Grupo Cultivaeco: a educação ambiental na agricultura e na segurança alimentar como geradora de cidadania

As atividades de extensão desenvolvidas no ensino fundamental, desde 2009 até o presente, pelos integrantes do Grupo Cultivaeco incentivam a mobilização de saberes técno-científicos relacionados à agricultura e suas inter-relações com a segurança alimentar e o equilíbrio sócio-ambiental. Esta dinâmica de saberes é dada através da interação entre os acadêmicos e a realidade do público do ensino fundamental, por meio de uma metodologia de ensino dialógica. Objetivos: conceituar a segurança alimentar no cotidiano dos educandos, através da realização de atividades educativas e sobre a origem dos produtos agrícolas; refletir sobre os conceitos contemporâneos de agricultura e segurança alimentar voltados para o equilíbrio sócio-ambiental e a cidadania, vinculando-os ao cenário agrícola brasileiro e mundial. Material e Métodos: A práxis da educação ambiental dada na relação entre os participantes do Cultivaeco e a escola (três quintas-séries) gera uma avaliação dos conceitos de agricultura que retroalimentam as atividades de arte-educação. É gerado um constante diagnóstico de conceitos, o qual é incorporado na elaboração das atividades educativas. Resultados: Há produção de material didático, como os cadernos de atividades "Passatempo Cultivação", nos quais há caça-palavras, palavras-cruzadas, ilustrações e pinturas. São compostas paródias sobre a temática em questão a partir de músicas de sucesso executadas na mídia, as quais são inclusas nestes cadernos. A produção de material didático e a aplicação das atividades educativas geram uma maior interação entre a equipe e a escola. Esta inter-relação é também definida quando os estudantes do ensino superior assumem o papel de educadores na aplicação das atividades na escola. Assim, há a valorização da auto-estima dos integrantes, enquanto autores de atividades educativas e sujeitos capazes de promover a aprendizagem no outro e com o outro. Tanto os integrantes do grupo como os educandos do ensino fundamental compreendem a importância da agricultura numa produção de alimentos voltada para o equilíbrio sócio-ambiental na segurança alimentar. Conclusão: Este processo educativo vivenciado na prática da extensão possibilita que os graduandos exercitem a cidadania na inter-relação entre a universidade e a comunidade. Este exercício é caracterizado pelos desafios do respeito aos saberes de todos os participantes e da responsabilidade do ensinar-aprender. Desta forma, as ações de educação ambiental na extensão articulam a cidadania e a segurança alimentar. (Bolsas e Recursos da PROEX)

Grupo Cultivaeco: a educação ambiental na agricultura e na segurança alimentar como geradora de cidadania

As atividades de extensão desenvolvidas no ensino fundamental, desde 2009 até o presente, pelos integrantes do Grupo Cultivaeco incentivam a mobilização de saberes técno-científicos relacionados à agricultura e suas inter-relações com a segurança alimentar e o equilíbrio sócio-ambiental. Esta dinâmica de saberes é dada através da interação entre os acadêmicos e a realidade do público do ensino fundamental, por meio de uma metodologia de ensino dialógica. Objetivos: conceituar a segurança alimentar no cotidiano dos educandos, através da realização de atividades educativas e sobre a origem dos produtos agrícolas; refletir sobre os conceitos contemporâneos de agricultura e segurança alimentar voltados para o equilíbrio sócio-ambiental e a cidadania, vinculando-os ao cenário agrícola brasileiro e mundial. Material e Métodos: A práxis da educação ambiental dada na relação entre os participantes do Cultivaeco e a escola (três quintas-séries) gera uma avaliação dos conceitos de agricultura que retroalimentam as atividades de arte-educação. É gerado um constante diagnóstico de conceitos, o qual é incorporado na elaboração das atividades educativas. Resultados: Há produção de material didático, como os cadernos de atividades "Passatempo Cultivação", nos quais há caça-palavras, palavras-cruzadas, ilustrações e pinturas. São compostas paródias sobre a temática em questão a partir de músicas de sucesso executadas na mídia, as quais são inclusas nestes cadernos. A produção de material didático e a aplicação das atividades educativas geram uma maior interação entre a equipe e a escola. Esta inter-relação é também definida quando os estudantes do ensino superior assumem o papel de educadores na aplicação das atividades na escola. Assim, há a valorização da auto-estima dos integrantes, enquanto autores de atividades educativas e sujeitos capazes de promover a aprendizagem no outro e com o outro. Tanto os integrantes do grupo como os educandos do ensino fundamental compreendem a importância da agricultura numa produção de alimentos voltada para o equilíbrio sócio-ambiental na segurança alimentar. Conclusão: Este processo educativo vivenciado na prática da extensão possibilita que os graduandos exercitem a cidadania na inter-relação entre a universidade e a comunidade. Este exercício é caracterizado pelos desafios do respeito aos saberes de todos os participantes e da responsabilidade do ensinar-aprender. Desta forma, as ações de educação ambiental na extensão articulam a cidadania e a segurança alimentar. (Bolsas e Recursos da PROEX)

Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial.

There is no specific antiviral therapy recommended for coronavirus disease 2019 (COVID-19). In vitro studies indicate that the antiviral effect of chloroquine diphosphate (CQ) requires a high concentration of the drug.To evaluate the safety and efficacy of 2 CQ dosages in patients with severe COVID-19. This parallel, double-masked, randomized, phase IIb clinical trial with 81 adult patients who were hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was conducted from March 23 to April 5, 2020, at a tertiary care facility in Manaus, Brazilian Amazon. - Patients were allocated to receive high-dosage CQ (ie, 600 mg CQ twice daily for 10 days) or low-dosage CQ (ie, 450 mg twice daily on day 1 and once daily for 4 days). - Label: Main Outcomes and Measures Primary outcome was reduction in lethality by at least 50% in the high-dosage group compared with the low-dosage group. Data presented here refer primarily to safety and lethality outcomes during treatment on day 13. Secondary end points included participant clinical status, laboratory examinations, and electrocardiogram results. Outcomes will be presented to day 28. Viral respiratory secretion RNA detection was performed on days 0 and 4. Out of a predefined sample size of 440 patients, 81 were enrolled (41 [50.6%] to high-dosage group and 40 [49.4%] to low-dosage group). Enrolled patients had a mean (SD) age of 51.1 (13.9) years, and most (60 [75.3%]) were men. Older age (mean [SD] age, 54.7 [13.7] years vs 47.4 [13.3] years) and more heart disease (5 of 28 [17.9%] vs 0) were seen in the high-dose group. Viral RNA was detected in 31 of 40 (77.5%) and 31 of 41 (75.6%) patients in the low-dosage and high-dosage groups, respectively. Lethality until day 13 was 39.0% in the high-dosage group (16 of 41) and 15.0% in the low-dosage group (6 of 40). The high-dosage group presented more instance of QTc interval greater than 500 milliseconds (7 of 37 [18.9%]) compared with the low-dosage group (4 of 36 [11.1%]). Respiratory secretion at day 4 was negative in only 6 of 27 patients (22.2%). - Label: Conclusions and Relevance The preliminary findings of this study suggest that the higher CQ dosage should not be recommended for critically ill patients with COVID-19 because of its potential safety hazards, especially when taken concurrently with azithromycin and oseltamivir. These findings cannot be extrapolated to patients with nonsevere COVID-19

High anti-SARS-CoV-2 antibody seroconversion rates before the second wave in Manaus, Brazil, and the protective effect of social behaviour measures: results from the prospective DETECTCoV-19 cohort

Background: The city of Manaus, Brazil, has seen two collapses of the health system due to the COVID-19 pandemic. We report anti-SARS-CoV-2 nucleocapsid IgG antibody seroconversion rates and associated risk factors in Manaus residents before the second wave of the epidemic in Brazil. Methods: A convenience sample of adult (aged ≥18 years) residents of Manaus was recruited through online and university website advertising into the DETECTCoV-19 study cohort. The current analysis of seroconversion included a subgroup of DETECTCoV-19 participants who had at least two serum sample collections separated by at least 4 weeks between Aug 19 and Oct 2, 2020 (visit 1), and Oct 19 and Nov 27, 2020 (visit 2). Those who reported (or had no data on) having a COVID-19 diagnosis before visit 1, and who were positive for anti-SARS-CoV-2 nucleocapsid IgG antibodies at visit 1 were excluded. Using an in-house ELISA, the reactivity index (RI; calculated as the optical density ratio of the sample to the negative control) for serum anti-SARS-CoV-2 nucleocapsid IgG antibodies was measured at both visits. We calculated the incidence of seroconversion (defined as RI values ≤1·5 at visit 1 and ≥1·5 at visit 2, and a ratio >2 between the visit 2 and visit 1 RI values) during the study period, as well as incidence rate ratios (IRRs) through cluster-corrected and adjusted Poisson regression models to analyse associations between seroconversion and variables related to sociodemographic characteristics, health access, comorbidities, COVID-19 exposure, protective behaviours, and symptoms. Findings: 2496 DETECTCoV-19 cohort participants returned for a follow-up visit between Oct 19 and Nov 27, 2020, of whom 204 reported having COVID-19 before the first visit and 24 had no data regarding previous disease status. 559 participants were seropositive for anti-SARS-CoV-2 nucleocapsid IgG antibodies at baseline. Of the remaining 1709 participants who were seronegative at baseline, 71 did not meet the criteria for seroconversion and were excluded from the analyses. Among the remaining 1638 participants who were seronegative at baseline, 214 showed seroconversion at visit 2. The seroconversion incidence was 13·06% (95% CI 11·52–14·79) overall and 6·78% (5·61–8·10) for symptomatic seroconversion, over a median follow-up period of 57 days (IQR 54–61). 48·1% of seroconversion events were estimated to be asymptomatic. The sample had higher proportions of affluent and higher-educated people than those reported for the Manaus city population. In the fully adjusted and corrected model, risk factors for seroconversion before visit 2 were having a COVID-19 case in the household (IRR 1·49 [95% CI 1·21–1·83]), not wearing a mask during contact with a person with COVID-19 (1·25 [1·09–1·45]), relaxation of physical distancing (1·31 [1·05–1·64]), and having flu-like symptoms (1·79 [1·23–2·59]) or a COVID-19 diagnosis (3·57 [2·27–5·63]) between the first and second visits, whereas working remotely was associated with lower incidence (0·74 [0·56–0·97]). Interpretation: An intense infection transmission period preceded the second wave of COVID-19 in Manaus. Several modifiable behaviours increased the risk of seroconversion, including non-compliance with non-pharmaceutical interventions measures such as not wearing a mask during contact, relaxation of protective measures, and non-remote working. Increased testing in high-transmission areas is needed to provide timely information about ongoing transmission and aid appropriate implementation of transmission mitigation measures. Funding: Ministry of Education, Brazil; Fundação de Amparo à Pesquisa do Estado do Amazonas; Pan American Health Organization (PAHO)/WHO.World Health OrganizationRevisión por pare

What causes hidradenitis suppurativa? - 15 years after

The 14 authors of the first review article on hidradenitis suppurativa (HS) pathogenesis published 2008 in EXPERIMENTAL DERMATOLOGY cumulating from the 1st International Hidradenitis Suppurativa Research Symposium held March 30?April 2, 2006 in Dessau, Germany with 33 participants were prophetic when they wrote "Hopefully, this heralds a welcome new tradition: to get to the molecular heart of HS pathogenesis, which can only be achieved by a renaissance of solid basic HS research, as the key to developing more effective HS therapy." (Kurzen et al. What causes hidradenitis suppurativa? Exp Dermatol 2008;17:455). Fifteen years later, there is no doubt that the desired renaissance of solid basic HS research is progressing with rapid steps and that HS has developed deep roots among inflammatory diseases in Dermatology and beyond, recognized as ?the only inflammatory skin disease than can be healed?. This anniversary article of 43 research-performing authors from all around the globe in the official journal of the European Hidradenitis Suppurativa Foundation e.V. (EHSF e.V.) and the Hidradenitis Suppurativa Foundation, Inc (HSF USA) summarizes the evidence of the intense HS clinical and experimental research during the last 15 years in all aspects of the disease and provides information of the developments to come in the near future

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

What causes hidradenitis suppurativa ?—15 years after

The 14 authors of the first review article on hidradenitis suppurativa (HS) pathogenesis published 2008 in EXPERIMENTAL DERMATOLOGY cumulating from the 1st International Hidradenitis Suppurativa Research Symposium held March 30–April 2, 2006 in Dessau, Germany with 33 participants were prophetic when they wrote “Hopefully, this heralds a welcome new tradition: to get to the molecular heart of HS pathogenesis, which can only be achieved by a renaissance of solid basic HS research, as the key to developing more effective HS therapy.” (Kurzen et al. What causes hidradenitis suppurativa? Exp Dermatol 2008;17:455). Fifteen years later, th