332 research outputs found
Characterization of seed nuclei in glucagon aggregation using light scattering methods and field-flow fractionation
- Publication venue
- BioMed Central
- Publication date
- 01/01/2008
- Field of study
<p>Abstract</p> <p>Background</p> <p>Glucagon is a peptide hormone with many uses as a therapeutic agent, including the emergency treatment of hypoglycemia. Physical instability of glucagon in solution leads to problems with the manufacture, formulation, and delivery of this pharmaceutical product. Glucagon has been shown to aggregate and form fibrils and gels <it>in vitro</it>. Small oligomeric precursors serve to initiate and nucleate the aggregation process. In this study, these initial aggregates, or seed nuclei, are characterized in bulk solution using light scattering methods and field-flow fractionation.</p> <p>Results</p> <p>High molecular weight aggregates of glucagon were detected in otherwise monomeric solutions using light scattering techniques. These aggregates were detected upon initial mixing of glucagon powder in dilute HCl and NaOH. In the pharmaceutically relevant case of acidic glucagon, the removal of aggregates by filtration significantly slowed the aggregation process. Field-flow fractionation was used to separate aggregates from monomeric glucagon and determine relative mass. The molar mass of the large aggregates was shown to grow appreciably over time as the glucagon solutions gelled.</p> <p>Conclusion</p> <p>The results of this study indicate that initial glucagon solutions are predominantly monomeric, but contain small quantities of large aggregates. These results suggest that the initial aggregates are seed nuclei, or intermediates which catalyze the aggregation process, even at low concentrations.</p
26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3 - Meeting Abstracts - Antwerp, Belgium. 15–20 July 2017
- Author
- Abeysuriya Romesh
- Abrams Mathew
- Aceves Ivan
- Adams Roderick
- Aerts H.
- Aerts Hannelore
- Albada Sacha J
- Albert Stefan
- Almasi Ali
- Almeida Lírio O B
- Almgren Hannes
- Amado María
- Amaducci Rodrigo
- Amakhin Dmitry V
- Amico E.
- Amin Hayder
- Angelini L.
- Angelo Egidio
- Antonel Stefano M
- Antonietti Alberto
- Arleo Angelo
- Arroyo David
- Ash Ryan
- Ashwin Peter
- Asl Mojtaba M
- Assadzadeh Sahand
- Atanasova Krasimira
- Aton Sara
- Aton Sara J
- Azab Habiba
- Bahmer Andreas
- Bakker Rembrandt
- Balasubramani Pragathi P
- Barnett William
- Barranca Victor J
- Bassez I.
- Başerdem Batuhan
- Bensmail Chama
- Berdondini Luca
- Bernal Salvador
- Bertolotti Elena
- Blackman Rachael K
- Blackwel Kim T
- Bologna Luca L
- Bologna Luca L
- Booth Victoria
- Boothe David L
- Bote Rubén
- Bratby Peter
- Brazhe Alexey R
- Brown Jonathan T
- Bruning Wesley
- Buckley Christopher L
- Budak Maral
- Burioni Raffaella
- Burwick Thomas
- Buzsáki György
- Bytschok Ilja
- Canals Santiago
- Capone Cristiano
- Capps Robert
- Carnevale Ted
- Carpaneto Jacopo
- Carr Catherine E
- Casalegno Francesco
- Casellato Claudia
- Cash Sydney S
- Castro Samy
- Ceballos César C
- Cervera Alberto
- Chafee Matthew V
- Chakravarthy Srinivasa V
- Changoluisa Vinicio
- Chatzikalymniou Alexandra P
- Chen Weiliang
- Chiang Ann-Shyn
- Chizhov Anton V
- Choi Ilhwan
- Chow Carson
- Ciba Manuel
- Clascá Francisco
- Cloherty Shaun L
- Coca Daniel
- Cohen Ben
- Cohen Netta
- Colet Núria
- Cordeiro Vinícius L
- Cortés J.
- Cossart Rosa
- Courcol Jean-Denis
- Creaser Jennifer L
- Crotty Patrick
- Curtu Rodica
- Darrow David P
- Daun Silvia
- Daun Silvia
- Dauwels Justin
- Davey Neil
- Delalondre Fabien
- Dendek Elżbieta
- Denham Jack
- Deredy Wael
- Destexhe Alain
- Devalle Federico
- Devresse Adrien
- Dibenedetto Domenica
- Diesmann Markus
- DiGregorio David
- Dimitrov Alexander G
- Dlotko Pawel
- Dold Dominik
- Dragoi Valentin
- Dubreuil Alexis M
- Duvarci Sevil
- Elibol Rahmi
- Elices Irene
- Endle Heiko
- Erö Csaba
- Espinal Andres
- Evangelio Marian
- Faes L.
- Faes Luca
- Falck Joanne
- Fan Wei
- Fauth Michael
- Felix Richard A
- Felton Melvin A
- Fenichel Allison L
- Fernandez Mariano
- Figueroa Marco A
- Fink Gereon R
- Florescu Dorian
- Floriano Bruno
- Forlim Caroline G
- Forlim Caroline G
- Franaszczuk Piotr J
- Franchina Francesco
- Gallimore Andrew R
- Garcia David
- Geit Werner
- Gernier Robin
- Gewaltig Marc-Oliver
- Gheorghiu Medorian D
- Gillespie Tom
- Giugliano Michele
- Glasauer Stefan
- Gleeson Padraig
- Goldsworthy Mitchell R
- Goncharenko Julia
- Gonzalez Horacio
- Goodarzinick Abdorreza
- Goodliffe Joseph
- Goodman Dan F M
- Grado Logan L
- Grayden David B
- Grefkes Christian
- Grethe Jeffrey S
- Gärtner Matthias
- Günay Cengiz
- Hadida Jonathan
- Haelterman Marc
- Haimerl Caroline
- Hayden Benjamin Y
- Hepburn Iain
- Herpich Juliane
- Hertäg Loreen
- Hess Kathryn
- Higgins David
- Hilgetag Claus C
- Hoebeek Freek
- Hordacre Brenton
- Hoskovcová Martina
- Huang Yu-Chi
- Huerta Ramon
- Huguet Gemma
- Iannella Nicolangelo
- Ibbotson Michael R
- Iyer Ramakrisnan
- Janjić Predrag
- Jbabdi Saad
- Jeong Jaeseung
- Ji Zilong
- Jin Jing
- Johnson Matthew D
- Jordan Henry O C
- Jorntell Henrik
- Kabbani Nadine
- Kamiji Nilton L
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- Kapoor Reena
- Karimian Maryam
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- Kirizs Tekla
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- Kleberg Florence I
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- Kozlovskiy Stanislav A
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- Kuebler Eric S
- Kuokkanen Paula T
- Káli Szabolcs
- Lamperski Andrew
- Lange Sigrun
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- Laureys S.
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- Levi Rafael
- Levi Ran
- Li Tianyi
- Lin Congping
- Liu Liqing
- Liu Xiao
- Lo Chung-Chuan
- Lonardoni Davide
- Lorusso Letizia
- Luboeinski Jannik
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- Lupascu Carmen A
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- Marinazzo D.
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- Markram Henry
- Marre Olivier
- Marsat Gary
- Martinoia Sergio
- Martone Maryann
- Marttunen Tuomo
- Maruyama Daniel
- Masoli Stefano
- Massar Serge
- Massobrio Paolo
- Maszczyk Tomasz
- Matsuo Toshihiko
- Mattia Maurizio
- Mavritsaki Eirini
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- Mazzoni Alberto
- McClintock Peter V E
- McColgan Thomas
- McDonnell Mark D
- McDougal Robert A
- Meffin Hamish
- Meier Karlheinz
- Mejias Jorge F
- Mellor Jack R
- Menzat Bayar
- Mercer Audrey
- Metzner Christoph
- Micera Silvestro
- Migliore Michele
- Migliore Rosanna
- Mihalas Stefan
- Mimica Bartul
- Mirasso Claudio R
- Mochol Gabriela
- Moerel Michelle
- Moezzi Bahar
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- Molino Luis C G
- Molkov Yaroslav
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- Montbrió Ernest
- Montero Aaron
- Mosqueiro Thiago
- Muddapu Vignayanandam R
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- Nagaraj Vivek
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- Naumann Laura B
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- Netoff Theoden I
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- Newton Adam J H
- Neymotin Samuel A
- Nguyen Anh
- Nielsen Benjamin
- Nieus Thierry
- Nold Andreas
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- Nusser Zoltan
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- Oddo Calogero M
- Ofer Netanel
- Ognjanovski Nicolette
- Oie Kelvin S
- Orio Patricio
- Ortiz Carlos L
- Ovcharenko Aleksandr
- Palmerduca Eric
- Panuccio Gabriella
- Papoutsi Athanasia
- Park Jiyoung
- Park Sol
- Parziale Antonio
- Pasquale Valentina
- Pastore Vito P
- Pazó Diego
- Pedrocchi Alessandra
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- Pereda Ernesto
- Pereira Fernando
- Petrovici Mihai A
- Pfister Jean-Pascal
- Pinto Reynaldo D
- Plogmacher Lukas
- Poirazi Panayiota
- Pollonini Luca
- Popovych Svitlana
- Portfors Christine
- Postnov Dmitry E
- Prince Luke Y
- Prinz Astrid A
- Priori Alberto
- Psarrou Maria
- Puhlmann Steffen
- Rabinovich Mikhail I
- Ragognetti Gianmarco
- Ranner Thomas
- Razi Adeel
- Rebola Nelson
- Remme Michiel
- Rentzelas Panos
- Reva Maria
- Rich Scott
- Richmond Paul
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- Ridler Thomas
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- Roeper Jochen
- Romani Armando
- Romito Luigi M
- Rongala Udaya B
- Roque Antonio C
- Rosa Manuela
- Rosay Sophie
- Rosenthal Joshua J C
- Rosjat Nils
- Rossum Mark
- Rössert Christian
- Růžička Evžen
- Sadeh Sadra
- Safaryan Karen
- Saha Susmita
- Salmasi Mehrdad
- Sandström Malin
- Saray Sára
- Schaworonkow Natalie
- Schemmel Johannes
- Schilstra Maria
- Schmack Katharina
- Schmidt Maximilian
- Schmuker Michael
- Schneider Gaby
- Schreiber Susanne
- Schultz Kelsey
- Schutter Erik
- Schweikard Achim
- Schürmann Felix
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- Seara Tere
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- Seifert Gerald
- Senatore Rosa
- Sengor Neslihan S
- Shaju Nikhita
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- Shen Hui-An
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- Shillcock Julian
- Shimono Masanori
- Shin Hee-sup
- Shuvaev Sergey A
- Silver R.
- Sinha Ankur
- Sinha Nishant
- Sivagnanam Subhashini
- Skiker Kaoutar
- Skilling Quinton M
- Skinner Frances K
- Smirnakis Stelios
- Smirnova Elena Y
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- Spalla Davide
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- Stankovski Tomislav
- Steen Frederik
- Stefanovska Aneta
- Steinhäuser Christian
- Stemmler Martin
- Stepanyants Armen
- Steuber Volker
- Stimberg Marcel
- Stramaglia S.
- Stramaglia S.
- Stramaglia Sebastiano
- Stringer Simon M
- Suffczyński Piotr
- Surace Simone C
- Suter Benjamin A
- Szmek Joanna
- Sánchez Manuel
- Tam Nicoladie
- Tang Rongxiang
- Tang Yi-Yuan
- Tang Yi-Yuan
- Tass Peter A
- Tauskela Joseph S
- Tchumatchenko Tatjana
- Teleńczuk Bartosz
- Teleńczuk Maria
- Tetzlaff Christian
- Thielemann Christiane
- Thivierge Jean-Philippe
- Thomas John
- Thomson Alex
- Ticcinelli Valentina
- Tiesinga Paul
- Todorov Dmitrii
- Tomkins Adam
- Torcini Alessandro
- Toth Tibor I
- Toyoizumi Taro
- Treves Alessandro
- Triesch Jochen
- Trujillo Abraham
- Tóth Tibor I
- Uchida Tetsuya
- Ukani Nikul H
- Ulmanová Olga
- Uludağ Kâmil
- Valizadeh Alireza
- Varona Pablo
- Varona Pablo
- Vartanov Alexander V
- Vattikuti Shashaank
- Verisokin Andrey Y
- Verveyko Darya V
- Vezzani Alessandro
- Viggiano Andrea
- Vives Maria V
- Vogels Tim P
- Vogt Johannes
- Volo Matteo
- Wagatsuma Nobuhiko
- Wagner John
- Wang Bin A
- Wang Xiao
- Wang Xiao-Jing
- Watson Brendon O
- Weaver Christina M
- Weber Simon N
- Weber Simon N
- Weerd Peter
- Westover M.
- Westra Ronald L
- Withlock Jonathan
- Wong Willy
- Wong Yan T
- Woolrich Mark
- Wrobel Borys
- Wu Jiaxing
- Wu Si
- Wu Si
- Xia Yan
- Xu Kesheng
- Yaari Gur
- Yang Guangyu R
- Yeh Chung-Heng
- Yger Pierre
- Yoshimoto Kenneth
- Yu Alfred B
- Zador Anthony
- Zaitsev Aleksey V
- Zaleshin Alexander
- Zaleshina Margarita
- Zamora Criseida
- Zang Yunliang
- Zapotocky Martin
- Zeeuw Chris
- Zhang Chi
- Zhang Danke
- Zhang Mingsha
- Zhou Xiaolong
- Zhou Yiyin
- Zhu George
- Zick Jennifer L
- Zochowski Michal
- Zouridakis George
- Zurowski Bartosz
- Çelikok Sami U
- Özdemir Mustafa Y
- Şengör Neslihan S
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
This work was produced as part of the activities of FAPESP Research,\ud
Disseminations and Innovation Center for Neuromathematics (grant\ud
2013/07699-0, S. Paulo Research Foundation). NLK is supported by a\ud
FAPESP postdoctoral fellowship (grant 2016/03855-5). ACR is partially\ud
supported by a CNPq fellowship (grant 306251/2014-0)
Monomer and aggregates have been separated by asymmetric flow FFF in the unfiltered sample
- Publication venue
- Publication date
- Field of study
Aggregates have been removed from the solution in the filtered sample.<p><b>Copyright information:</b></p><p>Taken from "Characterization of seed nuclei in glucagon aggregation using light scattering methods and field-flow fractionation"</p><p>http://www.jbioleng.org/content/2/1/10</p><p>Journal of Biological Engineering 2008;2():10-10.</p><p>Published online 9 Jul 2008</p><p>PMCID:PMC2483260.</p><p></p
Separation of protein standards by FFF/MALS showing 90 degree light scattering signal vs
- Publication venue
- Publication date
- Field of study
elution time.<p><b>Copyright information:</b></p><p>Taken from "Characterization of seed nuclei in glucagon aggregation using light scattering methods and field-flow fractionation"</p><p>http://www.jbioleng.org/content/2/1/10</p><p>Journal of Biological Engineering 2008;2():10-10.</p><p>Published online 9 Jul 2008</p><p>PMCID:PMC2483260.</p><p></p
Lessons from learner experiences in a field-based inquiry in geography using mobile devices
- Author
- Aixin Sun
- Baluja S.
- Bergin D. A.
- Buchana G.
- Buchanan G.
- Chadwick-Dias A.
- Chang C. H.
- Chang C. H.
- Chang C. H.
- Chatterjea K.
- Chew-Hung Chang
- Danesh A.
- Dillenbourg P.
- Dion Hoe-Lian Goh
- Dunphy A.
- Ee-Peng Lim
- Gerber R.
- Haapala O.
- Kalyani Chatterjea
- Keijzers J.
- Kent M.
- Khasfariyati Razikin
- Kim T. N.
- Krauss S.
- Lai K.
- Laws K.
- Lee S. H.
- Lida B.
- Lim E. P.
- Nielsen J.
- Patten B.
- Quang Minh Nguyen
- Razikin K.
- Razikin K.
- Roberts M.
- Roschelle J.
- Sharples M.
- Theng Y. L.
- Thi Nhu Quynh Kim
- Wong D.
- Yatani K.
- Yin Leng Theng
- Zurita G.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons
- Author
- A Ghosh
- A Ghosh
- A Igoe
- A Kauffmann
- A Le Campion
- A Rasmussen
- A Szymula
- A. Darise Farris
- AA Shabalin
- Adam J. Adler
- AE Wiedeman
- AG Hovanessian
- AJ Saldanha
- AL Price
- Andrew J. W. Huang
- Astrid Rasmussen
- B Kabakchiev
- B Segal
- Barbara M. Segal
- BD Poole
- BJ Barnes
- BN Howie
- Bo He
- BP Fairfax
- C Lien
- C Miceli-Richard
- C Miceli-Richard
- C Trapnell
- C Trapnell
- C Vitali
- CG Helmick
- Christopher J. Lessard
- CJ Lessard
- CJ Lessard
- CJ Willer
- Contessa E. Edgar
- Corinne Miceli-Richard
- Courtney G. Montgomery
- CP Mavragani
- Daniel J. Wallace
- David M. Lewis
- Deborah S. Cunninghame Graham
- Donald U. Stone
- E Lalonde
- E Theander
- E Theander
- E Toker
- E Zintzaras
- EA Stahl
- EC Baechler
- Erna Harboe
- ES Emamian
- Evan S. Vista
- F Hormozdiari
- G Hernandez-Molina
- G Nocturne
- G Nordmark
- Glen D. Houston
- Gosia Trynka
- Gunnel Nordmark
- H Li
- H Schulze-Koops
- H Thorvaldsdottir
- H-J Westra
- He Li
- HG Raterman
- I Halder
- IB Rogozin
- Ilias Alevizos
- Indra Adrianto
- J Justesen
- J Wang
- James Chodosh
- JB Harley
- JC Barrett
- JE Gottenberg
- Jennifer A. Kelly
- JK Lim
- JK Pickrell
- Joel M. Guthridge
- Johan G. Brun
- John A. Ice
- John B. Harley
- Juan-Manuel Anaya
- Judith A. James
- JW Bauer
- KA Frazer
- Kathy L. Sivils
- KB Nguyen
- Kenneth M. Kaufman
- Ketan Patel
- KH Kjaer
- Kiely M. Grundahl
- Kimberly S. Hefner
- L Ronnblom
- L Ronnblom
- LA Hindorff
- Lars Rönnblom
- Lasse G. Gøransson
- LB Ivashkiv
- LG van Baarsen
- Lida Radfar
- LJ Albert
- LL Field
- M Ding
- M Imran
- M Kamachi
- M O'Brien
- M Via
- M Voulgarelis
- Maija-Leena Eloranta
- Marie Wahren-Herlenius
- Marika Kvarnström
- Maureen Rischmueller
- Michael D. Rohrer
- Michael H. Weisman
- Michael T. Brennan
- MJ de Hoon
- MK Crow
- ML Weller
- N Zhang
- NC Kyriakidis
- Nelson L. Rhodus
- NG Bader El Din
- NL Barbosa-Morais
- O Stegle
- P Perez
- P Youinou
- Pamela J. Hughes
- Patrick M. Gaffney
- PB Mullan
- Per Eriksson
- PM McKeigue
- R Cagliani
- R. Hal Scofield
- RA Irizarry
- Rajaram Gopalakrishnan
- RB Cattell
- RH Silverman
- RI Fox
- RI Fox
- RM Gupta
- Roald Omdal
- Roland Jonsson
- S Anders
- S Noguchi
- S Purcell
- Sean Turner
- SG Pasoto
- Shaofeng Wang
- Simon Bowman
- SN Jauharoh
- SS Cho
- Stuart B. Glenn
- Sue Lester
- Susan Kovats
- Swamy Venuturupalli
- T Hung
- T Lovgren
- T Paisansinsup
- TC van der Pouw Kraan
- Timothy J. Vyse
- TO Hjelmervik
- Torsten Witte
- Tove Ragna Reksten
- TR Reksten
- U Bave
- V Bonnevie-Nielsen
- VA Lawless
- Wan-Fai Ng
- WE Johnson
- WJ Kent
- Xavier Mariette
- Y Kim
- Y Li
- Y Zhao
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2017
- Field of study
Sjogren's syndrome (SS) is a common, autoimmune exocrinopathy distinguished by keratoconjunctivitis sicca and xerostomia. Patients frequently develop serious complications including lymphoma, pulmonary dysfunction, neuropathy, vasculitis, and debilitating fatigue. Dysregulation of type I interferon (IFN) pathway is a prominent feature of SS and is correlated with increased autoantibody titers and disease severity. To identify genetic determinants of IFN pathway dysregulation in SS, we performed cis-expression quantitative trait locus (eQTL) analyses focusing on differentially expressed type I IFN-inducible transcripts identified through a transcriptome profiling study. Multiple cis-eQTLs were associated with transcript levels of 2'-5'-oligoadenylate synthetase 1 (OAS1) peaking at rs10774671 (PeQTL = 6.05 x 10(-14)). Association of rs10774671 with SS susceptibility was identified and confirmed through meta-analysis of two independent cohorts (P-meta = 2.59 x 10(-9); odds ratio = 0.75; 95% confidence interval = 0.66-0.86). The risk allele of rs10774671 shifts splicing of OAS1 from production of the p46 isoform to multiple alternative transcripts, including p42, p48, and p44. We found that the isoforms were differentially expressed within each genotype in controls and patients with and without autoantibodies. Furthermore, our results showed that the three alternatively spliced isoforms lacked translational response to type I IFN stimulation. The p48 and p44 isoforms also had impaired protein expression governed by the 3' end of the transcripts. The SS risk allele of rs10774671 has been shown by others to be associated with reduced OAS1 enzymatic activity and ability to clear viral infections, as well as reduced responsiveness to IFN treatment. Our results establish OAS1 as a risk locus for SS and support a potential role for defective viral clearance due to altered IFN response as a genetic pathophysiological basis of this complex autoimmune disease
Postulated intermediates and activated complexes in the permanganate ion oxidation of organic compounds
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- A. Bartecki
- A. Berka
- A. Carrington
- A. Poplavskaya
- A. Zanoboni
- A.A. Eddy
- A.M. Unrau
- A.P. Tulloch
- A.R.S. Kartha
- A.S. Jones
- B. Jzowska-Trzebiatowska
- B.H. Jennings
- B.H. Jennings
- B.J. Armitage
- C.D. Hurd
- C.D. Hurd
- C.J. Ballhausen
- C.J. Ballhausen
- C.J. Pedersen
- C.M. Starks
- D. Dimitrov
- D. Hopwood
- D. Vorländer
- D.D. Misra
- D.G. Lambert
- D.G. Lee
- D.G. Lee
- D.H. Rosenblatt
- D.J. Sam
- D.K. Vitorovic
- E. Klein
- E. Rudloff von
- E. Rudloff von
- E. Rudloff von
- E. Rudloff von
- E. Rudloff von
- E.M. Liliu
- E.S. Lewis
- F. Freeman
- F. Freeman
- F. Freeman
- F. Freeman
- F. Freeman
- F. Freeman
- F.E. Raurich Sas
- F.R. Duke
- Fillmore Freeman
- G. Grimmer
- G. Speroni
- G. Wagner
- G. Werner
- G.C. Buzby
- G.V. Bakore
- G.V. Bakore
- G.V. Bakore
- G.V. Bakore
- G.V. Bakore
- G.W. Hedrick
- H. Aebi
- H. Hayatsu
- H. Kwart
- H. Lux
- H. Selye
- H. Shechter
- H. Shechter
- H. Shecter
- H. Wachter
- H.Z. Sable
- J. Banerjee
- J. Böseken
- J. Böseken
- J. Cadet
- J. Halpern
- J. L. Kurz
- J. Lenard
- J. Roček
- J. Veprěk-Šiśka
- J. Veprěk-Šiśka
- J. Veprěk-Šiška
- J.A. MacPhee
- J.E. Coleman
- J.I. Brauman
- J.J. Christensen
- J.L. Warnell
- J.S. Littler
- J.S. Swinehart
- J.W. ApSimon
- J.W. Ladbury
- K. Fukui
- K.A. Powell
- K.B. Sharpless
- K.B. Wiberg
- K.B. Wiberg
- K.B. Wiberg
- K.B. Wiberg
- K.B. Wiberg
- K.B. Wiberg
- K.B. Wiberg
- K.B. Wiberg
- K.B. Yatsimirski
- K.H. Heckner
- K.H. Heckner
- K.H. Heckner
- K.H. Heckner
- K.K. Banerji
- K.K. Banerji
- K.K. Banerji
- K.K. Banerji
- K.K. Banerji
- K.K. Banerji
- L. Erdey
- L. Erdey
- L. Galzigna
- L.D. Petriashvilli
- L.E. Kolukanov
- L.H. Izurieta
- L.I. Simandi
- L.T. Bugaenko
- M. Fukujama
- M. Hedayatullah
- M. Jáky
- M. Sono
- M. Yano
- M.A. Sherova
- M.M. Wei
- N. Kornblum
- N.A. Gibson
- N.A. Khan
- Nguyen-Dinh-Nguyen
- O.Z. Tatic-Janjic
- P. Belluscio
- P. Day
- P. Nath
- P. Nath
- P. Nath
- P. Nath
- P. Nath
- P.C. Mathur
- P.G. Sant
- P.V.S. Rao
- P.W.K. Flanagan
- R. Huisgen
- R. Huisgen
- R. Scholder
- R. Stewart
- R. Stewart
- R. Stewart
- R. Stewart
- R. Stewart
- R.F. Bridger
- R.F. Bridger
- R.H. Eastman
- R.H. Hackman
- R.S. Goody
- R.U. Lemieux
- R.V. Escobar
- S. Iida
- S. Lida
- S. Senet-Perez
- S.E. Kharin
- S.E. Kharin
- S.E. Kharin
- S.M. Taylor
- S.S. Rawalay
- T. Hake
- T. Suga
- T.A. Turney
- V.B. Avilor
- V.B. Khanna
- V.I. Nikitin
- V.L. Loeblich
- W. A. Hadler
- W. Klemm
- W.A. Waters
- W.J. Plieth
- W.N. Krestinsky
- Y. Hirasaka
- Y. Kondo
- Y.K. Gupta
- Y.K. Gupta
- Y.T. Lin
- Z. Ambroz
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Long-term safety and efficacy of patisiran for hereditary transthyretin-mediated amyloidosis with polyneuropathy: 12-month results of an open-label extension study
- Author
- Abu-Manneh Rana
- Adams David
- Agathangelou Petros
- Ajroud-Driss Senda Ajroud-Driss
- Al-Salameh Abdallah
- Aldinc Emre
- Algalarrondo Vincent
- Allen Adriane C.
- Altinkurt Emre
- Alves Cristina
- Anan Intissar
- Ando Rina
- Arrouasse Raphaele
- Attarian Shahram
- aus dem Siepen Fabian
- Ayache Samar S.
- Balaya-Gouraya Line
- Barroso Fabio
- Baskin Amber
- Bauer Ralf
- Beaudonnet Guillemette
- Becquemont Laurent
- Berber Erhan
- Berk John L.
- Bernardo Daniela
- Berthelot Emeline
- Bisogni Giulia
- Blasco Pelicano Josep Miquel
- Blume Brianna
- Borrachero Cristina
- Boubrit Yasmine
- Bournane Halima
- Boyer Leslie
- Brannagan III Thomas H.
- Brice Sylvie
- Brueckner Caitlin
- Bulthuis-Kuiper Janita
- Burks Kathleen L.
- Cakar Arman
- Campana-Salort Emmanuelle
- Campistol Josep M.
- Cantú Brito Carlos Gerardo
- Cardoso Berensztejn Amanda
- Cardoso Marcio
- Carrillo Esmeralda
- Casey Patricia
- Castro Isabel
- Castro Jose
- Cauquil-Michon Cécile
- Chacko Liza
- Chahine Ilonah
- Chamova Teodora
- Chan Soo Looi
- Chao Chi-Chao
- Charlin Cyril
- Chaudhry Vinay
- Cherneva Zheyna
- Cherninkova-Gopina Sylvia
- Cho Eun Bin
- Choi Kyomin
- Choumert Ariane
- Chu Hanh
- Cioroiu Comana
- Cisneros Barroso Eugenia
- Coelho Teresa
- Cohen Oliver
- Conceição Isabel M.
- Correia Nuno
- Cortese Andrea
- Coskun Derya J.
- Criollo Mora Elia
- Cárdenas-Soto Karla
- Daccach Marques Vanessa
- Dalia Samir
- Dalton James
- Dang Lien
- de Azevedo Coutinho Conceição
- del Mar Saniger Alba Maria
- Delmont Emilien
- DeLong Douglas
- Deplanque Dominique
- Descals Cristina
- Di Paolantonio Andrea
- Diallo Saran
- Dias da Silva Moises
- Dimberg Elliot
- Dingli David
- Dioso Holly
- Dispenzieri Angela
- Dixon Stacy
- Do Thi Hoa (Therese)
- Durmus Hacer
- Dyck Peter
- Dávila Lucía Galán
- Echaniz-Laguna Andoni
- Ehinger Vincent
- Elabed Mongia
- Eliahou Ludivine
- Elitok Ali
- Elrezzi Elise
- Endo Hironobu
- Ernande Laura
- Falcao de Campos Catarina
- Falk Malin
- Fayerman Raisy
- Ferreira Natalia
- Figuerola Antoni
- Florence Julaine
- Focseneanu Cecile
- Fonder Amie
- Franco Ana
- Freimer Miriam
- Freitas Monica
- Frenzel Lukas F.
- Friebel Frauke
- Fujita Akemi
- Fukase Emi
- Gamez Martinez Jose M
- Gaouar Amina
- García Feijoo Julián
- Gauvain Clement
- Gendre Thierry
- Gentile Luca
- Gerk Olga
- Gertz Morie A.
- Gervais de Santa Rosa Renata
- Giang Lien
- Giardino Elena
- Gillmore Julian D.
- Gilmore Catherine
- Go Ronald
- Goh Khean Jin
- Gonsalves Wilson
- Gonzalez Leidy J.
- González Moreno Juan
- González-Duarte Alejandra
- Gorevic Peter
- Gragera Martínez Álvaro
- Grapperon Aude-Marie
- Green Sinikka
- Guerrero Sola Antonio
- Guglielmino Valeria
- Guimaraes Nadia
- Hachulla Eric
- Hamaguchi Hirotoshi
- Harada Masaya
- Hayman Suzanne R.
- Hein Selina
- Heintzman Sarah
- Hernandez Reyes Jose Pablo
- Hineno Akiyo
- Hipólito Reis Antonio
- Hobbs Miriam
- Hokezu Youichi
- Holtick Udo
- Horga Alejandro
- Hosokawa Yuko
- Hrkman Nicole
- Hsieh Sung-Tsang
- Huesing-Kabar Anna
- Hwa Lisa
- Imai Akira
- Inamo Jocelyn
- Itoya Amenze
- Jack Kristin
- Jarrett Raquel
- Jehan Lacour Nathalie
- Jeon Eun-Seok
- Jiménez López Brenda Poled
- Jose Vega Francisco
- Joslin Benjamin C.
- Jozefowicz Elsa
- Judge Daniel P.
- Kabar Iyad
- Kapoor Prashant
- Karamursel Sacit
- Kasprzyk Emmanuelle
- Katanazaka Kimitaka
- Kato Nagaaki
- Kenepp Amanda
- Khoshnoodi Mohammad
- Kim Arreum
- Kim Byoung-Joon
- Kim Hee Jin
- Kim JuHyeon
- Kishida Dai
- Kleinschmidt Natalia
- Kleyman Inna
- Kodaira Minori
- Koto Shusuke
- Koujin Yoko
- Kraus Deborah
- Kristen Arnt V.
- Kumar Shaji K.
- Kuzume Daisuke
- Kyriakides Theodoros
- Labeyrie Celine
- Lachmann Helen J.
- Lahme Larissa
- Lamas Filipa
- Lambrianides Sakis
- Lautre Andrea
- Law Steven
- Lazzari Victoria
- Le Corvoisier Philippe
- Le An
- Lebellec Loic
- Lecoq Anne-Lise
- Lee Ga Yeon
- Lee Hye Lim
- Lee Kia
- Lee Ming-Jen
- Lee Yi-Chung
- Leonidou Eleni
- Leung Nelson
- Li Steve
- Lim He Eng Li
- Lin Kon-Ping
- Lin Yi
- Lindqvist Per
- Litcanov Debora Cristina
- Liu Qingfeng
- Lopate Glenn
- Lopes Ana
- LoRusso Samantha
- Losada López Inés Asunción
- Low Soon Chai
- Lozza Alessandro
- Luigetti Marco
- Lust John A
- Marques Coutinho Barbara
- Marques Júnior Wilson
- Martin Nathalie
- Martinez-Naharro Ana
- Martins da Silva Ana
- Mason Garnette
- Masuda Teruaki
- Matsumoto Kazuhiko
- Mauricio Elizabeth A.
- May John
- Mazzeo Anna
- Megelin Thomas
- Meguig Sayah
- Mekhael Linda
- Meng Ulrike
- Merlini Giampaolo
- Meyle Eva
- Meyrath David
- Mezei Michelle M.
- Migaud-Chervy Maria-Claire
- Mihailovic Natasa
- Miller Sarah
- Min Ju-Hong
- Misumi Yohei
- Miyahara Teruyoshi
- Miyazawa Chinatsu
- Montala Carles
- Monte Julia R.
- Moreira Carolina Lavigne
- Morino Hiroyuki
- Moritaka Taiga
- Moscardini Mariana
- Munoz Beamud Francisco
- Nagai Masahiro
- Nakahara Keiichi
- Nakano Takahiro
- Neshige Shuichiro
- Neves Carlos
- Nezu Tomohisa
- Nguyen David
- Nguyen Tyler
- Nienhuis Hans
- Noe-Schwenn Simone
- Nordh Erik
- Not Adeline
- O'Riordan William
- Obici Laura
- Oda Junko
- Oda Tetsuya
- Oh Jeeyoung
- Orellana Lucas G.
- Oshita Tomohiko
- Overcash J. Scott
- Owusu-Sekyere Mercy
- Palacios Marta
- Paras Allan
- Park Jae Hong
- Parman Yesim
- Pedrosa Salve
- Pedrosa-Domellöf Fatima
- Pereira Pedro
- Perez de Isla Leopoldo
- Perez Javier M.
- Pessoa Bernardete
- Pester Lars
- Pilebro Bjorn
- Pinto Luiz Felipe
- Pinto Marcus Vinicius
- Planté-Bordeneuve Violaine
- Polydefkis Michael
- Pouget Jean
- Pu Helen
- Pytel Cordoba Vanesa
- Pérez-Castañeda Sandra Lorena
- Quan Dianna
- Rajkumar Vincent S.
- Rakotondratafika Fetra
- Ramalho Joana
- Rezk Tamer
- Rezzan Kus Jülide
- Rigo Oliver Elena
- Rivera de la Parra David
- Rodas Marin Lida Maria
- Rodrigues Leonardo
- Rodríguez Rodríguez Adrián
- Romano Angela
- Rosti Vittorio
- Rougeaux Isabelle
- Rousseau Antoine
- Ruiz Julie
- Russell Stephen J.
- Russo Massimo
- Ryder Julie
- Sabatelli Mario
- Sacko Niamey
- Sahin Erdi
- Sakurada Naonori
- Salhi Hayet
- Sankey Alison
- Santos Miguel Oliveira
- Sanz Monica
- Sarafov Staiko
- Scheid Christof
- Schilling Matthias
- Schmidt Hartmut H.
- Schubert Friederike
- Segawa Akiko
- Sekijima Yoshiki
- Sellers Peter
- Seok Jin Myoung
- Serbest Nail G.
- Shah Syed Mahmood
- Shije Jeffrey
- Shimomura Masahiro
- Shin Hyun Jin
- Signate Aissatou
- Sirin Inan Nermin G.
- Slama Michel S.
- Smith Ashley
- Soderberg Karin
- Sommerville R. Brian
- Stephant Maeva
- Stewart Graeme
- Stone Paula
- Su Jen-Jen
- Suan Daniel
- Suhr Ole
- Sweetser Marianne T.
- Tada Satoshi
- Takahashi Tetsuya
- Taniguchi Ikuko
- Taniwaki Takayuki
- Tard Celine
- Taylor Lenka
- Taylor Mark
- Thai Desmond
- Théaudin-Saliou Marie
- Tournev Ivaylo
- Tran Leyla
- Truong Nghi
- Tsai Li-Kai
- Tsang Steven
- Tsuruhisa Seiko
- Tugal Tutkun Nuriye Ilknur
- Ueda Akihiko
- Ueda Mitsuharu
- Ueno Hiroki
- Ulane Christina
- Ulbricht Hannah
- Uson Mercedes
- Valdrez Katia
- Verschueren Annie
- Vervoitte Laetitia
- Vest John
- Victory Jennifer
- Viera Lima Ana Flavia
- Vinas Maita
- Vista Geno
- Vorona Elena
- Vuong Thao
- Waddington-Cruz Márcia
- Wade N. Kevin
- Wajnsztajn Fernanda
- Walter Doreen
- Wang Jing Jing
- Waters Michael
- Waucquier Nawal
- Weimer Louis
- Wells Karen
- White Matthew T.
- Wiesman Janice
- Witzig Thomas E.
- Wixner Jonas
- Yamanishi Yuki
- Yamashita Taro
- Yang Chih-Chao
- Ye Jing
- Yeh Shin-Joe
- Yorita Akiko
- Yoshinaga Tsuneaki
- Zamba-Papanicolaou Eleni
- Zeldenrust Steven R
- Zepeda Karla A.
- Zhelyazkova-Glaveeva Sashka
- Zibert Andree
- Zueiter Andreas
- Zwijack Brittany
- Özdemir Betül
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
© 2020 Elsevier Ltd. All rights reserved.Background: Hereditary transthyretin-mediated amyloidosis is a rare, inherited, progressive disease caused by mutations in the transthyretin (TTR) gene. We assessed the safety and efficacy of long-term treatment with patisiran, an RNA interference therapeutic that inhibits TTR production, in patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy.
Methods: This multicentre, open-label extension (OLE) trial enrolled patients at 43 hospitals or clinical centres in 19 countries as of Sept 24, 2018. Patients were eligible if they had completed the phase 3 APOLLO or phase 2 OLE parent studies and tolerated the study drug. Eligible patients from APOLLO (patisiran and placebo groups) and the phase 2 OLE (patisiran group) studies enrolled in this global OLE trial and received patisiran 0·3 mg/kg by intravenous infusion every 3 weeks with plans to continue to do so for up to 5 years. Efficacy assessments included measures of polyneuropathy (modified Neuropathy Impairment Score +7 [mNIS+7]), quality of life, autonomic symptoms, nutritional status, disability, ambulation status, motor function, and cardiac stress, with analysis by study groups (APOLLO-placebo, APOLLO-patisiran, phase 2 OLE patisiran) based on allocation in the parent trial. The global OLE is ongoing with no new enrolment, and current findings are based on the interim analysis of the patients who had completed 12-month efficacy assessments as of the data cutoff. Safety analyses included all patients who received one or more dose of patisiran up to the data cutoff. This study is registered with ClinicalTrials.gov, NCT02510261.
Findings: Between July 13, 2015, and Aug 21, 2017, of 212 eligible patients, 211 were enrolled: 137 patients from the APOLLO-patisiran group, 49 from the APOLLO-placebo group, and 25 from the phase 2 OLE patisiran group. At the data cutoff on Sept 24, 2018, 126 (92%) of 137 patients from the APOLLO-patisiran group, 38 (78%) of 49 from the APOLLO-placebo group, and 25 (100%) of 25 from the phase 2 OLE patisiran group had completed 12-month assessments. At 12 months, improvements in mNIS+7 with patisiran were sustained from parent study baseline with treatment in the global OLE (APOLLO-patisiran mean change -4·0, 95 % CI -7·7 to -0·3; phase 2 OLE patisiran -4·7, -11·9 to 2·4). Mean mNIS+7 score improved from global OLE enrolment in the APOLLO-placebo group (mean change from global OLE enrolment -1·4, 95% CI -6·2 to 3·5). Overall, 204 (97%) of 211 patients reported adverse events, 82 (39%) reported serious adverse events, and there were 23 (11%) deaths. Serious adverse events were more frequent in the APOLLO-placebo group (28 [57%] of 49) than in the APOLLO-patisiran (48 [35%] of 137) or phase 2 OLE patisiran (six [24%] of 25) groups. The most common treatment-related adverse event was mild or moderate infusion-related reactions. The frequency of deaths in the global OLE was higher in the APOLLO-placebo group (13 [27%] of 49), who had a higher disease burden than the APOLLO-patisiran (ten [7%] of 137) and phase 2 OLE patisiran (0 of 25) groups.
Interpretation: In this interim 12-month analysis of the ongoing global OLE study, patisiran appeared to maintain efficacy with an acceptable safety profile in patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy. Continued long-term follow-up will be important for the overall assessment of safety and efficacy with patisiran.info:eu-repo/semantics/publishedVersio
Search for a high-mass dimuon resonance produced in association with b quark jets at s=13 TeV
- Author
- Aarrestad Thea Klaeboe
- Aarup Petersen Henriette
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbott Mark Samuel
- Abbrescia Marcello
- Abdullin Salavat
- Abreu Andrés
- Abu Zeid Shimaa
- Acharya Himal
- Acharya Shriniketan
- Acosta Darin
- Adam Wolfgang
- Adamidis Kosmas
- Adams Eric
- Adams Mark Raymond
- Adams Todd
- Addesa Francesca Maria
- Adloff Catherine
- Adzic Petar
- Aebi Devin
- Afanasiev Serguei
- Agapitos Antonis
- Agarwal Garvita
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Agyel Doruk
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmed Asar
- Aimè Chiara
- Ajmal Sehar
- Akchurin Nural
- Akgun Bora
- Akpinar Alp
- Al Kadhim Ali
- Albert Andreas
- Albrecht Anna
- Albrecht Steffen
- Albrow Michael
- Alcaraz Maestre Juan
- Alcerro Alcerro Luis Fernando
- Aldaya Martin Maria
- Aldá Júnior Walter Luiz
- Aleksandrov Aleksandar
- Alexander James
- Alhusseini Mohammad
- Alimena Juliette
- Alison John
- Allmond Braden
- Ally Daniel
- Almond John
- Alpana Alpana
- Alsufyani Bandar
- Alvarez Gonzalez Barbara
- Alverson George
- Alves Gallo Pereira Miguel
- Alves Gilvan
- Aly Reham
- Alyari Maral
- Amapane Nicola
- Ambrozas Marijus
- Ameen Mohammad Mobassir
- Amendola Chiara
- Amoroso Simone
- Amram Oz
- Amsler Claude
- An Sitong
- An Ying
- Anagnostou Georgios
- Andrea Jeremy
- Andreev Vladimir
- Andreev Yu.
- Andreev Yuri
- Andrejkovic Janik Walter
- Andrews Michael Benjamin
- Androsov Konstantin
- Anguiano Justin
- Antchev Georgy
- Anthony David
- Antonello Massimiliano
- Apollinari Giorgio
- Apparu Dylan
- Appelt Eric
- Apresyan Artur
- Araujo Mariana
- Aravind Anagha
- Arcaro Daniel
- Arcidiacono Roberta
- Ardino Rocco
- Argiro Stefano
- Arneodo Michele
- Aruta Caterina
- Asawatangtrakuldee Chayanit
- Asenov Patrick
- Asghar Muhammad Irfan
- Asilar Ece
- Askew Andrew
- Assiouras Panagiotis
- Assran Yasser
- Atakisi Ismail Okan
- Attikis Alexandros
- Auffray Etiennette
- Aushev Tagir
- Auzinger Georg
- Avati Valentina
- Avery Paul
- Avila Carlos
- Awais Ali
- Awan Muhammad Imran Malik
- Ayala Edy
- Ayala Gabriel
- Aydilek Orhan
- Azarkin Maksim
- Aziz Tariq
- Azzi Patrizia
- Azzurri Paolo
- Baarmand Marc M.
- Babbar Jyoti
- Bacchetta Nicola
- Bachtis Michail
- Backhaus Malte
- Baden A.
- Baden Drew
- Baechler Joachim
- Bagliesi Giuseppe
- Bahinipati Seema
- Bainbridge Robert
- Bak Gyeonghwan
- Bakas Georgios
- Bakhshiansohi Hamed
- Bakshi Amandeep Singh
- Bala Anirban
- Baldenegro Barrera Cristian
- Ball Austin
- Ban Yong
- Band Reyer
- Bandyopadhyay Hirak
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Baradia Sweta
- Barbagli Giuseppe
- Barberis Emanuela
- Barbosa Trujillo Diego Andres
- Bardelli Giulio
- Bargassa Pedrame
- Baringer Philip
- Barman Soumyadip
- Barnes Virgil E.
- Barney David
- Barria Patrizia
- Barroso Ferreira Filho Mapse
- Bartek Rachel
- Bartosik Nazar
- Bartók Márton
- Barzdukas Anders
- Basnet Aashwin
- Bastos Diogo
- Battilana Carlo
- Baty Austin
- Bauer Gerry
- Bauerdick Lothar A. T.
- Bautista Irais
- Baxter Samuel
- Bayatmakou Maryam
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Becerril Gonzalez Hugo
- Behera Prafulla Kumar
- Behera Subash Chandra
- Behnke Olaf
- Bein Samuel
- Beirão Da Cruz E Silva Cristóvão
- Belforte Stefano
- Bell Ken W.
- Bellan Riccardo
- Belloni Alberto
- Bellora Andrea
- Belvedere Alberto
- Belyaev Alexander
- Belyaev Andrey
- Benaglia Andrea
- Benato Lisa
- Bencze Gyorgy
- Bendavid Joshua
- Benecke Anna
- Benelli Gabriele
- Benitez Jose F.
- Bennett Clayton
- Benussi Luigi
- Bergauer Thomas
- Beri Suman Bala
- Bermúdez Martínez Armando
- Bernardes Cesar Augusto
- Berry Douglas
- Berryhill Jeffrey
- Besancon Marc
- Bestintzanos Ioannis
- Bethani Agni
- Bevilacqua Tiziano
- Beyrouthy Taha
- Bhardwaj Ashutosh
- Bharthuar Shudhashil
- Bhat Pushpalatha C.
- Bhatnagar Vipin
- Bhattacharya Rajarshi
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhattacharya Soham
- Bhowmik Debabrata
- Bhowmik Sandeep
- Bhyun Ji Hwan
- Bialkowska Helena
- Bianchini Lorenzo
- Bianco Michele
- Bianco Stefano
- Biino Cristina
- Bilei Gian Mario
- Bilin Bugra
- Bin Anuar Afiq Aizuddin
- Bin Norjoharuddeen Nurfikri
- Bisello Dario
- Black Kevin
- Blanco Fernández Sergio
- Blancon Benjamin
- Blekman Freya
- Blend Dylan
- Blinov Vladimir
- Bloch Daniel
- Bloch Philippe
- Bloom Kenneth
- Bluj Michal
- Blumenfeld Barry
- Boccali Tommaso
- Bocci Andrea
- Bodek Arie
- Boimska Bozena
- Boldrini Giacomo
- Boletti Alessio
- Bols Emil Sørensen
- Bonacorsi Daniele
- Bonanomi Matteo
- Bonilla Johan
- Boos Edouard
- Boran Fatma
- Borgonovi Lisa
- Bornheim Adolf
- Borras Kerstin
- Borshch Vladislav
- Bortignon Pierluigi
- Bose Tulika
- Bossini Edoardo
- Botta Cristina
- Botta Valeria
- Bouchamaoui Hichem
- Boudoul Gaelle
- Bouhali Othmane
- Bourilkov Dimitri
- Bower Nicholas
- Boyaryntsev Andriy
- Bozzo Marco
- Bragagnolo Alberto
- Braghieri Alessandro
- Brainerd Christopher
- Brandao Malbouisson Helena
- Branson James G.
- Breedon Richard
- Brennan Liam
- Brew Christopher
- Bright-Thonney Samuel
- Brigljevic Vuko
- Brinkerhoff Andrew
- Brivio Francesco
- Brochero Cifuentes Javier Andres
- Brom Jean-Marie
- Brommer Sebastian
- Brondolin Erica
- Brooke James John
- Brown Christopher Edward
- Brown Robert M.
- Brunner David
- Bruno Giacomo
- Bruschini Davide
- Bryant Patrick
- Bryson Miranda
- Brzhechko Danyyl
- Brücken Erik
- Bubanja Itana
- Bucci Rachael
- Buchmuller Oliver
- Buchot Perraguin Axel
- Budkouski Dzmitry
- Bueghly James
- Bundock Aaron
- Bunichev Viacheslav
- Bunkowski Karol
- Buontempo Salvatore
- Burkart Maximilian
- Burkett Kevin
- Bury Florian Joel J.
- Busson Philippe
- Busza Wit
- Butalla Stephen
- Butler Joel Nathan
- Butler Philip H.
- Butz Erik
- Bylsma Ben
- Bärtschi Pascal
- Cabrera Andrés
- Cabrillo Iban Jose
- Cacchio Vincenzo
- Cadamuro Luca
- Cagnotta Antimo
- Caillol Cécile
- Cakir Altan
- Calandri Alessandro
- Calderon De La Barca Sanchez Manuel
- Calderon Alicia
- Cali Ivan Amos
- Calligaris Luigi
- Calzaferri Simone
- Camaiani Benedetta
- Caminada Lea
- Campagnari Claudio
- Campana Mattia
- Campanini Renato
- Campbell Alan
- Camporesi Tiziano
- Candelise Vieri
- Canelli Maria Florencia
- Canepa Anadi
- Cankocak Kerem
- Capiluppi Paolo
- Cappati Alessandra
- Caputo Claudio
- Caraway Bryan
- Cardini Andrea
- Cardwell Bryan
- Carnahan Taylor
- Carnevali Francesco
- Carrera Jarrin Edgar
- Carrigan Michael
- Carrillo Montoya Camilo Andres
- Cartiglia Nicolo
- Carvalho Wagner
- Casarsa Massimo
- Cassese Antonio
- Castaldi Rino
- Castaneda Hernandez Alfredo
- Castells Sergi
- Castilla-Valdez Heriberto
- Castro Andrea
- Cavallari Francesca
- Cavallo Francesca Romana
- Cavallo Nicola
- Cavanaugh Richard
- Cazzaniga Cesare
- Ceard Ludivine
- Ceccarelli Rudy
- Cepeda Maria
- Cerati Giuseppe Benedetto
- Cerci Salim
- Cerminara Gianluca
- Cerrada Marcos
- Cerri Olmo
- Cetorelli Flavia
- Chabert Eric Christian
- Chahal Gurpreet Singh
- Chandra Soumik
- Chang Philip
- Chanon Nicolas
- Chao Yuan
- Charlot Claude
- Chatagnon Pierre
- Chatterjee Rajdeep Mohan
- Chatterjee Sayan
- Chatterjee Suman
- Chatzistavrou Theodoros
- Chaudhary Geetanjali
- Chauhan Sushil
- Chawla Ridhi
- Checchia Paolo
- Chekhovsky Vladimir
- Chen Guo-Ming
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- Yohay Rachel
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- Yoo Jaehyeok
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- Yu Shin-Shan
- Yuan Li
- Yuan Siqi
- Yuldashev Bekhzod S.
- Yusuff Imran
- Zabi Alexandre
- Zacharopoulou Anna
- Zaleski Shawn
- Zalewski Piotr
- Zanetti Marco
- Zarubin Anatoli
- Zarucki Mateusz
- Zaza Angela
- Zecchinelli Angelo Giacomo
- Zehetner Philipp
- Zeinali Maryam
- Zejdl Petr
- Zeuner Wolfram Dietrich
- Zghiche Amina
- Zhang Fengwangdong
- Zhang Huaqiao
- Zhang Jingyu
- Zhang Wenyu
- Zhang Yousen
- Zhang Yu
- Zhizhin Ilia
- Zhokin Alexander
- Zhou Chen
- Zhu Ren-Yuan
- Ziemons Tim
- Zilizi Gyula
- Zimermmane Castro Santos André
- Zipper Noah
- Zisopoulos Ilias
- Zoi Irene
- Zolkapli Zukhaimira
- Zorbakir Ibrahim Soner
- Zorbilmez Caglar
- Zotto Pierluigi
- Zotz Alexander
- Zou Rui
- Zucchetta Alberto
- Zumerle Gianni
- Zuo Xunwu
- Zuolo Davide
- Zygala Lara
- Publication venue
- HAL CCSD
- Publication date
- 01/01/2023
- Field of study
International audienceA search for high-mass dimuon resonance production in association with one or more b quark jets is presented. The study uses proton-proton collision data collected with the CMS detector at the LHC corresponding to an integrated luminosity of 138 fb−1 at a center-of-mass energy of 13 TeV. Model-independent limits are derived on the number of signal events with exactly one or more than one b quark jet. Results are also interpreted in a lepton-flavor-universal model with Z′ boson couplings to a bb quark pair (gb), an sb quark pair (gbδbs), and any same-flavor charged lepton (gℓ) or neutrino pair (gν), with ∣gν∣=∣gℓ∣. For a Z′ boson with a mass mZ′ = 350 GeV (2 TeV) and ∣δbs∣< 0.25, the majority of the parameter space with 0.0057 <∣gℓ∣< 0.35 (0.25 <∣gℓ∣< 0.43) and 0.0079 <∣gb∣< 0.46 (0.34 <∣gb∣< 0.57) is excluded at 95% confidence level. Finally, constraints are set on a Z′ model with parameters consistent with low-energy b → sℓℓ measurements. In this scenario, most of the allowed parameter space is excluded for a Z′ boson with 350 <mZ′< 500 GeV, while the constraints are less stringent for higher mZ′ hypotheses. This is the first dedicated search at the LHC for a high-mass dimuon resonance produced in association with multiple b quark jets, and the constraints obtained on models with this signature are the most stringent to date
Search for new physics in multijet events with at least one photon and large missing transverse momentum in proton-proton collisions at 13 TeV
- Author
- Aarrestad Thea Klaeboe
- Aarup Petersen Henriette
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbott Mark Samuel
- Abbrescia Marcello
- Abdalla Hassan
- Abdullin Salavat
- Abreu Andrés
- Abu Zeid Shimaa
- Acharya Himal
- Acosta Darin
- Adam Wolfgang
- Adamidis Kosmas
- Adams Eric
- Adams Mark Raymond
- Adams Todd
- Addesa Francesca Maria
- Adloff Catherine
- Adzic Petar
- Aebi Devin
- Afanasiev Serguei
- Agapitos Antonis
- Agarwal Garvita
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Agyel Doruk
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmed Asar
- Aimè Chiara
- Ajmal Sehar
- Akchurin Nural
- Akgun Bora
- Akpinar Alp
- Al Kadhim Ali
- Albert Andreas
- Albrecht Anna
- Albrecht Steffen
- Albrow Michael
- Alcaraz Maestre Juan
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- Tonelli Guido
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- Toriashvili Tengizi
- Tornago Marta
- Toropin Alexander
- Torres Da Silva De Araujo Felipe
- Tosi Mia
- Tosi Silvano
- Townsend Austin
- Tramontano Raffaella
- Tran Nhan Viet
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- Trapote Andrea
- Treille Daniel
- Trevisani Nicolò
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- Tuve Cristina
- Tytgat Michael
- Tziaferi Eirini
- Uchida Kirika
- Ujvari Balazs
- Ulmer Keith
- Ulrich Ralf
- Umoret Giulio
- Uniyal Rishabh
- Uplegger Lorenzo
- Urda Gómez Lourdes
- Uribe Estrada Cecilia
- Usai Emanuele
- Uslan Ebru
- Uttley George Peter
- Uvarov Lev
- Uzunian Andrey
- Vaandering Eric Wayne
- Vage Liv Helen
- Vagnerini Antonio
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- Valsecchi Davide
- Valuev Vyacheslav
- Van Den Bossche Niels
- van der Linden Jan
- Van Hove Pierre
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- Van Onsem Gerrit Patrick
- Van Putte Senne
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- Vander Donckt Muriel
- Vander Velde Catherine
- Vanlaer Pascal
- Vannerom David
- Varela Joao
- Varelas Nikos
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- Varghese Sanu
- Vats Diwakar
- Vazquez Escobar Julia
- Vazzoler Federico
- Veckalns Viesturs
- Veelken Christian
- Velasco Mayda
- Velkovska Julia
- Vellidis Konstantinos
- Venditti Rosamaria
- Ventura Barroso Ana
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- Verdini Piero Giorgio
- Veres Gabor Istvan
- Verma Sadhana
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- Verwilligen Piet
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- Viazlo Oleksandr
- Vico Villalba Carlos
- Vigilante Lorenzo
- Viinikainen Jussi
- Vila Ivan
- Vilela Pereira Antonio
- Viliani Lorenzo
- Virdee Tejinder
- Vischia Pietro
- Vitulo Paolo
- Vizan Garcia Jesus Manuel
- Vlasov Evgueni
- Vlimant Jean-Roch
- Vojinovic Milos
- Volobouev Igor
- Von Cube Ralf Florian
- Vora Jay
- Vorobyev Alexey
- Vourliotis Emmanouil
- Voutilainen Mikko
- Voytishin Nikolay
- Vámi Tamás Álmos
- Wachirapusitanand Vichayanun
- Wadud Mohammad Abrar
- Wagner Stephen Robert
- Walkingshaw Pass Katie
- Wallny Rainer
- Walsh Roberval
- Waltenberger Wolfgang
- Walter David
- Wanczyk Joanna
- Wang Bingran
- Wang Christina
- Wang Dayong
- Wang Fuqiang
- Wang Hui
- Wang Jian
- Wang Jin
- Wang Jing
- Wang Long
- Wang Quan
- Wang Qun
- Wang Sicheng
- Wang Xiao
- Wang Zhangqier
- Warden Abigail
- Wardle Nicholas
- Wassmer Michael
- Watson I. J.
- Wayne Mitchell
- Wei Kai
- Wei Wei
- Wen Yiwen
- Wertz Sébastien
- West Christopher
- Wezenbeek Liam
- Whitbeck Andrew
- White Robert
- Wichmann Katarzyna
- Wickramage Nadeesha
- Wiedenbeck Sebastian
- Wieland Sebastian
- Wiens Lucas
- Wightman Andrew
- Williams Ac
- Williams Thomas
- Willmott Carlos
- Wilson Graham
- Wilson Jonathan
- Wimpenny Stephen
- Winer Brian L.
- Winterbottom Daniel
- Wissing Christoph
- Wittich Peter
- Wittig Florian
- Wolf Moritz
- Wolf Roger
- Wong Kak
- Wong Wing Yan
- Wood Darien
- Wozniak Kinga Anna
- Wright Douglas
- Wu Hsin-yeh
- Wuchterl Sebastian
- Wulansatiti Meutia
- Wulz Claudia-Elisabeth
- Wunsch Stefan
- Wyslouch Bolek
- Würthwein Frank
- Xiang Yifan
- Xiao Jie
- Xiao Meng
- Xie Si
- Xie Wei
- Yagil Avraham
- Yalvac Metin
- Yan Furong
- Yan Xuli
- Yang Heng
- Yang Seungjin
- Yang Tianyu
- Yang Unki
- Yang Yewon
- Yang Yu Chul
- Yao Yao
- Yarar Hevjin
- Yates Brent
- Yazgan Efe
- Ye Zhenyu
- Yi Kai
- Yi Ruole
- Yigitbasi Efe
- Yockey Henry
- Yohay Rachel
- Yoo Hwi Dong
- Yoo Jaehyeok
- Yoo Jieun
- Yoon Inseok
- You Zhengyun
- Yu David
- Yu Intae
- Yu Shin-Shan
- Yuan Li
- Yuan Siqi
- Yuldashev Bekhzod S.
- Yumiceva Francisco
- Yusuff Imran
- Zabi Alexandre
- Zacharopoulou Anna
- Zaleski Shawn
- Zalewski Piotr
- Zanetti Marco
- Zarubin Anatoli
- Zarucki Mateusz
- Zaza Angela
- Zecchinelli Angelo Giacomo
- Zehetner Philipp
- Zeinali Maryam
- Zejdl Petr
- Zeuner Wolfram Dietrich
- Zghiche Amina
- Zhang Fengwangdong
- Zhang Huaqiao
- Zhang Jingyu
- Zhang Wenyu
- Zhang Yousen
- Zhang Yu
- Zhizhin Ilia
- Zhokin Alexander
- Zhou Chen
- Zhu Ren-Yuan
- Ziemons Tim
- Zilizi Gyula
- Zimermmane Castro Santos André
- Zipper Noah
- Zisopoulos Ilias
- Zoi Irene
- Zolkapli Zukhaimira
- Zorbakir Ibrahim Soner
- Zorbilmez Caglar
- Zotto Pierluigi
- Zotz Alexander
- Zou Rui
- Zucchetta Alberto
- Zumerle Gianni
- Zuo Xunwu
- Zuolo Davide
- Zygala Lara
- Publication venue
- HAL CCSD
- Publication date
- 01/01/2023
- Field of study
International audienceA search for new physics in final states consisting of at least one photon, multiple jets, and large missing transverse momentum is presented, using proton-proton collision events at a center-of-mass energy of 13 TeV. The data correspond to an integrated luminosity of 137 fb−1, recorded by the CMS experiment at the CERN LHC from 2016 to 2018. The events are divided into mutually exclusive bins characterized by the missing transverse momentum, the number of jets, the number of b-tagged jets, and jets consistent with the presence of hadronically decaying W, Z, or Higgs bosons. The observed data are found to be consistent with the prediction from standard model processes. The results are interpreted in the context of simplified models of pair production of supersymmetric particles via strong and electroweak interactions. Depending on the details of the signal models, gluinos and squarks of masses up to 2.35 and 1.43 TeV, respectively, and electroweakinos of masses up to 1.23 TeV are excluded at 95% confidence level
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