Patrimonio territorial: Una revisión teórico-conceptual. Aplicaciones y dificultades del caso Español / Territorial heritage: A theoretical-conceptual review. Applications and difficulties of the Spanish case

La noción de “patrimonio” ha permanecido en una constante evolución histórica, siguiendo un enfoque cohesionador que ha dado lugar a concepciones cada vez más integradoras de la misma en cuanto a sus ámbitos y alcance. Por lo demás, el desarrollo de las sociedades requiere de modelos que permitan comprender el patrimonio en clave integral, pues resulta fundamental para lograr el manejo y entendimiento holístico del territorio, lo cual hace confluir en el interés por el concepto de “Patrimonio Territorial”. De esta forma, el objetivo del presente trabajo es realizar una revisión teórico-conceptual sobre la noción de “Patrimonio Territorial” para aplicarla a un caso de estudio en España; un constructo complejo y dinámico, que permanece abierto. Para ello, la metodología se ha llevado a cabo en tres etapas y ha consistido en una revisión bibliográfica correspondiente al periodo comprendido entre los años 1990 a 2020, centrada en estudios disponibles online, que ha permitido identificar la discusión existente sobre el concepto, los principales tópicos y sus dificultades. Los resultados evidencian que la expresión “Patrimonio Territorial” ha tenido diversas aplicaciones teóricas, como en paisaje, turismo, desarrollo sostenible, tecnologías de información, ordenación del territorio, diseño y modelo de gestión, en ámbitos territoriales. Sin embargo, sigue siendo una noción que requiere de mayor determinación sobre las escalas de aplicación, en el universo de elementos que pretende abordar y en su implementación bajo instrumentos de gestión y/o planificación que hagan posible plasmarla. En definitiva, el concepto permanece en desarrollo, manteniendo viva la discusión científica, principalmente desde la arista teórica, pues su aplicación práctica aún sigue siendo incipiente.The notion of Heritage has remained within a constant historic evolution, following a cohesive approach which has led to ever more integrating concepts regarding its setting and scope. While, the development of societies requires models that allow understanding heritage as comprehensive, since it is essential to reach a holistic understanding and management of the territory, all of which leads to an interest about Territorial Heritage. In this way, the goal of this work is to make a theoretical-conceptual revision about the notion of Territorial Heritage in the case of Spain, a complex and dynamic concept that remains open. For this, the methodology has been developed in three stages and consists in a bibliographical review between the 1990s and 2020, focused on the studies available online, which has allowed identifying the existing discussion on the concept, the main topics and their difficulties. The results show that the concept of Territorial Heritage has had diverse theoretical applications like, for example in landscape, tourism, sustainable development, IT, territorial organization, design and management model. However, it continues to be a notion that requires a greater determination about the scales of application, in the universe of elements it intends to address and in their implementation under management and/or planning tools that can make its embodiment possible. Ultimately, the concept remains in development, keeping the scientific discussion alive, mainly from the technical point of view, as its practical application is still incipient. &nbsp

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Publisher Copyright: © 2022, The Author(s).Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results: To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3–5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Conclusions: Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.Peer reviewe

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Funding GMP, PN, and CW are supported by NHLBI R01HL127564. GMP and PN are supported by R01HL142711. AG acknowledge support from the Wellcome Trust (201543/B/16/Z), European Union Seventh Framework Programme FP7/2007–2013 under grant agreement no. HEALTH-F2-2013–601456 (CVGenes@Target) & the TriPartite Immunometabolism Consortium [TrIC]-Novo Nordisk Foundation’s Grant number NNF15CC0018486. JMM is supported by American Diabetes Association Innovative and Clinical Translational Award 1–19-ICTS-068. SR was supported by the Academy of Finland Center of Excellence in Complex Disease Genetics (Grant No 312062), the Finnish Foundation for Cardiovascular Research, the Sigrid Juselius Foundation, and University of Helsinki HiLIFE Fellow and Grand Challenge grants. EW was supported by the Finnish innovation fund Sitra (EW) and Finska Läkaresällskapet. CNS was supported by American Heart Association Postdoctoral Fellowships 15POST24470131 and 17POST33650016. Charles N Rotimi is supported by Z01HG200362. Zhe Wang, Michael H Preuss, and Ruth JF Loos are supported by R01HL142302. NJT is a Wellcome Trust Investigator (202802/Z/16/Z), is the PI of the Avon Longitudinal Study of Parents and Children (MRC & WT 217065/Z/19/Z), is supported by the University of Bristol NIHR Biomedical Research Centre (BRC-1215–2001) and the MRC Integrative Epidemiology Unit (MC_UU_00011), and works within the CRUK Integrative Cancer Epidemiology Programme (C18281/A19169). Ruth E Mitchell is a member of the MRC Integrative Epidemiology Unit at the University of Bristol funded by the MRC (MC_UU_00011/1). Simon Haworth is supported by the UK National Institute for Health Research Academic Clinical Fellowship. Paul S. de Vries was supported by American Heart Association grant number 18CDA34110116. Julia Ramierz acknowledges support by the People Programme of the European Union’s Seventh Framework Programme grant n° 608765 and Marie Sklodowska-Curie grant n° 786833. Maria Sabater-Lleal is supported by a Miguel Servet contract from the ISCIII Spanish Health Institute (CP17/00142) and co-financed by the European Social Fund. Jian Yang is funded by the Westlake Education Foundation. Olga Giannakopoulou has received funding from the British Heart Foundation (BHF) (FS/14/66/3129). CHARGE Consortium cohorts were supported by R01HL105756. Study-specific acknowledgements are available in the Additional file 32: Supplementary Note. The views expressed in this manuscript are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the U.S. Department of Health and Human Services.Peer reviewedPublisher PD

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Abstract Background Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3–5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Conclusions Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk

Cuentos de nunca acabar. Aproximaciones desde la interculturalidad

Cuentos de nunca acabar. Aproximaciones desde la interculturalidad, surge después de la pandemia y su imposibilidad de socializar “en persona” con los compañeros de eventuales encuentros, porque la Comprensión Lectora tenía que reinventarse para su nueva reflexión cognitiva, adaptación contextual y reconstrucción del conocimiento. Este renovado enfoque de la realidad postpandemia, concebido en el marco de la educación intercultural comunitaria, busca potencializar los entornos naturales, sociales y culturales como recursos de aprendizaje multidisciplinario a través del lenguaje animado de los cuentos. En este marco, había que dinamizar la asignatura de Comunicación Oral y Escrita, que se dicta en los Primeros Niveles de los Centros de Apoyo de Otavalo, Cayambe, Latacunga y Riobamba, mediante un eje transversal donde los estudiantes escriban fundamentados en valores de la cosmovisión andina, considerando que provienen de varios lugares de la sierra y amazonía ecuatoriana. Todo surgió del encuentro presencial de un sábado cualquiera donde los estudiantes realizaban ejercicios narrativos, logrando una apreciable respuesta de imaginación, más emotiva que la clásica tarea de las Unidades, tanto así que, pasados unos días, seguían llegando sus escritos a mi correo. Entonces nos pusimos manos a la obra, cada estudiante tendría dos opciones como Actividad Integradora, la primera consistía en escribir un cuento de su propia inspiración, y la segunda analizar un clásico para comentar sus valores y antivalores. La mayor parte de estudiantes decidió escribir su propio cuento, de donde se escogieron algunas participaciones que podrían considerarse originales, para una edición que, respetando la transcripción de la tradición oral que prima en los sectores comunitarios, nos concretamos en revisar la puntuación y ortografía para publicarlos. Con esto buscamos innovar la Actividad Integradora, por algo más práctico y operativo para configurar los Objetos de Aprendizaje que buscamos. Así nació, en medio del camino, este libro de Cuentos de nunca acabar. Aproximaciones desde la interculturalidad, que ponemos en sus manos. Hernán Hermosa Mantilla Quito, junio de 202

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Funding Information: GMP, PN, and CW are supported by NHLBI R01HL127564. GMP and PN are supported by R01HL142711. AG acknowledge support from the Wellcome Trust (201543/B/16/Z), European Union Seventh Framework Programme FP7/2007–2013 under grant agreement no. HEALTH-F2-2013–601456 (CVGenes@Target) & the TriPartite Immunometabolism Consortium [TrIC]-Novo Nordisk Foundation’s Grant number NNF15CC0018486. JMM is supported by American Diabetes Association Innovative and Clinical Translational Award 1–19-ICTS-068. SR was supported by the Academy of Finland Center of Excellence in Complex Disease Genetics (Grant No 312062), the Finnish Foundation for Cardiovascular Research, the Sigrid Juselius Foundation, and University of Helsinki HiLIFE Fellow and Grand Challenge grants. EW was supported by the Finnish innovation fund Sitra (EW) and Finska Läkaresällskapet. CNS was supported by American Heart Association Postdoctoral Fellowships 15POST24470131 and 17POST33650016. Charles N Rotimi is supported by Z01HG200362. Zhe Wang, Michael H Preuss, and Ruth JF Loos are supported by R01HL142302. NJT is a Wellcome Trust Investigator (202802/Z/16/Z), is the PI of the Avon Longitudinal Study of Parents and Children (MRC & WT 217065/Z/19/Z), is supported by the University of Bristol NIHR Biomedical Research Centre (BRC-1215–2001) and the MRC Integrative Epidemiology Unit (MC_UU_00011), and works within the CRUK Integrative Cancer Epidemiology Programme (C18281/A19169). Ruth E Mitchell is a member of the MRC Integrative Epidemiology Unit at the University of Bristol funded by the MRC (MC_UU_00011/1). Simon Haworth is supported by the UK National Institute for Health Research Academic Clinical Fellowship. Paul S. de Vries was supported by American Heart Association grant number 18CDA34110116. Julia Ramierz acknowledges support by the People Programme of the European Union’s Seventh Framework Programme grant n° 608765 and Marie Sklodowska-Curie grant n° 786833. Maria Sabater-Lleal is supported by a Miguel Servet contract from the ISCIII Spanish Health Institute (CP17/00142) and co-financed by the European Social Fund. Jian Yang is funded by the Westlake Education Foundation. Olga Giannakopoulou has received funding from the British Heart Foundation (BHF) (FS/14/66/3129). CHARGE Consortium cohorts were supported by R01HL105756. Study-specific acknowledgements are available in the Additional file : Supplementary Note. The views expressed in this manuscript are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the U.S. Department of Health and Human Services. Publisher Copyright: © 2022, The Author(s).Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results: To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3–5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Conclusions: Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.Peer reviewe

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

Paisaje de sal de mar en Chile. Desastre y Resiliencia. Breve reseña de la huella de algunos terremotos-tsunamis en las salinas costeras = Landscape of sea salt in Chile. Disaster and Resilience. Brief overview of the footprint of some earthquakes- tsunamis in coastal salt flats

RESUMEN:La presente investigación se enfoca en el paisaje de sal de mar en Chile en el contexto de desastres, tomando como estudio de caso algunos de los terremotos- tsunamis y su huella en las salinas costeras, a fin de observar la resiliencia de estospaisajes.La metodología se ha desarrollado en tres fases y ha consistido en un estudio descriptivo, mediante una recopilación y revisión bibliográfica de fuentes primarias y secundarias online, que permitieron identificar como casos de estudio los terremotos-tsunamis de 1730,1751, 1906, 1960 y 2010 y, las afectaciones en algunas de las salinas litorales.Los resultados arrojaron que hay salinas que han tenido una respuesta resiliente ante los efectos de al menos 6 terremotos-tsunamis en un periodo de 280 años. En definitiva, los paisajes de sal de mar activos en Chile conllevan la incertidumbre latente en ellos, en donde los eventos catastróficos han puesto a prueba su capacidad de adaptación, resiliencia y su memoria colectiva  para poder sobreponerse al desastre. De esta forma albergan la huella e internalizan la recurrencia de fenómenos que, aunque no son inusuales, son imprevisibles en elterritorio. ABSTRACT:The present investigation focuses on the sea salt landscape in Chile in the context of disasters, taking as a case study some of the earthquakes-tsunamis and their footprint on the coastal salt flats, in order to observe the resilience of theselandscapes.The methodology has been developed in three phases and has consisted of a descriptive study, through a collection and bibliographic review of primary and secondary sources online, that allowed to identify as case studies the earthquakes-Tsunamis of 1730, 1751, 1906, 1960 and 2010 and, the effects on some of the salines.The results showed that there are salines that have had a resilient response to the effects of at least 6 earthquakes-tsunamis over a period of 280 years. In short, the active sea salt landscapes in Chile carry the uncertainty inherent in them, where catastrophic events have tested their capacity to adapt, resilience and collective memory to overcome the disaster. In this way, they house the footprint and internalize the recurrence of phenomena that, although not unusual, are unpredictable in theterritory

Patrimonio territorial: una revisión teórico-conceptual. Aplicaciones y dificultades del caso Español

The notion of Heritage has remained within a constant historic evolution, following a cohesive approach which has led to ever more integrating concepts regarding its setting and scope. While, the development of societies requires models that allow understanding heritage as comprehensive, since it is essential to reach a holistic understanding and management of the territory, all of which leads to an interest about Territorial Heritage. In this way, the goal of this work is to make a theoretical-conceptual revision about the notion of Territorial Heritage in the case of Spain, a complex and dynamic concept that remains open. For this, the methodology has been developed in three stages and consists in a bibliographical review between the 1990s and 2020, focused on the studies available online, which has allowed identifying the existing discussion on the concept, the main topics and their difficulties. The results show that the concept of Territorial Heritage has had diverse theoretical applications like, for example in landscape, tourism, sustainable development, IT, territorial organization, design and management model. However, it continues to be a notion that requires a greater determination about the scales of application, in the universe of elements it intends to address and in their implementation under management and/or planning tools that can make its embodiment possible. Ultimately, the concept remains in development, keeping the scientific discussion alive, mainly from the technical point of view, as its practical application is still incipient.  La noción de “patrimonio” ha permanecido en una constante evolución histórica, siguiendo un enfoque cohesionador que ha dado lugar a concepciones cada vez más integradoras de la misma en cuanto a sus ámbitos y alcance. Por lo demás, el desarrollo de las sociedades requiere de modelos que permitan comprender el patrimonio en clave integral, pues resulta fundamental para lograr el manejo y entendimiento holístico del territorio, lo cual hace confluir en el interés por el concepto de “Patrimonio Territorial”. De esta forma, el objetivo del presente trabajo es realizar una revisión teórico-conceptual sobre la noción de “Patrimonio Territorial” para aplicarla a un caso de estudio en España; un constructo complejo y dinámico, que permanece abierto. Para ello, la metodología se ha llevado a cabo en tres etapas y ha consistido en una revisión bibliográfica correspondiente al periodo comprendido entre los años 1990 a 2020, centrada en estudios disponibles online, que ha permitido identificar la discusión existente sobre el concepto, los principales tópicos y sus dificultades. Los resultados evidencian que la expresión “Patrimonio Territorial” ha tenido diversas aplicaciones teóricas, como en paisaje, turismo, desarrollo sostenible, tecnologías de información, ordenación del territorio, diseño y modelo de gestión, en ámbitos territoriales. Sin embargo, sigue siendo una noción que requiere de mayor determinación sobre las escalas de aplicación, en el universo de elementos que pretende abordar y en su implementación bajo instrumentos de gestión y/o planificación que hagan posible plasmarla. En definitiva, el concepto permanece en desarrollo, manteniendo viva la discusión científica, principalmente desde la arista teórica, pues su aplicación práctica aún sigue siendo incipiente

Characterization of itinerant festivals in the salt landscape of Chile: the feast of Salt (Cáhuil) and the feast of San Andrés (Ciruelos)

El paisaje salinero artesanal constituye una serie de componentes tangibles e intangibles, en donde las celebraciones pueden ser un factor de diversidad cultural en un mundo globalizado. Así, el interés de esta investigación es aportar data empírica de fiestas itinerantes en torno al paisaje de la sal de mar chileno que han sido exiguamente estudiadas. Para ello, se investiga la fiesta de la sal (Cáhuil) y la fiesta de San Andrés (Ciruelos), adscritas a las salinas de la zona de Cáhuil, con el objeto de caracterizar sus dinámicas territoriales y vínculos con la actividad salinera. La metodología se basa en trabajo de campo, entrevistas y estudio de casos, mediante un análisis descriptivo y cualitativo. Los resultados han develado la relación socio-territorial entre las celebraciones y el paisaje, siendo elementos dinamizadores y difusivos. Concluyentemente, las fiestas pueden constituir componentes diferenciadores, siendo fundamental su caracterización para mayor compresión del paisaje y territorio.The artisanal salt landscape constitutes a plot of tangible and intangible components, where celebrations can be a factor of cultural diversity in a globalized world. Thus, the interest of this research is to provide empirical data on itinerant festivals around the Chilean sea salt landscape that have been meagerly studied. To do this, the festival of salt (Cáhuil) and the festival of San Andrés (Ciruelos), ascribed to the salt flats in the Cáhuil area, are investigated in order to characterize their territorial dynamics and links with the salt activity. The methodology is based on field work, interviews and case studies, through descriptive and qualitative analysis. The results have revealed the socio-territorial relationship between the celebrations and the landscape, being dynamic and diffusive elements. In conclusion, festivals can constitute differentiating components, their characterization being essential for a better understanding of the landscape and territory.Peer Reviewe