21 research outputs found

    Dissemination and Implementation Program in Hypertension in Rwanda: Report on Initial Training and Evaluation

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    BackgroundCardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide and in low- and middle-income countries, and hypertension (HTN) is a major risk factor for CVD. Although effective evidence-based interventions for control of HTN in high-income countries exist, implementation of these in low- and middle-income countries has been challenging due to limited capacity and infrastructure for late-phase translational research. In Rwanda, the 2015 STEPS NCD (STEPwise Approach to Surveillance of Noncommunicable Diseases) risk survey reported an overall prevalence of HTN of 15% (95% confidence interval [CI]: 13.8 to 16.3) for those ages 15 to 64 years; prevalence increased with increasing age to 39% (95% CI: 35.7 to 43.1) for those ages 55 to 64 years; CVD was the third most common cause of mortality (7%). Suboptimal infrastructure and capacity in Rwanda hinders research and community knowledge for HTN control.ObjectivesTo address the issue of suboptimal capacity to implement evidence-based interventions in HTN, this project was designed with the following objectives: 1) to develop a regional needs assessment of infrastructure for dissemination and implementation (D & I) strategies for HTN-CVD control; 2) to develop HTN-CVD research capacity through creation of countrywide resources such as core research facilities and training in the fields of HTN-CVD, D & I, and biostatistics; and 3) to engage and train multiple stakeholders in D & I and HTN-CVD evidence-based interventions.MethodsA weeklong training program in HTN-CVD, biostatistics, and D & I was conducted in Rwanda in August 2018, and pre- and post-D & I training competency questionnaires were administered.ResultsQuestionnaire results show a statistically significant increase in D & I knowledge and skills as a result of training (full scale pre- to post-test scores: 2.12 ± 0.78 vs. 3.94 ± 0.42; p < 0.0001).ConclusionsUsing principles of community engagement and train-the-trainer methods, we will continue to adapt guidelines and treatments for HTN-CVD developed in high-income countries to the context of Rwanda with the goal of establishing a sustainable platform to address the burden of disease from HTN-CVD

    Final Moments II: Observational Properties and Physical Modeling of CSM-Interacting Type II Supernovae

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    International audienceWe present ultraviolet/optical/near-infrared observations and modeling of Type II supernovae (SNe II) whose early-time (δt<2\delta t < 2 days) spectra show transient, narrow emission lines from shock ionization of confined (r<1015r < 10^{15} cm) circumstellar material (CSM). The observed electron-scattering broadened line profiles (i.e., IIn-like) of HI, He I/II, C III/IV, and N III/IV/V from the CSM persist on a characteristic timescale (tIInt_{\rm IIn}) that marks a transition to a lower-density CSM and the emergence of Doppler-broadened features from the fast-moving SN ejecta. Our sample, the largest to date, consists of 39 SNe with early-time IIn-like features in addition to 35 "comparison" SNe with no evidence of early-time IIn-like features, all with ultraviolet observations. The total sample consists of 50 unpublished objects with 474 previously unpublished spectra and 50 multiband light curves, collected primarily through the Young Supernova Experiment and Global Supernova Project collaborations. For all sample objects, we find a significant correlation between peak ultraviolet brightness and both tIInt_{\rm IIn} and the rise time, as well as evidence for enhanced peak luminosities in SNe II with IIn-like features. We quantify mass-loss rates and CSM density for the sample through matching of peak multiband absolute magnitudes, rise times, tIInt_{\rm IIn} and optical SN spectra with a grid of radiation hydrodynamics and non-local thermodynamic equilibrium (nLTE) radiative-transfer simulations. For our grid of models, all with the same underlying explosion, there is a trend between the duration of the electron-scattering broadened line profiles and inferred mass-loss rate: tIIn3.8[M˙/(0.01Myr1)]t_{\rm IIn} \approx 3.8[\dot{M}/(0.01 \textrm{M}_{\odot} \textrm{yr}^{-1})] days

    Perception and synthesis of biologically plausible motion: From human physiology to virtual reality

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    6th International Workshop on Gesture in Human-Computer Interaction and Simulation, Berder Isl, FRANCE, MAY 18-20, 2005International audienceTo model and simulate human gesture is a challenge which takes benefit from a close collaboration between scientists from several fields: psychology, physiology, biomechanics, cognitive and computer sciences, etc. As an a priori requirement, we need to better understand the so-called laws of biological motions, established all along the 20(th) century. When modelled and used to animate artificial creature, these laws makes these creatures (either virtual or robotic) move in a much more realistic, life-like, fashion
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