4,303 research outputs found
Understanding molecular representations in machine learning: The role of uniqueness and target similarity
The predictive accuracy of Machine Learning (ML) models of molecular
properties depends on the choice of the molecular representation. Based on the
postulates of quantum mechanics, we introduce a hierarchy of representations
which meet uniqueness and target similarity criteria. To systematically control
target similarity, we rely on interatomic many body expansions, as implemented
in universal force-fields, including Bonding, Angular, and higher order terms
(BA). Addition of higher order contributions systematically increases
similarity to the true potential energy and predictive accuracy of the
resulting ML models. We report numerical evidence for the performance of BAML
models trained on molecular properties pre-calculated at electron-correlated
and density functional theory level of theory for thousands of small organic
molecules. Properties studied include enthalpies and free energies of
atomization, heatcapacity, zero-point vibrational energies, dipole-moment,
polarizability, HOMO/LUMO energies and gap, ionization potential, electron
affinity, and electronic excitations. After training, BAML predicts energies or
electronic properties of out-of-sample molecules with unprecedented accuracy
and speed
Toward transferable interatomic van der Waals interactions without electrons: The role of multipole electrostatics and many-body dispersion
We estimate polarizabilities of atoms in molecules without electron density,
using a Voronoi tesselation approach instead of conventional density
partitioning schemes. The resulting atomic dispersion coefficients are
calculated, as well as many-body dispersion effects on intermolecular potential
energies. We also estimate contributions from multipole electrostatics and
compare them to dispersion. We assess the performance of the resulting
intermolecular interaction model from dispersion and electrostatics for more
than 1,300 neutral and charged, small organic molecular dimers. Applications to
water clusters, the benzene crystal, the anti-cancer drug
ellipticine---intercalated between two Watson-Crick DNA base pairs, as well as
six macro-molecular host-guest complexes highlight the potential of this method
and help to identify points of future improvement. The mean absolute error made
by the combination of static electrostatics with many-body dispersion reduces
at larger distances, while it plateaus for two-body dispersion, in conflict
with the common assumption that the simple correction will yield proper
dissociative tails. Overall, the method achieves an accuracy well within
conventional molecular force fields while exhibiting a simple parametrization
protocol.Comment: 13 pages, 8 figure
Noncommutative Field Theories and Gravity
We show that after the Seiberg-Witten map is performed the action for
noncommutative field theories can be regarded as a coupling to a field
dependent gravitational background. This gravitational background depends only
on the gauge field. Charged and uncharged fields couple to different
backgrounds and we find that uncharged fields couple more strongly than the
charged ones. We also show that the background is that of a gravitational plane
wave. A massless particle in this background has a velocity which differs from
the velocity of light and we find that the deviation is larger in the uncharged
case. This shows that noncommutative field theories can be seen as ordinary
theories in a gravitational background produced by the gauge field with a
charge dependent gravitational coupling.Comment: 8 pages. v2 and v3: minor corrections, added reference
Theoretical Analysis of STM Experiments at Rutile TiO_2 Surfaces
A first-principles atomic orbital-based electronic structure method is used
to investigate the low index surfaces of rutile Titanium Dioxide. The method is
relatively cheap in computational terms, making it attractive for the study of
oxide surfaces, many of which undergo large reconstructions, and may be
governed by the presence of Oxygen vacancy defects. Calculated surface charge
densities are presented for low-index surfaces of TiO, and the relation of
these results to experimental STM images is discussed. Atomic resolution images
at these surfaces tend to be produced at positive bias, probing states which
largely consist of unoccupied Ti 3 bands, with a small contribution from O
2. These experiments are particularly interesting since the O atoms tend to
sit up to 1 angstrom above the Ti atoms, so providing a play-off between
electronic and geometric structure in image formation.Comment: 9 pages, Revtex, 3 postscript figures, accepted by Surf. Scienc
Systematic review of the use of granulocyte-macrophage colony-stimulating factor in patients with advanced melanoma.
Several immunomodulatory checkpoint inhibitors have been approved for the treatment of patients with advanced melanoma, including ipilimumab, nivolumab and pembrolizumab. Talimogene laherparepvec is the first oncolytic virus to gain regulatory approval in the USA; it is also approved in Europe. Talimogene laherparepvec expresses granulocyte-macrophage colony-stimulating factor (GM-CSF), and with other GM-CSF-expressing oncolytic viruses in development, understanding the clinical relevance of this cytokine in treating advanced melanoma is important. Results of trials of GM-CSF in melanoma have been mixed, and while GM-CSF has the potential to promote anti-tumor responses, some preclinical data suggest that GM-CSF may sometimes promote tumor growth. GM-CSF has not been approved as a melanoma treatment. We undertook a systematic literature review of studies of GM-CSF in patients with advanced melanoma (stage IIIB-IV). Of the 503 articles identified, 26 studies met the eligibility criteria. Most studies investigated the use of GM-CSF in combination with another treatment, such as peptide vaccines or chemotherapy, or as an adjuvant to surgery. Some clinical benefit was reported in patients who received GM-CSF as an adjuvant to surgery, or in combination with other treatments. In general, outcomes for patients receiving peptide vaccines were not improved with the addition of GM-CSF. GM-CSF may be a valuable therapeutic adjuvant; however, further studies are needed, particularly head-to-head comparisons, to confirm the optimal dosing regimen and clinical effectiveness in patients with advanced melanoma
Scrambling and Gate Effects in Realistic Quantum Dots
We evaluate the magnitude of two important mesoscopic effects using a
realistic model of typical quantum dots. ``Scrambling'' and ``gate effect'' are
defined as the change in the single-particle spectrum due to added electrons or
gate-induced shape deformation, respectively. These two effects are
investigated systematically in both the self-consistent Kohn-Sham (KS) theory
and a Fermi liquid-like Strutinsky approach. We find that the genuine
scrambling effect is small because the potential here is smooth. In the KS
theory, a key point is the implicit inclusion of residual interactions in the
spectrum; these dominate and make scrambling appear larger. Finally, the gate
effect is comparable in the two cases and, while small, is able to cause
gate-induced spin transitions.Comment: 5 pages, 3 figure
Theoretical study of molecular electronic excitations and optical transitions of C60
We report results on ab initio calculations of excited states of the
fullerene molecule by using configuration interaction (CI) approach with singly
excited determinants (SCI). We have used both the experimental geometry and the
one optimized by the density functional method and worked with basis sets at
the cc-pVTZ and aug-cc-pVTZ level. Contrary to the early SCI semiempirical
calculations, we find that two lowest electron
optical lines are situated at relatively high energies of ~5.8 eV (214 nm) and
~6.3 eV (197 nm). These two lines originate from two transitions: from HOMO to (LUMO+1) () and from (HOMO--1)
to LUMO (). The lowest molecular excitation, which is the level, is found at ~2.5 eV. Inclusion of doubly excited determinants
(SDCI) leads only to minor corrections to this picture. We discuss possible
assignment of absorption bands at energies smaller than 5.8 eV (or
larger than 214 nm).Comment: 6 pages, 1 figure, 9 Table
The noncommutative degenerate electron gas
The quantum dynamics of nonrelativistic single particle systems involving
noncommutative coordinates, usually referred to as noncommutative quantum
mechanics, has lately been the object of several investigations. In this note
we pursue these studies for the case of multi-particle systems. We use as a
prototype the degenerate electron gas whose dynamics is well known in the
commutative limit. Our central aim here is to understand qualitatively, rather
than quantitatively, the main modifications induced by the presence of
noncommutative coordinates. We shall first see that the noncommutativity
modifies the exchange correlation energy while preserving the electric
neutrality of the model. By employing time-independent perturbation theory
together with the Seiberg-Witten map we show, afterwards, that the ionization
potential is modified by the noncommutativity. It also turns out that the
noncommutative parameter acts as a reference temperature. Hence, the
noncommutativity lifts the degeneracy of the zero temperature electron gas.Comment: 11 pages, to appear in J. Phys. A: Math. Ge
Main-belt Asteroids in the K2 Uranus Field
We present the K2 light curves of a large sample of untargeted main-belt asteroids (MBAs) detected with the Kepler Space Telescope. The asteroids were observed within the Uranus superstamp, a relatively large, continuous field with a low stellar background designed to cover the planet Uranus and its moons during Campaign 8 of the K2 mission. The superstamp offered the possibility of obtaining precise, uninterrupted light curves of a large number of MBAs and thus determining unambiguous rotation rates for them. We obtained photometry for 608 MBAs, and were able to determine or estimate rotation rates for 90 targets, of which 86 had no known values before. In an additional 16 targets we detected incomplete cycles and/or eclipse-like events. We found the median rotation rate to be significantly longer than that of the ground-based observations, indicating that the latter are biased toward shorter rotation rates. Our study highlights the need and benefits of further continuous photometry of asteroids
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