Genealogies of rapidly adapting populations

The genetic diversity of a species is shaped by its recent evolutionary history and can be used to infer demographic events or selective sweeps. Most inference methods are based on the null hypothesis that natural selection is a weak or infrequent evolutionary force. However, many species, particularly pathogens, are under continuous pressure to adapt in response to changing environments. A statistical framework for inference from diversity data of such populations is currently lacking. Toward this goal, we explore the properties of genealogies in a model of continual adaptation in asexual populations. We show that lineages trace back to a small pool of highly fit ancestors, in which almost simultaneous coalescence of more than two lineages frequently occurs. While such multiple mergers are unlikely under the neutral coalescent, they create a unique genetic footprint in adapting populations. The site frequency spectrum of derived neutral alleles, for example, is non-monotonic and has a peak at high frequencies, whereas Tajima's D becomes more and more negative with increasing sample size. Since multiple merger coalescents emerge in many models of rapid adaptation, we argue that they should be considered as a null-model for adapting populations.Comment: to appear in PNA

Droplets displacement and oscillations induced by ultrasonic surface acoustic waves: a quantitative study

We present an experimental study of a droplet interacting with an ultrasonic surface acoustic wave (SAW). Depending on the amplitude of the wave, the drop can either experience an internal flow with its contact-line pinned, or (at higher amplitude) move along the direction of the wave also with internal flow. Both situations appear together with oscillations of the drop free-surface. The physical origins of the internal mixing flow as well as the drop displacement and surface waves are still not well understood. In order to give insights of the underlying physics involved in these phenomena, we carried out an experimental and numerical study. The results suggest that the surface deformation of the drop can be related as a combination between acoustic streaming effect and radiation pressure inside the drop.Comment: 9 pages, 14 figures. To appear in Physical Review

An Intrisic Topology for Orthomodular Lattices

We present a general way to define a topology on orthomodular lattices. We show that in the case of a Hilbert lattice, this topology is equivalent to that induced by the metrics of the corresponding Hilbert space. Moreover, we show that in the case of a boolean algebra, the obtained topology is the discrete one. Thus, our construction provides a general tool for studying orthomodular lattices but also a way to distinguish classical and quantum logics.Comment: Under submission to the International Journal of Theoretical Physic

Characterization of microwave absorption in carbon nanotubes using resonance aperture transmission method

A new method to characterize microwave electromagnetic absorption of a bulk carbon nanotube material is proposed and experimentally evaluated in this paper. The method is based on the measurement of microwave transmission through a capacitive-resonator aperture in a conductive screen loaded with a CNT sample under test. This method allows to measure microwave permittivity and absorption of thin samples, several atomic layers to few micrometers thick, with linear dimensions much smaller than the wavelength of radiation in free space. This minimal sample requirement restricts the application of conventional microwave characterization methods such as free-space or waveguide permittivity characterization. It is demonstrated that the resonance E-field enhancement inside the CRA leads to strong EM interaction of the microwave E-field with the CNT sample under test thus enabling high sensitivity and dynamic range of the measurement procedure. Another advantage of the proposed technique over conventional non-resonance characterization methods is that in the resonance transmission band, the CRA operation is reflection-less which leads to a relatively simple qualitative algebraic de-embedding procedure of the material parameters based on the principle of energy conservation. The experimental microwave absorption data of the multiwall CNT samples are presented in the S frequency band (2-4GHz), demonstrating microwave absorption properties of the multiwall CNT ribbons

Inverse modeling of soil water content to estimate the hydraulic properties of a shallow soil and the associated weathered bedrock

International audienceSummary Modeling soil water flow requires the knowledge of numerous parameters associated to the water content and the soil hydraulic properties. Direct estimations of those parameters in laboratory require expensive equipment and the obtained parameters are generally not representative at the field scale because of the limitation of core sample size. Indirect methods such as inverse modeling are known to get efficient estimations and are easier to set up and process for large-scale studies. In this study, we investigated the capacity of an inverse modeling procedure to estimate the soil and the bedrock hydrodynamic properties only from in situ soil water content measurements at multiple depths under natural conditions. Multi-objective parameter optimization was performed using the HYDRUS-1D software and an external optimization procedure based on the NSGA-II algorithm. In a midslope shallow soil, water content was monitored at 3 depths, 20, 40, and 60cm during 12 intense rainfall events, whose amounts ranged between 50 and 250mm and duration between 1 and 5days. The vertical profile was considered as 2 layers of soils above a third layer representing the weathered schist rock. This deep layer acted as a deep boundary condition, which features the bedrock permeability and water storage. Each layer was described trough the 6 parameters of the Mualem\textendashvan Genuchten formulation. The calibrated parameters appeared to have very low uncertainty while allowing a good modelisation of the observed water content variations. The calibrated saturated water content was close to the laboratory porosity measurements while the saturated hydraulic conductivity showed that the soil was highly permeable, as measured in the field. The inverse modeling approach allowed an estimation of the hydraulic properties of the bedrock layer where no measurement was available. The bedrock layer was found to have a low saturated hydraulic conductivity (\textless5mmh-1), which means that the schist bedrock is poorly weathered and that saturated area can be generated above this depth, as it was observed. The simulated water contents were generally close to the measured water contents, but the model failed sometimes to reproduce the saturation of the soil in the deeper layers, probably because of sub-surface flux at the soil/bedrock interface. In these cases, further investigation will have to be made by using a 2D-model

Are Laparoscopic Staplers Effective for Ligation of Large Intraabdominal Arteries?

AbstractObjectives. To evaluate ligation of aortoiliac arteries with laparoscopic staplers in order to develop specifically designed staplers.Methods. Cadaveric study. Seven human cadaver aortas were stapled using EndoGIA60® staplers. Efficiency was evaluated macroscopically and on a hydrodynamic bench.Clinical study. Twelve patients had ligation of 14 large abdominal arteries (aorta: nine, iliac artery: four, hepatic artery: one) using a laparoscopic stapler. Stapling efficiency was judged on peroperative clinical and postoperative CT scan criteria.Results. Cadaveric study. Stapling was performed perfectly on four moderately calcified aortas, without leakage with a pulsatile pressure of >250 mmHg. For three aortas with severe calcification, stapling was not efficient and major leakage occurred.Clinical study. Stapling appeared clinically efficient on all arteries but one aorta: this severely calcified aorta was ligated conventionally. The staplers are not easy to use due to their shape and their lack of articulation. After a mean follow-up of 31.3 months, all the other stapled arteries were effectively ligated.Conclusion. The commercially available staplers can be used securely on moderately calcified arteries but stapling of severely calcified arteries should be avoided. These devices should be redesigned to facilitate their use in vascular surgery

Time trends and persistence in European temperature anomalies.

This paper looks at the level of persistence in the temperature anomalies series of 114 European cities. Once this level of persistence has been identified, the time trend coefficients are estimated and the results indicate that most of the series examined display positive trends, supporting thus climate warming. Moreover, the results obtained confirm the hypothesis that long-memory behaviour cannot be neglected in the study of temperature time series, changing, therefore, the estimated effect of global warming.pre-print825 K

Quasi-stationary regime of a branching random walk in presence of an absorbing wall

A branching random walk in presence of an absorbing wall moving at a constant velocity $v$ undergoes a phase transition as the velocity $v$ of the wall varies. Below the critical velocity $v_c$, the population has a non-zero survival probability and when the population survives its size grows exponentially. We investigate the histories of the population conditioned on having a single survivor at some final time $T$. We study the quasi-stationary regime for $v<v_c$ when $T$ is large. To do so, one can construct a modified stochastic process which is equivalent to the original process conditioned on having a single survivor at final time $T$. We then use this construction to show that the properties of the quasi-stationary regime are universal when $v\to v_c$. We also solve exactly a simple version of the problem, the exponential model, for which the study of the quasi-stationary regime can be reduced to the analysis of a single one-dimensional map.Comment: 2 figures, minor corrections, one reference adde

Last passage percolation and traveling fronts

We consider a system of N particles with a stochastic dynamics introduced by Brunet and Derrida. The particles can be interpreted as last passage times in directed percolation on {1,...,N} of mean-field type. The particles remain grouped and move like a traveling wave, subject to discretization and driven by a random noise. As N increases, we obtain estimates for the speed of the front and its profile, for different laws of the driving noise. The Gumbel distribution plays a central role for the particle jumps, and we show that the scaling limit is a L\'evy process in this case. The case of bounded jumps yields a completely different behavior