FACTORS AFFECTING MIGRATION FROM THE CROATIAN RURAL AREA

U radu se daju rezultati istraživanja migracija u seoskom području Republike Hrvatske. Cilj je istražiti čimbenike koji utječu na iseljavanje seoskog stanovništva Republike Hrvatske. Istraživanje je provedeno 2007. godine na uzorku od 914 ispitanika dobi od 24 do 45 godina u seoskom području Republike Hrvatske. Odabir naselja i ispitanika bio je slučajan. Provedeno istraživanje pokazuje da su najveće poteškoće života u hrvatskom seoskom području gospodarske naravi, manjak zaposlenja, slaba mogućnost izbora zanimanja i niža zarada u odnosu na zaposlenje u gradu. Petina ispitanika nije zadovoljna uvjetima seoskog života i namjerava se iseliti. To je zabrinjavajući pokazatelj budući da se radi o populaciji koja je u pravilu završila proces obrazovanja i većinom osnovala obitelj. Najviše mogućih iseljenika, što je bilo i za očekivati, je iz gospodarski nerazvijenih područja Republike Hrvatske. Daljnja depopulacija hrvatskog sela bila bi pogubna, a njene najveće posljedice bile bi: prevelika urbanizacija, posebice velikih gradova, daljnji neravnomjerni razvitak Republike Hrvatske te nedovoljno iskorištenje prostornog, proizvodnog i ljudskog potencijala. S obzirom na strateški cilj ulaska Republike Hrvatske u Europsku uniju, navedeno predstavlja bitno ograničenje njene uspješne prilagodbe europskoj ekonomskoj integraciji. Iseljavanje seoskog pučanstva može se spriječiti prvenstveno povećanjem zaposlenosti i dohotka te stvaranjem takve fizičke i društvene infrastrukture u seoskom području koja će bitno poboljšati životne uvjete seoskog pučanstva. Seoska područja, poglavito gospodarski nerazvijena, nemaju dovoljno vlastitih mogućnosti za ubrzanje razvoja odnosno za nužno smanjivanje razlika u kakvoći življenja prema gradskim područjima. Zbog toga je nužno da njihov razvojni proces više nego dosada potpomogne Država osmišljenim mjerama regionalnog razvoja, uz svekoliku potporu lokalne uprave i samouprave. U tome bi svoj znatan obol trebalo dati novo-osnovano Ministarstvo za regionalni razvoj.The paper presents results of the research study on migrations in rural areas of the Republic of Croatia. The aim was to determine factors influencing migrations of rural population in Croatia. The research was carried out in 2007 on 914 respondents from 25 to 45 years of age. The rural communities and respondents were selected on a random basis. The study results indicate that the major difficulties in rural life in Croatia are of economic nature: lack of employment opportunities, inadequate choice of profession and lower income in comparison with employment in urban areas. One fifth of the respondents is not satisfied with conditions of rural life and intends to leave villages. This is a very disturbing indicator, since it refers to population, which in general, has finished education and started a family. As we expect, the largest number of potential migrants comes from economically underdeveloped Croatian areas. Further depopulation of Croatian villages would have dramatic effects, and the worst consequences would be excessive urbanization, especially of large cities, further uneven development of the Republic of Croatia, and insufficient utilization of spatial, production and human resources. Since the strategic Croatian goal is to become a member of the European Union, this is a major obstacle to its successful adjustment to the European economic integration. The migration of rural population could be prevented primarily by increase in employment and income opportunities and creation of such physical and social infrastructure in rural areas that would considerably improve living conditions for rural population. The rural areas, particularly underdeveloped, have no adequate capacities for intensification of its development and diminishing differences in their quality of life compared to urban areas. Thus, the state support is increasingly required by introducing measures of regional development with complementary support of the local government. The newly founded Ministry of Regional Development is therefore inevitable in this process

The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase

Post-translational modification of proteins by poly(ADP-ribosyl)ation regulates many cellular pathways that are critical for genome stability, including DNA repair, chromatin structure, mitosis and apoptosis1. Poly(ADP-ribose) (PAR) is composed of repeating ADP-ribose units linked via a unique glycosidic ribose–ribose bond, and is synthesized from NAD by PAR polymerases1, 2. PAR glycohydrolase (PARG) is the only protein capable of specific hydrolysis of the ribose–ribose bonds present in PAR chains; its deficiency leads to cell death3, 4. Here we show that filamentous fungi and a number of bacteria possess a divergent form of PARG that has all the main characteristics of the human PARG enzyme. We present the first PARG crystal structure (derived from the bacterium Thermomonospora curvata), which reveals that the PARG catalytic domain is a distant member of the ubiquitous ADP-ribose-binding macrodomain family5, 6. High-resolution structures of T. curvata PARG in complexes with ADP-ribose and the PARG inhibitor ADP-HPD, complemented by biochemical studies, allow us to propose a model for PAR binding and catalysis by PARG. The insights into the PARG structure and catalytic mechanism should greatly improve our understanding of how PARG activity controls reversible protein poly(ADP-ribosyl)ation and potentially of how the defects in this regulation are linked to human disease

Unusual Regioselectivity and Active Site Topology of Human Cytochrome P450 2J2

International audienc

Behaviour of a floc population during a tidal cycle: Laboratory experiments and numerical modelling

International audienceAn approach combining laboratory experiments and numerical modelling was used to investigate the behaviour of a floc population during an idealized tidal cycle. The experiment was conducted on suspended sediments at a concentration of 93 mg l 1 collected in the field. It was based on a jar test device to reproduce tidal-induced turbulence and coupled with a CCD camera system and image post- processing software to monitor floc size distribution. At the same time, a 0D size-class based aggregation/fragmentation model (FLOCMOD) was developed to simulate changes in the floc population over the tidal cycle. Experimental results revealed strong variability of the behaviour of microfloc and macrofloc populations with respect to the varying shear rates observed in situ. In particular, the major dependency of floc sizes on the Kolmogorov microscale was confirmed. Time-scale differences were also observed for aggregation and fragmentation processes which led to asymmetrical floc behaviour despite symmetrical tidal forcing. Model results, i.e. average diameter, maximum diameter and floc size distribution, were in good agreement with experimental data with an RMS error between observed and computed average diameters of below 25 mm over the tidal cycle. FLOCMOD was optimized in terms of the time step, number of size classes and size range: only seven classes ranging from 50 to 643 mm associated with a dynamically-adaptable time step were needed to correctly reproduce experimental results, characterized by an RMS error of less than 5 mm with respect to the reference case (100 classes from 4 to 1500 mm). Sensitivity analyses were performed on major parameters or processes: initial floc size distribution, primary particle size, fractal dimension and fragmentation function (binary, ternary, erosion or collision-induced fragmentation). Results showed that initial floc size distribution played a role only during the first aggregation stage. Low variability of the fractal dimension did not significantly modify model results, while larger differences were observed when the primary particle size was changed, especially towards the largest sizes (10 mm). Nevertheless, these two structural parameters had a strong impact on the calculated mean settling velocity with differences of 0.2 mm scompared with the reference case. Different fragmentation functions were shown to significantly modify model results, except for collision-induced shear stress. In particular, combining floc erosion with binary breakup in the shear fragmentation term enabled us to reproduce bimodal distributions, patterns that are typically observed in situ

Galactofuranosidase – thioglycoligase potency for thiogalactofuranoside synthesis

International audienc

Design of furanoside-specific neolectins: bioengineering, imaging and diagnosis

International audienc

Controlling factors of rhythmic sedimentation processes on a macrotidal estuarine mudflat. Role of the turbidity maximum, the Seine estuary, France

The aim of this study is to analyse and to quantify the fine particles transfer (i.e. 7.1 m). Then, deposition of SPM from the turbidity maximum becomes important, allowing fine particles to settle on the mudflat, where the current velocities are low (< 0.4 m s− 1). On tides of lower range (< 7.1 m) bed elevation levels suggest that erosion of the mudflat surface dominates, however dewatering processes also occur in the soft mud deposits resulting in compaction. During periods of wave activity and periods of increasing river discharge, the mudflat surface experiences rapid erosion. These periods of erosion (sudden or progressive) imply a transfer of fine-grained material from the mudflat surface back into the TM.The long term (∼ 22 months), high frequency (1 measurement every 10 min) and high resolution (0.6 mm) dataset obtained from the altimeter allows quantification of the volume of material exchanged between the intertidal area and the estuarine standing stock of SPM. The maximum of deposition on the studied mudflat during the study was of 27 cm, with highest deposition occurring after the periods of highest river flow and implying that between 25 and 40% of the maximum estimated mass of SPM held within the estuarine TM (300,000–500,000 T) had been temporarily deposited on the mudflat. Likewise following periods of resuspension by wave activity, bed elevations reduced by an order of ∼ 1 cm, suggesting a release of between 1–1.5% of the TM load from the mudflat back into suspension.The study shows that lateral exchanges of sediment between the intertidal reaches of the estuary and the water column are an important part of the sediment budget, and that the supply of sediment available for deposition (i.e. the TM) has a causal relationship with sedimentation rates experienced by intertidal mudflats