La metodología de la investigación en Traductología

Empirical research methods in Translation Studies have been used in Spain for a decade. A glimpse of the most recent studies carried out in our country is given, as well as the actual trends in research. A research methodology based on the scientific method is proposed, and a research design to study the acquisition of translation competence in trainees is presented, including three original measuring instruments created for the study: the first instrument measures the translation notions of the students; the second one measures students' performance when faced with translation problems; and the third one measures performance regarding translation errors

The magnetic environment in the central region of nearby galaxies

The central regions of galaxies harbor some of the most extreme physical phenomena, including dense stellar clusters, non-circular motions of molecular clouds and strong and pervasive magnetic field structures. In particular, radio observations have shown that the central few hundred parsecs of our Galaxy has a striking magnetic field configuration. It is not yet clear whether these magnetic structures are unique to our Milky Way or a common feature of all similar galaxies. Therefore, we report on (a) a new radio polarimetric survey of the central 200 pc of the Galaxy to better characterize the magnetic field structure and (b) a search for large-scale and organized magnetized structure in the nuclear regions of nearby galaxies using data from the Very Large Array (VLA) archive. The high angular resolution of the VLA allows us to study the central 1 kpc of the nearest galaxies to search for magnetized nuclear features similar to what is detected in our own Galactic center. Such magnetic features play a important role in the nuclear regions of galaxies in terms of gas transport and the physical conditions of the interstellar medium in this unusual region of galaxies.Comment: 8 pages; Proceedings for "The Universe under the Microscope" (AHAR 2008), held in Bad Honnef (Germany) in April 2008, to be published in Journal of Physics: Conference Series by Institute of Physics Publishing, R. Schoedel, A. Eckart, S. Pfalzner, and E. Ros (eds.

The social value of a QALY : raising the bar or barring the raise?

Background: Since the inception of the National Institute for Health and Clinical Excellence (NICE) in England, there have been questions about the empirical basis for the cost-per-QALY threshold used by NICE and whether QALYs gained by different beneficiaries of health care should be weighted equally. The Social Value of a QALY (SVQ) project, reported in this paper, was commissioned to address these two questions. The results of SVQ were released during a time of considerable debate about the NICE threshold, and authors with differing perspectives have drawn on the SVQ results to support their cases. As these discussions continue, and given the selective use of results by those involved, it is important, therefore, not only to present a summary overview of SVQ, but also for those who conducted the research to contribute to the debate as to its implications for NICE. Discussion: The issue of the threshold was addressed in two ways: first, by combining, via a set of models, the current UK Value of a Prevented Fatality (used in transport policy) with data on fatality age, life expectancy and age-related quality of life; and, second, via a survey designed to test the feasibility of combining respondents’ answers to willingness to pay and health state utility questions to arrive at values of a QALY. Modelling resulted in values of £10,000-£70,000 per QALY. Via survey research, most methods of aggregating the data resulted in values of a QALY of £18,000-£40,000, although others resulted in implausibly high values. An additional survey, addressing the issue of weighting QALYs, used two methods, one indicating that QALYs should not be weighted and the other that greater weight could be given to QALYs gained by some groups. Summary: Although we conducted only a feasibility study and a modelling exercise, neither present compelling evidence for moving the NICE threshold up or down. Some preliminary evidence would indicate it could be moved up for some types of QALY and down for others. While many members of the public appear to be open to the possibility of using somewhat different QALY weights for different groups of beneficiaries, we do not yet have any secure evidence base for introducing such a system

Electromechanics of charge shuttling in dissipative nanostructures

We investigate the current-voltage (IV) characteristics of a model single-electron transistor where mechanical motion, subject to strong dissipation, of a small metallic grain is possible. The system is studied both by using Monte Carlo simulations and by using an analytical approach. We show that electromechanical coupling results in a highly nonlinear IV-curve. For voltages above the Coulomb blockade threshold, two distinct regimes of charge transfer occur: At low voltages the system behave as a static asymmetric double junction and tunneling is the dominating charge transfer mechanism. At higher voltages an abrupt transition to a new shuttle regime appears, where the grain performs an oscillatory motion back and forth between the leads. In this regime the current is mainly mediated by charges that are carried on the grain as it moves from one lead to the other.Comment: 8 pages, 10 figures, final version to be published in PR

Low frequency current noise of the single-electron shuttle

Coupling between electronic and mechanical degrees of freedom in a single electron shuttle system can cause a mechanical instability leading to shuttle transport of electrons between external leads. We predict that the resulting low frequency current noise can be enhanced due to amplitude fluctuations of the shuttle oscillations. Moreover, at the onset of mechanical instability a pronounced peak in the low frequency noise is expected.Comment: 14 pages, 3 figures, 1 tabl

Submillimeter galaxies behind the Bullet Cluster (1E 0657-56)

Clusters of galaxies are effective gravitational lenses able to magnify background galaxies and making it possible to probe the fainter part of the galaxy population. Submillimeter galaxies, which are believed to be star-forming galaxies at typical redshifts of 2 to 3, are a major contaminant to the extended Sunyaev-Zeldovich (SZ) signal of galaxy clusters. For a proper quantification of the SZ signal the contribution of submillimeter galaxies needs to be quantified. The aims of this study are to identify submillimeter sources in the field of the Bullet Cluster (1E 0657-56), a massive cluster of galaxies at z~0.3, measure their flux densities at 870 micron, and search for counterparts at other wavelengths to constrain their properties. We carried out deep observations of the submillimeter continuum emission at 870 micron using the Large APEX BOlometer CAmera (LABOCA) on the Atacama Pathfinder EXperiment (APEX) telescope. Several numerical techniques were used to quantify the noise properties of the data and extract sources. In total, seventeen sources were found. Thirteen of them lie in the central 10 arcminutes of the map, which has a pixel sensitivity of 1.2 mJy per 22 arcsec beam. After correction for flux boosting and gravitational lensing, the number counts are consistent with published submm measurements. Nine of the sources have infrared counterparts in Spitzer maps. The strongest submm detection coincides with a source previously reported at other wavelengths, at an estimated redshift z~2.7. If the submm flux arises from two images of a galaxy magnified by a total factor of 75, as models have suggested, its intrinsic flux would be around 0.6 mJy, consistent with an intrinsic luminosity below 10^12 L_sun.Comment: Accepted by A&A, 15 pages, 11 figure

Strong fragmentation of low-energy electromagnetic excitation strength in 117^{117}Sn

Results of nuclear resonance fluorescence experiments on $^{117}$Sn are reported. More than 50 $\gamma$ transitions with $E_{\gamma} < 4$ MeV were detected indicating a strong fragmentation of the electromagnetic excitation strength. For the first time microscopic calculations making use of a complete configuration space for low-lying states are performed in heavy odd-mass spherical nuclei. The theoretical predictions are in good agreement with the data. It is concluded that although the E1 transitions are the strongest ones also M1 and E2 decays contribute substantially to the observed spectra. In contrast to the neighboring even $^{116-124}$Sn, in $^{117}$Sn the $1^-$ component of the two-phonon $[2^+_1 \otimes 3^-_1]$ quintuplet built on top of the 1/2$^+$ ground state is proved to be strongly fragmented.Comment: 4 pages, 3 figure

Search for the electric dipole excitations to the 3s1/2⊗[21+⊗31−]3s_{1/2} \otimes [2^{+}_{1} \otimes 3^{-}_{1}] multiplet in 117^{117}Sn

The odd-mass $^{117}$Sn nucleus was investigated in nuclear resonance fluorescence experiments up to an endpoint energy of the incident photon spectrum of 4.1 MeV at the bremsstrahlung facility of the Stuttgart University. More than 50 mainly hitherto unknown levels were found. From the measurement of the scattering cross sections model independent absolute electric dipole excitation strengths were extracted. The measured angular distributions suggested the spins of 11 excited levels. Quasi-particle phonon model calculations including a complete configuration space were performed for the first time for a heavy odd-mass spherical nucleus. These calculations give a clear insight in the fragmentation and distribution of the $E1$, $M1$, and $E2$ excitation strength in the low energy region. It is proven that the $1^{-}$ component of the two-phonon $[2^{+}_{1} \otimes 3^{-}_{1}]$ quintuplet built on top of the $1/2^{+}$ ground state is strongly fragmented. The theoretical calculations are consistent with the experimental data.Comment: 10 pages, 5 figure

Ribosome Display Selection of a Murine IgG1 Fab Binding Affibody Molecule Allowing Species Selective Recovery Of Monoclonal Antibodies

Affinity reagents recognizing constant parts of antibody molecules are invaluable tools in immunotechnology applications, including purification, immobilization, and detection of immunoglobulins. In this article, murine IgG1, the primary isotype of monoclonal antibodies (mAbs) was used as target for selection of novel binders from a combinatorial ribosome display (RD) library of 1011 affibody molecules. Four rounds of selection using three different mouse IgG1 mAbs as alternating targets resulted in the identification of binders with broad mIgG1 recognition and dissociation constants (KD) in the low nanomolar to low micromolar range. For one of the binders, denoted Zmab25, competition in binding to full length mIgG1 by a streptococcal protein G (SPG) fragment and selective affinity capture of mouse IgG1 Fab fragments after papain cleavage of a full mAb suggest that an epitope functionally overlapping with the SPG-binding site in the CH1 domain of mouse IgG1 had been addressed. Interestingly, biosensor-based binding experiments showed that neither human IgG1 nor bovine Ig, the latter present in fetal bovine serum (FBS) was recognized by Zmab25. This selective binding profile towards murine IgG1 was successfully exploited in species selective recovery of two different mouse mAbs from complex samples containing FBS, resembling a hybridoma culture supernatant