Review of Drug Storage Conditions, A Case Report

High temperatures during the summer season are a very important factor to be considered due to their possible influence on drug stability and effectiveness. This is especially important in those patients included in clinical trials, polymedicated or with long-term pharmacological therapies

The ESEAS-RI Sea Level Test Station: Reliability and Accuracy of Different Tide Gauges

In December 2002 a test station of six tide gauges using four different technologies (acoustic, pressure, pulse radar and FMCW radar) was established by Puertos del Estado at the port of Vilagarcfa de Arousa (NW Spain), as part of the ESEAS-RI (European Sea Level Service- Research & Infrastructure) project. The aim was to compare the performance of the tide gauges in order to support the future decisions concerning the improving of the sea level observing systems. Although the comparison of the sea level time series showed that all the tide gauges met GLOSS (Global Sea Level Observing System) quality standards, the experiment also revealed some differences in the quality of the data for certain ranges of frequency.En diciembre de 2002, y como parte del proyecto europeo ESEAS-RI (European Sea Level Service Research&lnfrastructure), Puertos del Estado instalô una estaciôn piloto de seis mareôgrafos de tecnologîas diferentes (acustica, de presiôn, radar de pulso y radar de barrido de frecuencias) en el puerto de Vilagarcia de Arousa (NO Espaha). El objetivo era comparar el funcionamiento de los mareôgrafos con el fin de apoyar decisiones futuras concernientes a la mejora de las redes de medida del nivel del mar. A pesar de que las comparaciones realizadas con las series temporales de nivel del mar mostraron que todos los equipos satisfacen los requerimientos exigidos por GLOSS (Global Sea Level Observing System), el experimento también revelô algunas diferencias en la calidad de los datos para ciertos rangos de frecuencia.En décembre 2002, dans le cadre du projet européen ESEAS-RI (European Sea Level Service Research&lnfrastructure), une station pilote de six marégraphes utilisant quatre technologies différentes (acoustique, à pression, radar par impulsions et radar à onde entretenue modulée en fréquence) a été installée par Puertos del Estado au port de Vilagarcîa de Arousa (NO de l ’Espagne). L’objectif était de comparer le fonctionnement des marégraphes afin de soutenir les futures décisions relatives à l ’amélioration des systèmes d’observation du niveau de la mer. Bien que la comparaison des séries chronologiques du niveau de la mer ait montré que tous les marégraphes satisfont aux normes de qualité GLOSS (Système mondial d’observation du niveau de la mer), l ’expérience a également mis en lumière certaines différences dans la qualité des données pour certaines gammes de fréquence

Nivmar: a storm surge forecasting system for Spanish waters

In this paper, a storm surge prediction system for the Spanish Waters is presented. The system, named Nivmar, is based on the ocean circulation Hamsom model and on the harmonical prediction of tides computed from data measured by the tide gauge network Redmar, managed by Puertos del Estado. Nivmar is executed twice a day, running Hamsom forced by meteorological fields derived from the INM (Instituto Nacional de Meteorología) operational application of Hirlam atmospheric model. Data from Redmar tide gauges is used to to forecast the tidal elevations, to validate the system and to perform data assimilation, correcting systematic errors in the mean sea level due to physicals processes that are not included in the ocean model (i. e. steric height). The forecast horizon is 48 hours. In order to validate the system with measured data from Redmar a very stormy 5 months period was selected. Results from this test (November 95 to March 96) are presented. Data from this experiment shown that Nivmar is able to correctly predict sea level in the region. A simple data assimilation scheme for sea level is described and results from its application are studied. Finally, special focus is made in future plans and potential developments and applications of the system.No disponibl

Empleo, conducta adaptativa y discapacidad intelectual

Las personas con discapacidad intelectual tienen dificultades para acceder a un empleo competitivo, lo que dificulta su inclusión y participación sociolaboral, su independencia económica, una vida independiente, la confianza en sí mismo y el desarrollo de sus habilidades. Los estudios que han profundizado en los factores que dificultan el acceso al empleo de este colectivo son prácticamente inexistentes. En este trabajo se analiza si existen diferencias en algunos factores personales y sociales, y en conducta adaptativa en una muestra de 98 adultos con discapacidad intelectual leve, con edades comprendidas entre los 24 y 60 años (M = 28,74, DT = 11,11), de los cuales el 66,3% tiene un empleo remunerado y el 33,7 % no. Los resultados muestran que los varones con edades comprendidas entre los 31 y 50 años sin otro diagnóstico de problemas de salud mental son las personas que más posibilidad tienen de tener un empleo protegido frente a las mujeres, los menores de 30 años, los mayores de 50, y aquellos que presentan uno o más diagnósticos de enfermedad mental. También se observa que las personas con discapacidad intelectual leve que tienen empleo obtienen mejores puntuaciones en la mayoría de dominios de conducta adaptativa que las personas sin empleo, pero sólo de manera significativa en actividades económicas y prevocacionales-vocacionales.People with intellectual disabilities have difficulty accessing competitive employment, which hinders their social and labor inclusion and participation, economic independence, an independent life, self-confidence and develop their skills. Studies have explored factors that hinder access to employment for this group is practically nonexistent. In this paper we analyze whether there are differences in some personal and social, and adaptive behavior in a sample of 98 adults with intellectual disability, aged between 24 and 60 years old (M = 28.74, SD = 11.11), of which 66.3% have job and 33.7% do not. The results show that men aged between 31 and 50 years without a diagnosis of mental health problems are more likely people are to have a sheltered employment against women, fewer than 30, over 50, and those with one or more diagnoses of mental illness. It is also noted that people with mild intellectual disabilities who are employed get better scores in most domains of adaptive behavior, but only significantly in vocational and prevocational-economic activities that people without jobs

Left Atrium Assessment by Speckle Tracking Echocardiography in Cryptogenic Stroke: Seeking Silent Atrial Fibrillation

Enfermedad auricular; Fibrilación auricular; EcocardiografíaMalaltia auricular; Fibril·lació auricular; EcocardiografiaAtrial disease; Atrial fibrillation; EchocardiographySilent atrial fibrillation (AF) may be the cause of some cryptogenic strokes (CrS). The aim of the study was to analyse atrial size and function by speckle tracking echocardiography in CrS patients to detect atrial disease. Patients admitted to the hospital due to CrS were included prospectively. Echocardiogram analysis included left atrial ejection fraction (LAEF) and atrial strain. Insertable cardiac monitor was implanted, and AF was defined as an episode of ≥1 min in the first year after stroke. Left atrial enlargement was defined as indexed volume > 34 mL/m2. Seventy-five consecutive patients were included, aged 76 ± 9 years (arterial hypertension 75%). AF was diagnosed in 49% of cases. The AF group had higher atrial volume and worse atrial function: peak atrial longitudinal strain (PALs) 19.6 ± 5.7% vs. 29.5 ± 7.2%, peak atrial contraction strain (PACs) 8.9 ± 3.9% vs. 16.5 ± 6%, LAEF 46.8 ± 11.5% vs. 60.6 ± 5.2%; p < 0.001. AF was diagnosed in 20 of 53 patients with non-enlarged atrium, and in 18 of them, atrial dysfunction was present. The multivariate logistic regression analysis demonstrated an independent association between detection of AF and atrial volume, LAEF, and strain. Cut-off values were obtained: LAEF < 55%, PALs < 21.4%, and PACs < 12.9%. In conclusion, speckle tracking echocardiography in CrS patients improves silent atrial disease diagnosis, with or without atrial enlargement.This research was funded by Instituto de Salud Carlos III-FIS (Fondo de Investigación Sanitaria, PI13/01830)

Relationship between sensation seeking variable and its relation to the abuse of mobile phone in adolescents

En este estudio pretendemos analizar la relación existente entre las conductas de abuso de teléfono móvil y sustancias tóxicas con los componentes de la variable búsqueda de sensaciones (búsqueda de emoción, búsqueda de experiencias, susceptibilidad al aburrimiento y desinhibición). La muestra utilizada fue de 634 alumnos, escolarizados en centros de Burgos capital, que cursan segundo ciclo de ESO y Bachillerato. Es importante conocer los indicadores de uso disfuncional de las TIC y consumo abusivo de sustancias, para afinar la precocidad en los diagnósticos y diseñar estrategias adecuadas de prevención. Creemos que puede ser un estudio que contribuya a mejorar los posteriores programas preventivos.In the present work, we analyse the relationship between the abuse of mobile phone and the toxic substances with the components of the sensation seeking variable The sample was of 634 students who are enrolled in Burgos capital in second degree of Compulsory Secondary Education and Non-Compulsory Secondary Education. The aim of our study is to clarify some questions about the consequences that the abuse of Information and Communication Technology can be generating in our younger population in order to improve the precocity in the diagnosis, and propose alternatives and educational answers, so as to prevent and guide adolescents.peerReviewe

Estrategias europeas contra el discurso del odio

El objetivo es presentar un panorama global de las principales estrategias que se adoptan en Europa para frenar y contrarrestar los discursos de odio. Se realiza una reflexión crítica a partir de una selección de documentación oficial y literatura académica más relevantes. Se destacan, entre otras medidas, la necesidad de aplicar el marco jurídico común europeo y formar una ciberopinión pública mediante la educomunicación y la lucha contra la desinformación. Se concluye que las instituciones europeas deben desarrollar una estrategia común y global en la lucha contra el discurso del odio, que integre las intervenciones parciales en diversas áreas y las diferentes iniciativas nacionales

Analysis of Forces Involved in the Perching Maneuver of Flapping-Wing Aerial Systems and Development of an Ultra-Lightweight Perching System

Trying to optimize the design of aerial robotics systems, this work presents an optimized low-weight landing system for flapping-wing aerial robots. The design, based on the use of low-sized neodymium magnets, intends to provide that these aerial robots have the capability of landing in restricted areas by using the presented solution. This capacity will increase the application range of these robots. A study of this situation has been done to analyze the perching maneuver forces and evaluate the system. The solution presented is low-weight, lowsized, and also relatively inexpensive. Therefore, this solution may apply to most ornithopter robots. Design, analysis of the implied forces, development and experimental validation of the idea are presented in this work, demonstrating that the developed solution can overcome the ornithopter’s payload limitation providing an efficient and reliable solutionUnión Europea SI-1867/23/2018 ERC-AD

Influencia de la impulsividad y de la búsqueda de sensaciones en el consumo precoz de cannabis. Diferencias de género y orientaciones para la prevención

ABSTRACTAdolescence is a critical phase of development due to the vulnerability to the consumption of toxic substances. Impulsivity and sensation seeking are personality traits that traditionally appear associated with the early consumption of cannabis in adolescents. This study focuses on the analysis of the differences in impulsivity (functional and dysfunctional) and in sensation seeking (thrill and adventure-seeking, disinhibition, experience seeking, and boredom susceptibility) by gender, age and cannabis use. The sample consisted of 634 adolescents from public and private schools of Burgos (Spain). The Dickman’s Impulsivity Inventory, the Sensations Seeking Scale and a question about cannabis consumption were applied. The characteristics of the sample were analyzed with descriptive statistics and the differences in impulsivity and sensation seeking by gender, age, cannabis consumption and its interaction with the MANOVA test. In general, males are more functional impulsive and more thrills and adventures and experiences seekers than female. Participants aged 14 and 15 score higher in thrill and adventure-seeking, and less in experiences seeking. 22.5% of adolescents consumed cannabis. They scored higher in thrill and adventure-seeking, in experience seeking, and in disinhibition than non-consumers. There is an increase in dysfunctional impulsivity and boredom susceptibility associated with consumption in women. Therefore, preventive programs should take into account the gender and certain personality traits of adolescents to increase their effectiveness.RESUMENLa adolescencia es una fase crítica del desarrollo por la vulnerabilidad respecto al consumo de sustancias tóxicas. La impulsividad y la búsqueda de sensaciones son rasgos de personalidad que aparecen asociados tradicionalmente con el consumo precoz de cannabis en adolescentes. Se analizan las diferencias en impulsividad (funcional y disfuncional) y en búsqueda de sensaciones (búsqueda de emociones y aventuras, búsqueda de experiencias, desinhibición y susceptibilidad al aburrimiento) por género, edad y consumo de cannabis. La muestra estuvo constituida por 634 adolescentes de colegios públicos y concertados de Burgos (España). Se aplicó el Inventario de Impulsividad, el Cuestionario de Búsqueda de Sensaciones y una pregunta sobre el consumo de cannabis. Las características de la muestra se analizaron con estadística descriptiva y las diferencias en impulsividad y búsqueda de sensaciones por género, edad, consumo de cannabis y su interacción con la prueba MANOVA. Los varones son más impulsivos funcionales y más buscadores de emociones, aventuras y experiencias que las mujeres. Con 14 y 15 años puntúan más alto en búsqueda de emociones y aventuras y menos en búsqueda de experiencias. El 22.5% de los adolescentes consumía cannabis. Estos puntúan más alto en búsqueda de emociones y aventuras, en búsqueda de experiencias, y en desinhibición que los no consumidores. Aparece un incremento de la impulsividad disfuncional y de la susceptibilidad al aburrimiento asociada al consumo en las mujeres. Por lo tanto, los programas preventivos deberían tener en cuenta el género de los adolescentes y algunos rasgos de personalidad para incrementar su efectividad.ABSTRACTAdolescence is a critical phase of development due to the vulnerability to the consumption of toxic substances. Impulsivity and sensation seeking are personality traits that traditionally appear associated with the early consumption of cannabis in adolescents. This study focuses on the analysis of the differences in impulsivity (functional and dysfunctional) and in sensation seeking (thrill and adventure-seeking, disinhibition, experience seeking, and boredom susceptibility) by gender, age and cannabis use. The sample consisted of 634 adolescents from public and private schools of Burgos (Spain). The Dickman’s Impulsivity Inventory, the Sensations Seeking Scale and a question about cannabis consumption were applied. The characteristics of the sample were analyzed with descriptive statistics and the differences in impulsivity and sensation seeking by gender, age, cannabis consumption and its interaction with the MANOVA test. In general, males are more functional impulsive and more thrills and adventures and experiences seekers than female. Participants aged 14 and 15 score higher in thrill and adventure-seeking, and less in experiences seeking. 22.5% of adolescents consumed cannabis. They scored higher in thrill and adventure-seeking, in experience seeking, and in disinhibition than non-consumers. There is an increase in dysfunctional impulsivity and boredom susceptibility associated with consumption in women. Therefore, preventive programs should take into account the gender and certain personality traits of adolescents to increase their effectiveness

Difusión y orientación de las menciones de educación física y música en un entorno virtual, para estudiantes de grado en educación primaria.

El proyecto tiene como objetivo utilizar la plataforma Moodle como medio de difusión y orientación de las menciones de Educación Física y Música para los estudiantes de Grado en Educación Primaria