567 research outputs found
Фотодинамическая терапия заболеваний шейки матки
The experience of treatment for precancer and early cervical cancer by photodynamic therapy in 12 patients with primary diagnosis H-SIL (CIN II–III) and cancer in situ is described. Chlo-rine photosensitizer Photolon was given intravenously at a dose of 0.75–1.15 mg/kg body weight. 2.5 h later the treatment with polyposition laser exposure (light dose – 150 J/cm2, light power density – 400–500 mW/cm2) was made. Thirty days later conization of the cervix with endocervical curettage assessing therapeutic response of cervical tumor tissue was per-formed. According to histological data complete response was in 4 patients, minute foci of CIN I were determined in 7 patients, 1 patient had foci of CIN II. 8 of 10 HPV-positive patients had complete eradication of HPV after treatment. There were no serious adverse events after light exposure. Marked therapeutic response, high anti-viral activity and good feasibility allow to consider photodynamic therapy as alternative organ-sparing treatment of early cancer and pre-cancer of cervix. Описан опыт лечения предрака и раннего рака шейки матки методом фотодинамической терапии у 12 пациенток с диагнозом CIN II-III и cancer in situ. Фотосенсибилизатор хлоринового ряда фотолон вводили внутривенно в дозе 0,75–1,15 мг/кг массы тела пациентки. Через 1,5–2 ч выполняли сеанс облучения с использованием полипозиционной методики лазерного воздействия (плотность энергии лазерного излучения одной позиции 150 Дж/см2, плотность мощности 400–500 мВт/см2). Через 30 дней после лечения проводили конизацию шейки матки с выскабливанием цервикального канала, оценивая результат фотодинамической терапии. По результатам гистологического исследования послеоперационного материала эффект лечения у 4 пациенток оценен как полная регрессия, у 7 паци- енток обнаружены мелкие очаги CIN I, у 1 пациентки – очаги CIN II. У 8 из 10 ВПЧ-положительных пациенток после проведения лечения была получена полная эрадикация ВПЧ. При проведении процедуры облучения не было зарегистрировано серьезных нежелательных явлений. Выраженный терапевтический эффект, высокая противовирусная активность и хорошая переносимость позволяют рассматривать фотодинамическую терапию в качестве альтернативного органосохраняющего лечения раннего рака и предрака шейки матки.
Measurement of the branching ratios of the Z0 into heavy quarks
We measure the hadronic branching ratios of the Z0 boson into heavy quarks:
Rb=Gamma(Z0->bb)/Gamma(Z0->hadrons) and Rc=Gamma(Z0->cc/Gamma(Z0->hadrons)
using a multi-tag technique. The measurement was performed using about 400,000
hadronic Z0 events recorded in the SLD experiment at SLAC between 1996 and
1998. The small and stable SLC beam spot and the CCD-based vertex detector were
used to reconstruct bottom and charm hadron decay vertices with high efficiency
and purity, which enables us to measure most efficiencies from data. We obtain,
Rb=0.21604 +- 0.00098(stat.) +- 0.00073(syst.) -+ 0.00012(Rc) and, Rc= 0.1744
+- 0.0031(stat.) +- 0.0020(syst.) -+ 0.0006(Rb)Comment: 37 pages, 8 figures, to be submitted to Phys. Rev. D version 2:
changed title to ratios, used common D production fractions for Rb and Rc and
corrected Zgamma interference. Identical to PRD submissio
Direct Measurements of A_b and A_c using Vertex/Kaon Charge Tags at SLD
Exploiting the manipulation of the SLC electron-beam polarization, we present
precise direct measurements of the parity violation parameters A_c and A_b in
the Z boson - c quark and Z boson - b quark coupling. Quark/antiquark
discrimination is accomplished via a unique algorithm that takes advantage of
the precise SLD CCD vertex detector, employing the net charge of displaced
vertices as well as the charge of kaons that emanate from those vertices. From
the 1996-98 sample of 400,000 Z decays, produced with an average beam
polarization of 73.4%, we find A_c = 0.673 +/- 0.029 (stat.) +/- 0.023 (syst.)
and A_b = 0.919 +/- 0.018 (stat.) +/- 0.017 (syst.).Comment: 11 pages, 2 figures, 2 tables, to be submitted to Physical Review
Letters; version 2 reflects changes suggested by the refere
Dependence of the production cross section on the transverse momentum of the top quark
We present a measurement of the differential cross section for
events produced in collisions at TeV as a function
of the transverse momentum () of the top quark. The selected events
contain a high- lepton (), four or more jets, and a large imbalance
in , and correspond to 1 fb of integrated luminosity recorded
with the D0 detector. Each event must have at least one candidate for a
jet. Objects in the event are associated through a constrained kinematic fit to
the process. Results
from next-to-leading-order perturbative QCD calculations agree with the
measured differential cross section. Comparisons are also provided to
predictions from Monte Carlo event generators using QCD calculations at
different levels of precision.Comment: 8 pages, 6 figures, 4 tables, updated to reflect the published
versio
Measurements of differential cross sections of Z/gamma*+jets+X events in proton anti-proton collisions at sqrt{s}=1.96 TeV
We present cross section measurements for Z/gamma*+jets+X production,
differential in the transverse momenta of the three leading jets. The data
sample was collected with the D0 detector at the Fermilab Tevatron proton
anti-proton collider at a center-of-mass energy of 1.96 TeV and corresponds to
an integrated luminosity of 1 fb-1. Leading and next-to-leading order
perturbative QCD predictions are compared with the measurements, and agreement
is found within the theoretical and experimental uncertainties. We also make
comparisons with the predictions of four event generators. Two
parton-shower-based generators show significant shape and normalization
differences with respect to the data. In contrast, two generators combining
tree-level matrix elements with a parton shower give a reasonable description
of the the shapes observed in data, but the predicted normalizations show
significant differences with respect to the data, reflecting large scale
uncertainties. For specific choices of scales, the normalizations for either
generator can be made to agree with the measurements.Comment: Published in PLB. 11 pages, 3 figure
Search for new fermions ("quirks") at the Fermilab Tevatron Collider
We report results of a search for particles with anomalously high ionization
in events with a high transverse energy jet and large missing transverse energy
in fb of integrated luminosity collected by the D0 experiment at
the Fermilab Tevatron collider. Production of such particles
(quirks) is expected in scenarios with extra QCD-like {\it SU(N)} sectors, and
this study is the first dedicated search for such signatures. We find no
evidence of a signal and set a lower mass limit of 107 ~GeV for the mass of a
charged quirk with strong dynamics scale in the range from 10 keV to
1 MeV.Comment: submitted to Phys. Rev. Letter
Measurement of the t-channel single top quark production cross section
The D0 collaboration reports direct evidence for electroweak production of
single top quarks through the t-channel exchange of a virtual W boson. This is
the first analysis to isolate an individual single top quark production
channel. We select events containing an isolated electron or muon, missing
transverse energy, and two, three or four jets from 2.3 fb^-1 of ppbar
collisions at the Fermilab Tevatron Collider. One or two of the jets are
identified as containing a b hadron. We combine three multivariate techniques
optimized for the t-channel process to measure the t- and s-channel cross
sections simultaneously. We measure cross sections of 3.14 +0.94 -0.80 pb for
the t-channel and 1.05 +-0.81 pb for the s-channel. The measured t-channel
result is found to have a significance of 4.8 standard deviations and is
consistent with the standard model prediction.Comment: 7 pages, 6 figure
Double parton interactions in photon+3 jet events in ppbar collisions sqrt{s}=1.96 TeV
We have used a sample of photon+3 jets events collected by the D0 experiment
with an integrated luminosity of about 1 fb^-1 to determine the fraction of
events with double parton scattering (f_DP) in a single ppbar collision at
sqrt{s}=1.96 TeV. The DP fraction and effective cross section (sigma_eff), a
process-independent scale parameter related to the parton density inside the
nucleon, are measured in three intervals of the second (ordered in pT) jet
transverse momentum pT_jet2 within the range 15 < pT_jet2 < 30 GeV. In this
range, f_DP varies between 0.23 < f_DP < 0.47, while sigma_eff has the average
value sigma_eff_ave = 16.4 +- 0.3(stat) +- 2.3(syst) mb.Comment: 15 pages, 13 figure
Measurement of trilinear gauge boson couplings from WW + WZ to lnu jj events in pp-bar collisions at sqrt{s}=1.96 TeV
We present a direct measurement of trilinear gauge boson couplings at gammaWW
and ZWW vertices in WW and WZ events produced in pp-bar collisions at
sqrt{s}=1.96 TeV. We consider events with one electron or muon, missing
transverse energy, and at least two jets. The data were collected using the D0
detector and correspond to 1.1/fb of integrated luminosity. Considering two
different relations between the couplings at the gammaWW and ZWW vertices, we
measure these couplings at 68% C.L. to be kappa_{gamma}=1.07^{+0.26}_{-0.29},
lambda =0.00^{+0.06}_{-0.06} and g_{1}^{Z}=1.04^{+0.09}_{-0.09} in a scenario
respecting SU(2)_L x U(1)_Y gauge symmetry and kappa =1.04^{+0.11}_{-0.11} and
lambda=0.00^{+0.06}_{-0.06} in an "equal couplings" scenario.Comment: 14 pages, 7 figures, published in Phys. Rev. D, updated to published
versio
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