12 research outputs found
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.
- Author
- Abigail Hynes
- Aditya Mandal
- Adrian Barnardo
- Aftab Ala
- Agostino Colli
- Alan Shepherd
- Alan Watson
- Alastair McNair
- Alberto Mattalia
- Alexandra McKay
- Alice Wright
- Alison Brind
- Alison Loftus
- Alison Paton
- Alistair King
- Allister Grant
- Altaf Palegwala
- Amir Shah
- Amit Singhal
- Ana Lleo
- Andrea Broad
- Andrea Crosignani
- Andrea Galli
- Andrew Austin
- Andrew Bathgate
- Andrew Bell
- Andrew Burroughs
- Andrew Chilton
- Andrew Davis
- Andrew Douds
- Andrew Douglass
- Andrew Fraser
- Andrew Gibbins
- Andrew Higham
- Andrew L Mason
- Andrzej Piotrowicz
- Andy Li
- Angelo Andriulli
- Anna Fouracres
- Annarosa Floreani
- Anne Eastick
- Anton Gunasekera
- Antonio Benedetti
- Antonio Picciotto
- Aruna Dias
- Ashis Mukhopadhya
- Ashley Brown
- Asifabbas Naqvi
- Athar Saeed
- Bal Shinder
- Barbara Coco
- Barbara Foglieni
- Barbara Hoeroldt
- Becky Holbrook
- Beverley Longhurst
- Bob Grover
- Brian D. Juran
- Bridget Bird
- Bridget Gunson
- Bronwen Williams
- Bruce R Bacon
- Caradog Thomas
- Carl A. Anderson
- Carlo Ferrari
- Carly Brown
- Carmela Cursaro
- Carol Thomas
- Carole Collins
- Carole Foale
- Caroline Cowley
- Caroline Hamilton
- Caroline Lawlor
- Caroline Mulvaney-Jones
- Caroline Palmer
- Carolyn MacNicol
- Caron Innes
- Casey S. Greene
- Catherine Gray
- Catherine Vincent
- Charles Grimley
- Charles Millson
- Chin Lye Ch'ng
- Chris Evans
- Chris Ford
- Christine Dickson
- Christopher Healey
- Christopher Hovell
- Christopher I. Amos
- Christopher Macdonald
- Christopher Shallcross
- Christopher Shorrock
- Claire Duggan
- Claudio Tiribelli
- Craig Lammert
- Cristina Barlassina
- Cynthia Levy
- D Williams
- Dakai Zhu
- Daniel Forton
- Daniele Cusi
- Daniele Prati
- Darren Clement
- David C. Qian
- David Elphick
- David Gorard
- David Jones
- David Neal
- David Ramanaden
- David Tyrer
- Dawn Sirdefield
- Deb Ghosh
- Debashis Das
- Delyth Braim
- Denise Gocher
- Denise O'Donnell
- Dermot Gleeson
- Diane Simpson
- Domenico Alvaro
- Donna Cotterill
- Douglas Thorburn
- Earl Williams
- Eileen Marshall
- Eleanor Dungca
- Elizabeth J Atkinson
- Elizabeth Tanqueray
- Elva Wilhelmsen
- Emily Archer
- Emma Durant
- Emma Grieve
- Emma Gunter
- Erik M Schlicht
- Ervin Shpuza
- Estelle Nambela
- Esther Unitt
- Fabio Macaluso
- Fabio Marra
- Faiz Ali
- Federica Malinverno
- Filomena Morisco
- Fiona Gordon
- Fiona Wright
- Floriano Rosina
- Florin Muscariu
- Frances Hines
- Francesca Bernuzzi
- Gang Xie
- Gary Bray
- Gayle Clifford
- Geeta Prasad
- George Abouda
- George Bird
- George F. Mells
- George Lipscomb
- George MacFaul
- Giancarlo Spinzi
- Gianfranco Elia
- Gideon M. Hirschfield
- Gill Watts
- Giovanni Casella
- Glynis Stansfield
- Gordon Wood
- Graeme Alexander
- Graham Butcher
- Graham Foster
- Grazia A Niro
- Gregory Whatley
- Greta Van Duyvenvoorde
- Guan Lim
- Gwen Baxter
- Hannah Dewhurst
- Harriet Gordon
- Harriet Mitchison
- Heather J. Cordell
- Helen Doyle
- Helen Fairlamb
- Helen Sweeting
- Helen Wooldridge
- Hemant Gupta
- Henry C Bodenheimer Jr
- Hilary Pateman
- Howard Curtis
- Howard Klass
- Hyder Hussaini
- Hye-Jeong Lee
- Ian Drake
- Ian Gee
- Ian Gooding
- Ian Rees
- Ilaria Bianchi
- Ilaria Sogno
- Imran Patanwala
- Imroz Salam
- Isobel Amey
- Jaber Gasem
- Jacky Orpe
- Jacqueline Brighton
- James A. B. Floyd
- James Featherstone
- James Gotto
- James Neuberger
- Jane Bowles
- Jane Collier
- Jane Gitahi
- Jane Maiden
- Jane Metcalf
- Janeane Hails
- Janette Curtis
- Janie Keggans
- Janine Musselwhite
- Javaid Subhani
- Jayne Jones
- Jean Kordula
- Jeff Butterworth
- Jennie Kendall
- Jennifer Morrison
- Jeremy Shearman
- Jeremy Tibble
- Jessica Whiteman
- Jia Qu
- Jill Conder
- Jinyi Zhang
- Jo Ridpath
- Joanna Allison
- Joanna Sayer
- Jocelyn Fraser
- John Dillon
- John Mclindon
- John Ramage
- Jonathan Booth
- Jonathan Brown
- Joseph A Odin
- Joy Sadeghian
- Joy Wilkins
- Julia Maltby
- Julie Browning
- Julie Colley
- Julie Tregonning
- Juliette Verheyden
- Kapil Kapur
- Karen Hogben
- Karen Warner
- Karin Young
- Kate Martin
- Kate Ocker
- Katharine Pollock
- Katherine A. Siminovitch
- Katherine I. Morley
- Kathryn Houghton
- Katie Seward
- Katie Spurdle
- Keith Elliott
- Keith George
- Kelly Amor
- Kerenza Boulton
- Kerry Flahive
- Kevin Yoong
- Kimberley Netherton
- Kirsten Walker
- Kirsty Martin
- Konrad Koss
- Konstantinos N. Lazaridis
- LaiTing Tan
- Landon L Chan
- Leonie Grellier
- Linda Jones
- Linda Kent
- Linda March
- Lisa Morgan
- Liz Farrington
- Lizzie Stafford
- Lola Dali-kemmery
- Lorenzo Morini
- Lorraine Hankey
- Lory Saveria Crocè
- Louise Winter
- Lourdes Cumlat
- Luca Fabris
- Lucie Hobson
- Luigi Muratori
- Lyn Graves
- Lynn Currie
- Lynn O'Donohoe
- M. Eric Gershwin
- Maggie Hughes
- Mandy Carnahan
- Marco Carbone
- Marco Marzioni
- Marek Czajkowski
- Maria Consiglia Bragazzi
- Maria Francesca Donato
- Maria Hamilton
- Maria Hayes
- Maria Vinci
- Mariam Nasseri
- Marie Green
- Marie Quinn
- Marina Leoni
- Mario Strazzabosco
- Marisa Mills
- Mariza de Andrade
- Mark Ainsworth
- Mark Aldersley
- Mark Cox
- Mark Narain
- Mark Wilkinson
- Mark Wright
- Markus Gess
- Marta Spreafico
- Martin Lombard
- Martin Prince
- Martyn Carter
- Mary Crossey
- Mary Ninkovic
- Massimo Colombo
- Massimo Zuin
- Matthew Brookes
- Matthew Cowan
- Matthew Cramp
- Matthew Foxton
- Maurizia Brunetto
- Mauro Podda
- Maxton Pitcher
- Mazn Karmo
- Mcdonald Mupudzi
- Melanie Harrison
- Melanie Kent
- Mervyn Davies
- Mesbah Rahman
- Metod Oblak
- Michael F. Seldin
- Michael Heneghan
- Mike Mendall
- Minesh Patel
- Mirko Tarocchi
- Mohamed Dawwas
- Mousa Hani S
- Natalie Taylor
- Natalie Wheatley
- Neil Fisher
- Nicholas Sharer
- Nicola Lancaster
- Nikki White
- Noma Ncube
- null null
- null null
- null null
- Nurani Sivaramakrishnan
- Oza Chirag
- Paolo Muratori
- Parizade Raymode
- Patrick Goggin
- Paul Banim
- Paul Kitchen
- Paul Richardson
- Paul Southern
- Paula Townshend
- Peter Bramley
- Peter K Gregersen
- Peter Mills
- Phillipa Desousa
- Pier Maria Battezzati
- Pierluigi Toniutto
- Piero L Almasio
- Piero Portincasa
- Pietro Andreone
- Pietro Invernizzi
- Piotr Milkiewicz
- Pradeep Sanghi
- Pranab Gyawali
- PuiChing Chan
- Purushothaman Premchand
- Rachel Abrahams
- Raj Srirajaskanthan
- Ray Mathew
- Ray Shidrawi
- Rebecca Bishop
- Rebecca Casey
- Rebecca Cloudsdale
- Rebecca Jones
- Renzo Montanari
- Reuben Ayres
- Richard Aspinall
- Richard Evans
- Richard Marley
- Richard Miller
- Richard N. Sandford
- Richard Sturgess
- Robert P Myers
- Robert Przemioslo
- Roberta Lazzari
- Roger McCorry
- Roland Ede
- Roman Galaska
- Rory Harvey
- Rosanna Fontana
- Rose Damant
- Rupert Ransford
- Ruth Penn
- Saket Singhal
- Sally Batham
- Sally-Ann Rolls
- Sallyanne Pearson
- Samantha Ducker
- Sambit Sen
- Samir Vyas
- Sandra Greer
- Sanjiv Jain
- Sarah Besley
- Sarah Jones
- Sarah Thornthwaite
- Sass Levi
- Savino Bruno
- Senayon Desmennu
- Sharat Misra
- Sherill Tripoli
- Silvia Colombo
- Simon Dyer
- Simon Panter
- Simon Rushbrook
- Simon Taylor-Robinson
- Simon Whalley
- Simon Williams
- Sonia Rossi
- Sonia Tarallo
- Sophie Holder
- Stephen D Ryder
- Steve Pereira
- Steven Mann
- Stewart Campbell
- Subramaniam Ramakrishnan
- Subrata Saha
- Sue Glenn
- Sue Walsh
- Sunil Dolwani
- Susan Congreave
- Susan Gallagher
- Susan Jones
- Susan Lord
- Susan Slininger
- Sushma Saksena
- Suzie Marriott
- Syed Shaukat
- Talal Valliani
- Theodore Ngatchu
- Thiriloganathan Mathialahan
- Tim Harding
- Tobias Balschun
- Toby Delahooke
- Tom Lee
- Tom Yapp
- Tracey Shewan
- Udi Shmueli
- Valentina Liakina
- Valeria Silvestre
- Velimir A Luketic
- Victoria Lambourne
- Vincenzo O Palmieri
- Vincenzo Ronca
- Voi Shim Wong
- William Stableforth
- Yafang Li
- Yeng Ang
- Yolanda Baird
- Younghun Han
- Publication venue
- Nat Commun
- Publication date
- 01/01/2015
- Field of study
Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10(-8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
- Adeolu AA
- Adetoye A
- Adewale B
- Adigun T
- Adolfsson A
- Aflori L
- Africander C
- Afshari A
- Agarwal V
- Agodirin O
- Aguero Vera M
- Aguzzoli C
- Ahmad A
- Ahmad N
- Ahmad T
- Ahmad T
- Ahmad Y
- Ahmed A
- Ahmed J
- Ai Y
- Aignatoaie M
- Aimoniotou-Georgiou E
- Akanmu O
- Akerman N
- Akinwale M
- Akring I
- Al 'Amri K
- Al Anizi M
- Al hussaini S
- Al-Soudaine Y
- Aladin H
- Alagbe-Briggs O
- Alaman Laguarda G
- Albaj S
- Alcock D
- Alcock L
- Aldecoa C
- Aldecoa C
- Aleixo FB
- Alexander H
- Alexander M
- Alexander-Sefre F
- Alherz F
- Ali H
- Ali M
- Ali S
- Alias A
- Alias AH
- Alias RLR
- Alit MA
- Allen S
- Allen SJ
- Allison J
- Alloj C
- Allorto NL
- Allsop J
- Almeida W
- Alonso E
- Alphonsus C
- Alvares D
- Alves MJ
- Amador JCB
- Ameer Y
- Amendola CP
- Ami N
- Amstrup-Hansen L
- Anagnou A
- Andersen C
- Anderson C
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- Anderson F
- Anderson P
- Andreadaki E
- Andreou A
- Andreou P
- Andrew A
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- Angermair S
- Angus K
- Anillo V
- Antal O
- Antill P
- Antoniadou E
- Antonina W
- Apagaki E
- Apostolou K
- Applewhaite C
- Aquino LPG
- Ar P
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- Argue R
- Arkalaki E
- Armaganidis A
- Armstrong J
- Armstrong R
- Arnaoutoglou C
- Arnaoutoglou E
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- Arrandale L
- Arrich J
- Arrigo M
- Arshad H
- Arshad MA
- Arumugam S
- Arustei M
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- Arya A
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- Asimakos A
- Asudo F
- Athanasakis E
- Atiku M
- Attrill E
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- Avidan M
- Avila Sanchez FJ
- Avila EJD
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- Awad H
- Axioti E
- Ayyaz H
- Azam UAA
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- Azevedo C
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- Dumitrascu CO
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- Dwyer H
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- Echem R
- Edmond H
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- Edwards M
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- Endersby S
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- Fanfani LC
- Faponle F
- Faria e Maia D
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- Farid N
- Farina Z
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- Fasina O
- Fatungase OM
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- Van Mossevelde V
- van Rossum S
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- van Zeggeren L
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- van Zyl R
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- Veevaete L
- Veit S
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- Verdoodt H
- Veroniki F
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- Vetsiou E
- Vilela dos Santos AM
- Virdi P
- Visser L
- Visvalingam S
- Vivian M
- Vlachogianni G
- Vohra A
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- Volta CA
- Von Heymann C
- von Rhaden R
- Voruz F
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- Walder B
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- Walsh D
- Wan X
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- Ward J
- Wasmund C
- Wassall R
- Watanabe Oliveira HR
- Watson A
- Watson N
- Watt P
- Waugh D
- Waweru P
- Waworuntu N
- Waymouth E
- Weatherall L
- Weatherill J
- Webb S
- Weber E
- Wei J
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- Weller D
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- Wendling PR
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- Xu G-J
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- Xue R
- Yagnik A
- Yan Y
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- Yao Y
- Yap HL
- Yarwood J
- Yassaee A
- Ye H
- Ye H
- Yegnaram S
- Yeh E
- Yin N
- Yip CP
- Yong J
- Yu HC
- Yu S
- Yu T
- Yu Y
- Yuan D
- Yuan F
- Yuan J
- Yuan J
- Yuan Y
- Yuliana A
- Zaimi D
- Zakynthinos S
- Zamudio D
- Zangrillo A
- Zapata DDM
- Zbitnew G
- Zeidan L
- Zeng Q
- Zerman L
- Zettergren J
- Zhang B
- Zhang E
- Zhang H
- Zhang H
- Zhang H
- Zhang J
- Zhang K
- Zhang L
- Zhang M
- Zhang M
- Zhang Q
- Zhang R
- Zhang S
- Zhang W
- Zhang X
- Zhang X
- Zhang X
- Zhang X
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y
- Zhao B
- Zhao B
- Zhao C
- Zhao J
- Zhao J
- Zhao L
- Zhao L
- Zhao S
- Zhao T
- Zhao W
- Zhao W
- Zhao X
- Zhen J
- Zheng K
- Zheng L
- Zheng T
- Zhong Y
- Zhou C
- Zhou D
- Zhou H
- Zhou H
- Zhou J
- Zhou J
- Zhou J
- Zhou X-J
- Zhu X
- Zhu X
- Zhu Y
- Zhu Z
- Zhuang X
- Zilis G
- Zin NHM
- Zingerle N
- Zingg U
- Zoerner F
- Zonneveldt H
- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
Linezolid lock prophylaxis of central venous catheter infection
- Author
- Publication venue
- 'Microbiology Society'
- Publication date
- Field of study
Intoxication by gamma hydroxybutyrate and related analogues: Clinical characteristics and comparison between pure intoxication and that combined with other substances of abuse.
- Author
- Chevillard Lucie
- Dargan Paul
- Dines Alison M
- Eyer Florian
- Galicia Miguel
- Giraudon Isabelle
- Heyerdahl Fridtjof
- Homar Catalina
- Hovda Knut E
- Jürgens Gesche
- Kabata Piotr Maciej
- Lee Christopher
- Liakoni Evangelia
- Liechti Matthias
- Markey Gerard
- Miró Òscar
- Moughty Adrian
- Mégarbane Bruno
- O'Connor Niall
- O'Donohoe Patrick
- Paasma Raido
- Pedersen Carsten Boe
- Persett Per Sverre
- Puiguriguer Jordi
- Põld Kristiina
- Rabe Christian
- Sein Anand Jacek
- Vallersnes Odd Martin
- Waring W Stephen
- Wood David M
- Yates Christopher
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/08/2017
- Field of study
OBJECTIVE
To study the profile of European gamma-hydroxybutyrate (GHB) and gammabutyrolactone (GBL) intoxication and analyse the differences in the clinical manifestations produced by intoxication by GHB/GBL alone and in combination with other substances of abuse.
METHOD
We prospectively collected data on all the patients attended in the Emergency Departments (ED) of the centres participating in the Euro-DEN network over 12 months (October 2013 to September 2014) with a primary presenting complaint of drug intoxication (excluding ethanol alone) and registered the epidemiological and clinical data and outcomes.
RESULTS
We included 710 cases (83% males, mean age 31 years), representing 12.6% of the total cases attended for drug intoxication. Of these, 73.5% arrived at the ED by ambulance, predominantly during weekend, and 71.7% consumed GHB/GBL in combination with other substances of abuse, the most frequent additional agents being ethanol (50%), amphetamine derivatives (36%), cocaine (12%) and cannabis (8%). Among 15 clinical features pre-defined in the project database, the 3 most frequently identified were altered behaviour (39%), reduced consciousness (34%) and anxiety (14%). The severity ranged from mild cases requiring no treatment (308 cases, 43.4%) to severe cases requiring admission to intensive care (103 cases, 14.6%) and mechanical ventilation (49 cases, 6.9%). No deaths were reported. In comparison with only GHB/GBL consumption, patients consuming GHB/GBL with co-intoxicants presented more vomiting (15% vs. 3%, p12h, p<0.01).
CONCLUSIONS
The profile of the typical GHB/GBL-intoxicated European is a young male, requiring care for altered behaviour and reduced level of consciousness, mainly during the weekend. The clinical features are more severe when GHB is consumed in combination with other substances of abuse
Pretreatment prediction of response to ursodeoxycholic acid in primary biliary cholangitis: development and validation of the UDCA Response Score.
- Author
- Abouda George
- Adgey Carolyn
- Ainsworth Holly F
- Ala Aftab
- Aldersley Mark
- Alexander Graeme
- Alexander Graeme J
- Allison Joanna
- Alvaro Domenico
- Alvaro Domenico
- Amey Isobel
- Amore Kelly
- Andreone Pietro
- Ang Yeng
- Austin Andrew
- Ayres Reuben
- Azzaroli Francesco
- Badrock Jonathan
- Baird Yolanda
- Banim Paul
- Barnardo Adrian
- Batham Sally
- Bathgate Andrew
- Bathgate Andrew
- Battezzati Pier Maria
- Battezzati Pier Maria
- Baxter Gwen
- Bell Andrew
- Bernuzzi Francesca
- Bernuzzi Francesca
- Bird Bridget
- Bird George
- Bishop Rebecca
- Bonato Giulia
- Bonato Giulia
- Booth Jonathan
- Boulton Kerenza
- Bowles Jane
- Bragazzi Maria Consiglia
- Braim Delyth
- Bramley Peter
- Bray Gary
- Brighton Jacqueline
- Brind Alison
- Brookes Matthew
- Brown Ashley
- Brown Carly
- Brown Jonathan
- Browning Julie
- Burroughs Andrew
- Butcher Graham
- Butterworth Jeff
- Campbell Stewart
- Carbone Marco
- Carbone Marco
- Cardinale Vincenzo
- Carnahan Mandy
- Carpino Guido
- Carter Martyn
- Casey Rebecca
- Chapman Roger
- Chilton Andrew
- Clement Darren
- Clifford Gayle
- Colley Julie
- Collier Jane
- Collins Carole
- Conder Jill
- Cordell Heather J
- Cotterill Donna
- Cowan Matthew
- Cowley Caroline
- Cox Mark
- Cramp Matthew
- Cristoferi Laura
- Cristoferi Laura
- Crossey Mary
- Cumlat Lourdes
- Currie Lynn
- Curtis Howard
- Curtis Janette
- Czaijkowski Marek
- Dali-Kemmery Lola
- Damant Rose
- Das Debashis
- Das Debasish
- Davies Mervyn
- Davis Andrew
- Delahooke Toby
- Dewhurst Hannah
- Dickson Christine
- Dolwani Sunil
- Donato Maria F
- Donato Maria Francesca
- Douds Andrew
- Douglass Andrew
- Doyle Helen
- Drake Im
- Ducker Samantha
- Duggan Claire
- Dungca Eleanor
- Durant Emma
- Dyer Simon
- Eastick Anne
- Ede Roland
- Elliott Keith
- Evans Chris
- Evans Richard
- Fairlamb Helen
- Farrington Liz
- Featherstone James
- Fisher Neil
- Flack Steve
- Flahive Kerry
- Floreani Annarosa
- Floreani Annarosa
- Foale Carole
- Ford Chris
- Forton Daniel
- Foster Graham
- Fouracres Anna
- Foxton Matthew
- Fraser Andrew
- Fraser Jocelyn
- Galaska Roman
- Gallagher Susan
- Galli Andrea
- Gasbarrini Antonio
- Gasem Jaber
- Gaudio Eugenio
- Gavrila Caius
- Gee Ian
- George Keith
- Gerussi Alessio
- Gess Markus
- Ghosh Deb
- Giannini Edoardo
- Giannini Edoardo
- Gibbins Andrew
- Gitahi Jane
- Gleeson Dermot
- Gocher Denis
- Gocher Denise
- Goggin Patrick
- Gooding Ian
- Gorard David
- Gordon Fiona
- Gordon Harriet
- Gotto James
- Grant Allister
- Graves Lyn
- Gray Catherine
- Green Marie
- Greer Sandra
- Grellier Leonie
- Grieco Antonio
- Grieve Emma
- Griffiths Laura
- Grimley Charles
- Grover Bob
- Gunasekera Anton
- Gunson Bridget
- Gunter Emma
- Gupta Hemant
- Gyawli Pranab
- Hamilton Maria
- Harding Tim
- Harrison Melanie
- Harvey Rory
- Hayes Maria
- Healey Chris
- Heneghan Michael
- Heneghan Michael A
- Higham Andrew
- Hines Francis
- Hirschfield Gideon
- Hirschfield Gideon M
- Hobson Lucie
- Hoeroldt Barbara
- Hogben Karen
- Holbrook Becky
- Houghton Kathryn
- Hovell Chris
- Hughes Maggie
- Hussaini Hyder
- Hynes Abigail
- Innes Caron
- Invernizzi Pietro
- Invernizzi Pietro
- Jain Snjiv
- Jones David
- Jones David E
- Jones Jayne
- Jones Linda
- Jones Rebecca
- Jones Rebecca
- Jones Sarah
- Jones Susan
- Kapur Kapil
- Karmo Mazn
- Keggans Janie
- Kent Linda
- Kent Melanie
- King Alistair
- Kirby John
- Kitchen Paul
- Klass Howard
- Kordula Jean
- Koss Konrad
- Labbadia Giancarlo
- Lambourne Victoria
- Lancaster Nicola
- Lee Hye-Jeong
- Lee Tom
- Leoni Marina
- Levi Sass
- Li Andy
- Lim Guan
- Lim Reina Teegan
- Lipscomb George
- Loftus Alison
- Lombard Martin
- Lord Susan
- Lye Ch'ng Chin
- Macdonald Chris
- Macfaul George
- Macnicol Carolyn
- Maiden Jane
- Malinverno Federica
- Malinverno Federica
- Maltby Julia
- Mandal Adtya
- Mann Steven
- March Linda
- Maroni Luca
- Marra Fabio
- Marra Fabio
- Marriott Suzie
- Marrone Giuseppe
- Marshall Eileen
- Martin Kate
- Martin Kirsty
- Marzioni Marco
- Marzioni Marco
- Mathew Ray
- Mathialahan Thiriloganathan
- Mccorry Roger
- Mckay Alexandra
- Mclindon John
- Mcnair Alistair
- Mells George
- Mells George F
- Mendall Mike
- Metcalf Jane
- Miele Luca
- Miele Luca
- Mills Marisa
- Mills Peter
- Millson Charles
- Mitchell-Thain Robert
- Mitchison Harriet
- Mukhopadhya Ashis
- Mulvaney-Jones Caroline
- Mupudzi Mcdonald
- Muratori Luigi
- Muratori Luigi
- Muscariu Florin
- Musselwhite Janine
- Naqvi Asifabbas
- Narain Mark
- Nardi Alessandra
- Nasseri Mariam
- Ncube Noma
- Neal David
- Netherton Kimberley
- Neuberger James
- Neuberger James M
- Ngatchu Theodore
- Ninkovic Mary
- O'Donnell Denise
- O'Donohoe Lynn
- Oblak Metod
- Ocker Kate
- Orpe Jacky
- Palegwala Altaf
- Palmer Caroline
- Panter Simon
- Patanwala Imran
- Patel Minesh
- Pateman Hilary
- Paton Alison
- Pearson Sallyanne
- Penn Ruth
- Pereira Steve
- Picciotto Antonino
- Piotreowicz Andrzej
- Pitcher Maxton
- Pollock Katharine
- Premchand Purushothaman
- Prince Martin
- Przemioslo Robert
- Quinn Marie
- Quinne Mary
- Rahman Meshbah
- Ramage John
- Ramanaden David
- Ransford Rupert
- Raymode Parizade
- Rees Ian
- Ridpath Jo
- Rigamonti Cristina
- Ronca Vincenzo
- Rushbrook Simon
- Ryder Stephen D
- Sadeghian Joy
- Saeed Athar
- Saha Subrata
- Saksena Sushma
- Salam Imroz
- Sampaziotis Fotios
- Sandford Richard
- Sandford Richard N
- Sanghi Pradeep
- Sayer Joanna
- Sen Sambit
- Seward Katie
- Shah Amir
- Shallcross Chris
- Sharer Nicholas
- Shaukat Syed
- Shearman Jeremy
- Shepherd Alan
- Shewan Tracey
- Shidrawi Ray
- Shinder Bal
- Shmueli Udi
- Shorrock Christopher
- Shpuza Ervin
- Silvestre Valeria
- Simpson Diane
- Singhal Amit
- Singhal Saket
- Sirdefield Dawn
- Sivaramakrishnan Nurani
- Slininger Susan
- Southern Paul
- Spicer Ann
- Srirajaskanthan Raj
- Stableforth Bill
- Stafford Lizzie
- Stocken Deborah D
- Sturgess Richard
- Subhani Javaid
- Sweeting Helen
- Tanqueray Elizabeth
- Tarocchi Mirko
- Taylor Natalie
- Taylor-Robinson Simon
- Taylor-Robinson Simon
- Thomas Caradog
- Thorburn Douglas
- Thorburn Douglas
- Tibble Jeremy
- Ting Tan Lai
- Townshend Paula
- Tregonning Julie
- Trembling Paul
- Tripoli Sherill
- Tyrer David
- Unitt Esther
- Valenti Luca
- Valliani Talal
- Van Duyvenvoorde Greta
- Varvaropoulou Nikoletta
- Verheyden Juliette
- Vyas Samir
- Walker Kirsten
- Warner Karen
- Watson Alan
- Watson Alan
- Watts Gill
- Whalley Simon
- Whatley Gregory
- Wheatley Natalie
- White Nikki
- Whiteman Jessica
- Whiteman Jessica
- Wilhelmsen Elva
- Wilkins Joy
- Wilkinson Mark
- Williams Bronwen
- Williams Earl
- Williams Simon
- Williamson Kate
- Wong Voi Shim
- Wood Gordon
- Wright Alice
- Wright Mark
- Wrigth Aruna
- Yapp Tom
- Yoong Kevin
- Young Karin
- Zuin Massimo
- Zuin Massimo
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
BACKGROUND
Treatment guidelines recommend a stepwise approach to primary biliary cholangitis: all patients begin treatment with ursodeoxycholic acid (UDCA) monotherapy and those with an inadequate biochemical response after 12 months are subsequently considered for second-line therapies. However, as a result, patients at the highest risk can wait the longest for effective treatment. We determined whether UDCA response can be accurately predicted using pretreatment clinical parameters.
METHODS
We did logistic regression analysis of pretreatment variables in a discovery cohort of patients in the UK with primary biliary cholangitis to derive the best-fitting model of UDCA response, defined as alkaline phosphatase less than 1·67 times the upper limit of normal (ULN), measured after 12 months of treatment with UDCA. We validated the model in an external cohort of patients with primary biliary cholangitis and treated with UDCA in Italy. Additionally, we assessed correlations between model predictions and key histological features, such as biliary injury and fibrosis, on liver biopsy samples.
FINDINGS
2703 participants diagnosed with primary biliary cholangitis between Jan 1, 1998, and May 31, 2015, were included in the UK-PBC cohort for derivation of the model. The following pretreatment parameters were associated with lower probability of UDCA response: higher alkaline phosphatase concentration (p<0·0001), higher total bilirubin concentration (p=0·0003), lower aminotransferase concentration (p=0·0012), younger age (p<0·0001), longer interval from diagnosis to the start of UDCA treatment (treatment time lag, p<0·0001), and worsening of alkaline phosphatase concentration from diagnosis (p<0·0001). Based on these variables, we derived a predictive score of UDCA response. In the external validation cohort, 460 patients diagnosed with primary biliary cholangitis were treated with UDCA, with follow-up data until May 31, 2016. In this validation cohort, the area under the receiver operating characteristic curve for the score was 0·83 (95% CI 0·79-0·87). In 20 liver biopsy samples from patients with primary biliary cholangitis, the UDCA response score was associated with ductular reaction (r=-0·556, p=0·0130) and intermediate hepatocytes (probability of response was 0·90 if intermediate hepatocytes were absent vs 0·51 if present).
INTERPRETATION
We have derived and externally validated a model based on pretreatment variables that accurately predicts UDCA response. Association with histological features provides face validity. This model provides a basis to explore alternative approaches to treatment stratification in patients with primary biliary cholangitis.
FUNDING
UK Medical Research Council and University of Milan-Bicocca
Pretreatment prediction of response to ursodeoxycholic acid in primary biliary cholangitis: development and validation of the UDCA Response Score.
- Author
- Abouda George
- Adgey Carolyn
- Ainsworth Holly F
- Ala Aftab
- Aldersley Mark
- Alexander Graeme
- Alexander Graeme J
- Allison Joanna
- Alvaro Domenico
- Alvaro Domenico
- Amey Isobel
- Amore Kelly
- Andreone Pietro
- Ang Yeng
- Austin Andrew
- Ayres Reuben
- Azzaroli Francesco
- Badrock Jonathan
- Baird Yolanda
- Banim Paul
- Barnardo Adrian
- Batham Sally
- Bathgate Andrew
- Bathgate Andrew
- Battezzati Pier Maria
- Battezzati Pier Maria
- Baxter Gwen
- Bell Andrew
- Bernuzzi Francesca
- Bernuzzi Francesca
- Bird Bridget
- Bird George
- Bishop Rebecca
- Bonato Giulia
- Bonato Giulia
- Booth Jonathan
- Boulton Kerenza
- Bowles Jane
- Bragazzi Maria Consiglia
- Braim Delyth
- Bramley Peter
- Bray Gary
- Brighton Jacqueline
- Brind Alison
- Brookes Matthew
- Brown Ashley
- Brown Carly
- Brown Jonathan
- Browning Julie
- Burroughs Andrew
- Butcher Graham
- Butterworth Jeff
- Campbell Stewart
- Carbone Marco
- Carbone Marco
- Cardinale Vincenzo
- Carnahan Mandy
- Carpino Guido
- Carter Martyn
- Casey Rebecca
- Chapman Roger
- Chilton Andrew
- Clement Darren
- Clifford Gayle
- Colley Julie
- Collier Jane
- Collins Carole
- Conder Jill
- Cordell Heather J
- Cotterill Donna
- Cowan Matthew
- Cowley Caroline
- Cox Mark
- Cramp Matthew
- Cristoferi Laura
- Cristoferi Laura
- Crossey Mary
- Cumlat Lourdes
- Currie Lynn
- Curtis Howard
- Curtis Janette
- Czaijkowski Marek
- Dali-Kemmery Lola
- Damant Rose
- Das Debashis
- Das Debasish
- Davies Mervyn
- Davis Andrew
- Delahooke Toby
- Dewhurst Hannah
- Dickson Christine
- Dolwani Sunil
- Donato Maria F
- Donato Maria Francesca
- Douds Andrew
- Douglass Andrew
- Doyle Helen
- Drake IM
- Ducker Samantha
- Duggan Claire
- Dungca Eleanor
- Durant Emma
- Dyer Simon
- Eastick Anne
- Ede Roland
- Elliott Keith
- Evans Chris
- Evans Richard
- Fairlamb Helen
- Farrington Liz
- Featherstone James
- Fisher Neil
- Flack Steve
- Flahive Kerry
- Floreani Annarosa
- Floreani Annarosa
- Foale Carole
- Ford Chris
- Forton Daniel
- Foster Graham
- Fouracres Anna
- Foxton Matthew
- Fraser Andrew
- Fraser Jocelyn
- Galaska Roman
- Gallagher Susan
- Galli Andrea
- Gasbarrini Antonio
- Gasem Jaber
- Gaudio Eugenio
- Gavrila Caius
- Gee Ian
- George Keith
- Gerussi Alessio
- Gess Markus
- Ghosh Deb
- Giannini Edoardo
- Giannini Edoardo
- Gibbins Andrew
- Gitahi Jane
- Gleeson Dermot
- Gocher Denis
- Gocher Denise
- Goggin Patrick
- Gooding Ian
- Gorard David
- Gordon Fiona
- Gordon Harriet
- Gotto James
- Grant Allister
- Graves Lyn
- Gray Catherine
- Green Marie
- Greer Sandra
- Grellier Leonie
- Grieco Antonio
- Grieve Emma
- Griffiths Laura
- Grimley Charles
- Grover Bob
- Gunasekera Anton
- Gunson Bridget
- Gunter Emma
- Gupta Hemant
- Gyawli Pranab
- Hamilton Maria
- Harding Tim
- Harrison Melanie
- Harvey Rory
- Hayes Maria
- Healey Chris
- Heneghan Michael
- Heneghan Michael A
- Higham Andrew
- Hines Francis
- Hirschfield Gideon
- Hirschfield Gideon M
- Hobson Lucie
- Hoeroldt Barbara
- Hogben Karen
- Holbrook Becky
- Houghton Kathryn
- Hovell Chris
- Hughes Maggie
- Hussaini Hyder
- Hynes Abigail
- Innes Caron
- Invernizzi Pietro
- Invernizzi Pietro
- Jain Snjiv
- Jones David
- Jones David E
- Jones Jayne
- Jones Linda
- Jones Rebecca
- Jones Rebecca
- Jones Sarah
- Jones Susan
- Kapur Kapil
- Karmo Mazn
- Keggans Janie
- Kent Linda
- Kent Melanie
- King Alistair
- Kirby John
- Kitchen Paul
- Klass Howard
- Kordula Jean
- Koss Konrad
- Labbadia Giancarlo
- Lambourne Victoria
- Lancaster Nicola
- Lee Hye-Jeong
- Lee Tom
- Leoni Marina
- Levi Sass
- Li Andy
- Lim Guan
- Lim Reina Teegan
- Lipscomb George
- Loftus Alison
- Lombard Martin
- Lord Susan
- Lye Ch'ng Chin
- Macdonald Chris
- MacFaul George
- MacNicol Carolyn
- Maiden Jane
- Malinverno Federica
- Malinverno Federica
- Maltby Julia
- Mandal Adtya
- Mann Steven
- March Linda
- Maroni Luca
- Marra Fabio
- Marra Fabio
- Marriott Suzie
- Marrone Giuseppe
- Marshall Eileen
- Martin Kate
- Martin Kirsty
- Marzioni Marco
- Marzioni Marco
- Mathew Ray
- Mathialahan Thiriloganathan
- McCorry Roger
- McKay Alexandra
- Mclindon John
- McNair Alistair
- Mells George
- Mells George F
- Mendall Mike
- Metcalf Jane
- Miele Luca
- Miele Luca
- Mills Marisa
- Mills Peter
- Millson Charles
- Mitchell-Thain Robert
- Mitchison Harriet
- Mukhopadhya Ashis
- Mulvaney-Jones Caroline
- Mupudzi Mcdonald
- Muratori Luigi
- Muratori Luigi
- Muscariu Florin
- Musselwhite Janine
- Naqvi Asifabbas
- Narain Mark
- Nardi Alessandra
- Nasseri Mariam
- Ncube Noma
- Neal David
- Netherton Kimberley
- Neuberger James
- Neuberger James M
- Ngatchu Theodore
- Ninkovic Mary
- O'Donnell Denise
- O'Donohoe Lynn
- Oblak Metod
- Ocker Kate
- Orpe Jacky
- Palegwala Altaf
- Palmer Caroline
- Panter Simon
- Patanwala Imran
- Patel Minesh
- Pateman Hilary
- Paton Alison
- Pearson Sallyanne
- Penn Ruth
- Pereira Steve
- Picciotto Antonino
- Piotreowicz Andrzej
- Pitcher Maxton
- Pollock Katharine
- Premchand Purushothaman
- Prince Martin
- Przemioslo Robert
- Quinn Marie
- Quinne Mary
- Rahman Meshbah
- Ramage John
- Ramanaden David
- Ransford Rupert
- Raymode Parizade
- Rees Ian
- Ridpath Jo
- Rigamonti Cristina
- Ronca Vincenzo
- Rushbrook Simon
- Ryder Stephen D
- Sadeghian Joy
- Saeed Athar
- Saha Subrata
- Saksena Sushma
- Salam Imroz
- Sampaziotis Fotios
- Sandford Richard
- Sandford Richard N
- Sanghi Pradeep
- Sayer Joanna
- Sen Sambit
- Seward Katie
- Shah Amir
- Shallcross Chris
- Sharer Nicholas
- Shaukat Syed
- Shearman Jeremy
- Shepherd Alan
- Shewan Tracey
- Shidrawi Ray
- Shinder Bal
- Shmueli Udi
- Shorrock Christopher
- Shpuza Ervin
- Silvestre Valeria
- Simpson Diane
- Singhal Amit
- Singhal Saket
- Sirdefield Dawn
- Sivaramakrishnan Nurani
- Slininger Susan
- Southern Paul
- Spicer Ann
- Srirajaskanthan Raj
- Stableforth Bill
- Stafford Lizzie
- Stocken Deborah D
- Sturgess Richard
- Subhani Javaid
- Sweeting Helen
- Tanqueray Elizabeth
- Tarocchi Mirko
- Taylor Natalie
- Taylor-Robinson Simon
- Taylor-Robinson Simon
- Thomas Caradog
- Thorburn Douglas
- Thorburn Douglas
- Tibble Jeremy
- Ting Tan Lai
- Townshend Paula
- Tregonning Julie
- Trembling Paul
- Tripoli Sherill
- Tyrer David
- Unitt Esther
- Valenti Luca
- Valliani Talal
- Van Duyvenvoorde Greta
- Varvaropoulou Nikoletta
- Verheyden Juliette
- Vyas Samir
- Walker Kirsten
- Warner Karen
- Watson Alan
- Watson Alan
- Watts Gill
- Whalley Simon
- Whatley Gregory
- Wheatley Natalie
- White Nikki
- Whiteman Jessica
- Whiteman Jessica
- Wilhelmsen Elva
- Wilkins Joy
- Wilkinson Mark
- Williams Bronwen
- Williams Earl
- Williams Simon
- Williamson Kate
- Wong Voi Shim
- Wood Gordon
- Wright Alice
- Wright Mark
- Wrigth Aruna
- Yapp Tom
- Yoong Kevin
- Young Karin
- Zuin Massimo
- Zuin Massimo
- Publication venue
- Lancet Gastroenterol Hepatol
- Publication date
- 01/06/2017
- Field of study
BACKGROUND: Treatment guidelines recommend a stepwise approach to primary biliary cholangitis: all patients begin treatment with ursodeoxycholic acid (UDCA) monotherapy and those with an inadequate biochemical response after 12 months are subsequently considered for second-line therapies. However, as a result, patients at the highest risk can wait the longest for effective treatment. We determined whether UDCA response can be accurately predicted using pretreatment clinical parameters. METHODS: We did logistic regression analysis of pretreatment variables in a discovery cohort of patients in the UK with primary biliary cholangitis to derive the best-fitting model of UDCA response, defined as alkaline phosphatase less than 1·67 times the upper limit of normal (ULN), measured after 12 months of treatment with UDCA. We validated the model in an external cohort of patients with primary biliary cholangitis and treated with UDCA in Italy. Additionally, we assessed correlations between model predictions and key histological features, such as biliary injury and fibrosis, on liver biopsy samples. FINDINGS: 2703 participants diagnosed with primary biliary cholangitis between Jan 1, 1998, and May 31, 2015, were included in the UK-PBC cohort for derivation of the model. The following pretreatment parameters were associated with lower probability of UDCA response: higher alkaline phosphatase concentration (p<0·0001), higher total bilirubin concentration (p=0·0003), lower aminotransferase concentration (p=0·0012), younger age (p<0·0001), longer interval from diagnosis to the start of UDCA treatment (treatment time lag, p<0·0001), and worsening of alkaline phosphatase concentration from diagnosis (p<0·0001). Based on these variables, we derived a predictive score of UDCA response. In the external validation cohort, 460 patients diagnosed with primary biliary cholangitis were treated with UDCA, with follow-up data until May 31, 2016. In this validation cohort, the area under the receiver operating characteristic curve for the score was 0·83 (95% CI 0·79-0·87). In 20 liver biopsy samples from patients with primary biliary cholangitis, the UDCA response score was associated with ductular reaction (r=-0·556, p=0·0130) and intermediate hepatocytes (probability of response was 0·90 if intermediate hepatocytes were absent vs 0·51 if present). INTERPRETATION: We have derived and externally validated a model based on pretreatment variables that accurately predicts UDCA response. Association with histological features provides face validity. This model provides a basis to explore alternative approaches to treatment stratification in patients with primary biliary cholangitis. FUNDING: UK Medical Research Council and University of Milan-Bicocca
X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis.
- Author
- A Niro Grazia
- A Siminovitch Katherine
- Abe Masanori
- Abiru Seigo
- Abouda George
- Abrahams Rachel
- Affronti Andrea
- Aiba Yoshihiro
- Ainsworth Mark
- Ala Aftab
- Aldersley Mark
- Alexander Graeme
- Ali Faiz
- Allison Joanna
- Alvaro Domenico
- Amey Isobel
- Amor Kelly
- Amos Chris
- Andreone Pietro
- Andriulli Angelo
- Ang Yeng
- Arai Kuniaki
- Archer Emily
- Arinaga-Hino Teruko
- Ario Keisuke
- Aspinall Richard
- Asselta Rosanna
- Atkinson Elizabeth
- Austin Andrew
- Ayres Reuben
- Azzaroli Francesco
- Baird Yolanda
- Banim Paul
- Barisani Donatella
- Barnardo Adrian
- Batham Sally
- Bathgate Andrew
- Baxter Gwen
- Bell Andrew
- Benedetti Antonio
- Besley Sarah
- Bird Bridget
- Bird George
- Bishop Rebecca
- Booth Jonathan
- Boulton Kerenza
- Bowles Jane
- Bragazzi MariaConsiglia
- Braim Delyth
- Bramley Peter
- Bray Gary
- Brighton Jacqueline
- Brind Alison
- Broad Andrea
- Brookes Matthew
- Brown Ashley
- Brown Carly
- Brown Jonathan
- Browning Julie
- Brunetto Maurizia
- Bruno Savino
- Burroughs Andrew
- Butcher Graham
- Butterworth Jeff
- Calvaruso Vincenza
- Campbell Stewart
- Carbone Marco
- Cardamone Giulia
- Cardinale Vincenzo
- Carnahan Mandy
- Carter Martyn
- Casella Giovanni
- Casey Rebecca
- Cazzagon Nora
- Chan PuiChing
- Chayama Kazuaki
- Chilton Andrew
- Chirag Oza
- Ciaccio Antonio
- Clement Darren
- Clifford Gayle
- Cloudsdale Rebecca
- Coco Barbara
- Colley Julie
- Colli Agostino
- Collier Jane
- Collins Carole
- Colloredo Guido
- Colombo Massimo
- Colombo Silvia
- Conder Jill
- Congreave Susan
- Consortium Uk-Pbc
- Cotterill Donna
- Cowan Matthew
- Cowley Caroline
- Cox Mark
- Cramp Matthew
- Cristoferi Laura
- Crosignani Andrea
- Crossey Mary
- Cumlat Lourdes
- Currie Lynn
- Cursaro Carmela
- Curtis Howard
- Curtis Janette
- Czajkowski Marek
- D Ryder Stephen
- D'Amato Daphne
- Dali-Kemmery Lola
- Damant Rose
- Das Debasish
- Davies Mervyn
- Davis Andrew
- Dawwas Mohamed
- Delahooke Toby
- Desmennu Senayon
- Desousa Phillipa
- Dewhurst Hannah
- Dias Aruna
- Dickson Christine
- Dillon John
- Dolwani Sunil
- Donato Francesca
- Douds Andrew
- Douglass Andrew
- Doyle Helen
- Drake Ian
- Ducker Samantha
- Duga Stefano
- Duggan Claire
- Dungca Eleanor
- Durant Emma
- Dyer Simon
- E Jones David
- E O'Donnell Sarah
- Eastick Anne
- Ebinuma Hirotoshi
- Ede Roland
- Elia Gianfranco
- Elliott Keith
- Elphick David
- Eric Gershwin M
- Evans Chris
- Evans Richard
- F Mells George
- F Seldin Michael
- Fabris Luca
- Fagiuoli Stefano
- Fairlamb Helen
- Farrington Liz
- Featherstone James
- Ferrari Carlo
- Fisher Neil
- Flahive Kerry
- Floreani Annarosa
- Foale Carole
- Ford Chris
- Forton Daniel
- Foster Graham
- Fouracres Anna
- Foxton Matthew
- Fraser Andrew
- Fraser Jocelyn
- Fukushima Nobuyoshi
- Furuta Kiyoshi
- Galaska Roman
- Gallagher Susan
- Galli Andrea
- Gasem Jaber
- Gee Ian
- George Keith
- Gerussi Alessio
- Gervais Olivier
- Gess Markus
- Ghent Cameron
- Ghosh Deb
- Giannini Edoardo
- Gibbins Andrew
- Gitahi Jane
- Gleeson Dermot
- Glenn Sue
- Gocher Denise
- Goggin Patrick
- Gooding Ian
- Gorard David
- Gordon Fiona
- Gordon Harriet
- Gotto James
- Grant Allister
- Grattagliano Ignazio
- Graves Lyn
- Gray Catherine
- Green Marie
- Greer Sandra
- Grellier Leonie
- Grieve Emma
- Grimley Charles
- Grover Bob
- Gu Xiangjun
- Gunasekera Anton
- Gunson Bridget
- Gunter Emma
- Gupta Hemant
- Gyawali Pranab
- Hails Janeane
- Hamilton Caroline
- Hamilton Maria
- Hankey Lorraine
- Harada Kenichi
- Harada Masaru
- Harding Tim
- Harrison Melanie
- Harvey Rory
- Hashimoto Etsuko
- Hayashi Shigeki
- Hayes Maria
- Healey Christopher
- Heneghan Michael
- Higham Andrew
- Higuchi Nobito
- Himoto Takashi
- Hines Frances
- Hirano Katsuji
- Hirashima Noboru
- Hirata Keisuke
- Hirschfield Gideon
- Hitomi Yuki
- Hobson Lucie
- Hoeroldt Barbara
- Hogben Karen
- Holbrook Becky
- Holder Sophie
- Honda Koichi
- Honda Masao
- Houghton Kathryn
- Hovell Christopher
- Hughes Maggie
- Hussaini Hyder
- Hynes Abigail
- Ichida Takafumi
- Ichikawa Tatsuki
- Ido Akio
- Innes Caron
- Invernizzi Pietro
- Ishibashi Hiromi
- Ishida Jinya
- Ito Masahiro
- J Cordell Heather
- Jain Sanjiv
- Jing Kaiyan
- Jones David
- Jones Jayne
- Jones Linda
- Jones Rebecca
- Jones Sarah
- Jones Susan
- Joshita Satoru
- Juran Bruce
- Kamitsukasa Hiroshi
- Kanda Tatsuo
- Kaneko Shuichi
- Kapur Kapil
- Karmo Mazn
- Kato Michio
- Katsushima Shinji
- Kawai Yosuke
- Kawashima Minae
- Keggans Janie
- Kendall Jennie
- Kent Linda
- Kent Melanie
- Kikuchi Kentaro
- Kikuchi Masahiro
- King Alistair
- Kitchen Paul
- Klass Howard
- Kobata Tatsuro
- Kobayashi Masakazu
- Koda Masaharu
- Koga Michiaki
- Kohn Seik-Soon
- Kokudo Norihiro
- Komatsu Tatsuji
- Komeda Toshiki
- Komori Atsumasa
- Komura Takuya
- Kordula Jean
- Koss Konrad
- Kouno Hiroshi
- Kouno Hirotaka
- L Almasio Piero
- Lambourne Victoria
- Lampertico Pietro
- Lancaster Nicola
- Lawlor Caroline
- Lazaridis Kostas
- Lee Hye-Jeong
- Lee Tom
- Leoni Marina
- Levi Sass
- Li Andy
- Li Zhiqiang
- Lim Guan
- Lipscomb George
- Liu Xiangdong
- Lleo Ana
- Loftus Alison
- Lombard Martin
- Longhurst Beverley
- Lord Susan
- Lu Yue
- Lye Ch'ng Chin
- Macdonald Christopher
- MacFaul George
- MacNicol Carolyn
- Maehara Yoshihiko
- Maiden Jane
- Makita Fujio
- Malinverno Federica
- Maltby Julia
- Mancuso Clara
- Mandal Aditya
- Mann Steven
- Mannami Tomohiko
- Mano Yutaka
- March Linda
- Maria Battezzati Pier
- Maria Paraboschi Elvezia
- Marley Richard
- Marra Fabio
- Marriott Suzie
- Marshall Eileen
- Martin Kate
- Martin Kirsty
- Marzioni Marco
- Masaki Naohiko
- Mason Andy
- Massironi Sara
- Mathew Ray
- Mathialahan Thiriloganathan
- Matsushita Kouki
- Mattalia Alberto
- McCorry Roger
- McKay Alexandra
- Mclindon John
- McNair Alastair
- Mendall Mike
- Metcalf Jane
- Miele Luca
- Migita Kiyoshi
- Milani Chiara
- Miller Richard
- Mills Marisa
- Mills Peter
- Millson Charles
- Misra Sharat
- Mita Eiji
- Mitchison Harriet
- Miyake Yasuhiro
- Mizokami Masashi
- Morgan Lisa
- Mori Akira
- Morini Lorenzo
- Morisco Filomena
- Morrison Jennifer
- Mukhopadhya Ashis
- Mulvaney-Jones Caroline
- Mupudzi Mcdonald
- Murata Kazumoto
- Muratori Luigi
- Muratori Paolo
- Muro Toyokichi
- Muscariu Florin
- Musselwhite Janine
- Myers Robert
- N Sandford Richard
- Naeshiro Noriaki
- Naganuma Atsushi
- Nagaoka Shinya
- Nagaoki Yuko
- Nagasaki Masao
- Nakamura Hitomi
- Nakamura Minoru
- Nakamura Yoko
- Nakamuta Makoto
- Nakanuma Yasuni
- Nakao Kazuhiko
- Nambela Estelle
- Naqvi Asifabbas
- Narain Mark
- Nasseri Mariam
- Ncube Noma
- Neal David
- Netherton Kimberley
- Neuberger James
- Ngatchu Theodore
- Nikami Toshiki
- Ninkovic Mary
- Nishida Nao
- Nishimura Hideo
- O'Donnell Denise
- O'Donohoe Lynn
- Oblak Metod
- Ocker Kate
- Ohara Yukio
- Ohira Hiromasa
- Onji Morikazu
- Orpe Jacky
- Ota Hajime
- Palegwala Altaf
- Palmer Caroline
- Panter Simon
- Patanwala Imran
- Patel Minesh
- Pateman Hilary
- Paton Alison
- PBC Consortium Canadian-US
- PBC Genetics Study Group Italian
- PBC-GWAS Consortium Japan
- Pearson Sallyanne
- Peltekian Kevork
- Penn Ruth
- Pereira Steve
- Picciotto Antonio
- Piotrowicz Andrzej
- Pitcher Maxton
- Pollock Katharine
- Portincasa Piero
- Prasad Geeta
- Premchand Purushothaman
- Prince Martin
- Przemioslo Robert
- Quinn Marie
- Rahman Mesbah
- Ramage John
- Ramakrishnan Subramaniam
- Ramanaden David
- Ransford Rupert
- Raymode Parizade
- Rees Ian
- Richardson Paul
- Ridpath Jo
- Rigamonti Cristina
- Rolls Sally-Ann
- Ronca Vincenzo
- Rosina Floriano
- Rushbrook Simon
- Sadeghian Joy
- Saeed Athar
- Saha Subrata
- Sakai Hironori
- Sakisaka Shotaro
- Saksena Sushma
- Salam Imroz
- Sanghi Pradeep
- Saoshiro Takeo
- Sato Takeaki
- Saveria Croc\ue8 Lory
- Sayer Joanna
- Seike Masataka
- Sen Sambit
- Senju Michio
- Seward Katie
- Shah Amir
- Shallcross Christopher
- Sharer Nicholas
- Shaukat Syed
- Shearman Jeremy
- Shepherd Alan
- Shewan Tracey
- Shi Yongyong
- Shibata Hidetaka
- Shidrawi Ray
- Shim Wong Voi
- Shimada Masaaki
- Shimada Yusuke
- Shimoda Shinji
- Shinder Bal
- Shirabe Ken
- Shmueli Udi
- Shorrock Christopher
- Shpuza Ervin
- Silvestre Valeria
- Simpson Diane
- Singhal Amit
- Singhal Saket
- Sirdefield Dawn
- Sivaramakrishnan Nurani
- Slininger Susan
- Soejima Yuji
- Southern Paul
- Spinzi Giancarlo
- Spurdle Katie
- Srirajaskanthan Raj
- Stableforth William
- Stafford Lizzie
- Stansfield Glynis
- Strazzabosco Mario
- Sturgess Richard
- Subhani Javaid
- Sugawara Yasuhiro
- Sugi Kazuhiro
- Sugimoto Rie
- Sweeting Helen
- Takahashi Hironao
- Takaki Akinobu
- Takaki Hitoshi
- Takesaki Eiichi
- Taketomi Akinobu
- Takeyama Yasuaki
- Takikawa Hajime
- Tamura Sumito
- Tan LaiTing
- Tanaka Atsushi
- Tanaka Tomohiro
- Tang Ruqi
- Taniai Makiko
- Tanqueray Elizabeth
- Tarocchi Mirko
- Taylor Natalie
- Taylor-Robinson Simon
- Thomas Caradog
- Thomas Carol
- Thorburn Douglas
- Thornthwaite Sarah
- Tibble Jeremy
- Tiribelli Claudio
- Tokunaga Katsushi
- Toniutto Pierluigi
- Townshend Paula
- Tregonning Julie
- Tripoli Sherill
- Tsubouchi Hirohito
- Tsunematsu Seiji
- Tsuruta Satoru
- Tyrer David
- Uemoto Shinji
- Ueno Kazuko
- Ueno Yoshiyuki
- Umemura Takeji
- Unitt Esther
- Valenti Luca
- Valliani Talal
- Van Duyvenvoorde Greta
- Verheyden Juliette
- Vinci Maria
- Vyas Samir
- Walker Erin
- Walker Kirsten
- Walsh Sue
- Warner Karen
- Watanabe Yukio
- Watson Alan
- Watts Gill
- Whalley Simon
- Whatley Gregory
- Wheatley Natalie
- White Nikki
- Whiteman Jessica
- Wilhelmsen Elva
- Wilkins Joy
- Wilkinson Mark
- Williams Bronwen
- Williams D
- Williams Earl
- Williams Simon
- Winter Louise
- Wood Gordon
- Wooldridge Helen
- Wright Alice
- Wright Fiona
- Wright Mark
- Xie Gang
- Xiong Ma
- Yabuuchi Iwao
- Yagi Shintaro
- Yagura Michiyasu
- Yamagiwa Satoshi
- Yamamoto Kazuhide
- Yamamoto Tetsuo
- Yamashiki Noriyo
- Yamashita Tsutomu
- Yamauchi Kazuhiko
- Yapp Tom
- Yasunami Michio
- Yatsuhashi Hiroshi
- Yokosuka Osamu
- Yoong Kevin
- Yoshizawa Kaname
- Young Karin
- Zeniya Mikio
- Zuin Massimo
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
BACKGROUND & AIMS: Genome-wide association studies in primary biliary cholangitis (PBC) have failed to find X chromosome (chrX) variants associated with the disease. Here, we specifically explore the chrX contribution to PBC, a sexually dimorphic complex autoimmune disease. METHODS: We performed a chrX-wide association study, including genotype data from 5 genome-wide association studies (from Italy, United Kingdom, Canada, China, and Japan; 5244 case patients and 11,875 control individuals). RESULTS: Single-marker association analyses found approximately 100 loci displaying P < 5 × 10(-4), with the most significant being a signal within the OTUD5 gene (rs3027490; P = 4.80 × 10(-6); odds ratio [OR], 1.39; 95% confidence interval [CI], 1.028-1.88; Japanese cohort). Although the transethnic meta-analysis evidenced only a suggestive signal (rs2239452, mapping within the PIM2 gene; OR, 1.17; 95% CI, 1.09-1.26; P = 9.93 × 10(-8)), the population-specific meta-analysis showed a genome-wide significant locus in East Asian individuals pointing to the same region (rs7059064, mapping within the GRIPAP1 gene; P = 6.2 × 10(-9); OR, 1.33; 95% CI, 1.21-1.46). Indeed, rs7059064 tags a unique linkage disequilibrium block including 7 genes: TIMM17B, PQBP1, PIM2, SLC35A2, OTUD5, KCND1, and GRIPAP1, as well as a superenhancer (GH0XJ048933 within OTUD5) targeting all these genes. GH0XJ048933 is also predicted to target FOXP3, the main T-regulatory cell lineage specification factor. Consistently, OTUD5 and FOXP3 RNA levels were up-regulated in PBC case patients (1.75- and 1.64-fold, respectively). CONCLUSIONS: This work represents the first comprehensive study, to our knowledge, of the chrX contribution to the genetics of an autoimmune liver disease and shows a novel PBC-related genome-wide significant locus.The article is available via Open Access. Click on the 'Additional link' above to access the full-text.Published version, accepted versio
Prospective observational cohort study on grading the severity of postoperative complications in global surgery research
- Author
- Abayasinghe Chamika
- Abbas Muntadhar
- Abbott T. E. F.
- Abbott Tom
- Abdullah Noor Hairiza
- Abdur-Rahman Lukman
- Abeloos Jacques
- Abernethy Caroline
- Abidin Ucu Nurhadiat
- Abrunhosa Alexandra
- Absar Mohammed
- Adam Suwayba
- Adams George
- Adamson Michael
- Adekola Oyebola
- Adelaja Yemi
- Ademola Adeyinka
- Adenekan Anthony
- Adenike Odewabi
- Adeolu Augustine A
- Adetoye Adedapo
- Adewale Badru
- Adigun Tinuola
- Adolfsson Anne
- Aflori Laura
- Africander Cucu
- Afshari Arash
- Agarwal Vandana
- Agodirin Olayide
- Aguzzoli Crisitiano
- Ahmad Abdurrahman
- Ahmad Norfaizan
- Ahmad T.
- Ahmad Tahania
- Ahmad Yousra
- Ahmed Ahmed
- Ahmed Jamil
- Ahmed Tahania
- Ai Yanqiu
- Aignatoaie Mariana
- Aimoniotou-Georgiou Eleni
- Akanmu Olanrewaju
- Akerman Nik
- Akinwale Mukaila
- Al Amri Khalid
- Al Hussaini Sabah
- Al-Soudaine Yassr
- Aladin Hafiz
- Alagbe-Briggs Olubusola
- Albaj Safauldeensalem
- Alcock David
- Alcock Liam
- Aldecoa Cesar
- Aldecoa Cesar
- Aleixo Fábia Berganton
- Alexander Hazel
- Alexander Maini
- Alexander-Sefre Farhad
- Alherz Fadhel
- Ali Hani
- Ali Marlynn
- Ali Sarah
- Alias Abdul Hafiz
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- Allen Sara Jane
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- Alonso José Ignacio
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- Zangrillo Alberto
- Zapata Darcy Danitza Mari
- Zbitnew Geoff
- Zeggeren Laura
- Zeidan Lisa
- Zeng Qiuting
- Zettergren Jan
- Zhang Baoling
- Zhang Enman
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- Zhang Huan
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- Zhang Shihai
- Zhang Weiwei
- Zhang Xiaoguang
- Zhang Xiaolin
- Zhang Xiaoyan
- Zhang Yan
- Zhang Yapping
- Zhang Ye
- Zhang Yuan
- Zhao Bing
- Zhao Bo
- Zhao Chong
- Zhao Jiashi
- Zhao Jinning
- Zhao Lei
- Zhao Shuna
- Zhao Ting
- Zhao Weihong
- Zhao Weilu
- Zhao Xiaoying
- Zhen Jungang
- Zheng Kang
- Zheng Lina
- Zheng Tianzhao
- Zhong Yi
- Zhou Ce
- Zhou Dachun
- Zhou Haidong
- Zhou Haiyan
- Zhou Jiali
- Zhou Jialong
- Zhou Jing
- Zhou Xian-jin
- Zhu Xiaomao
- Zhu Yi
- Zhu Zhipeng
- Zhuang Xiuxiu
- Zilis Georgios
- Zin Nor Hafizah Mohd
- Zingerle Nicolette
- Zingg Urs
- Zoerner Frank
- Zonneveldt Harry
- Zou Xiaohua
- Zoulamoglou Menelaos
- Zsisku Lajos
- Zundert Tom
- Zyl Rebekka
- åkring Irene
- Ögren Katrin
- Publication venue
- 'Wiley'
- Publication date
- 22/10/2018
- Field of study
Background
The Clavien–Dindo classification is perhaps the most widely used approach for reporting postoperative complications in clinical trials. This system classifies complication severity by the treatment provided. However, it is unclear whether the Clavien–Dindo system can be used internationally in studies across differing healthcare systems in high- (HICs) and low- and middle-income countries (LMICs).
Methods
This was a secondary analysis of the International Surgical Outcomes Study (ISOS), a prospective observational cohort study of elective surgery in adults. Data collection occurred over a 7-day period. Severity of complications was graded using Clavien–Dindo and the simpler ISOS grading (mild, moderate or severe, based on guided investigator judgement). Severity grading was compared using the intraclass correlation coefficient (ICC). Data are presented as frequencies and ICC values (with 95 per cent c.i.). The analysis was stratified by income status of the country, comparing HICs with LMICs.
Results
A total of 44 814 patients were recruited from 474 hospitals in 27 countries (19 HICs and 8 LMICs). Some 7508 patients (16·8 per cent) experienced at least one postoperative complication, equivalent to 11 664 complications in total. Using the ISOS classification, 5504 of 11 664 complications (47·2 per cent) were graded as mild, 4244 (36·4 per cent) as moderate and 1916 (16·4 per cent) as severe. Using Clavien–Dindo, 6781 of 11 664 complications (58·1 per cent) were graded as I or II, 1740 (14·9 per cent) as III, 2408 (20·6 per cent) as IV and 735 (6·3 per cent) as V. Agreement between classification systems was poor overall (ICC 0·41, 95 per cent c.i. 0·20 to 0·55), and in LMICs (ICC 0·23, 0·05 to 0·38) and HICs (ICC 0·46, 0·25 to 0·59).
Conclusion
Caution is recommended when using a treatment approach to grade complications in global surgery studies, as this may introduce bias unintentionally
Critical care admission following elective surgery was not associated with survival benefit: prospective analysis of data from 27 countries
- Author
- A T Landers
- Aaron Lawson McLean
- Abbey Paton
- Abdel Razzaq Khalaf
- Abdul Hafiz Alias
- Abdurrahman Ahmad
- Abegail Salvana
- Abigail Keen
- Abigail Patrick
- Abraham Hulst
- Acela G Lopez
- Adam Evans
- Adam Rehak
- Adamu Muhammad Sarki
- Ade Nurkacan Dursin
- Ade Susanti
- Adela Ruiz
- Adeline Rankin
- Ademola Talabi
- Adenekan Adetoye
- Adeoluwa Tayo
- Adeyinka Ademola
- Aditi Kulkarni
- Aditi Naik
- Aditi Shrivastava
- Adriana Krepil
- Adrianna Woolsey
- Adrianna Woolsey
- Adrienne Carr
- Afolabi Owojuyigbe
- Aggeliki Bairaktari
- Agoritsa Tsioka
- Agostino Roasio
- Ahamed Khader
- Ahmad Sufian Ab Rahman
- Ahmed Ahmed
- Ahmed El-Sayed
- Ahmed Saloojee
- Ahmed Sayeed
- Aida Tantri
- Aida Tantri
- Aikaterini Chatzimichali
- Aikaterini Kyparissi
- Aikaterini Makatounaki
- Aisling Clarkson
- Ajay Gupta
- Akanmu Durodola
- Akbar Vohra
- Akbar Vohra
- Akbar Vohra
- Akbar Vohra
- Akram Fuad
- Alae Conradie
- Alasdair Scott
- Alastair Rose
- Alba Perez Gonzalez
- Albert Tsui
- Alberto Lisi
- Alberto Premoli
- Alberto Ramirez
- Alberto Zangrillo
- Alda Martins
- Aleaxandra Moustaka
- Alejandra Romero Rodrigo
- Alejandro Duca
- Alejandro Suarez-de-la-Rica
- Aleksandr Iurin
- Aleksandr Molkov
- Aleksandr Samoilenko
- Aleksandr Tchekulaev
- Alessandra Bettinelli
- Alessandro Gatta
- Alessandro Marchesi
- Alex Looseley
- Alex Ragan
- Alexander Bates
- Alexander Chan
- Alexander Durst
- Alexander Fowler
- Alexander Freethy
- Alexander Ishimaru
- Alexander Kulikov
- Alexander Tolmasov
- Alexandra Abrunhosa
- Alexandra Charlalampidoy
- Alexandra Dumitrescu
- Alexandra Papaioannou
- Alexandra Torborg
- Alexandra Williams
- Alexandra Wolfer
- Alexandra Wolfer
- Alexandre Ouattara
- Alexandros Andreou
- Alexey Karelov
- Alfonso Munoz-López
- Alhafidz Hamdan
- Alhassan Datti Mohammed
- Ali Elabib
- Ali Vahedi
- Aliaksandra Parashchanka
- Alice Stevens
- Alifia Tameem
- Alison Donna
- Alison Ghosh
- Alison Knaggs
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- Alison Paton
- Alison Wilson
- Alistair Hellewell
- Alycon Walker
- Alyson Andrew
- Amabra Dodiyi-Manuel
- Amanda Cowton
- Amanda Datson
- Amanda Finch
- Amanda Jansen van Vuuren
- Amanda Lofting
- Amanda Lyle
- Amanda Miñana
- Amos Obobolo
- Amy Stevens
- Ana Cristina Miranda Martins Costa
- Ana Flavia Brotto
- Ana Izquierdo Palomares
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- Ana Maria Vilela Dos Santos
- Anahi Perlas
- Anastasia Koutsikou
- Anastasia Spartinou
- Anastasia Vachlioti Vachlioti
- Anastasios Katsourakis
- Anders Oldner
- Andre Bernard
- Andre Bernard
- Andre Bernard
- Andrea Sibilio
- Andrea Stocker
- Andreas Asimakos
- Andreas Eichwalder
- Andreas Filippopoulos
- Andreas Fleischer
- Andreas Flossos
- Andreas Hoeft
- Andreas Hoeft
- Andreas Weyland
- Andreea Balanescu
- Andreea Stefan
- Andreu Cueva
- Andrew Barnett
- Andrew Berg
- Andrew Biffen
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- Andrew Brown
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- Andriy Krystopchuk
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- Andy Kwok
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- Angels Lozano
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- Arthur Bouwman
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- Arvind Karthikeyan
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- Arystarch Makowski
- Asako Shida
- Ashish Dasrath
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- Asuncion Marques Parra
- Athanasia Tsirogianni
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- Athena Lavrentieva
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- Atideb Mitra
- Atideb Mitra
- Attila Jonas
- Atul Garg
- Atul Kulkarni
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- Audrey Pospiech
- Augustine A Adeolu
- Aurélien Venara
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- Avesh Singh
- Axe Robert
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- Ayyaz Hussain
- Babatunde Babasola Osinaike
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- Bas van Zaane
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- Bhagyashree Netke
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- Bimalshakth Bunwarie
- Bin Li
- Binbin Ji
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- Bjorn Heyse
- Blaylock Heather
- Bo Li
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- Bobby Krishnachetty
- Bodil Steen Rasmussen
- Bonita Funk
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- Caixia Li
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- Carel Cairns
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- Changlin He
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- Chris Evans
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- Yuanming Pan
- Yuanyuan Pan
- Yue Fei
- Yuehong Qi
- Yuejiang Liu
- Yuelan Wang
- Yugang Shi
- Yuhong Li
- Yuksel Gercek
- Yun Bai
- Yun Ren
- Yunbin Fu
- Yunchang Mo
- Yunfei Cai
- Yunlin Feng
- Yunzhi Ling
- Yurui Yao
- Yushio Cheing
- Yusuf Ameer
- Yuting Wang
- Yves Jaquet
- Yvonne Hack
- Yvonne Selibea
- Zaheer Moolla
- Zaid Makzal
- Zane Farina
- Zhang Chen
- Zhen Dan Peng
- Zhen Wang
- Zhen Wang
- Zheng Guo
- Zhengyuan Liu
- Zhenrong Ji
- Zhi Wang
- Zhipeng Wang
- Zhipeng Zhu
- Zhisong Li
- Zhiting Wen
- Zhong-Yuan Xia
- Zhongming Cao
- Zi-Ying Shen
- Zin Nico
- Ziqiang Miao
- Zoe Davies
- Zoe Drinkwater
- Zoe Whitman
- Zulkarnain Hamzah
- Álvaro Réa-Neto
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
This was an investigator initiated study funded by Nestle Health Sciences through an unrestricted research grant, and by a National Institute for Health Research (UK) Professorship held by RP. The study was sponsored by Queen Mary University of London
The surgical safety checklist and patient outcomes after surgery: a prospective observational cohort study, systematic review and meta-analysis
- Author
- Ab Majid Mohd Azuan
- Ab Rahman Ahmad Sufian
- Ab Rahman Rusnah
- Abayasinghe Chamika
- Abbas Muntadhar
- Abbott T. E. F.
- Abbott Tom
- Abd Ghafar Fara Nur Idayu
- Abd Hadi Husni Zaeem
- Abdel Goad Ehab Helmy
- Abdullah Noor Hairiza
- Abdur-Rahman Lukman
- Abeloos Jacques
- Abernethy Caroline
- Abidin Ucu Nurhadiat
- Abrunhosa Alexandra
- Absar Mohammed
- Adam Suwayba
- Adams David
- Adams George
- Adamson Michael
- Adekola Oyebola
- Adelaja Yemi
- Ademola Adeyinka
- Adenekan Anthony
- Adenike Odewabi
- Adeolu Augustine A.
- Adetoye Adedapo
- Adewale Badru
- Adigun Tinuola
- Adolfsson Anne
- Africander Cucu
- Afshari Arash
- Agarwal Vandana
- Agodirin Olayide
- Aguzzoli Crisitiano
- Ahamed khader null
- Ahmad Azam Ummi Azmira
- Ahmad Abdurrahman
- Ahmad Norfaizan
- Ahmad T.
- Ahmad Tahania
- Ahmad Yousra
- Ahmed Ahmed
- Ahmed Jamil
- Ahmed Tahania
- Ai Yanqiu
- Aignatoaie Mariana
- Aimoniotou-Georgiou Eleni
- Akanmu Olanrewaju
- Akerman Nik
- Akinwale Mukaila
- Al Anizi Mashel
- Al hussaini Sabah
- Al'Amri Khalid
- Al-Soudaine Yassr
- Aladin Hafiz
- Alagbe-Briggs Olubusola
- Albaj Safauldeensalem
- Alberto Lisi Zaheer Moolla
- AlbertoVolta Carlo
- Alcock David
- Alcock Liam
- Aldecoa Cesar
- Aleixo Fábia Berganton
- Alexander Hazel
- Alexander Maini
- Alexander-Sefre Farhad
- Alherz Fadhel
- Ali Hani
- Ali Marlynn
- Ali Sarah
- Alias Abdul Hafiz
- Alias Anita
- Alit Mahaalit Aribawa
- Allen Samantha
- Allen Sara Jane
- Allison Joanna
- Alloj Chiara
- Allorto Nikki Leigh
- Allsop Joanne
- Almeida William
- Alonso Eduardo
- Alonso José Ignacio
- Alphonsus Christella
- Alvares Danielle
- Alves Maria Joao
- Amador Juan Carlos Bravo
- Ameer Yusuf
- Amendola Cristina Prata
- Ami Noam
- Amstrup-Hansen Louise
- Anagnou Athina
- Andersen Cheme
- Anderson Charlotte
- Anderson Colette
- Anderson Frank
- Anderson Philip
- Andreadaki Evangelia
- Andreou Alexandros
- Andreou Prematie
- Andrew Alyson
- Andrews Emma
- Angermair Stefan
- Angus Kirsty
- Anillo Victor
- Antal Oana
- Antill Philip
- Antoniadou Eleni
- Antonina Webombesa
- Apagaki Eymorfia
- Apostolou Konstantinos
- Applewhaite Christopher
- Aquino Laura Patricia González
- Ar Praburaj
- Arawwawala Dilshan
- Ardern Diane
- Argue Ruth
- Arkalaki Eleni
- Arlo whitehouse null
- Armaganidis Apostolos
- Armstrong John
- Armstrong Richard
- Arnaoutoglou Christina
- Arnaoutoglou Elena
- Arnold Glenn
- Arrandale Lindsay
- Arrich James
- Arrigo Mario
- Arshad Homa
- Arshad Mohammed Asif
- Artiles Tania Socorro
- Arumugam Swarna
- Arustei Mirela
- Arvaniti Kostoula
- Arya Aryabiantara
- Arya Shobhit
- Asimakos Andreas
- Aslam F Noorbhai M.
- Asudo Felicia
- Athanasakis Elias
- Atiku Mamuda
- Attrill Elizabeth
- Attwood Clare
- Auer Patrick
- Avidan Michael
- Avila Erendira Jocelin Dominguez
- Avis Joanne
- Awad Hadi
- Axioti Elena
- Azambuja Pedro
- Azevedo Caroline
- Aziz Faizal Zuhri
- Baas Peter
- Baghirzada Leyla
- Bai Hui-Ping
- Bai Yun
- Baillie Shelley
- Baines Duncan
- Baio Thalissa Hermínia
- Bairaktari Aggeliki
- Baker Gerard
- Baker Katie-Anne
- Baker Paul
- Balain Birender
- Balaji Packianathaswamy
- Balajonda Naraida
- Balanescu Andreea
- Balasubramaniam Madhu
- Baldisserotto Sérgio
- Baldwin Jacqueline
- Baldwin Matthew
- Balfoussia Danai
- Bali Christina
- Bandeira Maria Expedito
- Banerjee Robin
- Bankewitz Carla
- Banner-Goodspeed Valerie
- Bao Qi
- Barcraft-Barnes Helena
- Barneto Lisa
- Barnett Andrew
- Baroselli Antonio
- Barraclough James
- Barras Jean-Pierre
- Barrett Stephen
- Barrett Wendy Joan
- Basanth Sujith
- Batchelor Nick
- Bateman Brian
- Bates Alexander
- Bates Sarah
- Batista Hugo Dias
- Bauchmuller Kris
- Bauer Marlene
- Baumgarten Georg
- Baxter Linden
- Beaton Ceri
- Beattie Scott
- Beavis Vanessa
- Beavis Vanessa
- Bechan Sudha
- Bejia Tarek
- Belciu Ioana
- Belda Margarita Tormo
- Bell Gillian
- Bell Rachel
- Bell Stephanie
- Bellandi Mattia
- Bello Jibril
- Beloeil Helene
- Belskiy Vladislav
- Beltran Anna Valle
- Ben-Menachem Erez
- Benavent Pau
- Benedikt Preckel Osne Kirzner
- Benevento Angelo
- Bengeri Sheshagiri
- Bennett Cambell
- Bennett Michael
- Bennett Rachael
- Bennett Victoria
- Bentley Conor
- Beretta Luigi
- Berg Andrew
- Bergin Colin
- Bernard Andre
- Bernat Maria Jose
- Berntsen Emer
- Bertram Wendy
- Bester Delia
- Bester Marlet
- Bettega Fernanda
- Bettinelli Alessandra
- Bhardwaj Neeraj
- Bhatia Kailash
- Bhula Chettan
- Bi Yanbing
- Biais Matthieu
- Biccard B. M.
- Biccard Bruce
- Biccard Bruce M.
- Bidd Heena
- Bidgoli Jawad
- Biffen Andrew
- Bignami Elena
- Bilolikar Anjali
- Bin Mustapha Mohd Tarmimi
- Birch Julie
- Bishop David Gray
- Biyase Thuli
- Bizios Christol
- Blackwell Clare
- Blackwood Douglas
- Blaj Mihaela
- Blakemore Stephen P.
- Bland Martin
- Blunt Mark
- Blyth Katharine
- Bocchino Speranza
- Bodansky Daniella
- Bodger Phoebe
- Boer Christa
- Boereboom Catherine
- Boggiano Victoria
- Bogner Gerhard
- Bokkel-Andela Janneke ten
- Bolaji Benjamin
- Bolton David
- Boone Myles
- Boschi Luca
- Boshier Piers
- Botes Marisa
- Botis Ioannis
- Bottini Corrado
- Bottrill Fiona
- Bouchez Stefaan
- Boulton Kerenza
- Bouris Vasilios
- Bourner Lynsey
- Boutsikos Georgios
- Bouwman Arthur
- Bowrey Sarah
- Boxall Leigh
- Boyd Christine
- Bradburn Mike
- Bradley Jacqueline
- Branagan Graham
- Branco Teresa
- Brand Bastiaan
- Brandsborg Birgitte
- Breitenstein Stefan
- Brennan Andrew
- Brennan Emma
- Brenner Laura
- Brincat Maximilian
- Briscoe Richard
- Bristogiannis Sotirios
- Brooke Jenny
- Brookes Jamie
- Brookes Morag
- Brooks Carolyn
- Broomby Rupert
- Brotto Ana Flavia
- Brown Andrew
- Brown Caroline Wrey
- Brown Gemma
- Brown Jamie
- Brown Janette
- Brown Lynne
- Brown Richard
- Brown Robyn
- Browning Julie
- Bruma Dana
- Brunete Tamara
- Brunswicker Annemarie
- Bryant Helen
- Bua Emmanuel
- Buccimazza Ines
- Buckley Sarah
- Buerkle Christian
- Buhre Wolfgang
- Builu Pierre Monji
- Buise Marc
- Bullock Clare
- Bunwarie Bimalshakth
- Burns Karen
- Burrows Lorna
- Burrows Tom
- Burston Ben
- Burtenshaw Andrew
- Burton Megan
- Busuioc Mihai
- Butryn Izabella
- Butt Georgina
- Byrne Kelly
- Bührer Thomas
- Cabezuelo Estefania
- Cabral Raquel
- Cabral Tiago do Nascimento
- Cabrini Luca
- Cacala Sharon
- Cai Fang
- Cai Yunfei
- Cain Helen
- Cairns Carel
- Cakova Veronika
- Calderwood Claire
- Callaghan Mark
- Campbell Debbie
- Campbell Doug
- Campbell Douglas
- Campbell Gill
- Campbell Graham
- Campbell Kathleen
- Campbell Marta
- Campbell Tara
- Campey Lorraine
- Camsooksai Julie
- Cancho David
- Candido Keulle
- Cang Jing
- Cannavo' Maurizio
- Cao Jianqiao
- Cao Ying
- Cao Zhongming
- Cardellino Silvano
- Cardosa Jorge
- Cardoso Gutemberg
- Cardy Jon
- CarmenVaida Laura Aflori
- Carmino Livio
- Carp Cristina Paula
- Carr Adrienne
- Carrera Ronald
- Carroll Christine
- Carroll Jo
- Caser Eliana
- Castaño Beatriz
- Castle Gail
- Cavanagh Sarah
- Cawthorn Louise
- Cernea Daniela Denisa
- Chaddock Mark
- Chaloulis Panagiotis
- Chan Alexander
- Chan Mathew
- Chan Matthew
- Chan Peter
- Chan Vincent
- Chan Wai Kit Jacky
- Chan Weng Ken
- Chan Yik Lam
- Chande Shiv
- Chandler Ben
- Chandra Susilo
- Chandrasekharan Shardha
- Chang Yuan Hsuan
- Chaniotaki Fotini
- Charitos Efthimios
- Charlalampidoy Alexandra
- Charles Rob
- Chatterjee Devnandan
- Chatterjee Jayanta
- Chatzimichali Chatzimichali Aikaterini
- Chau Simon
- Chazova Elena
- Cheah Clarissa
- Cheah Seleen
- Cheeseman Michelle
- Cheing Yushio
- Chen Chao
- Chen Chen
- Chen Feifei
- Chen Fumei
- Chen Hong
- Chen James
- Chen Junping
- Chen Lee-lynn
- Chen Linbi
- Chen Liyong
- Chen Pushan
- Chen Qiang
- Chen Rong
- Chen Shasha
- Chen Shiyu
- Chen Sijia
- Chen Yaqiu
- Chen Yijiao
- Chen Yijun
- Chen Yongjie
- Chen Zhang
- Cheng Baoli
- Cheng Ka Ho
- Cheng Zhonggui
- Cheong Edward
- Cherian Ritchie
- Cherrett Veronica
- Chetty Rubendraj R.
- Chew M. S.
- Chew Michelle
- Chhabra Ashok
- Chicken Dennis-Wayne
- Chilinciuc Ion
- Chin Im Im
- Chirkut Subash
- Chlorou Dimitra
- Choi Hyun-min David
- Choi Stephen
- Chow Lorraine
- Christian Rachel
- Christiansen Ida Cecilie
- Christmas Natasha
- Christodoulidis Gregory
- Christodoulopoulou Theodora
- Christofaki Maria
- Christoforidis Dimitri
- Chronis Christos
- Chu Hiu Man
- Chu Susanna
- Chua Pandora
- Chukkambotla Srikanth
- Chung Chun Kwong Eric
- Cifra Elna
- Ciobanu Cristina
- Ciobotaru Oana Roxana
- Cirstea Emanuel
- Clark Richard
- Clarkson Aisling
- Clarkson Rachel
- Clavien Pierre-Alain
- Claxton Andrew
- Clemmons Karen
- Cloro Luigi Maria
- Clyde Antony
- Cobzaru Isabelle
- Codita Anisoara
- Colangelo Antonio
- Colangelo Chiara
- Colling Kerry
- Collins Hannah
- Collins Michelle
- Collins Nwokoro
- Colvin Carolyn
- Commey Thelma
- Comptaer Nicolas
- Conde Carlos
- Conradie Alae
- Constantin Kathryn
- Cook Tim
- Cooper Lauren
- Cooper Lucy
- Cooper Mariese
- Cooper Richard
- Cooper Sarah
- Copaciu Elena
- Cope Jennifer
- Copetti Elisa
- Copley Edward
- Copotoiu Sanda Maria
- Coppens Marc
- Corneci Dan
- Cornell Jonathan
- Cornish Julie
- Correia da Silva Rui Freitas Mendonça
- Corti Daniele
- Costa Ana Cristina Miranda Martins
- Costanzo Eleonora
- Costelloe Hannah
- Cotter Rochelle
- Cotterell Sharon
- Cotterill Donna
- Coughlan Elaine
- Coulter Ian
- Coulter Suzanne
- Coutinho Francisco
- Cowton Amanda
- Cox Hannah
- Cozar Octavian Ionut
- Craig Jayne
- Craven Rachael
- Craw Nicholas
- Craw Sarah
- Creary Thais
- Cripps Heather
- Critchley Rebecca
- Cronje Larissa
- Cruickshank Ross
- Cruikshanks Andrew
- Cruz Salome
- Cuenca Vicente Chisbert
- Cueva Andreu
- Cunha Pedro
- Curley Gerard
- Currow Helen
- Czepanski Carolyn
- Czeslick Elke
- D'Andrea Rocco
- Dafnios Nikolaos
- Dai Hanying
- Dai Qingqing
- Dai Qinxue
- Dai Si Yuan
- Daikou Panagoula
- Dalamagka Maria
- Dalampini Eleftheria
- Dali-Kemmery Lola
- Dalton Emma
- Damant Rose
- Daniel Conway
- Daniel Gayatri Daniel
- Daniel Harvey
- Daniel Hull
- Daniel Sonya
- Dankl Daniel
- Darko Julia
- Darwish Sharif
- Das Suparna
- Dasrath Ashish
- Datson Amanda
- Daubeny Thomas
- Daugaard Morten
- Davari Maria
- Dave Tejal
- Davies Charlotte
- Davies Helen
- Davies Keith
- Davies Kirsty
- Davies Leigh
- Davies Zoe
- Davis Edward
- Davis Fiona
- Davis Simon
- Daya Bhavika
- De Andrés Ibanez José Antonio
- De Baerdemaeker Luc
- de Beer Johan
- de Boer Hans Donald
- De Bruyne Ann
- de Fretes Jennifer
- de Gasperi Julia
- de Hert Stefan
- De Jongh Karen
- De Kegel Dirk
- De Meyer Jenine N.
- De Oliveira Mirella Cristine
- de Rudnicki Stéphane
- de Swardt Mathew
- de Vasconcellos Kim
- de Villiers Martin
- de Wet Jacques
- Deacon Matthew
- Deblaere Isabel
- Dedemadi Georgia
- Deen Tariq
- Deepak Shantal
- Deighton Kerry
- Deja Maria
- Del Valle Santiago Garcia
- Delgado García David R.
- Della Rocca Giorgio
- Demartines Nicolas
- Dempsey Ged
- Dempster Angie
- Denham Samuel
- Dent Kathy
- Dermitzaki Despina
- Desbordes Jacques
- Despotidis Vasileios
- Diaconescu Ciresica
- Diago Lorena Gómez
- Dias Fernando
- Dias Sandra
- Dickson Jane
- Ditai James
- Divatia Jigeeshu
- Dixon Liane
- Dobson Gary
- Docherty Philip
- Dodiyi-Manuel Amabra
- Dodsworth Kerry
- Dolan Rachael
- Dominguez Saul Velaz
- Doncel Ma Sherezade Tovar
- Dong Beibei
- Donohue Roana
- Donovan Andrew
- Douglas Jeanene
- Doumos Rodamanthos
- Downes Charlotte
- Doyle Donna
- Dragnea Dragos
- Dragoescu Nicoleta Alice
- Drake Matthew
- Drimala Maria
- Drinkwater Zoe
- Drummond Leanne
- Du Fang
- Du Xindan
- Duarte Célia
- Dube Nokukhanya Z.
- Duca Alejandro
- Dudgeon Lucy
- Dudson Rosie
- Duenser Martin
- Dumitrascu Clementina Oana
- Dumitrescu Alexandra
- Dunay Artem
- Dunk Nigel
- Durant Emma
- Durodola Adekunle
- Dursin Ade Nurkacan
- Durst Alexander
- Duttchen Kaylene
- Dutu Madalina
- Dwyer Heather
- Dylst Dimitri
- Dzhamullaev Parvin
- Dzulkipli Norizawati
- Echem Richard
- Edmond Holly
- Edwards Jayne
- Edwards Marc
- Edwards Mark
- Efthymiadi Andromachi
- Egan Thomas
- Eggleston Christopher
- Eichwalder Andreas
- Eikman Johan
- Ekelund Kim
- El-Sayed Ahmed
- Elabib Ali
- Elena Gkonezou
- Elferink-Vonk Renske
- Elgasim Magdi
- Ellis Jessica
- Ellis Kate
- Elna Cifra
- Emma Temlett
- Endersby Simon
- Eneje Philip
- Eng Kristen
- English Duane
- English Rose
- Epodoi Joseph
- Ernesto Ernesto Pastor Martinez
- Eskildsen Katrine Zwicky
- Esteves Simao
- Ethgen Sabine
- Evans Adam
- Evans Chris
- Everingham Kirsty
- Ewe Renee
- Ezekiel Emmanuel
- Ezike Humphrey
- Fagerlund Malin Jonsson
- Faina Lais
- Falk Elke
- Fan Hao
- Fan Lihua
- Fan Yu
- Fanfani Lucia Caterina
- Fang Xiangming
- Faponle Folayemi
- Faria e Maia Dionisio
- Faria Filomena
- Farid Nahla
- Farina Zane
- Farrell Helen
- Farrow Mehreen
- Fasina Oluyemi
- Fatungase Oluwabunmi Motunrayo
- Faulds Matthew
- Fei Yue
- Fellinger Paul
- Feng Yunlin
- Fengas Lior
- Fergey Lauren
- Ferguson Marissa
- Fernández Salvador
- Ferrando Carlos
- Ferreira da Costa Fischer Bruna
- Filipescu Daniela
- Filippopoulos Andreas
- Finch Amanda
- Fiorentza Klara
- Fischbach Norbert
- Flatt Jim
- Fleischer Andreas
- Fleisher Lee
- Fleisher Lee A.
- Flores Armando Adolfo Alvarez
- Flores Kathrina
- Flossos Andreas
- Foers William
- Foglia Julena
- Foley Julia
- Fonck Kristine
- Foord Denise
- Foot Helen
- Foot Jayne
- Ford David
- Forget Patrice
- Forsans Emma
- Forstner Karin
- Fosch de Campos Ferreira Mariana
- Foster Rebecca
- Foubert Luc
- Fouracres Anna
- Fowler A. J.
- Fowler Alexander
- Fowler Carolyn
- Fraga Julia Merladete
- Fragandreas George
- Francis Daren
- Franklin John
- Franks Romilla
- Frantzeskos Georgios
- Freeman David
- Freeman Victoria
- Freethy Alexander
- Freitas Katie
- Freschini Angela
- Freschini David
- Frewer Natasha
- Fritsch Gerhard
- Frost Victoria
- Fu Kaiwen
- Fu Shuying
- Fu Yunbin
- Fuad Akram
- Fuentes Isabel
- Fulton Graham
- Funk Bonita
- Funk Duane
- Furrer Markus
- Futier Emmanuel
- Gaitanakis Stylianos
- Gall Lewis
- Gallacher Pete
- Gallard Sian
- Gallego Laura
- Gama N. Sibusiso
- Gambhir Rajiv
- Ganter Donna Louise
- Ganter Michael T.
- Gao Hong
- Garcia Juliana
- Garcia-Saiz Irene
- García-Pérez Maria Luisa
- Gardikou Varvara Vanessa
- Gardiner Matthew
- Garg Atul
- Garg Sameer
- Garg Sanjeev
- Garrett Emily
- Gastaldi Christian
- Gatta Alessandro
- Gaudin Christophe
- Gavril Laura
- Gbolahan Olalere
- Ge Xiaodong
- Geddoa Burair
- Geddoa Emad
- Geisen Martin
- Geldenhuys Jacques
- Gemert Ankie Koopman-van
- Geng Wujun
- Georgakakis Georgios
- George Ronald
- Georgiou Georgios
- Georgopoulou Eleni
- Gercek Yuksel
- Germann Reinhard
- Geromarkaki Elisavet
- Ghignone Federico
- Ghosh Alison
- Ghushe Neil
- Giancarlo Luigi
- Giannaki Chrysavgi
- Gibson-Lapsley Hannah
- Giles Julian
- Gill James
- Gill Satwant
- Gill Talvinder
- Gille Jochen
- Gillespie David
- Gillies M.
- Gillies Michael
- Gilmore Jemma
- Gilmour Fiona
- Gkini Konstantia-Paraskevi
- Gkiokas Georgios
- Gkioni Panagiota
- Glasbey James
- Glasgow Emma
- Glister Georgina
- Glover Lyn
- Goebel Ulrich
- Goga Ismail E.
- Goga Riaz
- Goldberg Olivia
- Golder Kim
- Gondo Prisca
- Gong Haixia
- Gonzalez Alba Perez
- Gordon Paul
- Goss Harry
- Gouws Hanni
- Govender Komalan
- Govindasamy Vishendran
- Grace Anuforo
- Gracia Estefania
- Gradwohl-Matis Ilse
- Granum Simon Nørgaard
- Graterol Juan
- Gratrix Karen
- Graves Lynne
- Gray Carol
- Gray Catherine
- Gray Sophie
- Greaves Rosanna
- Green Garyth M.
- Green-Thompson Randolph
- Greene Michael
- Gregory Peter
- Grey Ben
- Griffiths Ewen
- Grigoras Ioana
- Grigoryev Evgeny
- Grintescu Ioana
- Grishkowez Elena
- Grocott Mike
- Grosu Ramona - Mihaela
- Grubmueller Karl Gernot
- Gudaca Mariethel
- Guimarães Mario
- Guizeline Jaqueline
- Gunn Jacqueline
- Guo Baolei
- Guo Fengying
- Guo Huinan
- Guo Yongqing
- Guo Zheng
- Guok Eng Ching
- Gupta Ajay
- Gupta Janesh Kumar
- Guttenthaler Vera
- Guy Kramer
- Gätke Mona Ring
- Haberl Claudia
- Habicher Marit
- Hack Yvonne
- Haddow James
- Hadebe Bernard
- Hadfield Daniel
- Hagau Natalia
- Haigh Kathryn
- Haisjackl Markus
- Hales Dawn
- Hall Andrew Macalister
- Hall Kathryn
- Hall Richard
- Hall Roger
- Halliwell Richard
- Hambidge Oliver
- Hamdan Alhafidz
- Hamilton Caroline
- Hamzah Zulkarnain
- Han Kunyuan
- Han Yangyang
- Handayani Dini
- Hanna George
- Harden Catherine
- Hare Gregory
- Hariharan Vimal
- Harper Mark
- Harrichandparsad R.
- Harries Rhiannon
- Harris Benjamin
- Harris Clair
- Harris James
- Harris Meredyth
- Harris Rudy
- Harris Sarah
- Harrison Jonathan
- Harsan Cristian Remus
- Hartmann Andreas
- Hartmann Cristina
- Haselberger Simone
- Hatton Jonathan
- Haunch Kirsty
- Hawes Elizabeth
- Hawkins Lesley
- Hay David
- Hayes Katia
- Hayes Morgan Philip
- He Changlin
- He Jie
- He Long
- He Miao
- He Xin
- Heather Blaylock
- Hedin Annika
- Heintzelmann Simon Bisgaard
- Helen Bryant
- Hellewell Alistair
- Helliwell Laurence
- Hellstrom Johanna
- Helmy Naeder
- Hennings Charles
- Hering Jens Peter
- Hernandez Carlos B.
- Hernandez Miguel
- Hesketh Sue
- Hewson R.
- Hewson Russ
- Hewson Russell
- Heymans Chan Hey Man
- Heyse Bjorn
- Hicks Catherine
- Hidayatullah Rahmat
- Hiesmayr Michael
- Higgie Kushlin
- Hill Gillian
- Hill Simon
- Hillermann Thomas
- Hills Vicky
- Hinther Ashley
- Hinxman Honor
- Hitchcock Rachael
- Hoare Siobhan
- Hobrok Maria
- Hodgkiss Tracey
- Hodgson Richard E.
- Hodzovic Emil
- Hoedt Marielle den
- Hoeft Andreas
- Hoelzenbein Thomas
- Hofer Christoph
- Hoffer Franz
- Hoffmann João
- Holaubek Caroline
- Holden Douglas
- Hollands Heidi
- Holliger Stephan
- Hollmann Markus
- Holmes Kerry
- Holmström Sandra
- Holt Peter
- Hong Bosun
- Hood Marion
- Hopkins Brian
- Hopkins Luke
- Hopkins Phil
- Hopkins Thomas
- Horn Rachel
- Hosdurga Gurunath
- Hou Benchao
- Hou Jiabao
- Houston Kendra
- Houweling Peter
- Hove Mazvangu Onie
- Hovendal Claus
- Hu Chun hua
- Hu Liu
- Hu Na
- Hu Nianqiang
- Hu Rong
- Hu Shuangfei
- Hu Tingju
- Hu Xianwen
- Hu Xiaolan
- Hu Xuming
- Huang Changshun
- Huang Haijin
- Huang Jian
- Huang Ledan
- Huang Lixia
- Huang Luping
- Huang Song
- Huang Wenhui
- Huang Yang
- Huang Yanming
- Hubert Ribeiro Gustavo Luis
- Hubner Martin
- Hughes Thomas
- Hugill Keith
- Hulme Jonathan
- Hulst Abraham
- Humphreys Sally
- Humphries Ryan
- Hung Ching Yue Janice
- Hunt Jane
- Husain Tauqeer
- Hussain Ayyaz
- Hussain Nabilah
- Hutchings Melanie
- Hutchins David
- Hutton Monica
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- Zapata Darcy Danitza Mari
- Zbitnew Geoff
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- Zerman Luiza
- Zettergren Jan
- Zhang Baoling
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- Zhang Yan
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- Zhang Ye
- Zhang Yuan
- Zhao Bing
- Zhao Bo
- Zhao Chong
- Zhao Jiashi
- Zhao Jinning
- Zhao Lei
- Zhao Lili
- Zhao Shuna
- Zhao Ting
- Zhao Weihong
- Zhao Weilu
- Zhao Xiaoying
- Zhen Jungang
- Zheng Kang
- Zheng Lina
- Zheng Tianzhao
- Zhong Yi
- Zhou Ce
- Zhou Dachun
- Zhou Haidong
- Zhou Haiyan
- Zhou Jiali
- Zhou Jialong
- Zhou Jing
- Zhou Xian-jin
- Zhu Xiaomao
- Zhu Xiaoping
- Zhu Yi
- Zhu Zhipeng
- Zhuang Xiuxiu
- Zilis Georgios
- Zingerle Nicolette
- Zingg Urs
- Zoerner Frank
- Zonneveldt Harry
- Zou Xiaohua
- Zoulamoglou Menelaos
- Zsisku Lajos
- Åkring Irene
- Ögren Katrin
- Publication venue
- Health Sciences Research Commons
- Publication date
- 30/10/2017
- Field of study
© 2017 British Journal of Anaesthesia Background: The surgical safety checklist is widely used to improve the quality of perioperative care. However, clinicians continue to debate the clinical effectiveness of this tool. Methods: Prospective analysis of data from the International Surgical Outcomes Study (ISOS), an international observational study of elective in-patient surgery, accompanied by a systematic review and meta-analysis of published literature. The exposure was surgical safety checklist use. The primary outcome was in-hospital mortality and the secondary outcome was postoperative complications. In the ISOS cohort, a multivariable multi-level generalized linear model was used to test associations. To further contextualise these findings, we included the results from the ISOS cohort in a meta-analysis. Results are reported as odds ratios (OR) with 95% confidence intervals. Results: We included 44 814 patients from 497 hospitals in 27 countries in the ISOS analysis. There were 40 245 (89.8%) patients exposed to the checklist, whilst 7508 (16.8%) sustained ≥1 postoperative complications and 207 (0.5%) died before hospital discharge. Checklist exposure was associated with reduced mortality [odds ratio (OR) 0.49 (0.32–0.77); P\u3c0.01], but no difference in complication rates [OR 1.02 (0.88–1.19); P=0.75]. In a systematic review, we screened 3732 records and identified 11 eligible studies of 453 292 patients including the ISOS cohort. Checklist exposure was associated with both reduced postoperative mortality [OR 0.75 (0.62–0.92); P\u3c0.01; I2=87%] and reduced complication rates [OR 0.73 (0.61–0.88); P\u3c0.01; I2=89%). Conclusions: Patients exposed to a surgical safety checklist experience better postoperative outcomes, but this could simply reflect wider quality of care in hospitals where checklist use is routine