Evaluation of structural intervention in the Quartel das Esquadras, Almeida (Portugal)

The Quartel das Esquadras is an 18th century infantry barrack located within the limits of the bulwarked fortress of Almeida, in Portugal. An ongoing adaptive reuse project of the building aims to recover its full capacity and also its importance to the fortified village of Almeida, by implementing a variety of new uses. While adaptive reuse projects of historical buildings are a very recommendable solution for maintaining those constructions whose use has become obsolete, these projects demand careful study because they may introduce changes in the structural behaviour of the buildings to preserve.The architectural intervention results in the need of the structure to withstand new and diverse imposed loads, as well as inserting passages and communication systems to enable a proper contemporary use of the building, fulfilling architectural requirements and current building codes. As the current configuration of the structure will be altered, the main objective of this paper is to evaluate the suitability of some of the proposed structural interventions. Such evaluation requires a good understanding of the current state of the structure and the alterations proposed by the project. The current condition has been characterized following a multidisciplinary approach comprising historical research, visual inspection, non-destructive testing and structural analysis. The alterations proposed by the project have been described, identifying possible sources of major structural problems. A portion of the building particularly affected by the alterations has been selected to carry out structural analysis. A comparative safety assessment of the selected area in both current and altered condition has been done through finite element modelling and nonlinear static analysis, resulting in an identification of the weaker points against the new implemented loads and alterations. Finally, proposals for the implementation of the studied intervention, as well as recommendations for future research and analyses, have been given.- (undefined

Replication, Pathogenesis and Transmission of Pandemic (H1N1) 2009 Virus in Non-Immune Pigs

The declaration of the human influenza A pandemic (H1N1) 2009 (H1N1/09) raised important questions, including origin and host range [1,2]. Two of the three pandemics in the last century resulted in the spread of virus to pigs (H1N1, 1918; H3N2, 1968) with subsequent independent establishment and evolution within swine worldwide [3]. A key public and veterinary health consideration in the context of the evolving pandemic is whether the H1N1/09 virus could become established in pig populations [4]. We performed an infection and transmission study in pigs with A/California/07/09. In combination, clinical, pathological, modified influenza A matrix gene real time RT-PCR and viral genomic analyses have shown that infection results in the induction of clinical signs, viral pathogenesis restricted to the respiratory tract, infection dynamics consistent with endemic strains of influenza A in pigs, virus transmissibility between pigs and virus-host adaptation events. Our results demonstrate that extant H1N1/09 is fully capable of becoming established in global pig populations. We also show the roles of viral receptor specificity in both transmission and tissue tropism. Remarkably, following direct inoculation of pigs with virus quasispecies differing by amino acid substitutions in the haemagglutinin receptor-binding site, only virus with aspartic acid at position 225 (225D) was detected in nasal secretions of contact infected pigs. In contrast, in lower respiratory tract samples from directly inoculated pigs, with clearly demonstrable pulmonary pathology, there was apparent selection of a virus variant with glycine (225G). These findings provide potential clues to the existence and biological significance of viral receptor-binding variants with 225D and 225G during the 1918 pandemic [5]

A selective metasurface absorber with an amorphous carbon interlayer for solar thermal applications

This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this recordData availability: Data shown in this paper is accessible via the University of Bristol data repository: 10.5523/bris.11twobtdyxfs1ib2fxhlvn107This paper presents fabrication, measurement and modelling results for a metal-dielectric-metal metasurface absorber for solar thermal applications. The structure uses amorphous carbon as an inter-layer between thin gold films with the upper film patterned with a 2D periodic array using focused ion beam etching. The patterned has been optimised to give high absorptance from 400-1200nm and low absorptance above this wavelength range to minimise thermal radiation and hence obtain higher temperature performance. Wide angle absorptance results are shown and detailed modelling of a realistic nanostructured upper layer results in excellent agreement between measured and modelled results. The use of gold in this paper is a first step towards a high temperature metasurface where gold can be replaced by other refractory metals such as tungsten or chrome.Engineering and Physical Sciences Research Council (EPSRC

Ohm's Law for Plasma in General Relativity and Cowling's Theorem

The general-relativistic Ohm's law for a two-component plasma which includes the gravitomagnetic force terms even in the case of quasi-neutrality has been derived. The equations that describe the electromagnetic processes in a plasma surrounding a neutron star are obtained by using the general relativistic form of Maxwell equations in a geometry of slow rotating gravitational object. In addition to the general-relativistic effect first discussed by Khanna \& Camenzind (1996) we predict a mechanism of the generation of azimuthal current under the general relativistic effect of dragging of inertial frames on radial current in a plasma around neutron star. The azimuthal current being proportional to the angular velocity $\omega$ of the dragging of inertial frames can give valuable contribution on the evolution of the stellar magnetic field if $\omega$ exceeds $2.7\times 10^{17} (n/\sigma) \textrm{s}^{-1}$ ($n$ is the number density of the charged particles, $\sigma$ is the conductivity of plasma). Thus in general relativity a rotating neutron star, embedded in plasma, can in principle generate axial-symmetric magnetic fields even in axisymmetry. However, classical Cowling's antidynamo theorem, according to which a stationary axial-symmetric magnetic field can not be sustained against ohmic diffusion, has to be hold in the general-relativistic case for the typical plasma being responsible for the rotating neutron star.Comment: Accepted for publication in Astrophysics & Space Scienc

Physics and Mathematics of Calogero particles

We give a review of the mathematical and physical properties of the celebrated family of Calogero-like models and related spin chains.Comment: Version to appear in Special Issue of Journal of Physics A: Mathematical and Genera

Stability and quasi-normal modes of charged black holes in Born-Infeld gravity

In this paper we study the stability and quasi-normal modes of scalar perturbations of black holes. The static charged black hole considered here is a solution to Born-Infeld electrodynamics coupled to gravity. We conclude that the black hole is stable. We also compare the stability of it with its linear counter-part Reissner-Nordstrom black hole. The quasi-normal modes are computed using the WKB method. The behavior of these modes with the non-linear parameter, temperature, mass of the scalar field and the spherical index are analyzed in detail.Comment: Latex, 17 pages, 13 figures, some sections edited, references adde

American Society of Hematology 2019 guidelines for management of venous thromboembolism : prevention of venous thromboembolism in surgical hospitalized patients

Background: Venous thromboembolism (VTE) is a common source of perioperative morbidity and mortality. Objective: These evidence-based guidelines from the American Society of Hematology (ASH) intend to support decision making about preventing VTE in patients undergoing surgery. Methods: ASH formed a multidisciplinary guideline panel balanced to minimize bias from conflicts of interest. The McMaster University GRADE Centre supported the guideline-development process, including performing systematic reviews. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to assess evidence and make recommendations, which were subject to public comment. Results: The panel agreed on 30 recommendations, including for major surgery in general (n = 8), orthopedic surgery (n = 7), major general surgery (n = 3), major neurosurgical procedures (n = 2), urological surgery (n = 4), cardiac surgery and major vascular surgery (n = 2), major trauma (n = 2), and major gynecological surgery (n = 2). Conclusions: For patients undergoing major surgery in general, the panel made conditional recommendations for mechanical prophylaxis over no prophylaxis, for pneumatic compression prophylaxis over graduated compression stockings, and against inferior vena cava filters. In patients undergoing total hip or total knee arthroplasty, conditional recommendations included using either aspirin or anticoagulants, as well as for a direct oral anticoagulant over low-molecular-weight heparin (LMWH). For major general surgery, the panel suggested pharmacological prophylaxis over no prophylaxis, using LMWH or unfractionated heparin. For major neurosurgery, transurethral resection of the prostate, or radical prostatectomy, the panel suggested against pharmacological prophylaxis. For major trauma surgery or major gynecological surgery, the panel suggested pharmacological prophylaxis over no prophylaxis.Peer reviewe

Epidemiology of Mycobacterium tuberculosis lineages and strain clustering within urban and peri-urban settings in Ethiopia

Background Previous work has shown differential predominance of certain Mycobacterium tuberculosis (M. tb) lineages and sub-lineages among different human populations in diverse geographic regions of Ethiopia. Nevertheless, how strain diversity is evolving under the ongoing rapid socio-economic and environmental changes is poorly understood. The present study investigated factors associated with M. tb lineage predominance and rate of strain clustering within urban and peri-urban settings in Ethiopia. Methods Pulmonary Tuberculosis (PTB) and Cervical tuberculous lymphadenitis (TBLN) patients who visited selected health facilities were recruited in the years of 2016 and 2017. A total of 258 M. tb isolates identified from 163 sputa and 95 fine-needle aspirates (FNA) were characterized by spoligotyping and compared with international M.tb spoligotyping patterns registered at the SITVIT2 databases. The molecular data were linked with clinical and demographic data of the patients for further statistical analysis. Results From a total of 258 M. tb isolates, 84 distinct spoligotype patterns that included 58 known Shared International Type (SIT) patterns and 26 new or orphan patterns were identified. The majority of strains belonged to two major M. tb lineages, L3 (35.7%) and L4 (61.6%). The observed high percentage of isolates with shared patterns (n = 200/258) suggested a substantial rate of overall clustering (77.5%). After adjusting for the effect of geographical variations, clustering rate was significantly lower among individuals co-infected with HIV and other concomitant chronic disease. Compared to L4, the adjusted odds ratio and 95% confidence interval (AOR; 95% CI) indicated that infections with L3 M. tb strains were more likely to be associated with TBLN [3.47 (1.45, 8.29)] and TB-HIV co-infection [2.84 (1.61, 5.55)]. Conclusion Despite the observed difference in strain diversity and geographical distribution of M. tb lineages, compared to earlier studies in Ethiopia, the overall rate of strain clustering suggests higher transmission and warrant more detailed investigations into the molecular epidemiology of TB and related factors

Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1

Disruption in membrane excitability contributes to malfunction and differential vulnerability of specific neuronal subpopulations in a number of neurological diseases. The adaptor protein p11, and background potassium channel TASK1, have overlapping distributions in the CNS. Here, we report that the transcription factor Sp1 controls p11 expression, which impacts on excitability by hampering functional expression of TASK1. In the SOD1-G93A mouse model of ALS, Sp1-p11-TASK1 dysregulation contributes to increased excitability and vulnerability of motor neurons. Interference with either Sp1 or p11 is neuroprotective, delaying neuron loss and prolonging lifespan in this model. Nitrosative stress, a potential factor in human neurodegeneration, stimulated Sp1 expression and human p11 promoter activity, at least in part, through a Sp1-binding site. Disruption of Sp1 or p11 also has neuroprotective effects in a traumatic model of motor neuron degeneration. Together our work suggests the Sp1-p11- TASK1 pathway is a potential target for treatment of degeneration of motor neurons

Anesthetic action on the transmission delay between cortex and thalamus explains the beta-buzz observed under propofol anesthesia

In recent years, more and more surgeries under general anesthesia have been performed with the assistance of electroencephalogram (EEG) monitors. An increase in anesthetic concentration leads to characteristic changes in the power spectra of the EEG. Although tracking the anesthetic-induced changes in EEG rhythms can be employed to estimate the depth of anesthesia, their precise underlying mechanisms are still unknown. A prominent feature in the EEG of some patients is the emergence of a strong power peak in the β–frequency band, which moves to the α–frequency band while increasing the anesthetic concentration. This feature is called the beta-buzz. In the present study, we use a thalamo-cortical neural population feedback model to reproduce observed characteristic features in frontal EEG power obtained experimentally during propofol general anesthesia, such as this beta-buzz. First, we find that the spectral power peak in the α– and δ–frequency ranges depend on the decay rate constant of excitatory and inhibitory synapses, but the anesthetic action on synapses does not explain the beta-buzz. Moreover, considering the action of propofol on the transmission delay between cortex and thalamus, the model reveals that the beta-buzz may result from a prolongation of the transmission delay by increasing propofol concentration. A corresponding relationship between transmission delay and anesthetic blood concentration is derived. Finally, an analytical stability study demonstrates that increasing propofol concentration moves the systems resting state towards its stability threshold