Increased Levels of Circulating Fatty Acids Are Associated with Protective Effects against Future Cardiovascular Events in Nondiabetics

Cardiovascular disease (CVD) is a major cause of morbidity and mortality worldwide, particularly in individuals with diabetes. The current study objective was to determine the circulating metabolite profiles associated with the risk of future cardiovascular events, with emphasis on diabetes status. Nontargeted metabolomics analysis was performed by LC–HRMS in combination with targeted quantification of eicosanoids and endocannabinoids. Plasma from 375 individuals from the IMPROVE pan-European cohort was included in a case-control study design. Following data processing, the three metabolite data sets were concatenated to produce a single data set of 267 identified metabolites. Factor analysis identified six factors that described 26.6% of the variability in the given set of predictors. An association with cardiovascular events was only observed for one factor following adjustment (p = 0.026). From this factor, we identified a free fatty acid signature (n = 10 lipids, including saturated, monounsaturated, and polyunsaturated fatty acids) that was associated with lower risk of future cardiovascular events in nondiabetics only (OR = 0.65, 0.27–0.80 95% CI, p = 0.030), whereas no association was observed among diabetic individuals. These observations support the hypothesis that increased levels of circulating omega-6 and omega-3 fatty acids are associated with protective effects against future cardiovascular events. However, these effects were only observed in the nondiabetic population, further highlighting the need for patient stratification in clinical investigations

Toward Improved Estimation of the Dynamic Topography and Ocean Circulation in the High Latitude and Arctic Ocean: The Importance of GOCE

The Norwegian Sea circulation plays a key role in maintaining the mild climate of the northwestern Europe via the transport of warm Atlantic Water pole-ward. The first paper addresses the advective currents connecting the two branches of the Norwegian Atlantic Current and shows the general spin up of the Norwegian Sea circulation during winter with the exception of the flow over the Mohn Ridge. The variability in the surface velocities in the Norwegian Sea is found to be deep reaching, which supports the use of altimetry to monitor the variability of the poleward transport of Atlantic Water. A strengthening and weakening of the Atlantic inflow east of the Faroe Islands has a consistent response along the entire slope current. However, a stronger western inflow, observed north of the Faroe Islands, is associated with more flow of Atlantic Water into the slope current. This finding suggest that a substantial fraction of Atlantic Water that eventually enters the Barents Sea or the Arctic through the Fram Strait, may originate from the western inflowing branch of Atlantic Water to the Nordic Seas, and that the two branches of northward flowing Atlantic Water cannot be considered as separate flows. Paper 2 examines the influence of the surface circulation, eddy activity and local heat loss on the spatial distribution and temporal evolution of dense water formation in the Lofoten Basin. Evidence of intrusion of Atlantic Water into the central Lofoten Basin due to buoyant waters in the eastern part of the basin is found. With the support of hydrographic and satellite datasets, the concept of separate western and eastern regions of the Lofoten Basin is introduced and a link between the western Lofoten Basin and Faroe Shetland overflow waters is identified. Paper 3 addresses an anomalous anticyclonic vortex in the Nordic Seas, which is situated in the western Lofoten Basin. The vortex’ surface and vertical characteristics on seasonal, inter-annual, and climatological time-scales are quantified, relevant forcing mechanisms are addressed, and its uniqueness in the Nordic Seas is documented. In the final paper, a new mean dynamic topography (MDT) is estimated for the North Atlantic and the Arctic from the Gravity field and steady-state Ocean Circulation Explorer (GOCE) satellite gravity anomaly data. The new GOCE-based MDT is assessed and compared to independent steric height observations, other state-of-the-art MDTs and three coupled sea-ice-ocean models, showing its usefulness in studies of high latitude ocean circulation

Health-promoting leadership: an integrative review and future research agenda

To provide a synthesis of the evidence of health-promoting leadership related to nursing by exploring definitions, core attributes and critical conditions.Increasing pressure in healthcare settings due to efficiency requirements, population ageing with complex illnesses and projected global shortage of nurses, is a potential threat to nurses' health and job satisfaction, and patient quality of care and safety. New ways of thinking about nursing leadership and evidence-based human resource management are required to improve nursing environments.Integrative literature review.Eight databases were searched: Academic Search Premier, CINAHL, Emerald, ERIC, Web of Science, MEDLINE, Psychinfo and Science Direct. Included papers were published between 2000-2016.Of 339 papers, 13 were eligible for inclusion: eight qualitative and five quantitative. Studies were assessed for quality using standardized checklists. Framework-based synthesis was used, allowing for themes identified a priori to be specified as coding categories. This method also allows new themes to emerge de novo.Four themes were identified. There are multiple definitions of health-promoting leadership, along with description of the non-health-promoting leader. The health-promoting nurse leader engages in employees' health promotion, and takes responsibility for actions and maintains open communication, accommodating nurses' participation in change processes. Through competence development, the health-promoting organization builds capacity.Health-promoting leadership may be a promising path to optimizing nursing outcomes through holistic thinking, which emphasizes the importance of context. Accumulated research is required to build a stronger line of international research, with attention to underlying mechanisms, limiting conditions and behaviours known to health-promoting leadership