Food systems under stress (FSUS) project FSUS/PRA workshop – Tanzania Magindu Village, Kibaha District, 23-25 August 1993.

This report is a chronological account of the Magindu Workshop, based mainly on the teams deliberations at the end of each day.Magindu village lies within the Coastal Region and is situated 25 km south of Chalinze (about 45 minutes by car along a sandy track) just beyond the intersection with the Central Railway Line. The village is inhabited by Wakwere and Kutu cultivators (90) %) and Maasai cattle keepers (10%). Magindu's history can be summed up as one of consecutive droughts and people moving in and out of the area. Al though drought occurs periodically, rainfall is not necessarily a limiting factor, and can go up to 800 mm a year. The soils, however, are not very deep. (Dodoma is much drier, but a lot of aid and research is already focused on that region). In 1990-1991 Magindu suffered terribly in the drought, which was so severe that it put Magindu on the political map. Ministers visited the area

Indigenous knowledge in seasonal rainfall prediction in Tanzania : a case of the South-western Highland of Tanzania

Early and significant flowering of Mihemi (Erythrina abyssinica) and Mikwe (Brachystegia speciformis) trees has been identified as a signal of good rainfall in the South-western Highland of Tanzania. Farmers have singled out the behaviour of the Dudumizi bird as another indicator. This study was conducted in Rungwe and Kilolo districts in Mbeya and Iringa regions. Systematic documentation and integration of indigenous knowledge into conventional weather forecasting is a recommended strategy for improving the accuracy and reliability of seasonal rainfall forecasts under increasing climate variability. Since agriculture in Tanzania is mainly rainfed, where, when and what to plant depends on the accuracy of rainfall forecasting

Evaluating watershed service availability under future management and climate change scenarios in the Pangani Basin

Watershed services are the benefits people obtain from the flow of water through a watershed. While demand for such services is increasing in most parts of the world, supply is getting more insecure due to human impacts on ecosystems such as climate or land use change. Population and water management authorities therefore require information on the potential availability of watershed services in the future and the trade-offs involved. In this study, the Soil and Water Assessment Tool (SWAT) is used to model watershed service availability for future management and climate change scenarios in the East African Pangani Basin. In order to quantify actual “benefits”, SWAT2005 was slightly modified, calibrated and configured at the required spatial and temporal resolution so that simulated water resources and processes could be characterized based on their valuation by stakeholders and their accessibility. The calibrated model was then used to evaluate three management and three climate scenarios. The results show that by the year 2025, not primarily the physical availability of water, but access to water resources and efficiency of use represent the greatest challenges. Water to cover basic human needs is available at least 95% of time but must be made accessible to the population through investments in distribution infrastructure. Concerning the trade-off between agricultural use and hydropower production, there is virtually no potential for an increase in hydropower even if it is given priority. Agriculture will necessarily expand spatially as a result of population growth, and can even benefit from higher irrigation water availability per area unit, given improved irrigation efficiency and enforced regulation to ensure equitable distribution of available water. The decline in services from natural terrestrial ecosystems (e.g. charcoal, food), due to the expansion of agriculture, increases the vulnerability of residents who depend on such services mostly in times of drought. The expected impacts of climate change may contribute to an increase or decrease in watershed service availability, but are only marginal and much lower than management impacts up to the year 2025

Managing water resources in dynamic settings: A multi-level, multi-stakeholder perspective

The aim of the present article is to contribute to the debate on the role of research in sustainable management of water and related resources, based on experiences in the Upper Ewaso Ng’iro and Pangani river basins in East Africa. Both basins are characterised by humid, resource-rich highlands and extensive semi-arid lowlands, by growing demand for water and related resources, and by numerous conflicting stakeholder interests. Issues of scale and level, on the one hand, and the normative dimension of sustainability, on the other hand, are identified as key challenges for research that seeks to produce relevant and applicable results for informed decision-making. A multi-level and multi-stakeholder perspective, defined on the basis of three minimal principles, is proposed here as an approach to research for informed decision-making. Key lessons learnt from applying these principles in the two river basins are presented and discussed in the light of current debate

Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein

Abstract Parkinson’s disease is a progressive neurodegenerative disorder characterised by the accumulation of misfolded α-synuclein in selected brain regions, including the substantia nigra pars compacta (SNpc), where marked loss of dopaminergic neurons is also observed. Yet, the relationship between misfolded α-synuclein and neurotoxicity currently remains unclear. As the principal route for degradation of misfolded proteins in mammalian cells, the ubiquitin-proteasome system (UPS) is critical for maintenance of cellular proteostasis. Misfolded α-synuclein impairs UPS function and contributes to neuronal death in vitro. Here, we examine its effects in vivo using adeno-associated viruses to co-express A53T α-synuclein and the ubiquitinated reporter protein UbG76V-GFP in rat SNpc. We found that α-synuclein over-expression leads to early-onset catalytic impairment of the 26S proteasome with associated UPS dysfunction, preceding the onset of behavioural deficits and dopaminergic neurodegeneration. UPS failure in dopaminergic neurons was also associated with selective accumulation of α-synuclein phosphorylated at the serine 129 residue, which has previously been linked to increased neurotoxicity. Our study highlights a role for α-synuclein in disturbing proteostasis which may contribute to neurodegeneration in vivo