Enfermedades emergentes: Infecciones por Arbovirus en nuestro medio.

Los virus Dengue, Zika y Chikungunya son Arbovirus transmitidos por los mosquitos Aedes aegypti y Aedes albopictus en regiones tropicales, aunque pueden transmitirse por otras vías. En la actualidad existe una pandemia por estos virus debido a la globalización y los viajes internacionales. La clínica se basa en fiebre, exantema y malestar general, aunque pueden tener síntomas típicos como las artralgias en el Chikungunya, la conjuntivitis en el Zika y las hemorragias en el Dengue. El diagnóstico se realiza mediante PCR y serología, neutralización si es necesario y el tratamiento es sintomático. Hipótesis: Evaluar las características de los casos de estas infecciones en nuestro medio. Material y métodos: Estudio observacional descriptivo de los pacientes que dieron positivo a pruebas de laboratorio para estos arbovirus en el Área de Salud Valladolid Oeste. Realizamos una revisión bibliográfica y analizamos los datos recogidos de nuestra muestra. Resultados: Se incluyeron en el estudio 54 pacientes a los que se les solicitó pruebas de laboratorio frente a estos arbovirus. Resultaron positivos para alguna de ellas 23, de los cuales 8 eran hombres y 15 mujeres, 5 de ellas embarazadas. Cumplieron criterios diagnósticos de laboratorio para Zika 7 pacientes, para Chikungunya 4 y 3 para Dengue. Además 8 tuvieron resultados combinados de Zika y Dengue y 1 de Chikungunya y Dengue. Los síntomas que con mayor frecuencia presentaron fueron fiebre (12), exantema (7) y artralgias (7). Sólo 6 pacientes fueron seguidos posteriormente en consulta de enfermedades infecciosas. Conclusiones: El Zika es el arbovirus más detectado en nuestra población por la preocupación que genera su asociación con malformaciones fetales. Es por esto que se diagnostican más mujeres, sobre todo embarazadas. En cuanto a la clínica de la muestra no corresponde exactamente con los síntomas típicos descritos en la literatura, dificultando el diagnóstico clínico. El manejo de estos pacientes es adecuado, aunque sería necesario un mayor seguimiento por el Servicio de Infecciosas y la notificación a los Servicios de Epidemiologia.Grado en Medicin

Lesson Plan, World History/United States History/Government, 10th, 11th & 12th Grade

TEKS (Texas Essential Knowledge and Skills): WH: 1D; 7B,F; 8A USH: 3B; 25C GOVT: 11 ECO: 3BC Lesson objective(s): 1. Students will understand the connection between cultural-social family gatherings to the emergence of the cattle industry as a major big business/industry. 2. Students will examine the impact of cattle ranching from Spanish colonization to rise of American big business. 3. Students will examine the supply and demand of beef within the cattle ranching industr

Implant-Supported Fixed Partial Dentures with Posterior Cantilevers: In Vitro Study of Mechanical Behavior

Rehabilitation with dental implants is not always possible due to the lack of bone quality or quantity, in many cases due to bone atrophy or the morbidity of regenerative treatments. We find ourselves in situations of performing dental prostheses with cantilevers in order to rehabilitate our patients, thus simplifying the treatment. The aim of this study was to analyze the mechanical behavior of four types of fixed partial dentures with posterior cantilevers on two dental implants (convergent collar and transmucosal internal connection) through an in vitro study (compressive loading and cyclic loading). This study comprised four groups (n = 76): in Group 1, the prosthesis was screwed directly to the implant platform (DS; n = 19); in Group 2, the prosthesis was screwed to the telescopic interface on the implant head (INS; n = 19); in Group 3, the prosthesis was cemented to the telescopic abutment (INC; n = 19); and in Group 4, the prosthesis was cemented to the abutment (DC; n = 19). The sets were subjected to a cyclic loading test (80 N load for 240,000 cycles) and compressive loading test (100 KN load at a displacement rate of 0.5 mm/min), applying the load until failure occurred to any of the components at the abutment–prosthesis–implant interface. Subsequently, an optical microscopy analysis was performed to obtain more data on what had occurred in each group. Results: Group 1 (direct screw-retained prosthesis, DS) obtained the highest mean strength value of 663.5 ± 196.0 N. The other three groups were very homogeneous: 428.4 ± 63.1 N for Group 2 (INS), 486.7 ± 67.8 N for Group 3 (INC), and 458.9 ± 38.9 N for Group 4 (DC). The mean strength was significantly dependent on the type of connection (p < 0.001), and this difference was similar for all of the test conditions (cyclic and compressive loading) (p = 0.689). Implant-borne prostheses with convergent collars and transmucosal internal connections with posterior cantilevers screwed directly to the implant connection are a good solution in cases where implant placement cannot avoid extensions.Odontologí

Chitosan Films Incorporated with Exopolysaccharides from Deep Seawater Alteromonas sp.

Two Alteromonas sp. strains isolated from deep seawater were grown to promote the production of exopolysaccharides (EPS, E611 and E805), which were incorporated into chitosan solutions to develop films. The combination of the major marine polysaccharides (chitosan and the isolated bacterial EPS) resulted in the formation of homogenous, transparent, colorless films, suggesting good compatibility between the two components of the film-forming formulation. With regards to optical properties, the films showed low values of gloss, in the range of 5–10 GU, indicating the formation of non-glossy and rough surfaces. In addition to the film surface, both showed hydrophobic character, with water contact angles higher than 100 º, regardless of EPS addition. Among the two EPS under analysis, chitosan films with E805 showed better mechanical performance, leading to resistant, flexible, easy to handle films.This research was funded by the Economic Development and Infrastructures Department of the Basque Government (grant number KK-2019/00076) and the Quality and Food Industry Department of the Basque Government (grant number 22-2018-00078)

An autopsy study of maternal mortality in Mozambique: the contribution of infectious diseases

Background Maternal mortality is a major health problem concentrated in resource-poor regions. Accurate data on its causes using rigorous methods is lacking, but is essential to guide policy-makers and health professionals to reduce this intolerable burden. The aim of this study was to accurately describe the causes of maternal death in order to contribute to its reduction, in one of the regions of the world with the highest maternal mortality ratios. Methods and Findings We conducted a prospective study between October 2002 and December 2004 on the causes of maternal death in a tertiary-level referral hospital in Maputo, Mozambique, using complete autopsies with histological examination. HIV detection was done by virologic and serologic tests, and malaria was diagnosed by histological and parasitological examination. During 26 mo there were 179 maternal deaths, of which 139 (77.6%) had a complete autopsy and formed the basis of this analysis. Of those with test results, 65 women (52.8%) were HIV-positive. Obstetric complications accounted for 38.2% of deaths; haemorrhage was the most frequent cause (16.6%). Nonobstetric conditions accounted for 56.1% of deaths; HIV/AIDS, pyogenic bronchopneumonia, severe malaria, and pyogenic meningitis were the most common causes (12.9%, 12.2%, 10.1% and 7.2% respectively). Mycobacterial infection was found in 12 (8.6%) maternal deaths. Conclusions In this tertiary hospital in Mozambique, infectious diseases accounted for at least half of all maternal deaths, even though effective treatment is available for the four leading causes, HIV/AIDS, pyogenic bronchopneumonia, severe malaria, and pyogenic meningitis. These observations highlight the need to implement effective and available prevention tools, such as intermittent preventive treatment and insecticide-treated bed-nets for malaria, antiretroviral drugs for HIV/AIDS, or vaccines and effective antibiotics for pneumococcal and meningococcal diseases. Deaths due to obstetric causes represent a failure of health-care systems and require urgent improvement

Minorías en el Estado de Israel

Memoria ID-138. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2018-2019

Association Between Insulin‐Like Growth Factor‐1 and Social Cognition in Huntington's Disease

Insulin-like growth factor 1 (IGF-1) seems to be involved in the neural circuits associated with social cognition and brain structure.Study funded by Gerencia Regional de Salud de Castilla y Leon (Sacyl GRS 1768/A/18)

Megalencephalic leukoencephalopathy with subcortical cysts: a personal biochemical retrospective

Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare type of leukodystrophy characterized by dysfunction of the role of glial cells in controlling brain fluid and ion homeostasis. Patients affected by MLC present macrocephaly, cysts and white matter vacuolation, which lead to motor and cognitive impairments. To date, there is no treatment for MLC, only supportive care. MLC is caused by mutations in the MLC1 and GLIALCAM genes. MLC1 is a membrane protein with low identity to the Kv1.1 potassium channel and GlialCAM belongs to an adhesion molecule family. Both proteins form a complex with an as-yet-unknown function that is expressed mainly in the astrocytes surrounding the blood-brain barrier and in Bergmann glia. GlialCAM also acts as an auxiliary subunit of the chloride channel ClC-2, thus regulating its localization at cell-cell junctions and modifying its functional properties by affecting the common gate of ClC-2. Recent studies in Mlc1-,GlialCAM-and Clcn2-knockout mice or Mlc1- knockout zebrafish have provided fresh insight into the pathophysiology of MLC and further details about the molecular interactions between these three proteins. Additional studies have shown that GlialCAM/MLC1 also regulates other ion channels (TRPV4, VRAC) or transporters (Na+/K+-ATPase) in a not-understood manner. Furthermore, it has been shown that GlialCAM/ MLC1 may influence signal transduction mechanisms, thereby affecting other proteins not related with transport such as the EGFreceptor. Here, we offer a personal biochemical retrospective of the work that has been performed to gain knowledge of the pathophysiology of MLC, and we discuss future strategies that may be used to identify therapeutic solutions for MLC patients

Sistemas de apoyo clínico en Atención primaria: uso de e-learning e ilustraciones médicas en la toma de decisiones compartidas

Comunicación oral presentada en la Segunda Conferencia Internacional de Comunicación en Salud, celebrada el 23 de octubre de 2015 en la Universidad Carlos III de MadridIntroducción: La digitalización de la historia clínica supone un nuevo paradigma en la consulta de atención primaria permitiendo la continuidad asistencial y una gran accesibilidad a la información. Incorporar la participación del paciente aumenta su confianza y satisfacción hacia el profesional disminuyendo la iatrogenia y el coste sanitario. Esta visita personalizada requiere más tiempo, pero el aprendizaje electrónico mutuo (e-learning) aumenta la precisión diagnóstica y terapéutica, minimizando errores y efectos secundarios. Objetivos: evaluar el uso del e-learning e ilustraciones médicas en la toma de decisiones compartidas en el Centro de Atención Primaria Raval Sud de Barcelona; valorar la efectividad en la utilización de imágenes y gráficos para empoderar a la población atendida para comprender y participar en la toma de decisiones referentes a su salud; conocer la satisfacción y preferencias de uso del paciente y del profesional. Metodología: Diseño: Estudio cualitativo fenomenológico. Ámbito de estudio: Centro de Atención Primaria Raval Sud de Barcelona (zona urbana socialmente deprimida, 60% población inmigrada). Población de estudio: Pacientes atendidos por cualquier motivo (muestreo por bola de nieve) que accedan a participar en nuestro estudio. Técnicas de recogida de información: Observaciones y entrevistas individuales semiestructuradas. Durante la visita se observa la comunicación médico-paciente mediante la utilización del soporte visual electrónico, posteriormente se entrevista al paciente y al profesional para conocer su opinión. Análisis: Las observaciones y entrevistas son grabadas (grabadora de sonido) con posterior transcripción literal del texto y marcaje de citas, códigos y categorías. Análisis de contenido temático y categorización a posteriori. Resultados: Tras una prueba piloto se observa mayor facilitación y comprensión tras la visita, el paciente se muestra satisfecho y prefiere el uso del e-learning e ilustraciones médicas a la visita tradicional

The end of the roman empire in northwestern iberia: Recent research at the site of O Castelo, in Valencia Do Sil (Ourense)

[ES] En este trabajo se presentan los resultados de dos intervenciones arqueológicas realizadas en 2019 en en el yacimiento de O Castelo, en Valencia do Sil (Ourense), así como una síntesis analítica de toda la información disponible sobre el sitio. Se trata de un asentamiento fortificado que, gracias al análisis estratigráfico y las dataciones radiocarbónicas, podemos situar en los momentos finales del imperio romano en el noroeste peninsular. Así, se interpreta el enclave como un espacio de control del territorio en un momento de gran transformación política y económica. Las diferentes excavaciones llevadas a cabo en el sitio han permitido documentar dos entornos domésticos que ofrecen una importante información sobre la organización social de sus habitantes. El trabajo concluye con unas reflexiones interpretativas sobre el contexto histórico en el que se insertan este tipo de asentamientos en el norte peninsular.[EN] In this paper, we present the results of two recent archaeological interventions carried out at the site of O Castelo, in Valencia do Sil (Ourense), together with an analytic synthesis of all prior available data. This is a fortified settlement which, thanks to stratigraphic analyses and radiocarbon analysis, it can be dated within the final moments of the Roman Empire in northwestern Iberia. Therefore, we interpret the site as a territorial control nucleus in a period of great political and economic changes. Different excavations have uncovered two large domestic areas which offer quite important information on the social organization of its inhabitants. This paper concludes with some interpretative thoughts on the historic context in which this type of sites are inserted in northwestern Iberia.SIEste trabajo ha sido realizado en el marco del Proyecto «Agencia campesina y complejidad sociopolítica en el noroeste de la Península Ibérica en época medieval» (Ministerio de Economía, Industria y Competitividad, AEI/FEDER UE HUM2016-76094-C4-2-R), del Grupo de Investigación en Arqueología Medieval, Patrimonialización y Paisajes Culturales / ErdiArokoArkeologia, Ondaregintza eta KulturPaisaiakIkerketaTaldea(Gobierno Vasco, IT1193-19) y del Grupo de Estudios Rurales (Unidad Asociada UPV/EHU-CSIC)