Niemeyer: the evolution of the female figure

[EN] The publication of the last few years of Oscar Niemeyer’s life has provoked an altered vision of his graphic production. In this article, the different variants of the female drawing are analyzed, starting from its beginnings to the iconic figures that have contributed to the formation of the myth.[ES] La divulgación realizada por las publicaciones de los últimos años de la vida de Oscar Niemeyer, han provocado una visión alterada de su producción gráfica. En este artículo se analizan las distintas variantes sobre el dibujo femenino partiendo de sus inicios hasta llegar a las figuras icónicas que han contribuido a la formación del mito.Novoa Rodríguez, FJ. (2018). Niemeyer: la evolución de la figura femenina. EGA. Revista de Expresión Gráfica Arquitectónica. 23(33):250-259. doi:10.4995/ega.2018.9496SWORD2502592333Oscar Niemeyer Foundation Archive. Rio de Janeiro: http://www.niemeyer.org.br/obrasCIRLOT, Juan Eduardo, [1958]1992. Dictionary of Symbols. Barcelona: WorkCOSTA, Lucio, [1995]1997. Lucio Costa. Registration of a life. São Paulo: Empresa das Artes.DAYS COMAS, Carlos Eduardo, 2010. The 1939 New York world fair: the Brazilian pavilion. ARQTEXT, no. 16, pp. 56-97.FRANCO TABOADA, Manuel, 2013. The architecture of Oscar Niemeyer from his drawings. A Coruña: UDC.GOODWIN, Philip L.,[1943]1944. Brazil Builds. Architecture new and old (1652-1942). New York: Museum of Modern Art.JUNG, Carl G.,[1934]2002. The Archetypes and the collective unconscious. Madrid: Trotta.LE CORBUSIER. [1955]2006. Poem of the Right Angle. Paris.MACEDO, Danilo Matoso, 2008. Da matéria à invenção: as obras de Oscar Niemeyer em Minas Gerais, 1938- 1955. Brasília: Chamber of Deputies.MONDADORI, Arnoldo (editor), 1975. Oscar Niemeyer. Milan: Mondadori.NIEMEYER, Oscar, 1935. Sport Club. Revista da diretoria de engenhería (P. D. F.), no. 14, vol. IV, pp. 236-240.NIEMEYER, Oscar, 1936a. Residence to be built in Urca. Revista da diretoria de engenhería (P. D. F.), no. 5, vol. III, pp. 258-259.NIEMEYER, Oscar et al., 1936b. Preliminary project for the Brazilian Printing Association. Revista da diretoria de engenhería (P. D. F.), no. 6, vol. III, pp. 334-341.NIEMEYER, Oscar, 1939. Residence for the writer Oswaldo de Andrade. Architeture and urbanism, no. 3, pp. 502-503.NIEMEYER, Oscar,[1978]2005. In the shape of architecture. Rio de Janeiro: Revan.NIEMEYER, Oscar,[1992]1999. Meu subsia e eu. Porto: Campo das letras.NIEMEYER, Oscar, 1997. Museum of Contemporary Art of Niterói. Rio de Janeiro: Revan.NIEMEYER, Oscar, 1999. Diante do Nada. Rio de Janeiro: Revan.NOVOA RODRÍGUEZ, Francisco J., 2016. Oscar Niemeyer: Drawing and Didactics through Myth. Doctoral Thesis in Architecture and Urbanism: Universidad da Coruña (UDC)PAPADAKI, Stamo,[1956]1958. Oscar Niemeyer: Works in Progress. New York: Reinhold

Oscar Niemeyer: dibujo y didáctica a través del mito

Programa de Doutoramento en Arquitectura e Urbanismo. 5003P01[Resumen] Esta Tesis doctoral acerca de la obra gráfica de Oscar Niemeyer discurre entre dos polos contrapuestos: la didáctica y el mito. Si la didáctica se ocupa de crear un discurso racionalizador, que explique de una forma consciente y ordenada la manera en que se elaboran sus propuestas, el mito se propone la creación de una historia a la vez verdadera e irreal. El proceso de decantación de ambos polos es estudiado en el tiempo. El análisis de los distintos procedimientos didácticos empleados por el arquitecto tendrá su origen en la formación positivista que impregna la enseñanza académica. Este pensamiento basado en la razón le permitirá reorganizar, a través del dibujo, las influencias de Lucio Costa y Le Corbusier, creando un discurso propio que se irá consolidando desde su obra de Pampulha. La evolución de este discurso de la razón hacia el simbolismo, todo ello analizado fundamentalmente desde la perspectiva del grafismo, permite explicar numerosas claves que aclaran el significado de sus dibujos como medio de expresión que trasciende el oficio del arquitecto.[Resumo] Esta Tese Doutoral acerca da obra gráfica de Oscar Niemeyer desenrólase entre dous polos contrapostos: a didáctica e o mito. Se a didáctica ocupase de crear un discurso racionalizante, que explique dunha forma consciente e ordenada o xeito en que se elaboran as súas propostas, o mito proponse a creación dunha historia á vez verdadeira e irreal. O proceso de decantación de ambos polos é estudado no tempo. O análise dos distintos procedementos didácticos empregados polo arquitecto terá a súa orixe na formación positivista que impregna o ensino académico. Este pensamento baseado na razón permitiralle reorganizar, a través do debuxo, as influencias de Lucio Costa e Le Corbusier, creando un discurso propio que irase consolidando dende a súa obra de Pampulha A evolución deste discurso da razón para o simbolismo, todo elo analizado fundamentalmente dende a perspectiva do grafismo, permite explicar numerosas claves que aclaran o significado dos seus debuxos como medio de expresión que transcende o oficio do arquitecto.[Abstract] This PhD dissertation about the graphic work of Oscar Niemeyer runs between two opposite poles: the teaching and myth. If teaching is concerned with creating a rationalizing discourse that explains consciously and orderly way their proposals are made, the myth creating a story to the real and unreal is proposed. The process of decantation both poles is studied over time. The analysis of different teaching methods used by architect will originate in the positivist training that permeates academic teaching. This thought based on reason will allow you to reorganize, through drawing, the influences of Lucio Costa and Le Corbusier, creating a discourse that will be consolidated from the work of Pampulha. The evolution of this discourse of reason to the symbolism, all analyzed primarily from the perspective of graphics, can explain many clues that explain the meaning of his drawings as a means of expression that transcends the office of the architect

Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER Registry

Objectives. This article estimates the frequency of polyautoimmunity and associated factors in a large retrospective cohort of patients with SLE. Methods. RELESSER (Spanish Society of Rheumatology Lupus Registry) is a nationwide multicentre, hospital-based registry of SLE patients. This is a cross-sectional study. The main variable was polyautoimmunity, which was defined as the co-occurrence of SLE and another autoimmune disease, such as autoimmune thyroiditis, RA, scleroderma, inflammatory myopathy and MCTD. We also recorded the presence of multiple autoimmune syndrome, secondary SS, secondary APS and a family history of autoimmune disease. Multiple logistic regression analysis was performed to investigate possible risk factors for polyautoimmunity. Results. Of the 3679 patients who fulfilled the criteria for SLE, 502 (13.6%) had polyautoimmunity. The most frequent types were autoimmune thyroiditis (7.9%), other systemic autoimmune diseases (6.2%), secondary SS (14.1%) and secondary APS (13.7%). Multiple autoimmune syndrome accounted for 10.2% of all cases of polyautoimmunity. A family history was recorded in 11.8%. According to the multivariate analysis, the factors associated with polyautoimmunity were female sex [odds ratio (95% CI), 1.72 (1.07, 2.72)], RP [1.63 (1.29, 2.05)], interstitial lung disease [3.35 (1.84, 6.01)], Jaccoud arthropathy [1.92 (1.40, 2.63)], anti-Ro/SSA and/or anti-La/SSB autoantibodies [2.03 (1.55, 2.67)], anti-RNP antibodies [1.48 (1.16, 1.90)], MTX [1.67 (1.26, 2.18)] and antimalarial drugs [0.50 (0.38, 0.67)]. Conclusion. Patients with SLE frequently present polyautoimmunity. We observed clinical and analytical characteristics associated with polyautoimmunity. Our finding that antimalarial drugs protected against polyautoimmunity should be verified in future studies

Association of Candidate Gene Polymorphisms With Chronic Kidney Disease: Results of a Case-Control Analysis in the Nefrona Cohort

Chronic kidney disease (CKD) is a major risk factor for end-stage renal disease, cardiovascular disease and premature death. Despite classical clinical risk factors for CKD and some genetic risk factors have been identified, the residual risk observed in prediction models is still high. Therefore, new risk factors need to be identified in order to better predict the risk of CKD in the population. Here, we analyzed the genetic association of 79 SNPs of proteins associated with mineral metabolism disturbances with CKD in a cohort that includes 2, 445 CKD cases and 559 controls. Genotyping was performed with matrix assisted laser desorption ionizationtime of flight mass spectrometry. We used logistic regression models considering different genetic inheritance models to assess the association of the SNPs with the prevalence of CKD, adjusting for known risk factors. Eight SNPs (rs1126616, rs35068180, rs2238135, rs1800247, rs385564, rs4236, rs2248359, and rs1564858) were associated with CKD even after adjusting by sex, age and race. A model containing five of these SNPs (rs1126616, rs35068180, rs1800247, rs4236, and rs2248359), diabetes and hypertension showed better performance than models considering only clinical risk factors, significantly increasing the area under the curve of the model without polymorphisms. Furthermore, one of the SNPs (the rs2248359) showed an interaction with hypertension, being the risk genotype affecting only hypertensive patients. We conclude that 5 SNPs related to proteins implicated in mineral metabolism disturbances (Osteopontin, osteocalcin, matrix gla protein, matrix metalloprotease 3 and 24 hydroxylase) are associated to an increased risk of suffering CKD

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

Capitulo 2. Ciencias Naturales y Ciencias Básicas, Ingeniería y Tecnología

La diseminación de la Levitación Magnética, a pesar de lo antiguo de su tecnología, ha sido limitada. Debido a sus inconvenientes prácticos de implementación, su uso es bastante restringido, comparado con otras tecnologías (SCMaglev japonés, Transrapid alemán, o productos comerciales para ocio y entretenimiento). Con el boom de las tecnologías limpias y amigables con el medio ambiente y en concordancia con los objetivos del milenio, es pertinente plantearse el objetivo de optimizar el proceso de Levitación Magnética para generar un aprovechamiento de las ventajas de esta tecnología a nivel mecánico, eléctrico, y ambiental.&nbsp; Actualmente la UNAD adelanta un proyecto de investigación cuyo objetivo es generar un modelo físico matemático de levitación magnética para aplicaciones en ingeniería. De este proyecto se ha derivado una primera revisión sistemática de los principios físicos y los modelos vigentes en Levitación Magnética

Validación de los sistemas de evaluación de un programa de enseñanza práctica de las habilidades clínicas y quirúrgicas en las asignaturas de Fundamentos de Cirugia de los grados de Medicina y Odontología

Memoria ID11-030. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2011-2012

Identification of serum endoglin as a novel prognostic marker after acute myocardial infarction

Abstract Endoglin is a proliferation-associated and hypoxia-inducible protein expressed in endothelial cells. The levels of soluble circulating endoglin and their prognostic significance in patients with acute myocardial infarction (AMI) are not known. In this observational prospective study serum endoglin levels were measured by ELISA in 183 AMI patients upon admission to hospital and 48 hrs later and in 72 healthy controls. Endoglin levels in AMI patients on admission were significantly lower than in healthy controls (4.25 ± 0.99 ng/ml versus 4.59 ± 0.87 ng/ml; P= 0.013), and decreased further in the first 48 hours (3.65 ± 0.76 ng/ml, P < 0.001). Upon follow-up (median 319 days), patients who died had a significantly greater decrease in serum endoglin level over the first 48 hrs than those who survived (1.03 ± 0.91 versus 0.54 ± 0.55 ng/ml; P= 0.025). Endoglin decrease was an independent predictor of short-term (30 days) (hazard ratio 2.33;95% CI = 1.27–4.23; P= 0.006) cardiovascular mortality, and also predicts overall cardiovascular mortality during the follow-up (median 319 days) in AMI patients (hazard ratio 2.13;95% CI = 1.20–3.78; P= 0.01). In conclusion, early changes in serum endoglin may predict mortality after AMI