Nanoparticles in explosives detection – the state-of-the-art and future directions

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Two-Parameter Differential Calculus on the h-Exterior Plane

We construct a two-parameter covariant differential calculus on the quantum $h$-exterior plane. We also give a deformation of the two-dimensional fermionic phase space.Comment: 7 page

Sensitive and specific detection of explosives in solution and vapour by surface-enhanced Raman spectroscopy on silver nanocubes

Surface-enhanced Raman spectroscopy (SERS) has been widely utilised as a sensitive analytical technique for the detection of trace levels of organic molecules. The detection of organic compounds in the gas phase is particularly challenging due to the low concentration of adsorbed molecules on the surface of the SERS substrate. This is particularly the case for explosive materials, which typically have very low vapour pressures, limiting the use of SERS for their identification. In this work, silver nanocubes (AgNCs) were developed as a highly sensitive SERS substrate with very low limit-of-detection (LOD) for explosive materials down to the femtomolar (10−15 M) range. Unlike typical gold-based nanostructures, the AgNCs were found suitable for the detection of both aromatic and aliphatic explosives, enabling detection with high specificity at low concentration. SERS studies were first carried out using a model analyte, Rhodamine-6G (Rh-6G), as a probe molecule. The SERS enhancement factor was estimated as 8.71 × 1010 in this case. Further studies involved femtomolar concentrations of 2,4-dinitrotoluene (DNT) and nanomolar concentrations of 1,3,5-trinitroperhydro-1,3,5-triazine (RDX), as well as vapour phase detection of DNT

The Genetics of Amyotrophic Lateral Sclerosis: Current Insights

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that results in loss of the upper and lower motor neurons from motor cortex, brainstem and spinal cord. Whilst the majority of cases are sporadic, around 10% show familial inheritance. ALS is usually inherited in an autosomal dominant manner, though autosomal recessive and X-linked inheritance do occur. To date, 24 of the genes at 26 loci have been identified; these include loci linked to ALS as well as to FTD-ALS, where family pedigrees contain individuals with frontotemporal dementia with/without ALS. The most commonly established genetic causes of FALS to date are the presence of a hexanucleotide repeat expansion in the C9ORF72 gene (39.3% FALS) and mutation of SOD1, TARDBP and FUS, with frequencies of 12-23.5%, 5% and 4.1% respectively. However, with the increasing use of next generation sequencing of small family pedigrees, this has led to an increasing number of genes associated with ALS. This review provides a comprehensive review on the genetics of ALS and an update of the pathogenic mechanisms associated with these genes. Commonly implicated pathways have been established, including RNA processing, the protein degradation pathways of autophagy and ubiquitin-proteasome-system as well as protein trafficking and cytoskeletal function. Elucidating the role genetics plays in both FALS and SALS is essential for understanding the subsequent cellular dysregulation that leads to motor neuron loss, in order to develop future effective therapeutic strategies

Vacancy clustering and diffusion in silicon: Kinetic lattice Monte Carlo simulations

Diffusion and clustering of lattice vacancies in silicon as a function of temperature, concentration, and interaction range are investigated by Kinetic Lattice Monte Carlo simulations. It is found that higher temperatures lead to larger clusters with shorter lifetimes on average, which grow by attracting free vacancies, while clusters at lower temperatures grow by aggregation of smaller clusters. Long interaction ranges produce enhanced diffusivity and fewer clusters. Greater vacancy concentrations lead to more clusters, with fewer free vacancies, but the size of the clusters is largely independent of concentration. Vacancy diffusivity is shown to obey power law behavior over time, and the exponent of this law is shown to increase with concentration, at fixed temperature, and decrease with temperature, at fixed concentration.Comment: 14 pages, 12 figures. To appear in Physical Review

The vertical cloud structure of the West African monsoon: a 4 year climatology using CloudSat and CALIPSO

The West African summer monsoon (WAM) is an important driver of the global climate and locally provides most of the annual rainfall. A solid climatological knowledge of the complex vertical cloud structure is invaluable to forecasters and modelers to improve the understanding of the WAM. In this paper, 4 years of data from the CloudSat profiling radar and CALIPSO are used to create a composite zonal mean vertical cloud and precipitation structure for the WAM. For the first time, the near-coincident vertical radar and lidar profiles allow for the identification of individual cloud types from optically thin cirrus and shallow cumulus to congestus and deep convection. A clear diurnal signal in zonal mean cloud structure is observed for the WAM, with deep convective activity enhanced at night producing extensive anvil and cirrus, while daytime observations show more shallow cloud and congestus. A layer of altocumulus is frequently observed over the Sahara at night and day, extending southward to the coastline, and the majority of this cloud is shown to contain supercooled liquid in the top. The occurrence of deep convective systems and congestus in relation to the position of the African easterly jet is studied, but only the daytime cumulonimbus distribution indicates some influence of the jet position

Droplet actuation induced by coalescence: experimental evidences and phenomenological modeling

This paper considers the interaction between two droplets placed on a substrate in immediate vicinity. We show here that when the two droplets are of different fluids and especially when one of the droplet is highly volatile, a wealth of fascinating phenomena can be observed. In particular, the interaction may result in the actuation of the droplet system, i.e. its displacement over a finite length. In order to control this displacement, we consider droplets confined on a hydrophilic stripe created by plasma-treating a PDMS substrate. This controlled actuation opens up unexplored opportunities in the field of microfluidics. In order to explain the observed actuation phenomenon, we propose a simple phenomenological model based on Newton's second law and a simple balance between the driving force arising from surface energy gradients and the viscous resistive force. This simple model is able to reproduce qualitatively and quantitatively the observed droplet dynamics

Microevents produced by gas migration and expulsion at the seabed: A study based on sea bottom recordings from the Sea of Marmara

International audienceDifferent types of 4-component ocean bottom seismometers (OBS) were deployed for variable durations ranging from 1 week to about 4 months in 2007, over soft sediments covering the seafloor of the Tekirdag Basin (western part of the Sea of Marmara, Turkey). Non-seismic microevents were recorded by the geophones, but generally not by the hydrophones, except when the hydrophone is located less than a few tens of centimetres above the seafloor. The microevents are characterized by short durations of less than 0.8 s, by frequencies ranging between 4 and 30 Hz, and by highly variable amplitudes. In addition, no correlation between OBSs was observed, except for two OBSs, located 10 m apart. Interestingly, a swarm of ∼400 very similar microevents (based on principal component analysis) was recorded in less than one day by an OBS located in the close vicinity of an active, gas-prone fault cutting through the upper sedimentary layers. The presence of gas in superficial sediments, together with analogies with laboratory experiments, suggest that gas migration followed by the collapse of fluid-filled cavities or conduits could be the source of the observed microevents. This work shows that OBSs may provide valuable information to improve our understanding of natural degassing processes from the seafloor

Synaptic Integration of Adult-Born Hippocampal Neurons Is Locally Controlled by Astrocytes.

Adult neurogenesis is regulated by the neurogenic niche, through mechanisms that remain poorly defined. Here, we investigated whether niche-constituting astrocytes influence the maturation of adult-born hippocampal neurons using two independent transgenic approaches to block vesicular release from astrocytes. In these models, adult-born neurons but not mature neurons showed reduced glutamatergic synaptic input and dendritic spine density that was accompanied with lower functional integration and cell survival. By taking advantage of the mosaic expression of transgenes in astrocytes, we found that spine density was reduced exclusively in segments intersecting blocked astrocytes, revealing an extrinsic, local control of spine formation. Defects in NMDA receptor (NMDAR)-mediated synaptic transmission and dendrite maturation were partially restored by exogenous D-serine, whose extracellular level was decreased in transgenic models. Together, these results reveal a critical role for adult astrocytes in local dendritic spine maturation, which is necessary for the NMDAR-dependent functional integration of newborn neurons