558 research outputs found
Mapping our Universe in 3D with MITEoR
Mapping our universe in 3D by imaging the redshifted 21 cm line from neutral
hydrogen has the potential to overtake the cosmic microwave background as our
most powerful cosmological probe, because it can map a much larger volume of
our Universe, shedding new light on the epoch of reionization, inflation, dark
matter, dark energy, and neutrino masses. We report on MITEoR, a pathfinder
low-frequency radio interferometer whose goal is to test technologies that
greatly reduce the cost of such 3D mapping for a given sensitivity. MITEoR
accomplishes this by using massive baseline redundancy both to enable automated
precision calibration and to cut the correlator cost scaling from N^2 to NlogN,
where N is the number of antennas. The success of MITEoR with its 64
dual-polarization elements bodes well for the more ambitious HERA project,
which would incorporate many identical or similar technologies using an order
of magnitude more antennas, each with dramatically larger collecting area.Comment: To be published in proceedings of 2013 IEEE International Symposium
on Phased Array Systems & Technolog
Agulhas Plateau Cretaceous Climate: drilling the Agulhas Plateau and Transkei Basin to reconstruct the CretaceousâPaleogene tectonic and climatic evolution of the Southern Ocean basin
During International Ocean Discovery Program Expedition 392, three sites were drilled on the Agulhas Plateau and one site was drilled in the Transkei Basin in the Southwest Indian Ocean. This region was positioned at paleolatitudes of ~53°â61°S during the Late Cretaceous (van Hinsbergen et al., 2015) (100â66 Ma) and within the new and evolving gateway between the South Atlantic, Southern Ocean, and southern Indian Ocean basins. Recovery of basement rocks and sedimentary sequences from the Agulhas Plateau sites and a thick sedimentary sequence in the Transkei Basin provides a wealth of new data to (1) determine the nature and origin of the Agulhas Plateau; (2) significantly advance the understanding of how Cretaceous temperatures, ocean circulation, and sedimentation patterns evolved as CO2 levels rose and fell and the breakup of Gondwana progressed; (3) document long-term paleoceanographic variability through the Late Cretaceous and Paleogene; and (4) investigate geochemical interactions between igneous rocks, sediments, and pore waters through the life cycle of a large igneous province (LIP). Importantly, postcruise analysis of Expedition 392 drill cores will allow testing of competing hypotheses concerning Agulhas Plateau LIP formation and the role of deep ocean circulation changes through southern gateways in controlling Late Cretaceousâearly Paleogene climate evolution
WSClean : an implementation of a fast, generic wide-field imager for radio astronomy
This article has been accepted for publication in Monthly Notices of the Royal Astronomical Society. © 2014 The Authors. Published by Oxford University Press on behalf of the Royal Astronomical Society.Astronomical widefield imaging of interferometric radio data is computationally expensive, especially for the large data volumes created by modern non-coplanar many-element arrays. We present a new widefield interferometric imager that uses the w-stacking algorithm and can make use of the w-snapshot algorithm. The performance dependencies of CASA's w-projection and our new imager are analysed and analytical functions are derived that describe the required computing cost for both imagers. On data from the Murchison Widefield Array, we find our new method to be an order of magnitude faster than w-projection, as well as being capable of full-sky imaging at full resolution and with correct polarisation correction. We predict the computing costs for several other arrays and estimate that our imager is a factor of 2-12 faster, depending on the array configuration. We estimate the computing cost for imaging the low-frequency Square-Kilometre Array observations to be 60 PetaFLOPS with current techniques. We find that combining w-stacking with the w-snapshot algorithm does not significantly improve computing requirements over pure w-stacking. The source code of our new imager is publicly released.Peer reviewedFinal Published versio
Immune Phenotype and Function of Natural Killer and T Cells in Chronic Hepatitis C Patients Who Received a Single Dose of Anti-MicroRNA-122, RG-101
MicroRNAâ122 is an important host factor for the hepatitis C virus (HCV). Treatment with RGâ101, an Nâacetylgalactosamineâconjugated antiâmicroRNAâ122 oligonucleotide, resulted in a significant viral load reduction in patients with chronic HCV infection. Here, we analyzed the effects of RGâ101 therapy on antiviral immunity. Thirtyâtwo chronic HCV patients infected with HCV genotypes 1, 3, and 4 received a single subcutaneous administration of RGâ101 at 2 mg/kg (n = 14) or 4 mg/kg (n = 14) or received a placebo (n = 2/dosing group). Plasma and peripheral blood mononuclear cells were collected at multiple time points, and comprehensive immunological analyses were performed. Following RGâ101 administration, HCV RNA declined in all patients (mean decline at week 2, 3.27 log10 IU/mL). At week 8 HCV RNA was undetectable in 15/28 patients. Plasma interferonâÎłâinduced protein 10 (IPâ10) levels declined significantly upon dosing with RGâ101. Furthermore, the frequency of natural killer (NK) cells increased, the proportion of NK cells expressing activating receptors normalized, and NK cell interferonâÎł production decreased after RGâ101 dosing. Functional HCVâspecific interferonâÎł Tâcell responses did not significantly change in patients who had undetectable HCV RNA levels by week 8 postâRGâ101 injection. No increase in the magnitude of HCVâspecific Tâcell responses was observed at later time points, including 3 patients who were HCV RNAânegative 76 weeks postdosing. Conclusion: Dosing with RGâ101 is associated with a restoration of NKâcell proportions and a decrease of NK cells expressing activation receptors; however, the magnitude and functionality of ex vivo HCVâspecific Tâcell responses did not increase following RGâ101 injection, suggesting that NK cells, but not HCV adaptive immunity, may contribute to HCV viral control following RGâ101 therapy
WSCLEAN: an implementation of a fast, generic wide-field imager for radio astronomy
Astronomical wide-field imaging of interferometric radio data is computationally expensive, especially for the large data volumes created by modern non-coplanar many-element arrays. We present a new wide-field interferometric imager that uses the w-stacking algorithm and can make use of the w-snapshot algorithm. The performance dependences of CASA's w-projection and our new imager are analysed and analytical functions are derived that describe the required computing cost for both imagers. On data from the Murchison Widefield Array, we find our new method to be an order of magnitude faster than w-projection, as well as being capable of full-sky imaging at full resolution and with correct polarization correction. We predict the computing costs for several other arrays and estimate that our imager is a factor of 2-12 faster, depending on the array configuration. We estimate the computing cost for imaging the lowfrequency Square Kilometre Array observations to be 60 PetaFLOPS with current techniques. We find that combining w-stacking with the w-snapshot algorithm does not significantly improve computing requirements over pure w-stacking. The source code of our new imager is publicly released
An evaluation of factors predicting long-term response to thalidomide in 234 patients with relapsed or resistant multiple myeloma
Antarctic climate, Southern Ocean circulation patterns, and deep water formation during the Eocene
We assess early-to-middle Eocene seawater neodymium (Nd) isotope records from seven Southern Ocean deep-sea drill sites to evaluate the role of Southern Ocean circulation in long-term Cenozoic climate change. Our study sites are strategically located on either side of the Tasman Gateway and are positioned at a range of shallow (Nd(t) = â9.3 ± 1.5). IODP Site U1356 off the coast of AdĂ©lie Land, a locus of modern-day Antarctic Bottom Water production, is identified as a site of persistent deep water formation from the early Eocene to the Oligocene. East of the Tasman Gateway an additional local source of intermediate/deep water formation is inferred at ODP Site 277 in the SW Pacific Ocean (ΔNd(t) = â8.7 ± 1.5). Antarctic-proximal shelf sites (ODP Site 1171 and Site U1356) reveal a pronounced erosional event between 49 and 48 Ma, manifested by ~2 ΔNd unit negative excursions in seawater chemistry toward the composition of bulk sediments at these sites. This erosional event coincides with the termination of peak global warmth following the Early Eocene Climatic Optimum and is associated with documented cooling across the study region and increased export of Antarctic deep waters, highlighting the complexity and importance of Southern Ocean circulation in the greenhouse climate of the Eocene
Science Impacts of the SPHEREx All-Sky Optical to Near-Infrared Spectral Survey: Report of a Community Workshop Examining Extragalactic, Galactic, Stellar and Planetary Science
SPHEREx is a proposed SMEX mission selected for Phase A. SPHEREx will carry
out the first all-sky spectral survey and provide for every 6.2" pixel a
spectra between 0.75 and 4.18 m [with R41.4] and 4.18 and 5.00
m [with R135]. The SPHEREx team has proposed three specific science
investigations to be carried out with this unique data set: cosmic inflation,
interstellar and circumstellar ices, and the extra-galactic background light.
It is readily apparent, however, that many other questions in astrophysics and
planetary sciences could be addressed with the SPHEREx data. The SPHEREx team
convened a community workshop in February 2016, with the intent of enlisting
the aid of a larger group of scientists in defining these questions. This paper
summarizes the rich and varied menu of investigations that was laid out. It
includes studies of the composition of main belt and Trojan/Greek asteroids;
mapping the zodiacal light with unprecedented spatial and spectral resolution;
identifying and studying very low-metallicity stars; improving stellar
parameters in order to better characterize transiting exoplanets; studying
aliphatic and aromatic carbon-bearing molecules in the interstellar medium;
mapping star formation rates in nearby galaxies; determining the redshift of
clusters of galaxies; identifying high redshift quasars over the full sky; and
providing a NIR spectrum for most eROSITA X-ray sources. All of these
investigations, and others not listed here, can be carried out with the nominal
all-sky spectra to be produced by SPHEREx. In addition, the workshop defined
enhanced data products and user tools which would facilitate some of these
scientific studies. Finally, the workshop noted the high degrees of synergy
between SPHEREx and a number of other current or forthcoming programs,
including JWST, WFIRST, Euclid, GAIA, K2/Kepler, TESS, eROSITA and LSST.Comment: Report of the First SPHEREx Community Workshop,
http://spherex.caltech.edu/Workshop.html , 84 pages, 28 figure
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