Crecimiento y eficiencia de uso del nitrógeno en maíz de regadío en una región semiárida según la fertilización nitrogenada utilizada

The main groundwater pollution factor in irrigated maize production areas is leaching of nitrogen below the root zone. During the years 1999-2001, experiments were carried out on irrigated maize in the semiarid region of Castilla- La Mancha to evaluate the effect of nitrogen in the growth and yield of maize. Three rates of nitrogen were tested: No (0 kg N ha-1), Nop (175, 150 and 130 kg N ha-1 in 1999, 2000 and 2001, respectively), and Nc (300 kg N ha-1). A high initial level of residual soil NO-3 was found in the spring of 1999 as a consequence of fertilization carryover from the previous years. Although there was no plant response to N fertilization in 1999, significant responses were obtained during the following two years. Moreover, in 2000, the grain production did not show significant differences between Nop and Nc. However, in 2001, maize yield was slightly decreased due to an attempt to decrease the Nop to 130 kg N ha-1, showing significant differences with regard to Nc. The differences in grain yield among nitrogen levels were mainly due to a significant variation in maximum leaf area index, leaf area duration and crop growth rate. There was a decreasing pattern in nitrogen use efficiency values with increasing fertilizer rates, indicating that crop production could be sustained with lower fertilizer applications. Fertilizer practices must be revised in order to control and prevent insofar as possible water pollution in "La-Mancha Oriental" aquifer.El principal contaminante del agua subterránea en las áreas de regadío cultivadas de maíz es la lixiviación del nitrógeno. Durante los años 1999 a 2001 se han realizado ensayos en maíz regado en la región semiárida de Castilla-La Mancha, con el objetivo de evaluar su producción y crecimiento ante tres dosis de nitrógeno: No (0 kg N ha-1), Nop (175, 150 y 130 kg N ha-1 en 1999, 2000 y 2001, respectivamente), y Nc (300 kg N ha-1). El alto nivel inicial de NO-3 residual en el suelo durante la primavera de 1999, consecuencia de la fertilización anterior, propició la falta de respuesta a la fertilización con N. Sin embargo, se obtuvieron respuestas significativas los dos años siguientes. Además, en el año 2000, la producción de grano no registró diferencias significativas entre Nop y Nc. Sin embargo, disminuyó ligeramente la producción en el año 2001 al tratar de reducir la dosis óptima a 130 kg N ha-1, presentando diferencias significativas respecto a Nc. Este hecho fue debido, principalmente, a una variación significativa en el índice de área foliar máximo, la duración del área foliar y la tasa de crecimiento del cultivo. Las dosis más elevadas de fertilizante originaron una disminución de la eficiencia de uso del nitrógeno, por lo que la producción podría obtenerse con unos aportes menores de nitrógeno. Se debe revisar la fertilización para contribuir a controlar y prevenir, en la medida de lo posible, la contaminación en el acuífero de La Mancha Oriental

Determinación del estado hídrico en viña a través de imágenes RGB y multiespectrales adquiridas por un VANT

La teledetección se ha convertido en una herramienta muy utilizada en la agricultura de precisión. La existencia de sensores ligeros, calibrados geométrica y radiométricamente, ha hecho que los vehículos aéreos no tripulados (VANTs) sean una de las plataformas más utilizadas en teledetección por obtener datos de muy alta resolución espacial y temporal. En el marco de la viticultura de precisión, haciendo uso de VANTs para la obtención de imágenes aéreas de la cubierta vegetal que proporcionen información agronómicamente útil para hacer un manejo y una gestión del riego sostenible y eficiente frente a la escasez hídrica existente principalmente en zonas áridas y semiáridas, se llevó a cabo un estudio en un viñedo localizado en Fuente-Álamo (Albacete) durante 2018 y 2019. Para obtener un amplio rango de condiciones de estado hídrico de la vid, varias estrategias de riego fueron aplicadas incluyendo regímenes con diferentes niveles de salinidad del agua, estableciendo diferencias en el estado hídrico de la cepa. Los vuelos se hicieron a lo largo del ciclo fenológico usando sensores convencionales (o RGB -red, green, blue-) y multiespectrales a bordo de un VANT, obteniendo ortoimágenes. Estas ortoimágenes fueron segmentadas para incluir solo la vegetación obteniendo el grado de cobertura verde como un parámetro geométrico representativo del desarrollo vegetal del cultivo. El potencial hídrico de tallo fue medido a mediodía con cámaras de presión, y la integral de estrés hídrico fue calculada a partir de estas medidas de estado hídrico, como una variable representativa del efecto acumulado de la intensidad y duración del estrés hídrico desde el comienzo del ciclo de desarrollo hasta el momento de la medida. Modelos de regresión lineal simple usando índices de vegetación basados en la respuesta espectral de la vegetación y el grado de cobertura verde fueron evaluados para predecir la integral de estrés hídrico. Técnicas de regresión no lineal usando redes neuronales artificiales con bandas de los sensores multiespectral y RGB y el grado de cobertura verde como variables predictoras de la integral de estrés hídrico también fueron empleadas. Ambos modelos mostraron que los datos del rango visible (pese a la menor reflectividad de la vegetación en este rango espectral) fueron más útiles para predecir la integral de estrés hídrico que los datos del rango multiespectral, que consideran la reflectividad en el red-edge y en el infrarrojo cercano, proporcionando mejores resultados los modelos no lineales de redes neuronales artificiales con valores de R2 próximos a 1 y errores relativos de 1.5 % o ligeramente superiores. La mayor resolución espacial, calidad radiométrica, facilidad de uso de la cámara RGB, su menor precio y fácil procesamiento de las imágenes RGB hace que estos sensores, utilizados en menor medida con usos agrícolas, sean una buena opción para usarse en la predicción del estado hídrico en viña

The Mars Environmental Dynamics Analyzer, MEDA. A Suite of Environmental Sensors for the Mars 2020 Mission

86 pags., 49 figs., 24 tabs.NASA’s Mars 2020 (M2020) rover mission includes a suite of sensors to monitor current environmental conditions near the surface of Mars and to constrain bulk aerosol properties from changes in atmospheric radiation at the surface. The Mars Environmental Dynamics Analyzer (MEDA) consists of a set of meteorological sensors including wind sensor, a barometer, a relative humidity sensor, a set of 5 thermocouples to measure atmospheric temperature at ∼1.5 m and ∼0.5 m above the surface, a set of thermopiles to characterize the thermal IR brightness temperatures of the surface and the lower atmosphere. MEDA adds a radiation and dust sensor to monitor the optical atmospheric properties that can be used to infer bulk aerosol physical properties such as particle size distribution, non-sphericity, and concentration. The MEDA package and its scientific purpose are described in this document as well as how it responded to the calibration tests and how it helps prepare for the human exploration of Mars. A comparison is also presented to previous environmental monitoring payloads landed on Mars on the Viking, Pathfinder, Phoenix, MSL, and InSight spacecraft.This work has been funded by the Spanish Ministry of Economy and Competitiveness, through the projects No. ESP2014-54256-C4-1-R (also -2-R, -3-R and -4-R) and AYA2015-65041-P; Ministry of Science, Innovation and Universities, projects No. ESP2016-79612-C3-1-R (also -2-R and -3-R), ESP2016-80320-C2-1-R, RTI2018-098728-B-C31 (also -C32 and -C33) and RTI2018-099825-B-C31; Instituto Nacional de Técnica Aeroespacial; Ministry of Science and Innovation’s Centre for the Development of Industrial Technology; Grupos Gobierno Vasco IT1366-19; and European Research Council Consolidator Grant no 818602. The US co-authors performed their work under sponsorship from NASA’s Mars 2020 project, from the Game Changing Development program within the Space Technology Mission Directorate and from the Human Exploration and Operations Directorate

New insights into the genetic etiology of Alzheimer's disease and related dementias.

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Seguimiento de las guías españolas para el manejo del asma por el médico de atención primaria: un estudio observacional ambispectivo

Objetivo Evaluar el grado de seguimiento de las recomendaciones de las versiones de la Guía española para el manejo del asma (GEMA 2009 y 2015) y su repercusión en el control de la enfermedad. Material y métodos Estudio observacional y ambispectivo realizado entre septiembre del 2015 y abril del 2016, en el que participaron 314 médicos de atención primaria y 2.864 pacientes. Resultados Utilizando datos retrospectivos, 81 de los 314 médicos (25, 8% [IC del 95%, 21, 3 a 30, 9]) comunicaron seguir las recomendaciones de la GEMA 2009. Al inicio del estudio, 88 de los 314 médicos (28, 0% [IC del 95%, 23, 4 a 33, 2]) seguían las recomendaciones de la GEMA 2015. El tener un asma mal controlada (OR 0, 19, IC del 95%, 0, 13 a 0, 28) y presentar un asma persistente grave al inicio del estudio (OR 0, 20, IC del 95%, 0, 12 a 0, 34) se asociaron negativamente con tener un asma bien controlada al final del seguimiento. Por el contrario, el seguimiento de las recomendaciones de la GEMA 2015 se asoció de manera positiva con una mayor posibilidad de que el paciente tuviera un asma bien controlada al final del periodo de seguimiento (OR 1, 70, IC del 95%, 1, 40 a 2, 06). Conclusiones El escaso seguimiento de las guías clínicas para el manejo del asma constituye un problema común entre los médicos de atención primaria. Un seguimiento de estas guías se asocia con un control mejor del asma. Existe la necesidad de actuaciones que puedan mejorar el seguimiento por parte de los médicos de atención primaria de las guías para el manejo del asma. Objective: To assess the degree of compliance with the recommendations of the 2009 and 2015 versions of the Spanish guidelines for managing asthma (Guía Española para el Manejo del Asma [GEMA]) and the effect of this compliance on controlling the disease. Material and methods: We conducted an observational ambispective study between September 2015 and April 2016 in which 314 primary care physicians and 2864 patients participated. Results: Using retrospective data, we found that 81 of the 314 physicians (25.8%; 95% CI 21.3–30.9) stated that they complied with the GEMA2009 recommendations. At the start of the study, 88 of the 314 physicians (28.0%; 95% CI 23.4–33.2) complied with the GEMA2015 recommendations. Poorly controlled asthma (OR, 0.19; 95% CI 0.13–0.28) and persistent severe asthma at the start of the study (OR, 0.20; 95% CI 0.12–0.34) were negatively associated with having well-controlled asthma by the end of the follow-up. In contrast, compliance with the GEMA2015 recommendations was positively associated with a greater likelihood that the patient would have well-controlled asthma by the end of the follow-up (OR, 1.70; 95% CI 1.40–2.06). Conclusions: Low compliance with the clinical guidelines for managing asthma is a common problem among primary care physicians. Compliance with these guidelines is associated with better asthma control. Actions need to be taken to improve primary care physician compliance with the asthma management guidelines