Tris[μ-2,2′-(azinodimethylidyne)diphenolato-κ4 O,N:N′,O′]diiron(III) tetra­hydro­furan tetra­solvate

In the title binuclear iron(III) complex, [Fe2(C14H10N2O2)3]·4C4H8O or [Fe2(salda)3]·4THF [H2salda = 2,2′-(azinidimethyl­ene)diphenolate and THF is tetra­hydro­furan], the ligand possesses a rotationally flexible single N—N bond. Three dinucleating O,N:N′,O′-donor ligands provide three diazine (=N—N=) bridges between the metal ions, yielding a binuclear triple helicate structure with crystallographic C 2 symmetry, the rotation axis bis­ecting one N—N bond

MIF coordinates the cell cycle with DNA damage checkpoints. Lessons from knockout mouse models

Macrophage migration inhibitory factor (MIF) is a ubiquitously expressed pro-inflammatory mediator that has also been implicated in the process of oncogenic transformation and tumor progression. We used a genetic approach to show that deletion of the MIF gene in mice has several major consequences for the proliferative and transforming properties of cells. MIF-deficient cells exhibit increased resistance to oncogenic transformation. The transformation defects associated with MIF deficiency can be overcome through concomitant inactivation of the p53 and Rb/E2F tumor suppressor pathways. We have produced compelling evidence that the effects of MIF on cell survival and tumorigenesis are mediated through overlapping pathways, wherein MIF and p53 functionally antagonize each other in the cell. However, the involvement of MIF in p53 function is secondary to p53-independent mechanisms controlling protein stability, DNA damage checkpoints, and the integrity of the genome. Given the broad spectrum of cell types that normally express MIF and its elevated levels at sites of chronic inflammation, this pathway may be generic for many early stage tumors

3C Seismic Interferometry at the Polymetallic Kylylahti Deposit, Outokumpu District, Finland

Non peer reviewe

Contemporary Financial And Legal Factors Of Activity And The Status Of Collective Investment Institutions In Ukraine

Article discraibe the mechanism of state regulation of the investment sphere, the activities of collective investment institutions.Admits traditional method, the competitive source of investment in Ukraine is the collective investment institutions. The legal regulation of the activities of collective investment institutions in Ukraine is complicated to apply, has many inconsistencies, the investment process is sophisticated for both internal and external investors. The elimination of these contradictions determines the relevance of the research, since the latest consistent research of the current problems of applying the legislation of Ukraine to collective investment institutions is appropriate. The purpose of the research is to assessment of key factors of legal regulation of collective investment institutions in Ukraine, analysis of functioning problems of collective investment institutions in Ukraine and ways of addressing them. Regulatory inconsistencies in the status of collective investment institutions have been identified, proposals to enhance the activities of collective investment institutions have been formulated, proposals aimed to improve the effectiveness of state supervision of collective investment institutions have been suggested, proposals of taxing investors have been submitte

Розвій франкових ідей еволюції, поступу і просвітництва у сучасному орелігійненні (Franco and the kingdom of god: the idea of progress in modern religiosity)

Погляди Франка становлять єдиний комплекс еволюціонізму – поступовства – просвітництва у річищі розвитку європейської думки. «Еволюція як основний закон природи» тотожна розвитку і розкриває його «движучі сили і форми». Розвиток тотожний поступу, який буває поступом вперед і поступом назад (виродженням). Поступ становить собою 1) «зміни» 2) «на ліпше». Особливостями поступу є 1) його «вогнища», 2) «хвилі поступу» і 3) перехідність поступу. Запорукою поступу є поширення знань, а сам поступ постає як розвиток духовних здібностей. «Ідеї головний двигач суспільного життя». «Немає панацеї» від суперечностей розвитку. Підвалинами поступу постають 1) «голод», 2) «любов» і 3) «розум, якого довго не буде». Ідеї Франка отримують розвиток у сучасній науково-філософській думці, де поступ розглядається як 1) повнота здійснення законотенденцій розвитку, 2) перевершення старого новим і 3) збільшення свідомісно-духовних чинників розвитку (соціально-культурна парадигма), чим є здійснення соціально-культурних проектів, які вимагають віроздійснення і звершуються тотальним духовним перетворенням (Царством Божим) як процесом. (Frank views constitute a single set of evolutionism – giving up – the enlightenment in Wake of European thought. «The evolution as the fundamental law of nature» of identical development and reveals his «dynamics strength and shape.» The development of gradual identical, which is step forward and step back (degeneration). Progress is 1) «changes» 2) «for the better». Features progress are 1) its «fi re», 2) «wave of accession» and 3) transitional development. Guarantee of progress is the dissemination of knowledge and the development progress appears as a spiritual abilities. «Ideas chief engine of public life.» No panacea of development contradictions. The foundations of progress appear 1) «hunger», 2) «love» and 3) «the mind for a long time will not.» Frank’s ideas are developed in the modern scientifi c and philosophical thought, where progress is seen as 1) completeness of implementation of the law trends, 2) predominate of old to new and 3) increase of consciousness and spiritual development factors (socio-cultural paradigm), what is the implementation of socio-cultural projects that require faith implementation and termination of total spiritual transformation (Kingdom of God) as a process.

Lithospheric studies along seismic profile KOKKY, between Gulf of Bothnia and Gulf of Finland, Baltic Shield

Volume: 19 Host publication title: Geophysical Research AbstractsNon peer reviewe

Synthetic metallomolecules as agents for the control of DNA structure

This tutorial review summarises B-DNA structure and metallomolecule binding modes and illustrates some DNA structures induced by molecules containing metallic cations. The effects of aquated metal ions, cobalt amines, ruthenium octahedral metal complexes, metallohelicates and platinum complexes such as cis-platin are discussed alongside the techniques of NMR, X-ray crystallography, gel electrophoresis, circular dichroism, linear dichroism and molecular dynamics. The review will be of interest to people interested in both DNA structure and roles of metallomolecules in biological systems

New trends for metal complexes with anticancer activity

Medicinal inorganic chemistry can exploit the unique properties of metal ions for the design of new drugs. This has, for instance, led to the clinical application of chemotherapeutic agents for cancer treatment, such as cisplatin. The use of cisplatin is, however, severely limited by its toxic side-effects. This has spurred chemists to employ different strategies in the development of new metal-based anticancer agents with different mechanisms of action. Recent trends in the field are discussed in this review. These include the more selective delivery and/or activation of cisplatin-related prodrugs and the discovery of new non-covalent interactions with the classical target, DNA. The use of the metal as scaffold rather than reactive centre and the departure from the cisplatin paradigm of activity towards a more targeted, cancer cell-specific approach, a major trend, are discussed as well. All this, together with the observation that some of the new drugs are organometallic complexes, illustrates that exciting times lie ahead for those interested in ‘metals in medicine

Os2-Os4 switch controls DNA knotting and anticancer activity

Dinuclear trihydroxido-bridged osmium–arene complexes are inert and biologically inactive, but we show here that linking dihydroxido-bridged OsII–arene fragments by a bridging di-imine to form a metallacycle framework results in strong antiproliferative activity towards cancer cells and distinctive knotting of DNA. The shortened spacer length reduces biological activity and stability in solution towards decomposition to biologically inactive dimers. Significant differences in behavior toward plasmid DNA condensation are correlated with biological activity

Sub-ensemble monitoring of DNA strand displacement using multiparameter single-molecule FRET

Non-enzymatic DNA strand displacement is an important mechanism in dynamic DNA nanotechnology. Here we show that the large parameter space that is accessible by single-molecule FRET is ideal for the simultaneous monitoring of multiple reactants and products of DNA strand exchange reactions. We monitored the strand displacement from double-stranded DNA (dsDNA) by single-stranded DNA (ssDNA) at 37 °C; the data were modelled as a second-order reaction approaching equilibrium, with a rate constant of ca. 10 M-1 s-1. We also followed the displacement from a DNA three-way junction (3WJ) by ssDNA. The presence of three internal mismatched bases in the middle of the invading strand did not prevent displacement from the 3WJ, but reduced the second-order rate constant by ca. 50 %. We attribute strand exchange in the dsDNA and 3WJ to a zero-toehold pathway from the blunt-ended duplex arms. The single-molecule approach demonstrated here will be useful for studying complex DNA networks