Production of: Foghorn Requiem

Richard Hollinshead was invited by the National Trust to develop a high-profile temporary artwork for Souter Lighthouse, South Shields. In response to this opportunity he developed an Artists’ Brief and curated a proposal by artists Lise Autogena and Joshua Portway. Their proposal Foghorn Requiem became a major site-specific project, and on June 22nd 2013 more than 50 ships gathered on the North Sea to perform an ambitious musical score by composer Orlando Gough, marking the disappearance of the sound of the foghorn from the UK’s coastal landscape. Specially tuned shipshorns and air supply systems installed on those vessels were accompanied by the Foghorn at Souter and three Championship-level brass bands, and Foghorn Requiem was performed to an audience of 8000

Plan estratégico para la producción de biocombustibles en el Perú con enfoque de economía circular

La presente investigación muestra el plan estratégico para la producción de biocombustibles en el Perú con enfoque de economía circular para el período 2015 - 2030, el cual se responde a un contexto en el cual el país viene experimentando cambios en el ámbito energético que han beneficiado a diversas industrias y ello significa que progresivamente también se incursionará con bastante mayor ímpetu en la economía circular para alcanzar un desarrollo sostenible. Si bien es cierto que lograr tal cometido todavía demandará varios años, lo importante es que las empresas que operan en el ámbito local se sientan en la obligación de considerar este escenario con anticipación para oportunamente direccionar su accionar en tal sentido. Bajo las circunstancias expresadas, el presente estudio ha mostrado cómo es que este rubro partiendo de una visión puede hacer frente a los desafíos existentes tanto a nivel interno, considerando los fortalezas y debilidades, como externo, considerando las oportunidades y amenazas, para en base a ello determinar estrategias que requieren de ciertos recursos para hacerse efectivas mejoras que se encuentran emparejadas con objetivos tanto a largo como a corto plazo, siendo estos últimos los que requerirán de monitoreo y control en base a métricas para conocer el avance conseguido. Finalmente, cabe señalar que cualquier iniciativa de mejora debe surgir luego de efectuar el respectivo seguimiento a la propuesta realizada y considerar que en la actualidad los negocios se desenvuelven bajo condiciones de constante cambio, por lo cual apoyarse en el método del proceso estratégico resulta la más adecuada herramienta de gestión para enfrentar la dinámica con que se desenvuelven los negocios en torno a las diversas energías renovables.This research presents the strategic plan for the production of biofuels in Peru with a focus on circular economy for the period 2015 - 2030, which responds to a context in which the country has been experiencing changes in the energy sector that have benefited various industries and it also means that progressively will enter with much greater momentum in the circular economy to achieve sustainable development. While still committed to achieve this will require several years, it is important that companies operating locally feel obliged to consider this scenario in advance to promptly address their actions in this regard. Under the stated circumstances, the present study has shown how this category based on a vision can cope with current challenges both internally considering the strengths and weaknesses, and external opportunities and threats considering for based on thus determine strategies that require certain resources to be effective improvements that are paired with goals both long and short term, the latter being those who require monitoring and control based on metrics to know the progress achieved. Finally, it should be noted that any improvement initiative should arise after performing the respective follow the proposal made and consider that today business they operate under conditions of constant change, which rely on the method of the strategic process is the most appropriate management tool to address the dynamic business that are developed around the various renewable energies.Tesi

High performance aluminum–cerium alloys for high-temperature applications

Light-weight high-temperature alloys are important to the transportation industry where weight, cost, and operating temperature are major factors in the design of energy efficient vehicles. Aluminum alloys fill this gap economically but lack high-temperature mechanical performance. Alloying aluminum with cerium creates a highly castable alloy, compatible with traditional aluminum alloy additions, that exhibits dramatically improved high-temperature performance. These compositions display a room temperature ultimate tensile strength of 400 MPa and yield strength of 320 MPa, with 80% mechanical property retention at 240 °C. A mechanism is identified that addresses the mechanical property stability of the Al-alloys to at least 300 °C and their microstructural stability to above 500 °C which may enable applications without the need for heat treatment. Finally, neutron diffraction under load provides insight into the unusual mechanisms driving the mechanical strength

Vertebral Augmentation: Is It Time to Get Past the Pain? A Consensus Statement from the Sardinia Spine and Stroke Congress

Vertebral augmentation has been used to treat painful vertebral compression fractures and metastatic lesions in millions of patients around the world. An international group of subject matter experts have considered the evidence, including but not limited to mortality. These considerations led them to ask whether it is appropriate to allow the subjective measure of pain to so dominate the clinical decision of whether to proceed with augmentation. The discussions that ensued are related below

Qualitative study of system-level factors related to genomic implementation

PURPOSE: Research on genomic medicine integration has focused on applications at the individual level, with less attention paid to implementation within clinical settings. Therefore, we conducted a qualitative study using the Consolidated Framework for Implementation Research (CFIR) to identify system-level factors that played a role in implementation of genomic medicine within Implementing GeNomics In PracTicE (IGNITE) Network projects. METHODS: Up to four study personnel, including principal investigators and study coordinators from each of six IGNITE projects, were interviewed using a semistructured interview guide that asked interviewees to describe study site(s), progress at each site, and factors facilitating or impeding project implementation. Interviews were coded following CFIR inner-setting constructs. RESULTS: Key barriers included (1) limitations in integrating genomic data and clinical decision support tools into electronic health records, (2) physician reluctance toward genomic research participation and clinical implementation due to a limited evidence base, (3) inadequate reimbursement for genomic medicine, (4) communication among and between investigators and clinicians, and (5) lack of clinical and leadership engagement. CONCLUSION: Implementation of genomic medicine is hindered by several system-level barriers to both research and practice. Addressing these barriers may serve as important facilitators for studying and implementing genomics in practice

A Temporal Threshold for Formaldehyde Crosslinking and Fixation

Formaldehyde crosslinking is in widespread use as a biological fixative for microscopy and molecular biology. An assumption behind its use is that most biologically meaningful interactions are preserved by crosslinking, but the minimum length of time required for an interaction to become fixed has not been determined.Using a unique series of mutations in the DNA binding protein MeCP2, we show that in vivo interactions lasting less than 5 seconds are invisible in the microscope after formaldehyde fixation, though they are obvious in live cells. The stark contrast between live cell and fixed cell images illustrates hitherto unsuspected limitations to the fixation process. We show that chromatin immunoprecipitation, a technique in widespread use that depends on formaldehyde crosslinking, also fails to capture these transient interactions.Our findings for the first time establish a minimum temporal limitation to crosslink chemistry that has implications for many fields of research

String Theory on Warped AdS_3 and Virasoro Resonances

We investigate aspects of holographic duals to time-like warped AdS_3 space-times--which include G\"odel's universe--in string theory. Using worldsheet techniques similar to those that have been applied to AdS_3 backgrounds, we are able to identify space-time symmetry algebras that act on the dual boundary theory. In particular, we always find at least one Virasoro algebra with computable central charge. Interestingly, there exists a dense set of points in the moduli space of these models in which there is actually a second commuting Virasoro algebra, typically with different central charge than the first. We analyze the supersymmetry of the backgrounds, finding related enhancements, and comment on possible interpretations of these results. We also perform an asymptotic symmetry analysis at the level of supergravity, providing additional support for the worldsheet analysis.Comment: 24 pages + appendice

A population of gamma-ray emitting globular clusters seen with the Fermi Large Area Telescope

Globular clusters with their large populations of millisecond pulsars (MSPs) are believed to be potential emitters of high-energy gamma-ray emission. Our goal is to constrain the millisecond pulsar populations in globular clusters from analysis of gamma-ray observations. We use 546 days of continuous sky-survey observations obtained with the Large Area Telescope aboard the Fermi Gamma-ray Space Telescope to study the gamma-ray emission towards 13 globular clusters. Steady point-like high-energy gamma-ray emission has been significantly detected towards 8 globular clusters. Five of them (47 Tucanae, Omega Cen, NGC 6388, Terzan 5, and M 28) show hard spectral power indices $(0.7 < \Gamma <1.4)$ and clear evidence for an exponential cut-off in the range 1.0-2.6 GeV, which is the characteristic signature of magnetospheric emission from MSPs. Three of them (M 62, NGC 6440 and NGC 6652) also show hard spectral indices $(1.0 < \Gamma < 1.7)$, however the presence of an exponential cut-off can not be unambiguously established. Three of them (Omega Cen, NGC 6388, NGC 6652) have no known radio or X-ray MSPs yet still exhibit MSP spectral properties. From the observed gamma-ray luminosities, we estimate the total number of MSPs that is expected to be present in these globular clusters. We show that our estimates of the MSP population correlate with the stellar encounter rate and we estimate 2600-4700 MSPs in Galactic globular clusters, commensurate with previous estimates. The observation of high-energy gamma-ray emission from a globular cluster thus provides a reliable independent method to assess their millisecond pulsar populations that can be used to make constraints on the original neutron star X-ray binary population, essential for understanding the importance of binary systems in slowing the inevitable core collapse of globular clusters.Comment: Accepted for publication in A&A. Corresponding authors: J. Kn\"odlseder, N. Webb, B. Pancraz