EFFICACY AND TOLERABILITY OF LERCANIDIPINE IN ELDERLY PATIENTS WITH MILD TO MODERATE HYPERTENSION IN A PLACEBO-CONTROLLED, DOUBLE-BLIND STUDY

Цель. Оценить эффективность лерканидипина (антагониста кальция из группы дигидропиридинов) у пожилых больных артериальной гипертонией (АГ). Материал и методы. В многоцентровое рандомизированное двойное слепое плацебо-контролируемое исследование включены 144 больных в возрасте 60-85 лет, разделенных на группы, получавших лерканидипин в дозе 10 мг или плацебо в течение 4 нед. При недостаточной антигипертензивной эффективности исходную дозу лерканидипина увеличивали (вплоть до 30 мг один раз/день в течение 12 нед).  Результаты. Диастолическое артериальное давление (АД) под действием лерканидипина в дозе 10 мг снижалось в большей степени (-10,3 мм рт.ст.), чем под действием плацебо (-6,1 мм рт.ст.; p<0,05). Доля больных, положительно ответивших на прием лерканидипина, также была выше, чем при приеме плацебо (59,1% и 37,8 %, соответственно; p<0,05). При увеличении дозы препарата до 20 мг доля больных, положительно ответивших на лечение, возросла до 69,4%; увеличение дозы до 30 мг потребовалось лишь небольшому числу пациентов. Частота сердечных сокращений и лабораторные показатели на фоне лечения не менялись. Процент больных с побочными эффектами был одинаковым в обеих группах. Заключение. Прием лерканидипина один раз в день значительно снижает АД у пожилых пациентов с легкой и умеренной АГ . Эффект сохраняется в течение 24 ч и не сопровождается рефлекторной тахикардией. Препарат хорошо переносится и, учитывая его фармакологические и фармакодинамические особенности, может быть рекомендован, особенно пожилым пациентам

The artificial retina processor for track reconstruction at the LHC crossing rate

We present results of an R&D study for a specialized processor capable of precisely reconstructing, in pixel detectors, hundreds of charged-particle tracks from high-energy collisions at 40 MHz rate. We apply a highly parallel pattern-recognition algorithm, inspired by studies of the processing of visual images by the brain as it happens in nature, and describe in detail an efficient hardware implementation in high-speed, high-bandwidth FPGA devices. This is the first detailed demonstration of reconstruction of offline-quality tracks at 40 MHz and makes the device suitable for processing Large Hadron Collider events at the full crossing frequency.Comment: 4th draft of WIT proceedings modified according to JINST referee's comments. 10 pages, 6 figures, 2 table

Observation of J/ψpJ/\psi p resonances consistent with pentaquark states in Λb0→J/ψK−p{\Lambda_b^0\to J/\psi K^-p} decays

Observations of exotic structures in the $J/\psi p$ channel, that we refer to as pentaquark-charmonium states, in $\Lambda_b^0\to J/\psi K^- p$ decays are presented. The data sample corresponds to an integrated luminosity of 3/fb acquired with the LHCb detector from 7 and 8 TeV pp collisions. An amplitude analysis is performed on the three-body final-state that reproduces the two-body mass and angular distributions. To obtain a satisfactory fit of the structures seen in the $J/\psi p$ mass spectrum, it is necessary to include two Breit-Wigner amplitudes that each describe a resonant state. The significance of each of these resonances is more than 9 standard deviations. One has a mass of $4380\pm 8\pm 29$ MeV and a width of $205\pm 18\pm 86$ MeV, while the second is narrower, with a mass of $4449.8\pm 1.7\pm 2.5$ MeV and a width of $39\pm 5\pm 19$ MeV. The preferred $J^P$ assignments are of opposite parity, with one state having spin 3/2 and the other 5/2.Comment: 48 pages, 18 figures including the supplementary material, v2 after referee's comments, now 19 figure

Search for hidden-sector bosons in B0 ⁣→K∗0μ+μ−B^0 \!\to K^{*0}\mu^+\mu^- decays

A search is presented for hidden-sector bosons, $\chi$, produced in the decay ${B^0\!\to K^*(892)^0\chi}$, with $K^*(892)^0\!\to K^{+}\pi^{-}$ and $\chi\!\to\mu^+\mu^-$. The search is performed using $pp$-collision data corresponding to 3.0 fb$^{-1}$ collected with the LHCb detector. No significant signal is observed in the accessible mass range $214 \leq m({\chi}) \leq 4350$ MeV, and upper limits are placed on the branching fraction product $\mathcal{B}(B^0\!\to K^*(892)^0\chi)\times\mathcal{B}(\chi\!\to\mu^+\mu^-)$ as a function of the mass and lifetime of the $\chi$ boson. These limits are of the order of $10^{-9}$ for $\chi$ lifetimes less than 100 ps over most of the $m(\chi)$ range, and place the most stringent constraints to date on many theories that predict the existence of additional low-mass bosons.Comment: All figures and tables, along with supplementary material, are available at https://lhcbproject.web.cern.ch/lhcbproject/Publications/LHCbProjectPublic/LHCb-PAPER-2015-036.htm

Measurement of the branching fraction ratio B(Bc+→ψ(2S)π+)/B(Bc+→J/ψπ+)\mathcal{B}(B_c^+ \rightarrow \psi(2S)\pi^+)/\mathcal{B}(B_c^+ \rightarrow J/\psi \pi^+)

Using $pp$ collision data collected by LHCb at center-of-mass energies $\sqrt{s}$ = 7 TeV and 8 TeV, corresponding to an integrated luminosity of 3 fb$^{-1}$, the ratio of the branching fraction of the $B_c^+ \rightarrow \psi(2S)\pi^+$ decay relative to that of the $B_c^+ \rightarrow J/\psi\pi^+$ decay is measured to be 0.268 $\pm$ 0.032 (stat) $\pm$ 0.007 (syst) $\pm$ 0.006 (BF). The first uncertainty is statistical, the second is systematic, and the third is due to the uncertainties on the branching fractions of the $J/\psi \rightarrow \mu^+\mu^-$ and $\psi(2S) \rightarrow \mu^+\mu^-$ decays. This measurement is consistent with the previous LHCb result, and the statistical uncertainty is halved.Comment: 17 pages including author list, 2 figure

Study of B−→DK−π+π−B^{-}\to DK^-\pi^+\pi^- and B−→Dπ−π+π−B^-\to D\pi^-\pi^+\pi^- decays and determination of the CKM angle γ\gamma

We report a study of the suppressed $B^-\to DK^-\pi^+\pi^-$ and favored $B^-\to D\pi^-\pi^+\pi^-$ decays, where the neutral $D$ meson is detected through its decays to the $K^{\mp}\pi^{\pm}$ and CP-even $K^+K^-$ and $\pi^+\pi^-$ final states. The measurement is carried out using a proton-proton collision data sample collected by the LHCb experiment, corresponding to an integrated luminosity of 3.0~fb$^{-1}$. We observe the first significant signals in the CP-even final states of the $D$ meson for both the suppressed $B^-\to DK^-\pi^+\pi^-$ and favored $B^-\to D\pi^-\pi^+\pi^-$ modes, as well as in the doubly Cabibbo-suppressed $D\to K^+\pi^-$ final state of the $B^-\to D\pi^-\pi^+\pi^-$ decay. Evidence for the ADS suppressed decay $B^{-}\to DK^-\pi^+\pi^-$, with $D\to K^+\pi^-$, is also presented. From the observed yields in the $B^-\to DK^-\pi^+\pi^-$, $B^-\to D\pi^-\pi^+\pi^-$ and their charge conjugate decay modes, we measure the value of the weak phase to be $\gamma=(74^{+20}_{-19})^{\rm o}$. This is one of the most precise single-measurement determinations of $\gamma$ to date.Comment: 22 pages, 9 figures; All figures and tables, along with any supplementary material and additional information, are available at https://lhcbproject.web.cern.ch/lhcbproject/Publications/LHCbProjectPublic/LHCb-PAPER-2015-020.htm

Study of WW boson production in association with beauty and charm

The associated production of a $W$ boson with a jet originating from either a light parton or heavy-flavor quark is studied in the forward region using proton-proton collisions. The analysis uses data corresponding to integrated luminosities of 1.0 and $2.0\,{\rm fb}^{-1}$ collected with the LHCb detector at center-of-mass energies of 7 and 8 TeV, respectively. The $W$ bosons are reconstructed using the $W\to\mu\nu$ decay and muons with a transverse momentum, $p_{\rm T}$, larger than 20 GeV in the pseudorapidity range $2.0 20$ GeV and $2.2 < \eta < 4.2$. The sum of the muon and jet momenta must satisfy $p_{\rm T} > 20$ GeV. The fraction of $W+$jet events that originate from beauty and charm quarks is measured, along with the charge asymmetries of the $W\!+\!b$ and $W\!+\!c$ production cross-sections. The ratio of the $W+$jet to $Z+$jet production cross-sections is also measured using the $Z\to\mu\mu$ decay. All results are in agreement with Standard Model predictions

Amplitude analysis of B0→Dˉ0K+π−B^0 \rightarrow \bar{D}^0 K^+ \pi^- decays

The Dalitz plot distribution of $B^0 \rightarrow \bar{D}^0 K^+ \pi^-$ decays is studied using a data sample corresponding to $3.0\rm{fb}^{-1}$ of $pp$ collision data recorded by the LHCb experiment during 2011 and 2012. The data are described by an amplitude model that contains contributions from intermediate $K^*(892)^0$, $K^*(1410)^0$, $K^*_2(1430)^0$ and $D^*_2(2460)^-$ resonances. The model also contains components to describe broad structures, including the $K^*_0(1430)^0$ and $D^*_0(2400)^-$ resonances, in the $K\pi$ S-wave and the $D\pi$ S- and P-waves. The masses and widths of the $D^*_0(2400)^-$ and $D^*_2(2460)^-$ resonances are measured, as are the complex amplitudes and fit fractions for all components included in the amplitude model. The model obtained will be an integral part of a future determination of the angle $\gamma$ of the CKM quark mixing matrix using $B^0 \rightarrow D K^+ \pi^-$ decays.Comment: 33 pages, 12 figures; updated for publicatio

Measurement of the ratio of branching fractions B(B‾0→D∗+τ−ν‾τ)/B(B‾0→D∗+μ−ν‾μ)\mathcal{B}(\overline{B}^0 \to D^{*+}\tau^{-}\overline{\nu}_{\tau})/\mathcal{B}(\overline{B}^0 \to D^{*+}\mu^{-}\overline{\nu}_{\mu})

The branching fraction ratio $\mathcal{R}(D^{*}) \equiv \mathcal{B}(\overline{B}^0 \to D^{*+}\tau^{-}\overline{\nu}_{\tau})/\mathcal{B}(\overline{B}^0 \to D^{*+}\mu^{-}\overline{\nu}_{\mu})$ is measured using a sample of proton-proton collision data corresponding to 3.0\invfb of integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The tau lepton is identified in the decay mode $\tau^{-} \to \mu^{-}\overline{\nu}_{\mu}\nu_{\tau}$. The semitauonic decay is sensitive to contributions from non-Standard-Model particles that preferentially couple to the third generation of fermions, in particular Higgs-like charged scalars. A multidimensional fit to kinematic distributions of the candidate $\overline{B}^0$ decays gives $\mathcal{R}(D^{*}) = 0.336 \pm 0.027(stat) \pm 0.030 (syst)$. This result, which is the first measurement of this quantity at a hadron collider, is $2.1$ standard deviations larger than the value expected from lepton universality in the Standard Model.Comment: 17 pages, 1 figure. v2 after referees' comment