ПРЕДСТАВЛЕНИЯ РОДИТЕЛЕЙ ОБ ЭМОЦИОНАЛЬНОЙ ГОТОВНОСТИ РЕБЕНКА К ШКОЛЕ ПРИ АНАЛИЗЕ ОСОБЕННОСТЕЙ ЭМОЦИОНАЛЬНОЙ ГОТОВНОСТИ ДЕТЕЙ ПРИ ПЕРЕХОДЕ ИЗ ДЕТСКОГО САДА В ПЕРВЫЙ КЛАСС

The article examines the importance of emotional understanding of parents child’s readiness for school. The aim of the study was to determine the characteristics of parental influence perceptions about the emotional readiness of children to the actual level of emotional readiness of the child. An experimental study was conducted comparing the methods, testing, questionnaires, observations, interviews, expert assessments, Longitude. We compared the performance of emotional readiness of children in the preparatory group of the kindergarten and the beginning of the school year in first grade. The study revealed that parents consider the emotional readiness primarily in the structure of the psychological readiness; representations of parents about the emotional readiness to occupy the last place among the other groups of ideas. Weak concrete definition of representations of parents about the emotional school readiness issues contributes to the emotional sphere of the child at an early stage of learning in first grade.В статье анализируется понимание родителями значения эмоционального готовности ребенка к школе. Задачей исследования было выявление особенностей влияния родительских представлений об эмоциональной готовности детей на собственно уровень эмоциональной готовности ребенка. Экспериментальное исследование проводилось методами сравнения, тестирования, анкетирования, наблюдения, интервью, экспертных оценок, лонгитюда. Сравнивались показатели эмоциональной готовности детей в подготовительной группе детского сада и в начале учебного года в первом классе. В результате исследования выявлено, что родители рассматривают эмоциональную готовность преимущественно в структуре психологической готовности; представления родителей об эмоциональной готовности занимают последнее место среди прочих групп представлений. Слабая конкретизация представлений родителей об эмоциональной готовности к школе способствует возникновению проблем эмоциональной сферы у ребенка на начальном этапе обучения в первом классе

Role of ACTN4 in Tumorigenesis, Metastasis, and EMT

The actin-binding protein ACTN4 belongs to a family of actin-binding proteins and is a non-muscle alpha-actinin that has long been associated with cancer development. Numerous clinical studies showed that changes in ACTN4 gene expression are correlated with aggressiveness, invasion, and metastasis in certain tumors. Amplification of the 19q chromosomal region where the gene is located has also been reported. Experimental manipulations with ACTN4 expression further confirmed its involvement in cell proliferation, motility, and epithelial-mesenchymal transition (EMT). However, both clinical and experimental data suggest that the effects of ACTN4 up- or down-regulation may vary a lot between different types of tumors. Functional studies demonstrated its engagement in a number of cytoplasmic and nuclear processes, ranging from cytoskeleton reorganization to regulation of different signaling pathways. Such a variety of functions may be the reason behind cell type and cell line specific responses. Herein, we will review research progress and controversies regarding the prognostic and functional significance of ACTN4 for tumorigenesis

Correlation of Multi-scale Modeling and Experimental Results for the Elastic Modulus of Trabecular Bone

Trabecular bone is a porous nanocomposite material with a hierarchical structure. In this study, a multi-scale modeling approach, addressing scales spanning from the nanometer (collagen-mineral) to mesoscale (trabecular bone) levels, was developed to determine the elastic moduli of trabecular bone. Then, the predicted modeling results were compared with experimental data obtained by compression testing of bovine femur trabecular bone samples loaded in two different directions; parallel to the femur neck axis and perpendicular to that. Optical microscopy, scanning electron microscopy and micro-computed tomography techniques were employed to characterize the structure and composition of the samples at different length scales and provide the inputs needed for the modeling. To obtain more insights on the structure of bone, especially on the interaction of its main constituents (collagen and mineral phases), trabecular bone samples were deproteinized or demineralized and, afterwards, tested mechanically in compression. The experimental observations were used, in turn, to fine-tune the multi-scale model of bone as an interpenetrating composite material. Good agreement was found between the theoretical and experimental results for elastic moduli of untreated, deproteinized, and demineralized trabecular bones

Optimized Scintillator YAG:Pr Nanoparticles for X-ray Inducible Photodynamic Therapy.

We describe a sol-gel synthetic method for the production of praseodymium-doped yttrium aluminum garnet (YAG) nanoparticles suitable for X-ray inducible photodynamic therapy (X-PDT). Our sol-gel based approach was optimized by varying temperature and time of calcination, resulting in nanoparticles that were smooth, spherical, and 50-200 nm in crystallite size. The powders were uniformly coated with a thin (10 nm) layer of silica to facilitate surface conjugation with functional moieties. Measurements of photon flux revealed that coated and uncoated powders emitted a similar photon emission spectrum in response to 50 keVp X-rays. We also determined that the presence of silica did not significantly reduce flux and the emission peak had a maximum at approximately 320 nm. Thus, these YAG:Pr powders are suitable candidates for future in vivo X-PDT studies