10 research outputs found
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
- Acevedo-Arozena A
- Adamopoulos IE
- Adeli K
- Adolph TE
- Adornetto A
- Aflaki E
- Agam G
- Agarwal A
- Aggarwal BB
- Agnello M
- Agostinis P
- Agrewala JN
- Agrotis A
- Aguilar PV
- Ahmad ST
- Ahmed ZM
- Ahumada-Castro U
- Aits S
- Aizawa S
- Akkoc Y
- Akoumianaki T
- Akpinar HA
- Al-Abd AM
- Al-Akra L
- Al-Gharaibeh A
- Alaoui-Jamali MA
- Alberti S
- Alcocer-Gómez E
- Alessandri C
- Ali M
- Alim Al-Bari MA
- Aliwaini S
- Alizadeh J
- Almacellas E
- Almasan A
- Alonso A
- Alonso GD
- Altan-Bonnet N
- Altieri DC
- Alves da Costa C
- Alves S
- Alzaharna MM
- Amadio M
- Amantini C
- Amaral C
- Ambrosio S
- Amer AO
- Ammanathan V
- An Z
- Andersen SU
- Andrabi SA
- Andrade-Silva M
- Andres AM
- Angelini S
- Ann D
- Anozie UC
- Ansari MY
- Antas P
- Antebi A
- Antón Z
- Anwar T
- Apetoh L
- Apostolova N
- Araki T
- Araki Y
- Arasaki K
- Araya J
- Araújo WL
- Arden C
- Arguelles S
- Arias E
- Arikkath J
- Arimoto H
- Ariosa AR
- Armstrong-James D
- Arnauné-Pelloquin L
- Aroca A
- Arroyo DS
- Arsov I
- Artero R
- Arévalo M-A
- Asaro DML
- Aschner M
- Ashrafizadeh M
- Ashur-Fabian O
- Atanasov AG
- Au AK
- Auberger P
- Auner HW
- Aurelian L
- Autelli R
- Avagliano L
- Aveic S
- Aveleira CA
- Avin-Wittenberg T
- Aydin Y
- Ayton S
- Ayyadevara S
- Azzopardi M
- Baba M
- Backer JM
- Backues SK
- Bae D-H
- Bae O-N
- Bae SH
- Baehrecke EH
- Baek A
- Baek S-H
- Baek SH
- Bagetta G
- Bagniewska-Zadworna A
- Bai H
- Bai J
- Bai X
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- Balazadeh S
- Balbi T
- Baldari CT
- Balduini W
- Ballabio A
- Ballester M
- Balzan R
- Bandopadhyay R
- Banerjee S
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- Bao Y
- Baptista MS
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- Barlow PG
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- Barreiro E
- Barreto GE
- Bartek J
- Bartel B
- Bartolome A
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- Bassham DC
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- Batten I
- Baulieu EE
- Baumgarner BL
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- Beaumatin F
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- Benbrook DM
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- Benito-Cuesta I
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- Berchtold MW
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- Bergmann A
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- Besirli CG
- Besteiro S
- Betin VM
- Beyaert R
- Bezbradica JS
- Bhaskar K
- Bhatia-Kissova I
- Bhattacharya R
- Bhattacharya S
- Bhattacharyya S
- Bhuiyan MS
- Bhutia SK
- Bi L
- Bi X
- Biden TJ
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- Blasiak J
- Blomgran R
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- Braus GH
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- Bravo-San Pedro JM
- Brest P
- Bringer M-A
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- Broaddus VC
- Brodersen P
- Brodsky JL
- Brody SL
- Bronson PG
- Bronstein JM
- Brown CN
- Brown RE
- Brum PC
- Brumell JH
- Brunetti-Pierri N
- Bruno D
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- Buckingham EM
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- Budini M
- Bueno M
- Buitrago-Molina LE
- Bultynck G
- Burada F
- Buraschi S
- Burgoyne JR
- Burón MI
- Bustos V
- Butturini E
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- Büttner S
- Cabas I
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- Cadwell K
- Cai J
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- Calbet JA
- Caldwell GA
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- Call JA
- Calvani R
- Calvo AC
- Calvo-Rubio Barrera M
- Camara NO
- Camonis JH
- Camougrand N
- Campanella M
- Campbell EM
- Campbell-Valois F-X
- Campello S
- Campesi I
- Campos JC
- Camuzard O
- Cancino J
- Candido de Almeida D
- Canesi L
- Caniggia I
- Canonico B
- Cantí C
- Cao B
- Caraglia M
- Caramés B
- Carchman EH
- Cardenal-Muñoz E
- Cardenas C
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- Cardoso SM
- Carew JS
- Carle GF
- Carleton G
- Carloni S
- Carmona-Gutierrez D
- Carneiro LA
- Carnevali O
- Carosi JM
- Carra S
- Carrier A
- Carrier L
- Carroll B
- Carter AB
- Carvalho AN
- Casanova M
- Casas C
- Casas J
- Cassioli C
- Castillo EF
- Castillo K
- Castillo-Lluva S
- Castoldi F
- Castori M
- Castro AF
- Castro-Caldas M
- Castro-Hernandez J
- Castro-Obregon S
- Catz SD
- Cavadas C
- Cavaliere F
- Cavallini G
- Cavinato M
- Cayuela ML
- Cebollada Rica P
- Cecarini V
- Cecconi F
- Cechowska-Pasko M
- Cenci S
- Ceperuelo-Mallafré V
- Cerqueira JJ
- Cerutti JM
- Cervia D
- Cetintas VB
- Cetrullo S
- Chae H-J
- Chagin AS
- Chai C-Y
- Chakrabarti G
- Chakrabarti O
- Chakraborty T
- Chakraborty T
- Chami M
- Chamilos G
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- Chan H
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- Chan YS
- Chandra PK
- Chang C
- Chang C-P
- Chang H-C
- Chang K
- Chao J
- Chapman T
- Charlet-Berguerand N
- Chatterjee S
- Chaube SK
- Chaudhary A
- Chauhan S
- Chaum E
- Checler F
- Cheetham ME
- Chen C-S
- Chen G-C
- Chen J-F
- Chen L
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- Chen LL
- Chen M
- Chen M-K
- Chen N
- Chen Q
- Chen R-H
- Chen S
- Chen W
- Chen W
- Chen X
- Chen X-M
- Chen X-W
- Chen Y
- Chen Y
- Chen Y
- Chen Y-G
- Chen Y-J
- Chen Y-Q
- Chen Z
- Chen Z
- Chen Z
- Chen Z-H
- Chen ZJ
- Chen ZS
- Cheng H
- Cheng J
- Cheng S-Y
- Cheng W
- Cheng X
- Cheng X-T
- Cheng Y
- Cheng Z
- Cheong H
- Cheong JK
- Chernyak BV
- Cherry S
- Cheung CFR
- Cheung CHA
- Cheung K-H
- Chevet E
- Chi RJ
- Chiang AKS
- Chiaradonna F
- Chiarelli R
- Chiariello M
- Chica N
- Chiocca S
- Chiong M
- Chiou S-H
- Chiramel AI
- Chiurchiù V
- Cho D-H
- Choe S-K
- Choi AMK
- Choi ME
- Choudhury KR
- Chow NS
- Chu CT
- Chua JJE
- Chua JP
- Chung H
- Chung KP
- Chung S
- Chung S-H
- Chung Y-L
- Cianfanelli V
- Ciechomska IA
- Cifuentes M
- Cinque L
- Cirak S
- Cirone M
- Clague MJ
- Clarke R
- Clementi E
- Coccia EM
- Codogno P
- Cohen E
- Cohen MM
- Colasanti T
- Colasuonno F
- Colbert RA
- Colell A
- Coll NS
- Collins MO
- Colombo MI
- Colón-Ramos DA
- Combaret L
- Comincini S
- Cominetti MR
- Consiglio A
- Conte A
- Conti F
- Contu VR
- Cookson MR
- Coombs KM
- Coppens I
- Corasaniti MT
- Cordes N
- Corkery DP
- Cortese K
- Costa MDC
- Costantino S
- Costelli P
- Coto-Montes A
- Crack PJ
- Crespo JL
- Criollo A
- Crippa V
- Cristofani R
- Csizmadia T
- Cuadrado A
- Cui B
- Cui J
- Cui Y
- Cui Y
- Culetto E
- Cumino AC
- Cybulsky AV
- Czaja MJ
- Czuczwar SJ
- D'Adamo S
- D'Amelio M
- D'Arcangelo D
- D'Lugos AC
- D'Orazi G
- da Silva JA
- Dafsari HS
- Dagda RK
- Dagdas Y
- Daglia M
- Dai X
- Dai Y
- Dai Y
- Dal Col J
- Dalhaimer P
- Dalla Valle L
- Dallenga T
- Dalmasso G
- Damme M
- Dando I
- Dantuma NP
- Darling AL
- Das H
- Dasarathy S
- Dasari SK
- Dash S
- Daumke O
- Dauphinee AN
- Davies JS
- Davis RJ
- Davis T
- Dayalan Naidu S
- De Amicis F
- De Bosscher K
- De Felice F
- De Franceschi L
- De Leonibus C
- de Mattos Barbosa MG
- De Meyer GRY
- De Milito A
- De Nunzio C
- De Palma C
- De Santi M
- De Virgilio C
- De Zio D
- Debnath J
- DeBosch BJ
- Decuypere J-P
- Deehan MA
- Deflorian G
- DeGregori J
- Dehay B
- Del Rio G
- Delaney JR
- Delbridge LMD
- Delorme-Axford E
- Delpino MV
- Demarchi F
- Dembitz V
- Demers ND
- Deng H
- Deng Z
- Dengjel J
- Dent P
- Denton D
- DePamphilis ML
- Der CJ
- Deretic V
- Descoteaux A
- Devis L
- Devkota S
- Devuyst O
- Dewson G
- Dharmasivam M
- Dhiman R
- di Bernardo D
- Di Cristina M
- Di Domenico F
- Di Fazio P
- Di Fonzo A
- Di Guardo G
- Di Guglielmo GM
- Di Leo L
- Di Malta C
- Di Nardo A
- Di Rienzo M
- Di Sano F
- Diallinas G
- Diao J
- Diaz-Araya G
- Dickinson JM
- Diederich M
- Dieudé M
- Dikic I
- Ding S
- Ding W-X
- Dini L
- Dinic M
- Dinić J
- Dinkova-Kostova AT
- Dionne MS
- Distler JHW
- Diwan A
- Dixon IMC
- Djavaheri-Mergny M
- Dobrinski I
- Dobrovinskaya O
- Dobrowolski R
- Dobson RCJ
- Dokmeci Emre S
- Donadelli M
- Dong B
- Dong X
- Dong XC
- Dong Z
- Dorn Ii GW
- Dotsch V
- Dou H
- Dou J
- Dowaidar M
- Dridi S
- Drucker L
- du Toit A
- Du A
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- Duan S-B
- Duan X
- Duarte SP
- Dubrovska A
- Dunlop EA
- Dupont N
- Durán RV
- Dwarakanath BS
- Dyshlovoy SA
- Dávila VA
- Díaz-Laviada I
- Ebrahimi-Fakhari D
- Eckhart L
- Edelstein CL
- Efferth T
- Eftekharpour E
- Eichinger L
- Eid N
- Eisenberg T
- Eissa NT
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- Ejarque M
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- El-Hage N
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- El-Shafey ES
- Eleuteri AM
- Elgendy M
- Eliopoulos AG
- Elizalde MM
- Elks PM
- Elsasser H-P
- Elsherbiny ES
- Emerling BM
- Emre NCT
- Eng CH
- Engedal N
- Engelbrecht A-M
- Engelsen AST
- Enserink JM
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- Eusebio M-O
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- Faesen AC
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- Fernie AR
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- Figueras A
- Filadi R
- Filigheddu N
- Filippi-Chiela E
- Filomeni G
- Fimia GM
- Fineschi V
- Finetti F
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- Fisher EA
- Fisher PB
- Flamigni F
- Fliesler SJ
- Flo TH
- Florance I
- Florey O
- Florio T
- Fodor E
- Follo C
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- Franco B
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- Franconi F
- Frankel LB
- Friedman SL
- Fröhlich LF
- Frühbeck G
- Fuentes JM
- Fujiki Y
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- Fujiwara Y
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- Joffre C
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- Joosten LAB
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- Keulers TG
- Khalfin B
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- Khan SY
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- Kho W
- Khobrekar NV
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- Killackey SA
- Kim D
- Kim D-E
- Kim D-H
- Kim DR
- Kim E-K
- Kim EY
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- Voitsekhovskaja OV
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- Waguri S
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- Walker DW
- Walker MJ
- Walker SA
- Walter J
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- Wang D
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- Warnes G
- Warnsmann V
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- Weaver TE
- Wegrzyn G
- Wehman AM
- Wei H
- Wei L
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- Wei Y
- Weiergräber OH
- Weihl CC
- Weindl G
- Weiskirchen R
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- Wildenberg ME
- Wileman T
- Wilkinson S
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- Winner B
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- Wodrich H
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- Wu A-G
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- Wu S-Y
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- Wu WKK
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- Wu Y-W
- Xavier RJ
- Xia H
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- Xiang G
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- Xiang M
- Xiang W
- Xiao B
- Xiao G
- Xiao H
- Xiao H-T
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- Xu J
- Xu L
- Xu WW
- Xu X
- Xue Y
- Yakhine-Diop SMS
- Yamaguchi M
- Yamaguchi O
- Yamamoto A
- Yamashina S
- Yan S
- Yan S-J
- Yan Z
- Yanagi Y
- Yang C
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- Yang H-T
- Yang J
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- Yao H
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- Yao Y-G
- Yao Y-M
- Yasui T
- Yazdankhah M
- Yen PM
- Yi C
- Yi-Ren Hong C-WH
- Yin X-M
- Yin Y
- Yin Z
- Yin Z
- Ying M
- Ying Z
- Yip CK
- Yiu SPT
- Yoo YH
- Yoshida K
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- Yousefi B
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- Yun J
- Yung RL
- Zacks DN
- Zaffagnini G
- Zambelli VO
- Zanella I
- Zang QS
- Zanivan S
- Zappavigna S
- Zaragoza P
- Zarbalis KS
- Zarebkohan A
- Zarrouk A
- Zeitlin SO
- Zeng J
- Zeng J-D
- Zhan L
- Zhang B
- Zhang DD
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- Zhang H-L
- Zhang J
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- Zhang J-P
- Zhang KYB
- Zhang L
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- Zhang M
- Zhang P
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- Zhang W
- Zhang X
- Zhang X
- Zhang X
- Zhang X
- Zhang X
- Zhang X-W
- Zhang XD
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y-D
- Zhang Y-Y
- Zhang Z
- Zhang Z
- Zhang Z
- Zhang Z
- Zhang Z
- Zhang Z
- Zhao H
- Zhao L
- Zhao S
- Zhao T
- Zhao X-F
- Zhao Y
- Zhao Y
- Zhao Y
- Zhao Y
- Zheng G
- Zheng K
- Zheng L
- Zheng S
- Zheng X-L
- Zheng Y
- Zheng Z-G
- Zhivotovsky B
- Zhong Q
- Zhou A
- Zhou B
- Zhou C
- Zhou G
- Zhou H
- Zhou H
- Zhou H
- Zhou J
- Zhou J
- Zhou J
- Zhou J
- Zhou K
- Zhou R
- Zhou X-J
- Zhou Y
- Zhou Y
- Zhou Y
- Zhou Z
- Zhou Z-Y
- Zhu B
- Zhu C
- Zhu G-Q
- Zhu H
- Zhu H
- Zhu H
- Zhu W-G
- Zhu Y
- Zhu Y
- Zhuang H
- Zhuang X
- Zientara-Rytter K
- Zimmermann CM
- Ziviani E
- Zoladek T
- Zong W-X
- Zorov DB
- Zorzano A
- Zou W
- Zou Z
- Zou Z
- Zuryn S
- Zwerschke W
- Álvarez ÉMC
- Ávalos Y
- Önal G
- Üstün S
- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Suitable Habitats for Endangered Frugivorous Mammals: Small-Scale Comparison, Regeneration Forest and Chimpanzee Density in Kibale National Park, Uganda
- Author
- A Matsumoto-Oda
- A Matsumoto-Oda
- Andrew Seguya
- AR Ives
- BG Mulley
- CA Chapman
- CA Chapman
- CA Chapman
- CA Chapman
- CA Chapman
- CA Chapman
- CA Chapman
- CB Stanford
- CEG Tutin
- CEG Tutin
- CH Cannon
- CP Van Schaik
- Cédric Sueur
- D Quiatt
- DA Onderdonk
- DP Anderson
- F Wanyama
- Flora Pennec
- G Ohashi
- G Yamakoshi
- H Pontzer
- J Hartter
- J Junker
- JA Wiens
- JC Mitani
- JC Mitani
- JGH Cant
- JH Brown
- John Kasenene
- JS Lwanga
- JU Ganzhorn
- K Potts
- KB Potts
- KB Potts
- Kevin Potts
- KJ Hockings
- KRL Jammaat
- L Naughton-Treves
- M Tweheyo
- M Tweheyo
- Marianne Cohen
- ME Thompson
- ME Thompson
- MJ Remis
- NE Newton-Fisher
- NH Carter
- NL Conklin
- Protase Rwaburindore
- Quentin Vignaud
- RH Green
- RW Wrangham
- RW Wrangham
- S Masi
- Sabrina Krief
- Sarah Bortolamiol
- TM Butynski
- V Narat
- V Reynolds
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Multiple Cavernous Angiomas of the Cauda Equina-Case Report-
- Author
- Acciarri N Padovani R, Pozzati E,
- Cervoni L Celli P, Gagliardi FM
- Crispino M Vecchioni S, Galli G, O
- Falavigna A Righesso Neto O, dos S
- Hirsch J Pradat P, David M
- Makino K Takamura H, Gotoh S, Ando
- Moreno Rojas AJ Romero J, Serrano
- Newton TM Potts D
- Ondra SL Troupp H, George ED, Schw
- Pansini A Lo Re F
- Ramos F Jr de Toffol B, Aesch B, J
- Rigamonti D Johnson PC, Spetzler R
- Robinson JR Awad IA, Little JR
- Ueda S Saito A, Inomori S, Kim I
- Publication venue
- 'Japan Neurosurgical Society'
- Publication date
- 01/01/2007
- Field of study
Comparative Feeding Ecology of Two Communities of Chimpanzees (Pan troglodytes) in Kibale National Park, Uganda
- Author
- A Fiore Di
- A Houle
- A Koenig
- AH Korstjens
- AH Korstjens
- AM Felton
- AM Felton
- B Simmen
- BB Schultz
- BMF Galdikas
- C Grassi
- C Ross
- C Tutin
- CA Chapman
- CA Chapman
- CA Chapman
- CA Chapman
- CA Chapman
- CA Chapman
- CA Chapman
- CM Murray
- D Morgan
- D Raubenheimer
- David P. Watts
- DP Watts
- DP Watts
- DP Watts
- DP Watts
- DP Watts
- DW Stephens
- EA Williamson
- EC Pielou
- EL Charnov
- FB Bercovitch
- FJ White
- G Hanya
- G Hohmann
- G Hohmann
- G Isabirye-Basuta
- G Isabirye-Basuta
- G Pyke
- G Yamakoshi
- J Altmann
- J Ganas
- J Goodall
- J Terborgh
- JC Mitani
- JC Mitani
- JC Mitani
- JL Gittleman
- JN McNair
- JR Poulsen
- JS Brown
- JS Brown
- JS Lwanga
- K Basabose
- KB Potts
- KB Strier
- KB Strier
- Kevin B. Potts
- KM Kool
- KR McConkey
- LD Wing
- LL Klein
- M Emery Thompson
- M Leighton
- MA Bowers
- ME Rogers
- MM Symington
- MN Muller
- MN Muller
- MO Hill
- MP Ghiglieri
- N Badrian
- N Newton-Fisher
- N Yamashita
- NL Conklin
- NL Conklin-Brittain
- OT Oftedal
- P Muruthi
- P Whitten
- PA Hancock
- PC Lee
- PS Rodman
- RH MacArthur
- Richard W. Wrangham
- RIM Dunbar
- RIM Dunbar
- RR Sokal
- RW Wrangham
- RW Wrangham
- RW Wrangham
- RW Wrangham
- RW Wrangham
- RW Wrangham
- SC Stearns
- SS Utami
- T Kano
- T Nishida
- TM Butynski
- TM Butynski
- TR Harris
- TT Struhsaker
- TW Schoener
- W Dittus
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Dietary Ecology of the Nigeria–Cameroon Chimpanzee (Pan troglodytes ellioti)
- Author
- A Fowler
- A Marshall
- A Whiten
- AE Russon
- AJ Marshall
- AK Basabose
- AK Basabose
- AK Piel
- Albert Mounga
- Alvine Dadjo
- Bernard Fosso
- Bethan J. Morgan
- BJ Morgan
- BJ Morgan
- BJ Morgan
- C Astaras
- C Boesch
- C Dillis
- C Tutin
- CA Chapman
- CA Chapman
- CA Chapman
- CA Chapman
- CA Chapman
- CA Chapman
- CB Stanford
- CB Stanford
- CE Tutin
- CEG Tutin
- CHD Freitas
- CM Sanz
- CP van Schaik
- D Doran
- D Morgan
- Dana M. Venditti
- DP Watts
- DP Watts
- EA Fox
- EE Abwe
- EE Abwe
- EG Wessling
- Ekwoge E. Abwe
- ER Vogel
- F Maisels
- Fabrice Kentatchime
- Flaubert Mba
- G Hanya
- G Hohmann
- G Yamakoshi
- H Ogawa
- HS Kühl
- I Deblauwe
- I Deblauwe
- I Deblauwe
- I Herbinger
- J Bessa
- J Carvalho
- J Cristóbal-Azkarate
- J Kulp
- J Moore
- J Prado-Martinez
- J Yamagiwa
- J Yamagiwa
- JB Nkurunungi
- JD Pruetz
- JD Pruetz
- JE Lambert
- JF Oates
- JO Caldecott
- JS Head
- KA Abernethy
- KB Potts
- KB Potts
- KD Hunt
- KJ Hockings
- KJ Hockings
- KR McConkey
- KR McConkey
- L Moscovice
- M Tweheyo
- Mary Katherine Gonder
- Matthew W. Mitchell
- MM Robbins
- MR Berenbaum
- MR McLennan
- MS Pavelka
- MW Mitchell
- MW Mitchell
- MW Mitchell
- N Itoh
- NE Newton-Fisher
- NE Newton-Fisher
- OM Chaves
- P Dutton
- PF Fan
- PR Sesink Clee
- R Chancellor
- R Core Team
- R Stumpf
- R Wrangham
- RA Hernandez-Aguilar
- RA Mittermeier
- RB Wallace
- RC Whytock
- Roger C. Fotso
- Roger Doudja
- RW Wrangham
- S Strindberg
- SA Kamgang
- SA Lahm
- SA Suarez
- SE Russo
- SL Bogart
- SL Bogart
- T Furuichi
- T Humle
- TB Smith
- TM Eppley
- V Sommer
- WC McGrew
- WC McGrew
- Y Sugiyama
- Y Tsuji
- ÓM Chaves
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Palmitoylation: a protein S-acylation with implications for breast cancer
- Author
- A Gauthier-Kemper
- A Pedram
- A Taherian-Fard
- A Vazquez-Martin
- AE Karnoub
- AE Schneider
- AHY Lin
- AJ Minn
- AL Schechter
- AS Azmi
- B Calippe
- B Chini
- C Sharma
- C Stellato
- C-C Su
- CE Ducker
- CG Wang
- CL Kinlough
- CS Ross-Innes
- D Alvarado
- D DiSepio
- D Khan
- D Liu
- DA Towler
- DC Allred
- DC Koboldt
- DC Marquez
- DT Coleman
- DTS Lin
- E Morrison
- E Young
- EB Mardian
- F Acconcia
- F Acconcia
- F Barmania
- GA Kozloski
- GP Gupta
- GS Brigidi
- I Izawa
- I Navarro-Lerida
- IS Babina
- J Frasor
- JM Draper
- JS Yount
- K Davalieva
- K Lemonidis
- K Subramanian
- L Doubravska
- L Li
- L Sevenich
- LC Murphy
- LH Chamberlain
- LH Chamberlain
- LK Diaz
- LR Bollu
- LR Bollu
- M Blazar
- M Chen
- M Iizuka
- M Le Romancer
- M Luo
- M Morales
- M Yeste-Velasco
- M Zoller
- MA Bennesch
- MB Potts
- MD Resh
- ME Linder
- MF Press
- MFG Schmidt
- ML Yaremko
- MN Adams
- MS Niu
- N Picard
- N Takahashi
- N Takahashi
- N Takahashi
- N Vartak
- O Guvench
- P Bottoni
- P Galluzzo
- P La Rosa
- P Nagy
- PD Bos
- Philipp Kruger
- PK Newton
- QR Jin
- R Anbazhagan
- R Kang
- R Roskoski Jr
- R Zeidman
- RA Chaudhri
- RJ Kang
- RL Stewart
- S Dave
- S Heiler
- S Hua
- S Kovats
- S Kuhn
- S Lobo
- S Sasaki
- S Trousil
- S Valastyan
- S Yoon
- SB Coffelt
- SC Su
- SJ Kim
- SM Crusz
- SN Zaman
- SO Lim
- SP Thankamony
- Stéphanie Charrin
- T Hornemann
- T Oyama
- T Tsukamoto
- T Uyama
- TH Hsu
- TM Horm
- U Krishnamurti
- V Berg
- V Miskolci
- V Pelekanou
- W Wang
- WJ Guo
- X Xu
- XC Wei
- XT Zhang
- XW Yang
- Y Kubo
- Y Percherancier
- YB Kang
- YM Tao
- YX Ma
- Z Liu
- ZY Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Growth in human population and consumption both need to be addressed to reach an ecologically sustainable future
- Author
- A Estrada
- A Muller
- A Parodi
- AC Ezeh
- AE Cahill
- BC Lister
- BP Heard
- C Batavia
- C Huntingford
- C Le Quéré
- C Mora
- C Mora
- C Mora
- C Mora
- C Mora
- C Moritz
- C Sheppard
- CA Hallmann
- CD Thomas
- CJ Bradshaw
- CJ Bradshaw
- CJM Musters
- D Connolly
- D Gil Pérez
- D Spears
- D Tilman
- DE Bloom
- DE Harter
- E Crist
- E Crist
- E Dinerstein
- Elias Ganivet
- EO Wilson
- F Götmark
- F Sánchez-Bayo
- FAO
- FAOSTAT
- G Ceballos
- G Ceballos
- G Ceballos
- G Nelson
- G Sedgh
- GA Olah
- GB Bonan
- GC Daily
- GC Daily
- GC Daily
- GJ Abel
- GK Meffe
- H Kopnina
- H Washington
- H Washington
- H Washington
- H Washington
- H Washington
- H Washington
- HJ Geist
- HK Gibbs
- HT Pinheiro
- I Lowe
- IAASTD
- IG Mason
- International Energy Agency
- IPCC
- IPCC
- J Bongaarts
- J Clay
- J Cleland
- J Eder
- J Guillebaud
- J Hansen
- J-Y Meyer
- JA Foley
- JA Foley
- JA Foley
- JA Foley
- JC Steckel
- JE Watson
- JEM Baillie
- JN O’Sullivan
- K Henderson
- K Klein Goldewijk
- K Newton
- KD Burke
- KR Smith
- L Aleksandrowicz
- L Brown
- L Clarke
- L Kemp
- M Blowfield
- M Hulme
- M Kaidbey
- M Potts
- M Ravallion
- M Springmann
- M Springmann
- MC Urban
- MC Urban
- MM Campbell
- MR Chertow
- MR Raupach
- MZ Jacobson
- MZ Jacobson
- N Alexandratos
- N Nakicenovic
- N Prata
- NF Sayre
- NJ Cook
- P Cafaro
- P Curry
- P Raven
- P Smith
- PA Murtaugh
- PL Pingali
- PR Ehrlich
- PR Ehrlich
- PR Ehrlich
- R Bolla
- R Dietz
- R Engelman
- R Engelman
- R Engelman
- R Fletcher
- R Lee
- RF Noss
- RJ Keenan
- S Custer
- S Díaz
- S Halfon
- S Singer
- S Singh
- S Wynes
- SH Mayhew
- SL Lewis
- SL Maxwell
- SW Sinding
- T Berry
- TM Smeeding
- TML Wigley
- UNEP
- UNFCCC
- USDE
- USGCRP
- V Vijay
- W Cates
- W Sanderson
- W Staples
- W Steffen
- W Willett
- WB Meyer
- WF Laurance
- WJ Ripple
- WJ Ripple
- World Bank
- World Resources Institute
- Y Malhi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Recommended from our members
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19
- Author
- Abdelrazik M
- Abedalthagafi M
- Abel L
- Abel L
- Abellan J
- Abernathy C
- Abraheem A
- Acklery A
- Acosta-Isaac R
- Adam R
- Adams C
- Adams K
- Adams N
- Adanini O
- Afolabi D
- Agasou A
- Agravante K
- Agravante K
- Agrawal S
- Aguado JM
- Aguilar C
- Aguilar PM
- Aguilera-Albesa S
- Ahmad N
- Ahmadhaider N
- Ahmed A
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- Zechner M
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- Álvarez BG
- Álvarez-Benítez Y
- Álvarez-Navia F
- Íñiguez M
- Publication venue
- Springer Nature
- Publication date
- 17/05/2023
- Field of study
Data availability: Downloadable summary data are available through the GenOMICC data site (https://genomicc.org/data). Summary statistics are available, but without the 23andMe summary statistics, except for the 10,000 most significant hits, for which full summary statistics are available. The full GWAS summary statistics for the 23andMe discovery dataset will be made available through 23andMe to qualified researchers under an agreement with 23andMe that protects the privacy of the 23andMe participants. For further information and to apply for access to the data, see the 23andMe website (https://research.23andMe.com/dataset-access/). All individual-level genotype and whole-genome sequencing data (for both academic and commercial uses) can be accessed through the UKRI/HDR UK Outbreak Data Analysis Platform (https://odap.ac.uk). A restricted dataset for a subset of GenOMICC participants is also available through the Genomics England data service. Monocyte RNA-seq data are available under the title ‘Monocyte gene expression data’ within the Oxford University Research Archives (https://doi.org/10.5287/ora-ko7q2nq66). Sequencing data will be made freely available to organizations and researchers to conduct research in accordance with the UK Policy Framework for Health and Social Care Research through a data access agreement. Sequencing data have been deposited at the European Genome–Phenome Archive (EGA), which is hosted by the EBI and the CRG, under accession number EGAS00001007111.Extended data figures and tables are available online at https://www.nature.com/articles/s41586-023-06034-3#Sec21 .Supplementary information is available online at https://www.nature.com/articles/s41586-023-06034-3#Sec22 .Code availability:
Code to calculate the imputation of P values on the basis of SNPs in linkage disequilibrium is available at GitHub (https://github.com/baillielab/GenOMICC_GWAS).Acknowledgements: We thank the members of the Banco Nacional de ADN and the GRA@CE cohort group; and the research participants and employees of 23andMe for making this work possible. A full list of contributors who have provided data that were collated in the HGI project, including previous iterations, is available online (https://www.covid19hg.org/acknowledgements).Change history: 11 July 2023: A Correction to this paper has been published at: https://doi.org/10.1038/s41586-023-06383-z. -- In the version of this article initially published, the name of Ana Margarita Baldión-Elorza, of the SCOURGE Consortium, appeared incorrectly (as Ana María Baldion) and has now been amended in the HTML and PDF versions of the article.Copyright © The Author(s) 2023, Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown1 to be highly efficient for discovery of genetic associations2. Despite the advanced stage of illness at presentation, we have shown that host genetics in patients who are critically ill with COVID-19 can identify immunomodulatory therapies with strong beneficial effects in this group3. Here we analyse 24,202 cases of COVID-19 with critical illness comprising a combination of microarray genotype and whole-genome sequencing data from cases of critical illness in the international GenOMICC (11,440 cases) study, combined with other studies recruiting hospitalized patients with a strong focus on severe and critical disease: ISARIC4C (676 cases) and the SCOURGE consortium (5,934 cases). To put these results in the context of existing work, we conduct a meta-analysis of the new GenOMICC genome-wide association study (GWAS) results with previously published data. We find 49 genome-wide significant associations, of which 16 have not been reported previously. To investigate the therapeutic implications of these findings, we infer the structural consequences of protein-coding variants, and combine our GWAS results with gene expression data using a monocyte transcriptome-wide association study (TWAS) model, as well as gene and protein expression using Mendelian randomization. We identify potentially druggable targets in multiple systems, including inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).GenOMICC was funded by Sepsis Research (the Fiona Elizabeth Agnew Trust), the Intensive Care Society, a Wellcome Trust Senior Research Fellowship (to J.K.B., 223164/Z/21/Z), the Department of Health and Social Care (DHSC), Illumina, LifeArc, the Medical Research Council, UKRI, a BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070 and BBS/E/D/30002275) and UKRI grants MC_PC_20004, MC_PC_19025, MC_PC_1905 and MRNO2995X/1. A.D.B. acknowledges funding from the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z), the Edinburgh Clinical Academic Track (ECAT) programme. This research is supported in part by the Data and Connectivity National Core Study, led by Health Data Research UK in partnership with the Office for National Statistics and funded by UK Research and Innovation (grant MC_PC_20029). Laboratory work was funded by a Wellcome Intermediate Clinical Fellowship to B.F. (201488/Z/16/Z). We acknowledge the staff at NHS Digital, Public Health England and the Intensive Care National Audit and Research Centre who provided clinical data on the participants; and the National Institute for Healthcare Research Clinical Research Network (NIHR CRN) and the Chief Scientist’s Office (Scotland), who facilitate recruitment into research studies in NHS hospitals, and to the global ISARIC and InFACT consortia. GenOMICC genotype controls were obtained using UK Biobank Resource under project 788 funded by Roslin Institute Strategic Programme Grants from the BBSRC (BBS/E/D/10002070 and BBS/E/D/30002275) and Health Data Research UK (HDR-9004 and HDR-9003). UK Biobank data were used in the GSMR analyses presented here under project 66982. The UK Biobank was established by the Wellcome Trust medical charity, Medical Research Council, Department of Health, Scottish Government and the Northwest Regional Development Agency. It has also had funding from the Welsh Assembly Government, British Heart Foundation and Diabetes UK. The work of L.K. was supported by an RCUK Innovation Fellowship from the National Productivity Investment Fund (MR/R026408/1). J.Y. is supported by the Westlake Education Foundation. SCOURGE is funded by the Instituto de Salud Carlos III (COV20_00622 to A.C., PI20/00876 to C.F.), European Union (ERDF) ‘A way of making Europe’, Fundación Amancio Ortega, Banco de Santander (to A.C.), Cabildo Insular de Tenerife (CGIEU0000219140 ‘Apuestas científicas del ITER para colaborar en la lucha contra la COVID-19’ to C.F.) and Fundación Canaria Instituto de Investigación Sanitaria de Canarias (PIFIISC20/57 to C.F.). We also acknowledge the contribution of the Centro National de Genotipado (CEGEN) and Centro de Supercomputación de Galicia (CESGA) for funding this project by providing supercomputing infrastructures. A.D.L. is a recipient of fellowships from the National Council for Scientific and Technological Development (CNPq)-Brazil (309173/2019-1 and 201527/2020-0)
Mapping the human genetic architecture of COVID-19
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- Vari MS
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- Vedage D
- Veelo D
- Veerapen K
- Veerapen K
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- Verdugo RA
- Vergori A
- Verlander M
- Verma A
- Verma SS
- Vertue M
- Vertue M
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- Vollenweider P
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- von Hohenstaufen K
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- Waddy S
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- Yoshiyama T
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- Zanelli G
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- zu Bentrup FM
- Zucchi P
- Zwinderman AHK
- Zyndorf M
- Publication venue
- Publication date
- 01/01/2021
- Field of study
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease
A second update on mapping the human genetic architecture of COVID-19
- Author
- Abd Elghafar MS
- Abdel-Aziz M
- Abdelrazik M
- Abdullah MS
- Abe R
- Abe S
- Abel L
- Abel L
- Abernathy C
- Abraham R
- Abraheem A
- Abu Alragheb BO
- Abulail JA
- Acklery A
- Acosta-Herrera M
- Adachi T
- Adachi Y
- Adam R
- Adams C
- Adams K
- Adams N
- Adanini O
- Afifi N
- Afilalo J
- Afilalo M
- Afolabi D
- Afrasiabi Z
- Afset JE
- Agasou A
- Aghemo A
- Agravante K
- Agrawal A
- Agrawal S
- Aguado JM
- Aguilar C
- Aguilar SEV
- Aguilar-Salinas CA
- Aguilera-Albesa S
- Agüero D
- Ahmad HF
- Ahmad N
- Ahmadhaider N
- Ahmed A
- Ahmed C
- Ahram M
- Ai M
- Ain Q
- Aitkin E
- Akeroyd L
- Akhtar MN
- Akinkugbe O
- Al-Ani A
- Al-Ja’afreh MM
- Al-Kadash A
- Al-Kasasbeh MM
- Al-Moasseb H
- Al-Muftah W
- Al-Sarraj Y
- Alamer LM
- Alasdair F
- Alawneh FM
- Alawneh LM
- Albaiceta GM
- Albano G
- Albillos A
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- Ward G
- Ward K
- Ward L
- Ward M
- Ward S
- Warden S
- Warren D
- Warrington J
- Washington NL
- Wassall H
- Wasson C
- Watanabe H
- Watanabe K
- Waters A
- Waters E
- Watkins C
- Watson E
- Watson G
- Watson J
- Watters M
- Watts S
- Waugh V
- Weaver J
- Webb N
- Webster A
- Webster D
- Webster K
- Wei S
- Wei Z
- Weiss ST
- Weldon CH
- Welford A
- Wells C
- Welters I
- Wendorff M
- Wendtner CM
- Werge T
- Wesse T
- West J
- Westergaard D
- Weston H
- Whileman A
- Whitaker E
- Whitbread J
- White D
- White I
- White K
- White M
- White N
- White N
- White S
- Whitehead V
- Whitelaw L
- Whiteley S
- Whiteside J
- Whitney J
- Whitton C
- Whyte C
- Wicks SJ
- Wiegrebe S
- Wienbrandt L
- Wignall A
- Wilby L
- Wilcox L
- Wild H
- Wild L
- Wilding L
- Wiles M
- Wilfling S
- Wiliams A
- Wilkin F
- Wilkins J
- Wilkinson A
- Wilkinson B
- Williams A
- Williams A
- Williams C
- Williams D
- Williams E
- Williams E
- Williams G
- Williams H
- Williams J
- Williams K
- Williams M
- Williams P
- Williams S
- Williams T
- Willis C
- Willis H
- Wills M
- Willson J
- Wilson A
- Wilson DJ
- Wilson J
- Wilson JF
- Wiltfang J
- Winchester J
- Winkler TW
- Winmill H
- Winnard S
- Winter C
- Winter K
- Winter-Goodwin B
- Wittig M
- Witzke O
- Wolf-Roberts R
- Wolford BN
- Wong I
- Wong J
- Wong J
- Wood D
- Wood H
- Wood S
- Wood S
- Wood T
- Woodford C
- Woodruff M
- Woods L
- Woodward E
- Woodward J
- Woolcock M
- Woolley AE
- Worner R
- Worsley L
- Wray G
- Wren L
- Wreybrown C
- Wright C
- Wright DJ
- Wright J
- Wright M
- Wright S
- Wrobel N
- Wu Y
- Wulandari R
- Wylie K
- Wyllie DH
- Wynter I
- Xavier K
- Xue X
- Yagi K
- Yamada M
- Yamada Y
- Yamagata K
- Yamasaki M
- Yang J
- Yaspan B
- Yassen AM
- Yasui Y
- Yates B
- Yatomi M
- Ye C
- Yermakovich D
- Yeung RSM
- Yi X
- Yonekawa A
- Yoo S
- Yoon K
- Yoshida K
- Yoshida S
- Yoshida S
- Yoshida T
- Yoshihara T
- Yoshiya K
- Yoshiyama T
- Young M
- Yue F
- Yun N
- Yáñez CE
- Yáñez Z
- Zainulabid UA
- Zainy T
- Zak A
- Zaki A
- Zamikula J
- Zamudio IPM
- Zanella A
- Zapata-Contreras D
- Zapatamartinez M
- Zarate R
- Zarei N
- Zavaleta DAF
- Zawadzki P
- Zawati MH
- Zborowski AC
- Zeberg H
- Zechner M
- Zhang Q
- Zhao X
- Zheng C
- Zheng T
- Zhlawi HJ
- Zhlawi MWJ
- Zholdybayeva E
- Zhou W
- Zhu W
- Zitter L
- Zoller H
- Zongo O
- Zorloni C
- Zuñiga-Pacheco P
- Zárate RN
- Zúñiga-Ramos J
- Álvarez BG
- Ávila-Arcos MA
- Ávila-Arcos MC
- Özer O
- Überla K
- Þorsteinsdóttir U
- Publication venue
- Nature Research
- Publication date
- 21/06/2023
- Field of study