The use of neighbourhood intensity comparisons, morphological gradients and Fourier analysis for automated precipitate counting & Pendell¨osung fringe analysis in X-ray topography

Crystal distortions modify the propagation of X-rays in single crystal materials, and X-ray topography can be used to record these modifications on a film thus providing images of the distributions and nature of defects, dislocations, strains, precipitates, etc. in semiconductors. Small variations of contrast, which often need to be analysed can be rendered invisible. Furthermore, artefacts in the films must be removed. This study examines the use of advanced image analysis techniques applied to a selection of X-ray topographs in section transmission mode: (i) the automated counting of oxygen-related precipitates and (ii) the enhancement of Pendell¨osung fringes. The technique also succeeds in removing unwanted features in the original x-ray topographs such as vertical streaking due to collimating slit phase contrast and strain features near the surface due to the presence of integrated circuit process strains

Coerced Mechanical Coarsening of Nanoparticle Assemblies

Coarsening is a ubiquitous phenomenon [1-3] that underpins countless processes in nature, including epitaxial growth [1,3,4], the phase separation of alloys, polymers and binary fluids [2], the growth of bubbles in foams5, and pattern formation in biomembranes6. Here we show, in the first real-time experimental study of the evolution of an adsorbed colloidal nanoparticle array, that tapping-mode atomic force microscopy (TM-AFM) can drive the coarsening of Au nanoparticle assemblies on silicon surfaces. Although the growth exponent has a strong dependence on the initial sample morphology, our observations are largely consistent with modified Ostwald ripening processes [7-9]. To date, ripening processes have been exclusively considered to be thermally activated, but we show that nanoparticle assemblies can be mechanically coerced towards equilibrium, representing a new approach to directed coarsening. This strategy enables precise control over the evolution of micro- and nanostructures

Red Optical Planet Survey : A radial velocity search for low mass M dwarf planets

This is an Open Access article distributed under the terms of the Creative Commons Attribution License 2.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citedWe present radial velocity results from our Red Optical Planet Survey (ROPS), aimed at detecting low-mass planets orbiting mid-late M dwarfs. The similar to 10 ms(-1) precision achieved over 2 consecutive nights with the MIKE spectrograph at Magellan Clay is also found on week long timescales with UVES at VLT. Since we find that UVES is expected to attain photon limited precision of order 2 ms-1 using our novel deconvolution technique, we are limited only by the

Color Difference Makes a Difference: Four Planet Candidates around τ Ceti

The removal of noise typically correlated in time and wavelength is one of the main challenges for using the radial-velocity (RV) method to detect Earth analogues. We analyze τ Ceti RV data and find robust evidence for wavelength-dependent noise. We find that this noise can be modeled by a combination of moving average models and the so-called "differential radial velocities." We apply this noise model to various RV data sets for τ Ceti, and find four periodic signals at 20.0, 49.3, 160, and 642 days, which we interpret as planets. We identify two new signals with orbital periods of 20.0 and 49.3 days while the other two previously suspected signals around 160 and 600 days are quantified to a higher precision. The 20.0 days candidate is independently detected in Keck data. All planets detected in this work have minimum masses less than 4M⊕ with the two long-period ones located around the inner and outer edges of the habitable zone, respectively. We find that the instrumental noise gives rise to a precision limit of the High Accuracy Radial Velocity Planet Searcher (HARPS) around 0.2 m s−1. We also find correlation between the HARPS data and the central moments of the spectral line profile at around 0.5 m s−1 level, although these central moments may contain both noise and signals. The signals detected in this work have semi-amplitudes as low as 0.3 m s−1, demonstrating the ability of the RV technique to detect relatively weak signals

Katsaus puolustusvoimien sähköteknilliseen toimialaan

Johdannon mukaan sähköteknillinen toimiala sai alkunsa keväällä 1943 maahamme saatujen ilmapuolustuksemme suorituskykyä lisäävien tutkakalustojen myötä. Kirjoittajien mukaan sähkötekniikasta ei ole tullut omaa aselajiaan, koska siitä on muodostunut kaikkia puolustushaaroja ja aselajeja palveleva monipuolinen työväline. Artikkelin on katsaus sähköteknilliseen toimialaan. "Taustana on tutkatekniikka, joka kuitenkin oheislaitteiden kehittymisen ja elektroniikan uusien aluevaltausten myötä on laajentunut teknillisesti erittäin monipuoliseksi kokonaisuudeksi." Katsauksessa käsitellään sähköteknillisen alan historiaa Suomessa, nykyisiä toiminnan muotoja sekä arvioita tulevan teknologian kehityksen asettamista vaateista. Johdannon mukaan historiikki on laitesidonnaista. Perustana on suhteellisen hyvä arkisto- ja tietomateriaali. Sähköteknillisen toiminnan nykytilan kuvaus rajoittuu osin turvallisuusnäkökohtien johdosta yleisesitykseen, menemättä kalustojärjestelmien tai laitteiden yksityiskohtaiseen selostamiseen. Organisaation esittelyn tavoitteena "on antaa lukijalle kuva sähköteknillisestä toimialasta puolustushaarojen ja aselajien kehittyvänä elektroniikka-alan palvelujen toimittajana." Seuraavan noin kymmenvuotiskauden kehitysnäkymille on artikkelissa asetettu merkittävä painoarvo

Main Clinical Use of Additive Manufacturing (Three-Dimensional Printing) in Finland Restricted to the Head and Neck Area in 2016-2017

Background and Aims: Additive manufacturing or three-dimensional printing is a novel production methodology for producing patient-specific models, medical aids, tools, and implants. However, the clinical impact of this technology is unknown. In this study, we sought to characterize the clinical adoption of medical additive manufacturing in Finland in 2016-2017. We focused on non-dental usage at university hospitals. Materials and Methods: A questionnaire containing five questions was sent by email to all operative, radiologic, and oncologic departments of all university hospitals in Finland. Respondents who reported extensive use of medical additive manufacturing were contacted with additional, personalized questions. Results: Of the 115 questionnaires sent, 58 received answers. Of the responders, 41% identified as non-users, including all general/gastrointestinal (GI) and vascular surgeons, urologists, and gynecologists; 23% identified as experimenters or previous users; and 36% identified as heavy users. Usage was concentrated around the head area by various specialties (neurosurgical, craniomaxillofacial, ear, nose and throat diseases (ENT), plastic surgery). Applications included repair of cranial vault defects and malformations, surgical oncology, trauma, and cleft palate reconstruction. Some routine usage was also reported in orthopedics. In addition to these patient-specific uses, we identified several off-the-shelf medical components that were produced by additive manufacturing, while some important patient-specific components were produced by traditional methodologies such as milling. Conclusion: During 2016-2017, medical additive manufacturing in Finland was routinely used at university hospitals for several applications in the head area. Outside of this area, usage was much less common. Future research should include all patient-specific products created by a computer-aided design/manufacture workflow from imaging data, instead of concentrating on the production methodology.Peer reviewe

Synchrotron x-ray topographic and high-resolution diffraction analysis of mask-induced strain in epitaxial laterally overgrown GaAs layers

Synchrotron x-ray back reflection section topographs of epitaxial lateral overgrown (ELO) GaAs samples grown on (001) GaAs substrates show images of the GaAs layers bent due to the interaction between the layer and the SiO2 mask. The topographs are simulated under the assumption of orientational contrast. Using the same data the measured x-ray diffraction curve is simulated. The calculations, which are in good agreement with the measurements, are used to gain information on the tilted (001) lattice planes in each ELO layer. We show that the bending of ELO lattice planes reaches a maximum at the center of the ELO stripes, where misorientation is at a minimum, and decreases towards the edges of the stripes, where misorientation reaches a maximum

Systemic inflammatory responses following welding inhalation challenge test

Peer reviewe

GAD Antibody Positivity Predicts Type 2 Diabetes in an Adult Population

OBJECTIVE-To evaluate the significance of GAD antibodies (GADAs) and family history for type 1 diabetes (FHT1) or type 2 diabetes (FHT2) in nondiabetic subjects. RESEARCH DESIGN AND METHODS-GADAs were analyzed in 4,976 nondiabetic relatives of type 2 diabetic patients or control subjects from Finland. Altogether, 289 (5.9%) were GADA(+)-a total of 253 GADA(+) and 2,511 GADA(-) subjects participated in repeated oral glucose tolerance tests during a median time of 8.1 years. The risk of progression to diabetes was assessed using Cox regression analysis. RESULTS-Subjects within the highest quartile of GADA(+) (GADA(high)(+)) had more often first-degree FHT1 (29.2 vs. 7.9%, P < 0.00001) and GADA(+) type 2 diabetic (21.3 vs. 13.7%, P = 0.002) or nondiabetic (26.4 vs. 13.3%, P = 0.010) relatives than GADA(-) subjects. During the follow-up, the GADA(+) subjects developed diabetes significantly more often than the GADA(-) subjects (36/253 [14.2%] vs. 134/2,511 [5.3%], P < 0.00001). GADA(high)(+) conferred a 4.9-fold increased risk of diabetes (95% CI 2.8-8.5) compared with GADA(-)-seroconversion to positive during the follow-up was associated with 6.5-fold (2.8-15.2) and first-degree FHT1 with 2.2-fold (1.2-4.1) risk of diabetes. Only three subjects developed type 1 diabetes, and others had a non-insulin-dependent phenotype 1 year after diagnosis. GADA(+) and GADA(-) subjects did not clinically differ at baseline, but they were leaner and less insulin resistant after the diagnosis of diabetes. CONCLUSIONS-GADA positivity clusters in families with type 1 diabetes or latent autoimmune diabetes in adults. GADA positivity predicts diabetes independently of family history of diabetes, and this risk was further increased with high GADA concentrations

ROPS: A New Search for Habitable Earths in the Southern Sky

We present the first results from our Red Optical Planet Survey (ROPS) to search for low mass planets orbiting late type dwarfs (M5.5V - M9V) in their habitable zones (HZ). Our observations, with the red arm of the MIKE spectrograph (0.5 - 0.9 microns) at the 6.5 m Magellan Clay telescope at Las Campanas Observatory indicate that >= 92 per cent of the flux lies beyond 0.7 microns. We use a novel approach that is essentially a hybrid of the simultaneous iodine and ThAr methods for determining precision radial velocities. We apply least squares deconvolution to obtain a single high S/N ratio stellar line for each spectrum and cross correlate against the simultaneously observed telluric line profile, which we derive in the same way. Utilising the 0.62 - 0.90 micron region, we have achieved an r.m.s. precision of 10 m/s for an M5.5V spectral type star with spectral S/N ~160 on 5 minute timescales. By M8V spectral type, a precision of ~30 m/s at S/N = 25 is suggested, although more observations are needed. An assessment of our errors and scatter in the radial velocity points hints at the presence of stellar radial velocity variations. Of our sample of 7 stars, 2 show radial velocity signals at 6-sigma and 10-sigma of the cross correlation uncertainties. If the signals are planetary in origin, our findings are consistent with estimates of Neptune mass planets that predict a frequency of 13 - 27 per cent for early M dwarfs.Our current analysis indicates the we can achieve a sensitivity that is equivalent to the amplitude induced by a 6 M_Earth planet orbiting in the habitable zone. Based on simulations, we estimate that <10 M_Earth habitable zone planets will be detected in a new stellar mass regime, with <=20 epochs of observations.Comment: MNRAS accepted: 14 pages, 8 figures, 3 table