Preparing the foundations for video-based, practice-placement support: establishing the role from a students’ perspective

Currently, many placement-based health programme students within the UK are supported through face-to-face visits from university staff. Whilst cited in literature as being of value, the face-to-face nature of this contact is not supported. Alternatives including video-based communications methods offer the potential for cost effective, environmentally responsible support. However, in order to establish the fitness for purpose of alternative approaches, the content and purpose of current support needs to be understood. This project aimed to investigate student perceptions of the ideal content and purpose of clinical support visits, and alternatives to the current face-to-face approach. Fifty-six Physiotherapy undergraduate students responded to questionnaires with a further nine participating in a follow-up focus group. Participants emphasised the value of the visit in guiding learning, ensuring progression and resolving arising issues, and highlighted concerns over alternative approaches. Focus group participants discussed the importance of personal and professional confidence in directing requirements for support, and went on to propose a menu of options for methods of communication.Whilst limited in some applications, video technologies may be one of the options. Overall, however, this project supports the need for consideration of individualised learning journeys within curriculum planning

Epidermal growth factor receptor variant III mediates head and neck cancer cell invasion via STAT3 activation.

Epidermal growth factor receptor (EGFR) is frequently overexpressed in head and neck squamous cell carcinoma (HNSCC) where aberrant signaling downstream of this receptor contributes to tumor growth. EGFR variant III (EGFRvIII) is the most commonly altered form of EGFR and contains a truncated ligand-binding domain. We previously reported that EGFRvIII is expressed in up to 40% of HNSCC tumors where it is associated with increased proliferation, tumor growth and chemoresistance to antitumor drugs including the EGFR-targeting monoclonal antibody cetuximab. Cetuximab was FDA-approved in 2006 for HNSCC but has not been shown to prevent invasion or metastasis. This study was undertaken to evaluate the mechanisms of EGFRvIII-mediated cell motility and invasion in HNSCC. We found that EGFRvIII induced HNSCC cell migration and invasion in conjunction with increased signal transducer and activator of transcription 3 (STAT3) activation, which was not abrogated by cetuximab treatment. Further investigation showed that EGF-induced expression of the STAT3 target gene HIF1-α, was abolished by cetuximab in HNSCC cells expressing wild-type EGFR under hypoxic conditions, but not in EGFRvIII-expressing HNSCC cells. These results suggest that EGFRvIII mediates HNSCC cell migration and invasion by increased STAT3 activation and induction of HIF1-α, which contribute to cetuximab resistance in EGFRvIII-expressing HNSCC tumors

A search for L dwarf binary systems

We present analysis of HST Planetary Camera images of twenty L dwarfs identified in the course of the Two Micron All-Sky Survey. Four of the targets have faint, red companions at separations between 0.07 and 0.29 arcseconds (1.6 to 7.6 AU). In three cases, the bolometric magnitudes of the components differ by less than 0.3 magnitudes. Since the cooling rate for brown dwarfs is a strong function of mass, similarity in luminosities implies comparable masses. The faint component in the 2M0850 system, however, is over 1.3 magnitudes fainter than the primary in the I-band, and ~0.8 magnitudes fainter in M(bol). Indeed, 2M0850B is ~0.8 magnitudes fainter in I than the lowest luminosity L dwarf currently known, while the absolute magnitude we deduce at J is almost identical with M_J for Gl 229B. Theoretical models indicate a mass ratio of \~0.75. The mean separation of the L dwarf binaries in the current sample is smaller by a factor of two than amongst M dwarfs. We discuss the implications of these results for the temperature scale in the L/T transition region and for the binary frequency amongst L dwarfs.Comment: 38 pages, 11 figures; accepted for A

Constructing a WISE High Resolution Galaxy Atlas

After eight months of continuous observations, the Wide-field Infrared Survey Explorer (WISE) mapped the entire sky at 3.4 {\mu}m, 4.6 {\mu}m, 12 {\mu}m and 22 {\mu}m. We have begun a dedicated WISE High Resolution Galaxy Atlas (WHRGA) project to fully characterize large, nearby galaxies and produce a legacy image atlas and source catalogue. Here we summarize the deconvolution technique used to significantly improve the spatial resolution of WISE imaging, specifically designed to study the internal anatomy of nearby galaxies. As a case study, we present results for the galaxy NGC 1566, comparing the WISE super-resolution image processing to that of Spitzer, GALEX and ground-based imaging. The is the first paper in a two part series; results for a much larger sample of nearby galaxies is presented in the second paper.Comment: Published in the AJ (2012, AJ, 144, 68

An international network to monitor the structure, composition and dynamics of Amazonian forests (RAINFOR)

The Amazon basin is likely to be increasingly affected by environmental changes: higher temperatures, changes in precipitation, CO2 fertilization and habitat fragmentation. To examine the important ecological and biogeochemical consequences of these changes, we are developing an international network, RAINFOR, which aims to monitor forest biomass and dynamics across Amazonia in a co-ordinated fashion in order to understand their relationship to soil and climate. The network will focus on sample plots established by independent researchers, some providing data extending back several decades. We will also conduct rapid transect studies of poorly monitored regions. Field expeditions analysed local soil and plant properties in the first phase (2001–2002). Initial results suggest that the network has the potential to reveal much information on the continental-scale relations between forest and environment. The network will also serve as a forum for discussion between researchers, with the aim of standardising sampling techniques and methodologies that will enable Amazonian forests to be monitored in a coherent manner in the coming decades

Type Ia Supernovae Rates and Galaxy Clustering from the CFHT Supernova Legacy Survey

The Canada-France-Hawaii Telescope Supernova Legacy Survey (SNLS) has created a large homogeneous database of intermediate redshift (0.2 < z < 1.0) type Ia supernovae (SNe Ia). The SNLS team has shown that correlations exist between SN Ia rates, properties, and host galaxy star formation rates. The SNLS SN Ia database has now been combined with a photometric redshift galaxy catalog and an optical galaxy cluster catalog to investigate the possible influence of galaxy clustering on the SN Ia rate, over and above the expected effect due to the dependence of SFR on clustering through the morphology-density relation. We identify three cluster SNe Ia, plus three additional possible cluster SNe Ia, and find the SN Ia rate per unit mass in clusters at intermediate redshifts is consistent with the rate per unit mass in field early-type galaxies and the SN Ia cluster rate from low redshift cluster targeted surveys. We also find the number of SNe Ia in cluster environments to be within a factor of two of expectations from the two component SNIa rate model.Comment: 21 pages, 2 figures, 6 tables, accepted for publication in A

SDSS J042348.57-041403.5AB: A Brown Dwarf Binary Straddling the L/T Transition

We present the discovery of SDSS J042348.57-041403.5 as a closely-separated (0"16) brown dwarf binary, resolved by the Hubble Space Telescope Near Infrared Camera and Multi-Object Spectrometer. Physical association is deduced from the angular proximity of the components and constraints on their common proper motion. SDSS0423-0414AB appears to be composed of two brown dwarfs with spectral types L6+/-1 and T2+/-1. Hence, this system straddles the transition between L dwarfs and T dwarfs, a unique evolutionary phase of brown dwarfs characterized by substantial shifts in spectral morphology over an apparently narrow effective temperature range. Binarity explains a number of unusual properties of SDSS 0423-0414, including its overluminosity and high effective temperature compared to other early-type T dwarfs, and possibly its conflicting spectral classifications (L7.5 in the optical, T0 in the near infrared). The relatively short estimated orbital period of this system (~15-20 yr) and the presence of Li I absorption in its combined light spectrum make it an ideal target for both resolved spectroscopy and dynamical mass measurements. SDSS 0423-0414AB joins a growing list of late-L/early-T dwarf binaries, the high percentage of which (~50%) may provide a natural explanation for observed peculiarities across the L/T transition.Comment: 6 pages, 2 figures, accepted for publication in Astrophysical Journal Letter

Reviews

The following publications have been reviewed by the mentioned authors;Getting Things Right Design and Realization by Adrian Marden, reviewed by Michael RobertsVisual Messages: An Introduction to Graphics by C. J. Breckon, L. J. Jones and C. E. Moorhouse, reviewed by John BaleErgonomics in the Computerized Office by Etienne Grandjean, reviewed by T. LawleyTeaching GCSE Craft, Design and Technology by David Rees, reviewed by Brian OppenheimComputers at Work by H. Scott, B. Frost, S. Alexander and G. Bowie, reviewed by S.R. St. J. NeillScience Report for Teachers: 10 Metals at age 15, reviewed by David BarlexThe Anti-Colouring Book by Susan Striker & Edward Kimmel, reviewed by Marshall HughesUnderstanding and Using Technology by A. Todd, C. McRory and D. Todd, reviewed by David Perry