the cementation exponent (1.59 m < 1.87) and the formation factor (21 F < 103) do not compare with other granites from the published literature; they point at a type of porosity closer to clastic sedimentary rocks than to crystalline rocks. Permeabilities of the granitoid rocks range from 0.1 to 7.1 mD under an effective pressure of similar to 10 MPa. Unlike other fresh to deformed and altered granitoid rocks from the literature compared in this study, this permeability appears to be relatively insensitive to increasing stress (up to similar to 40 MPa), with implications for the nature of the porous network, again, behaving more like cemented clastic rocks than fractured crystalline rocks. Other analyzed lithologies include suevite and impact melt rocks. Relatively low permeability (10(-3) mD) measured in melt-rich facies suggest that, at the matrix scale, these lithologies cutting through more permeable peak-ring granitoid rocks may have been a barrier to fluid flow, with implications for hydrothermal systems.Peer reviewe
Time-lapse cross-hole electrical resistivity tomography (CHERT) for monitoring seawater intrusion dynamics in a Mediterranean aquifer
Surface electrical resistivity tomography (ERT) is a widely used tool to study seawater intrusion (SWI). It is noninvasive and offers a high spatial coverage at a low cost, but its imaging capabilities are strongly affected by decreasing resolution with depth. We conjecture that the use of CHERT (cross-hole ERT) can partly overcome these resolution limitations since the electrodes are placed at depth, which implies that the model resolution does not decrease at the depths of interest. The objective of this study is to test the CHERT for imaging the SWI and monitoring its dynamics at the Argentona site, a well-instrumented field site of a coastal alluvial aquifer located 40Âżkm NE of Barcelona. To do so, we installed permanent electrodes around boreholes attached to the PVC pipes to perform time-lapse monitoring of the SWI on a transect perpendicular to the coastline. After 2 years of monitoring, we observe variability of SWI at different timescales: (1) natural seasonal variations and aquifer salinization that we attribute to long-term drought and (2) short-term fluctuations due to sea storms or flooding in the nearby stream during heavy rain events. The spatial imaging of bulk electrical conductivity allows us to explain non-monotonic salinity profiles in open boreholes (step-wise profiles really reflect the presence of freshwater at depth). By comparing CHERT results with traditional in situ measurements such as electrical conductivity of water samples and bulk electrical conductivity from induction logs, we conclude that CHERT is a reliable and cost-effective imaging tool for monitoring SWI dynamics.This work was funded by the project CGL2016-77122-C2-1-R/2-R of the Spanish Government. This project also received funding from the European Commission, Horizon 2020 research and innovation programme (Marie Sklodowska-Curie (grant no. 722028)). The author Albert Folch is a Serra HĂșnter Fellow.Peer ReviewedPostprint (published version
Randomness Increases Order in Biological Evolution
n this text, we revisit part of the analysis of anti-entropy in Bailly and Longo (2009} and develop further theoretical reflections. In particular, we analyze how randomness, an essential component of biological variability, is associated to the growth of biological organization, both in ontogenesis and in evolution. This approach, in particular, focuses on the role of global entropy production and provides a tool for a mathematical understanding of some fundamental observations by Gould on the increasing phenotypic complexity along evolution. Lastly, we analyze the situation in terms of theoretical symmetries, in order to further specify the biological meaning of anti-entropy as well as its strong link with randomness
Comparison of alternative methodologies for identifying and characterizing preferential flow paths in heterogeneous aquifers
The possibility of evidence-based psychiatry: depression as a case
Considering psychiatry as a medical discipline, a diagnosis identifying a disorder should lead to an effective therapy. Such presumed causality is the basis of evidence-based psychiatry. We examined the strengths and weaknesses of research onto the causality of relationship between diagnosis and therapy of major depressive disorder and suggest what could be done to strengthen eventual claims on causality. Four obstacles for a rational evidence-based psychiatry were recognised. First, current classification systems are scientifically nonfalsifiable. Second, cerebral processes areâat least to some extentânondeterministic, i.e. they are random, stochastic and/or chaotic. Third, the vague or lack of relationship between therapeutic regimens and suspected pathogenesis. Fourth, the inadequacy of tools to diagnose and delineate a functional disorder. We suggest a strategy to identify diagnostic prototypes that are characterised by a limited number of parameters (symptoms, markers and other characteristics). A prototypical diagnosis that may either support or reject particular elements of current diagnostic systems. Nevertheless, one faces the possibility that psychiatry will remain a relatively weak evidence-based medical discipline
Drilling-induced and logging-related features illustrated from IODP-ICDP Expedition 364 downhole logs and borehole imaging tools
Expedition 364 was a joint IODP and ICDP mission-specific platform (MSP) expedition to explore the Chicxulub impact crater buried below the surface of the YucatĂĄn continental shelf seafloor. In April and May 2016, this expedition drilled a single borehole at Site M0077 into the crater's peak ring. Excellent quality cores were recovered from ~ 505 to ~1335m below seafloor (m b.s.f.), and high-resolution open hole logs were acquired between the surface and total drill depth. Downhole logs are used to image the borehole wall, measure the physical properties of rocks that surround the borehole, and assess borehole quality during drilling and coring operations. When making geological interpretations of downhole logs, it is essential to be able to distinguish between features that are geological and those that are operation-related. During Expedition 364 some drilling-induced and logging-related features were observed and include the following: effects caused by the presence of casing and metal debris in the hole, logging-tool eccentering, drilling-induced corkscrew shape of the hole, possible re-magnetization of low-coercivity grains within sedimentary rocks, markings on the borehole wall, and drilling-induced changes in the borehole diameter and trajectory
Models of hydrothermal circulation within 106 Ma seafloor : constraints on the vigor of fluid circulation and crustal properties, below the Madeira Abyssal Plain
Author Posting. © American Geophysical Union, 2005. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geochemistry Geophysics Geosystems 6 (2005): Q11001, doi:10.1029/2005GC001013.Heat flow measurements colocated with seismic data across 106 Ma seafloor of the Madeira Abyssal Plain (MAP) reveal variations in seafloor heat flow of ±10â20% that are positively correlated with basement relief buried below thick sediments. Conductive finite element models of sediments and upper basement using reasonable thermal properties are capable of generating the observed positive correlation between basement relief and seafloor heat flow, but with variability of just ±4â8%. Conductive simulations using a high Nusselt number (Nu) proxy for vigorous local convection suggest that Nu = 2â10 within the upper 600â100 m of basement, respectively, is sufficient to achieve a reasonable match to observations. These Nu values are much lower than those inferred on younger ridge flanks where greater thermal homogeneity is achieved in upper basement. Fully coupled simulations suggest that permeability below the MAP is on the order of 10â12â10â10 m2 within the upper 300â600 m of basement. This permeability range is broadly consistent with values determined by single-hole experiments and from modeling studies at other (mostly younger) sites. We infer that the reduction in basement permeability with age that is thought to occur within younger seafloor may slow considerably within older seafloor, helping hydrothermal convection to continue as plates age.Funding in support of this work was provided by the U.S. National Science Foundation (OCE-0001892), the U.S. Science Support Program for IODP (T301A7), and the Institute for Geophysics and Planetary Physics/Los Alamos National Laboratory (1317)
Sublethal Doses of Anthrax Lethal Toxin on the Suppression of Macrophage Phagocytosis
BACKGROUND: Lethal toxin (LT), the major virulence factor produced by Bacillus anthracis, has been shown to suppress the immune system, which is beneficial to the establishment of B. anthracis infections. It has been suggested that the suppression of MEK/MAPK signaling pathways of leukocytes contributes to LT-mediated immunosuppressive effects. However, the involvement of MAPK independent pathways has not been clearly elucidated; nor has the crucial role played by LT in the early stages of infection. Determining whether LT exerts any pathological effects before being enriched to an MEK inhibitory level is an important next step in the furtherance of this field. METHODOLOGY/PRINCIPAL FINDINGS: Using a cell culture model, we determined that low doses of LT inhibited phagocytosis of macrophages, without influencing MAPK pathways. Consistent low doses of LT significantly suppressed bacterial clearance and enhanced the mortality of mice with bacteremia, without suppressing the MEK1 of splenic and peripheral blood mononuclear cells. CONCLUSION/SIGNIFICANCE: These results suggest that LT suppresses the phagocytes in a dose range lower than that required to suppress MEK1 in the early stages of infection
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