595 research outputs found
Flux profile scanners for scattered high-energy electrons
The paper describes the design and performance of flux integrating Cherenkov
scanners with air-core reflecting light guides used in a high-energy, high-flux
electron scattering experiment at the Stanford Linear Accelerator Center. The
scanners were highly radiation resistant and provided a good signal to
background ratio leading to very good spatial resolution of the scattered
electron flux profile scans.Comment: 22 pages, 17 figure
Comprehensive molecular characterization of urachal adenocarcinoma reveals commonalities with colorectal cancer, including a hypermutable phenotype
Purpose Urachal adenocarcinoma is a rare type of primary bladder adenocarcinoma that comprises less than 1% of all bladder cancers. The low incidence of urachal adenocarcinomas does not allow for an evidence-based approach to therapy. Transcriptome profiling of urachal adenocarcinomas has not been previously reported.Wehypothesized that an in-depth molecular understanding of urachal adenocarcinoma would uncover rational therapeutic strategies. Patients and Methods We performed targeted exon sequencing and global transcriptome profiling of 12 urachal tumors to generate a comprehensive molecular portrait of urachal adenocarcinoma. A single patient with an MSH6 mutation was treated with the anti-programmed death-ligand 1 antibody, atezolizumab. Results Urachal adenocarcinoma closely resembles colorectal cancer at the level of RNA expression, which extends previous observations that urachal tumors harbor genomic alterations that are found in colorectal adenocarcinoma. A subset of tumors was found to have alterations in genes that are associated with microsatellite instability (MSH2 and MSH6) and hypermutation (POLE).Apatient with anMSH6mutation was treated withimmunecheckpoint blockade, which resulted in stable disease. Conclusion Because clinical trials are next to impossible for patients with rare tumors, precision oncology may be an important adjunct for treatment decisions. Our findings demonstrate that urachal adenocarcinomas molecularly resemble colorectal adenocarcinomas at the level ofRNA expression, are the first report, to our knowledge, of MSH2andMSH6mutations in this disease, and support the consideration of immune checkpoint blockade as a rational therapeutic treatment of this exceedingly rare tumor
Adaptive Mesh Refinement for Characteristic Grids
I consider techniques for Berger-Oliger adaptive mesh refinement (AMR) when
numerically solving partial differential equations with wave-like solutions,
using characteristic (double-null) grids. Such AMR algorithms are naturally
recursive, and the best-known past Berger-Oliger characteristic AMR algorithm,
that of Pretorius & Lehner (J. Comp. Phys. 198 (2004), 10), recurses on
individual "diamond" characteristic grid cells. This leads to the use of
fine-grained memory management, with individual grid cells kept in
2-dimensional linked lists at each refinement level. This complicates the
implementation and adds overhead in both space and time.
Here I describe a Berger-Oliger characteristic AMR algorithm which instead
recurses on null \emph{slices}. This algorithm is very similar to the usual
Cauchy Berger-Oliger algorithm, and uses relatively coarse-grained memory
management, allowing entire null slices to be stored in contiguous arrays in
memory. The algorithm is very efficient in both space and time.
I describe discretizations yielding both 2nd and 4th order global accuracy.
My code implementing the algorithm described here is included in the electronic
supplementary materials accompanying this paper, and is freely available to
other researchers under the terms of the GNU general public license.Comment: 37 pages, 15 figures (40 eps figure files, 8 of them color; all are
viewable ok in black-and-white), 1 mpeg movie, uses Springer-Verlag svjour3
document class, includes C++ source code. Changes from v1: revised in
response to referee comments: many references added, new figure added to
better explain the algorithm, other small changes, C++ code updated to latest
versio
Quantum Interference in Superconducting Wire Networks and Josephson Junction Arrays: Analytical Approach based on Multiple-Loop Aharonov-Bohm Feynman Path-Integrals
We investigate analytically and numerically the mean-field
superconducting-normal phase boundaries of two-dimensional superconducting wire
networks and Josephson junction arrays immersed in a transverse magnetic field.
The geometries we consider include square, honeycomb, triangular, and kagome'
lattices. Our approach is based on an analytical study of multiple-loop
Aharonov-Bohm effects: the quantum interference between different electron
closed paths where each one of them encloses a net magnetic flux. Specifically,
we compute exactly the sums of magnetic phase factors, i.e., the lattice path
integrals, on all closed lattice paths of different lengths. A very large
number, e.g., up to for the square lattice, exact lattice path
integrals are obtained. Analytic results of these lattice path integrals then
enable us to obtain the resistive transition temperature as a continuous
function of the field. In particular, we can analyze measurable effects on the
superconducting transition temperature, , as a function of the magnetic
filed , originating from electron trajectories over loops of various
lengths. In addition to systematically deriving previously observed features,
and understanding the physical origin of the dips in as a result of
multiple-loop quantum interference effects, we also find novel results. In
particular, we explicitly derive the self-similarity in the phase diagram of
square networks. Our approach allows us to analyze the complex structure
present in the phase boundaries from the viewpoint of quantum interference
effects due to the electron motion on the underlying lattices.Comment: 18 PRB-type pages, plus 8 large figure
First record of Pseudoryzomys simplex (Cricetidae, Sigmodontinae) in a flooded area of the Pantanal, Brazil
Longitudinal double-spin asymmetry and cross section for inclusive neutral pion production at midrapidity in polarized proton collisions at sqrt(s) = 200 GeV
We report a measurement of the longitudinal double-spin asymmetry A_LL and
the differential cross section for inclusive Pi0 production at midrapidity in
polarized proton collisions at sqrt(s) = 200 GeV. The cross section was
measured over a transverse momentum range of 1 < p_T < 17 GeV/c and found to be
in good agreement with a next-to-leading order perturbative QCD calculation.
The longitudinal double-spin asymmetry was measured in the range of 3.7 < p_T <
11 GeV/c and excludes a maximal positive gluon polarization in the proton. The
mean transverse momentum fraction of Pi0's in their parent jets was found to be
around 0.7 for electromagnetically triggered events.Comment: 6 pages, 3 figures, submitted to Phys. Rev. D (RC
Partonic flow and -meson production in Au+Au collisions at = 200 GeV
We present first measurements of the -meson elliptic flow
() and high statistics distributions for different
centralities from = 200 GeV Au+Au collisions at RHIC. In
minimum bias collisions the of the meson is consistent with the
trend observed for mesons. The ratio of the yields of the to those of
the as a function of transverse momentum is consistent with a model
based on the recombination of thermal quarks up to GeV/,
but disagrees at higher momenta. The nuclear modification factor () of
follows the trend observed in the mesons rather than in
baryons, supporting baryon-meson scaling. Since -mesons are
made via coalescence of seemingly thermalized quarks in central Au+Au
collisions, the observations imply hot and dense matter with partonic
collectivity has been formed at RHIC.Comment: 6 pages, 4 figures, submit to PR
Measurement of Transverse Single-Spin Asymmetries for Di-Jet Production in Proton-Proton Collisions at GeV
We report the first measurement of the opening angle distribution between
pairs of jets produced in high-energy collisions of transversely polarized
protons. The measurement probes (Sivers) correlations between the transverse
spin orientation of a proton and the transverse momentum directions of its
partons. With both beams polarized, the wide pseudorapidity () coverage for jets permits separation of Sivers functions for the valence
and sea regions. The resulting asymmetries are all consistent with zero and
considerably smaller than Sivers effects observed in semi-inclusive deep
inelastic scattering (SIDIS). We discuss theoretical attempts to reconcile the
new results with the sizable transverse spin effects seen in SIDIS and forward
hadron production in pp collisions.Comment: 6 pages total, 1 Latex file, 3 PS files with figure
Longitudinal scaling property of the charge balance function in Au + Au collisions at 200 GeV
We present measurements of the charge balance function, from the charged
particles, for diverse pseudorapidity and transverse momentum ranges in Au + Au
collisions at 200 GeV using the STAR detector at RHIC. We observe that the
balance function is boost-invariant within the pseudorapidity coverage [-1.3,
1.3]. The balance function properly scaled by the width of the observed
pseudorapidity window does not depend on the position or size of the
pseudorapidity window. This scaling property also holds for particles in
different transverse momentum ranges. In addition, we find that the width of
the balance function decreases monotonically with increasing transverse
momentum for all centrality classes.Comment: 6 pages, 3 figure
Energy and system size dependence of \phi meson production in Cu+Cu and Au+Au collisions
We study the beam-energy and system-size dependence of \phi meson production
(using the hadronic decay mode \phi -- K+K-) by comparing the new results from
Cu+Cu collisions and previously reported Au+Au collisions at \sqrt{s_NN} = 62.4
and 200 GeV measured in the STAR experiment at RHIC. Data presented are from
mid-rapidity (|y|<0.5) for 0.4 < pT < 5 GeV/c. At a given beam energy, the
transverse momentum distributions for \phi mesons are observed to be similar in
yield and shape for Cu+Cu and Au+Au colliding systems with similar average
numbers of participating nucleons. The \phi meson yields in nucleus-nucleus
collisions, normalised by the average number of participating nucleons, are
found to be enhanced relative to those from p+p collisions with a different
trend compared to strange baryons. The enhancement for \phi mesons is observed
to be higher at \sqrt{s_NN} = 200 GeV compared to 62.4 GeV. These observations
for the produced \phi(s\bar{s}) mesons clearly suggest that, at these collision
energies, the source of enhancement of strange hadrons is related to the
formation of a dense partonic medium in high energy nucleus-nucleus collisions
and cannot be alone due to canonical suppression of their production in smaller
systems.Comment: 20 pages and 5 figure
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