Generations No.9: The UNAB children's orchestra

Hacer parte del grupo de 38 Instituciones de Educación Superior (IES) con Acreditación de Alta Calidad de un total de 288 en el país, es fruto de un trabajo arduo y minucioso a lo largo del tiempo, basado en la premisa fundamental de ofrecer estándares de excelencia en la educación, y formar ciudadanos con capacidades profesionales que contribuyan al desarrollo de la sociedad. Ustedes, graduados UNAB, como parte de ese grupo de profesionales, son además de nuestro orgullo, una de las razones por la cuales este año iniciamos nuevamente el proceso de Autoevaluación con miras a la renovación de la Acreditación Institucional y alcanzarla por segunda vez, será una recompensa a la gratificante misión educativa que ha consolidado la UNAB por más de 60 años en la región.Editorial; Por Alberto Montoya Puyana…3 Lenguaje musical que une la ciudad; Por Redacción Generaciones UNAB…4 La voz del graduado…7 Nuevo convenio con trabajando.com; Por Luz Yaqueline Hernández Castañeda…8 En busca de renovar la Acreditación Institucional; Por Redacción Generaciones UNAB…10 “Contrapunto en la rivera y en la montaña”; Por Carlos Ernesto Acosta Posada…14 Desafíos para el ejercicio de la salud pública; Por Rafael Pérez Rincón…17 Logística: Ventaja competitiva para el éxito; Por Victoria Andrea Sarmiento Gómez…21 La investigación en el campo musical; Por Johanna Calderón Ochoa…24 Emprendimiento hecho en Santander; Por Redacción Generaciones UNAB…27 Graduados destacados; Por Redacción Generaciones UNAB…30 Generaciones en cifras; Por Redacción Generaciones UNAB…37 Mercadeo Institucional; Por Redacción Generaciones UNAB…38 Noticias breves…40 Encuentros…42Being part of the group of 38 Higher Education Institutions (IES) with High Quality Accreditation out of a total of 288 in the country, is the result of arduous and meticulous work over time, based on the fundamental premise of offering standards of excellence in education, and train citizens with professional skills that contribute to the development of society. You, UNAB graduates, as part of this group of professionals, are also our pride, one of the reasons why this year we started the Self-Assessment process again with a view to renewing Institutional Accreditation and achieving it for the second time, will be a reward for the gratifying educational mission that UNAB has consolidated for more than 60 years in the region

Generations No.7: Annual rendezvous with culture

Nuestra Institución se mueve articulada en tres ejes misionales: docencia, investigación y extensión; es precisamente en esta última, como parte de la labor de extensión cultural de la Universidad, que anualmente efectuamos la Feria del Libro de Bucaramanga, Ulibro. Cito al periodista mexicano Sergio González Rodríguez: “Tenemos que reaprender que la literatura no es solo entretener, tiene que servir para pensar, para analizar”, y a eso le apuesta la UNAB desde hace 12 años con Ulibro: una excusa para promover la cultura y el hábito de la lectura.Editorial; Por Alberto Montoya Puyana…3 Ulibro; Por Laura Camila Romero Martínez…4 La voz del graduado…6 Recomendaciones para elaborar una hoja de vida; Por Ana Carolina Torres P.…8 ABC de los posgrados; Por Carolina Toscano V....10 Comunicación y Artes Mensaje integral; Por Claudia Santamaría Valbuena…16 La conversación como salud; Por Carlos Germán Celis E....18 Ciudades inteligentes; Por Clara Inés Peña de Carrillo…20 Educación farmacéutica; Por Yaneth Rocío Orellana Hernández y Sergio Daniel Quiroga Flórez…22 La enseñanza del Derecho; Por Mario Guevara Mendoza…25 También comienza por casa; Por Hugo F. Prada A…28 Los macroproyectos Investigaciones UNAB; Por Miguel Ángel Hernández Rey…30 Graduados destacados; Por Redacción Generaciones UNAB…34 Generaciones en cifras; Por Redacción Generaciones UNAB…42 Centro de Apoyo y Formación Empresarial; Por Redacción Generaciones UNAB…43 6ª Feria del Empleo; Por Redacción Generaciones UNAB…46 Encuentros…48Our Institution moves articulated in three missionary axes: teaching, research and extension; It is precisely in the latter, as part of the cultural outreach work of the University, that we annually hold the Bucaramanga Book Fair, Ulibro. I quote the Mexican journalist Sergio González Rodríguez: “We have to relearn that literature is not only entertaining, it has to serve to think, to analyze”, and that is what the UNAB has been betting on for 12 years with Ulibro: an excuse to promote culture and the habit of reading

The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

Libro de Proyectos Finales 2021 primer semestre

PregradoIngeniero CivilIngeniero de SistemasIngeniero ElectricistaIngeniero ElectrónicoIngeniero IndustrialIngeniero Mecánic

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele