Peer-to-Peer Knowledge Management: Overcoming Bottlenecks and Improving Information Quality

Access to current, complete and relevant knowledge is a key competitive differentiator in the present economic market space. But most knowledge management today only shifts the traditional, expert-based KM processes onto electronic media. This paper discusses a paradigm shift from an expert-centric to a peer-to-peer approach to knowledge creation and management. Leveraging the lowered transaction costs provided by Internet technology, methods and tools of collaboration that have been invented and refined by the Open Source and Free Software community over the last two decades are now being adopted by early movers in the Knowledge Management space. This new approach, based on a peer-to-peer approach and open collaboration, has shown the potential to revolutionize the way knowledge is created, developed and managed. We outline the characteristics of the two opposing paradigms and present ways in which the peer-to-peer knowledge management approach is already being successfully used in practice today. We address how the quality of information is kept high without a traditional review/quality-check role by using a revision control system and distributing the task to all interested practitioners. Finally, we discuss four key challenges for introducing the new paradigm within companies

Innovating for and with your service customers: An assessment of the current practice of collaborative service innovation in Germany

AbstractMethods for managing innovation have been described in academia in many contexts. Service innovation processes pose particular challenges compared to those of product innovation – one of the core reasons being the lack of dedicated R&D structures in service firms or units. Collaborative innovation both with employees and with customers can be an effective means to drive innovation in services. Based on empirical evidence of a study of German innovation managers, this paper discusses findings of service innovation in organizational practice. We review the current extent and future potential of the involvement of employees and customers in the innovation process, as well implications for companies and academia

Zinsswaps - Funktionsweise, Bewertung und Diskussion

Ein Swap ist ein Vertrag zwischen zwei Parteien, die sich zum gegenseitigen Austausch zukünftiger Zahlungen verpflichten. Die Vereinbarung determiniert die Zeitpunkte, an denen die Zahlungen zu erfolgen haben, und in welcher Weise deren Betrag zu bestimmen ist. Während bei Forward-Geschäften der Transfer von Zahlungen zu einem einzigen Zeitpunkt in der Zukunft stattfindet, führen Swaps zu deren Übertragung an mehreren künftigen Zeitpunkten. Swaps lassen sich daher auch als eine Folge von Forward-Geschäften interpretieren. Infolge ihrer großen Bedeutung werden Zinsswaps in allen wesentlichen Lehrbüchern zur Bankwirtschaft und zur Finanzwirtschaft angesprochen. Ziel dieses Beitrags ist es, die diskussionsbedürftigen Aspekte offenzulegen und zu kommentieren sowie einen elementaren Bewertungsansatz vorzustellen. Da sich die kritischen Anmerkungen auf Lehrbücher beziehen, ist die Darstellung auf die Adressaten von Lehrbüchern zugeschnitten

Growth and reductive transformation of a gold shell around pyramidal cadmium selenide nanocrystals

We report the growth of an unstable shell-like gold structure around dihexagonal pyramidal CdSe nanocrystals in organic solution and the structural transformation to spherical domains by two means: i) electron beam irradiation (in situ) and (ii) addition of a strong reducing agent during synthesis. By varying the conditions of gold deposition, such as ligands present or the geometry of the CdSe nanocrystals, we were able to tune the gold domain size between 1.4 nm to 3.9 nm and gain important information on the role of surface chemistry in hetero nanoparticle synthesis and seed reactivity, both of which are crucial points regarding the chemical design of new materials for photocatalysis and optoelectronic applications.Comment: 5 pages, 4 figure

Sun-induced chlorophyll fluorescence II:Review of passive measurement setups, protocols, and their application at the leaf to canopy level

Satellite gravimetry allows for determining large scale mass transport in the system Earth and to quantify ice mass change in polar regions. We provide, evaluate and compare a long time-series of monthly gravity field solutions derived either by satellite laser ranging (SLR) to geodetic satellites, by GPS and K-band observations of the GRACE mission, or by GPS observations of the three Swarm satellites. While GRACE provides gravity signal at the highest spatial resolution, SLR sheds light on mass transport in polar regions at larger scales also in the pre- and post-GRACE era. To bridge the gap between GRACE and GRACE Follow-On, we also derive monthly gravity fields using Swarm data and perform a combination with SLR. To correctly take all correlations into account, this combination is performed on the normal equation level. Validating the Swarm/SLR combination against GRACE during the overlapping period January 2015 to June 2016, the best fit is achieved when down-weighting Swarm compared to the weights determined by variance component estimation. While between 2014 and 2017 SLR alone slightly overestimates mass loss in Greenland compared to GRACE, the combined gravity fields match significantly better in the overlapping time period and the RMS of the differences is reduced by almost 100 Gt. After 2017, both SLR and Swarm indicate moderate mass gain in Greenland

Piezoelectric templates : new views on biomineralization and biomimetics

Biomineralization in general is based on electrostatic interactions and molecular recognition of organic and inorganic phases. These principles of biomineralization have also been utilized and transferred to bio-inspired synthesis of functional materials during the past decades. Proteins involved in both, biomineralization and bio-inspired processes, are often piezoelectric due to their dipolar character hinting to the impact of a template's piezoelectricity on mineralization processes. However, the piezoelectric contribution on the mineralization process and especially the interaction of organic and inorganic phases is hardly considered so far. We herein report the successful use of the intrinsic piezoelectric properties of tobacco mosaic virus (TMV) to synthesize piezoelectric ZnO. Such films show a two-fold increase of the piezoelectric coefficient up to 7.2 pm V⁻¹ compared to films synthesized on non-piezoelectric templates. By utilizing the intrinsic piezoelectricity of a biotemplate, we thus established a novel synthesis pathway towards functional materials, which sheds light on the whole field of biomimetics. The obtained results are of even broader and general interest since they are providing a new, more comprehensive insight into the mechanisms involved into biomineralization in living nature

High TNFRSF14 and low BTLA are associated with poor prognosis in Follicular Lymphoma and in Diffuse Large B-cell Lymphoma transformation

The microenvironment influences the behavior of follicular lymphoma (FL) but the specific roles of the immunomodulatory BTLA and TNFRSF14 (HVEM) are unknown. Therefore, we examined their immunohistochemical expression in the intrafollicular, interfollicular and total histological compartments in 106 FL cases (57M/49F; median age 57-years), and in nine relapsed-FL with transformation to DLBCL (tFL). BTLA expression pattern was of follicular T-helper cells (TFH) in the intrafollicular and of T-cells in the interfollicular compartments. The mantle zones were BTLA+ in 35.6% of the cases with similar distribution of IgD. TNFRSF14 expression pattern was of neoplastic B lymphocytes (centroblasts) and "tingible body macrophages". At diagnosis, the averages of total BTLA and TNFRSF14-positive cells were 19.2%±12.4STD (range, 0.6%-58.2%) and 46.7 cells/HPF (1-286.5), respectively. No differences were seen between low-grade vs. high-grade FL but tFL was characterized by low BTLA and high TNFRSF14 expression. High BTLA correlated with good overall survival (OS) (total-BTLA, Hazard Risk=0.479, P=0.022) and with high PD-1 and FOXP3+Tregs. High TNFRSF14 correlated with poor OS and progression-free survival (PFS) (total-TNFRSF14, HR=3.9 and 3.2, respectively, P<0.0001), with unfavorable clinical variables and higher risk of transformation (OR=5.3). Multivariate analysis including BTLA, TNFRSF14 and FLIPI showed that TNFRSF14 and FLIPI maintained prognostic value for OS and TNFRSF14 for PFS. In the GSE16131 FL series, high TNFRSF14 gene expression correlated with worse prognosis and GSEA showed that NFkB pathway was associated with the "High-TNFRSF14/dead-phenotype". In conclusion, the BTLA-TNFRSF14 immune modulation pathway seems to play a role in the pathobiology and prognosis of FL

Global analysis of the apple fruit microbiome: are all apples the same?

We present the first worldwide study on the apple (Malus × domestica) fruit microbiome that examines questions regarding the composition and the assembly of microbial communities on and in apple fruit. Results revealed that the composition and structure of the fungal and bacterial communities associated with apple fruit vary and are highly dependent on geographical location. The study also confirmed that the spatial variation in the fungal and bacterial composition of different fruit tissues exists at a global level. Fungal diversity varied significantly in fruit harvested in different geographical locations and suggests a potential link between location and the type and rate of postharvest diseases that develop in each country. The global core microbiome of apple fruit was represented by several beneficial microbial taxa and accounted for a large fraction of the fruit microbial community. The study provides foundational information about the apple fruit microbiome that can be utilized for the development of novel approaches for the management of fruit quality and safety, as well as for reducing losses due to the establishment and proliferation of postharvest pathogens. It also lays the groundwork for studying the complex microbial interactions that occur on apple fruit surfaces.info:eu-repo/semantics/publishedVersio

A comparison of DSM-IV-TR and DSM-5 diagnostic criteria for gambling disorder in a large clinical sample

Background and Aims: gambling-related crimes are known to be associated with gambling disorder (GD). Due to a lack of consensus in the scientific community regarding the relevance of this diagnostic criterion, it was removed from the DSM-5. The primary aim of this study was to investigate through structural equation modeling (SEM) whether higher GD severity in treatment-seeking GD patients with a criminal record is mediated through the illegal acts criterion itself, or whether it can be better explained by other related clinical factors. Methods: an initial sample of 2,081 patients seeking treatment for gambling problems was included in the sample. SEM was used to evaluate the mediational role of the illegal acts criterion between the sex, age and personality traits, gambling severity, and comorbid depression levels. Comparisons between patients with coinciding and divergent DSM criterion for GD diagnosis were carried out. Results: illegal acts mediated the relationship between personality traits and GD severity: younger age, high levels of novelty seeking, and low levels of self-transcendence increased the risk of endorsing the illegal acts criterion. No differences between coincident-divergent groups in terms of DSM-IV and DSM-5 diagnosis were found with regards to sex (p = 0.878), education level (p = 0.387), or civil status (p = 0.792). Discussion and Conclusion: the results obtained in the present study offer new insights into the utility of using a history of illegal acts, their different personality characteristics, and psychopathology to categorize GD patients. Our findings suggest that patients who engage in criminal behavior may require a more comprehensive intervention

Palaeogenomics of Upper Palaeolithic to Neolithic European hunter-gatherers

: Modern humans have populated Europe for more than 45,000 years1,2. Our knowledge of the genetic relatedness and structure of ancient hunter-gatherers is however limited, owing to the scarceness and poor molecular preservation of human remains from that period3. Here we analyse 356 ancient hunter-gatherer genomes, including new genomic data for 116 individuals from 14 countries in western and central Eurasia, spanning between 35,000 and 5,000 years ago. We identify a genetic ancestry profile in individuals associated with Upper Palaeolithic Gravettian assemblages from western Europe that is distinct from contemporaneous groups related to this archaeological culture in central and southern Europe4, but resembles that of preceding individuals associated with the Aurignacian culture. This&nbsp;ancestry profile survived during the Last Glacial Maximum (25,000 to 19,000 years ago) in human populations from southwestern Europe associated with the Solutrean&nbsp;culture, and with&nbsp;the following Magdalenian culture&nbsp;that re-expanded northeastward after the Last Glacial Maximum. Conversely, we reveal a genetic turnover in southern Europe suggesting a local replacement of human groups around the time of the Last Glacial Maximum, accompanied by a north-to-south dispersal of populations associated with the Epigravettian culture. From at least 14,000 years ago, an ancestry related to this culture spread from the south across the rest of Europe, largely replacing the Magdalenian-associated gene pool. After a period of limited admixture that spanned the beginning of the Mesolithic, we find genetic interactions between western and eastern European hunter-gatherers,&nbsp;who were also characterized by marked differences in phenotypically relevant variants