Dispersion and the electron-phonon interaction in a single heterostructure

We investigate the electron-phonon interaction in a polar-polar single heterostructure through the use of the linear combination of hybrid phonon modes, considering the role of longitudinal optical, transverse optical and interface modes, using a continuum model that accounts for both mechanical and electrical continuity over a heterostructure interface. We discuss the use of other models for such systems, such as the bulk phonon (3DP) and dielectric continuum (DC) models, using previously developed sum-rules to explain the limitations on their validity. We find that our linear combination (LC) model gives an excellent agreement with scattering rates previously derived using the 3DP and DC models when the lattice dispersion is weak enough to be ignored, however, when there is a noticeable lattice dispersion, the LC model returns a different answer, suggesting that interface modes play a much greater part in the scattering characteristics of the system under certain conditions. We also discuss the remote phonon effect in polar/polar heterostructures

Hot phonon effects on high field transport in GaN & AlN

We have studied the effects of hot phonons on the high-field transport in GaN & AlN. The dynamics of the non-equilibrium electron-LO phonon system is studied via an ensemble Monte-Carlo code. We find that under steady-state conditions the hot-phonons cause the randomization of the electron momentum and increase their mean energy leading to diffusive heating. Average electron energies of three and two times those in the equilibrium phonon cases are found for GaN and AlN at applied fields of 100 kV/cm and 350 kV/cm respectively. The electron velocity is reduced compared to the case with equilibrium phonons at the lattice temperature. In the transient regime peak velocities reached at overshoot are reduced when non-equilibrium phonons are taken into account

Voice SourceWaveform Analysis and Synthesis Using Principal Component Analysis and Gaussian Mixture Modelling

The paper presents a voice source waveform modeling techniques based on principal component analysis (PCA) and Gaussian mixture modeling (GMM). The voice source is obtained by inverse-filtering speech with the estimated vocal tract filter. This decomposition is useful in speech analysis, synthesis, recognition and coding. Here, a data-driven approach is presented for signal decomposition and classification based on the principal components of the voice source. The principal components are analyzed and the 'prototype' voice source signals corresponding to the Gaussian mixture means are examined. We show how an unknown signal can be decomposed into its components and/or prototypes and resynthesized. We show how the techniques are suited for both low bitrate or high quality analysis/synthesis schemes

Resonance line-profile calculations based on hydrodynamical models of cataclysmic variable winds

We present synthetic line profiles as predicted by the models of 2-D line- driven disk winds due to Proga, Stone & Drew. We compare the model line profiles with HST observations of the cataclysmic variable IX Vel. The model wind consists of a slow outflow that is bounded on the polar side by a fast stream. We find that these two components of the wind produce distinct spectral features. The fast stream produces profiles which show features consistent with observations. These include the appearance of the P-Cygni shape for a range of inclinations, the location of the maximum depth of the absorption component at velocities less than the terminal velocity, and the transition from absorption to emission with increasing inclination. However the model profiles have too little absorption or emission equivalent width. This quantitative difference between our models and observations is not a surprise because the line-driven wind models predict a mass loss rate that is lower than the rate required by the observations. We note that the model profiles exhibit a double-humped structure near the line center which is not echoed in observations. We identify this structure with a non-negligible redshifted absorption which is formed in the slow component of the wind where the rotational velocity dominates over expansion velocity. We conclude that the next generation of disk wind models, developed for application to CVs, needs to yield stronger wind driving out to larger disk radii than do the present models.Comment: LaTeX, 19 pages, to appear in Ap

On the accumulation of planetesimals near disc gaps created by protoplanets

We have performed three-dimensional two-fluid (gas-dust) hydrodynamical models of circumstellar discs with embedded protoplanets (3 - 333 M\oplu) and small solid bodies (radii 10cm to 10m). We find that high mass planets (\gtrsim Saturn mass) open sufficiently deep gaps in the gas disc such that the density maximum at the outer edge of the gap can very efficiently trap metre-sized solid bodies. This allows the accumulation of solids at the outer edge of the gap as solids from large radii spiral inwards to the trapping region. This process of accumulation occurs fastest for those bodies that spiral inwards most rapidly, typically metre-sized boulders, whilst smaller and larger objects will not migrate sufficiently rapidly in the discs lifetime to benefit from the process. Around a Jupiter mass planet we find that bound clumps of solid material, as large as several Earth masses, may form, potentially collapsing under self-gravity to form planets or planetesimals. These results are in agreement with Lyra et al. (2009), supporting their finding that the formation of a second generation of planetesimals or of terrestrial mass planets may be triggered by the presence of a high mass planet.Comment: 14 pages, 10 figures. Accepted for publication in MNRA

ELF5 modulates the estrogen receptor cistrome in breast cancer.

Acquired resistance to endocrine therapy is responsible for half of the therapeutic failures in the treatment of breast cancer. Recent findings have implicated increased expression of the ETS transcription factor ELF5 as a potential modulator of estrogen action and driver of endocrine resistance, and here we provide the first insight into the mechanisms by which ELF5 modulates estrogen sensitivity. Using chromatin immunoprecipitation sequencing we found that ELF5 binding overlapped with FOXA1 and ER at super enhancers, enhancers and promoters, and when elevated, caused FOXA1 and ER to bind to new regions of the genome, in a pattern that replicated the alterations to the ER/FOXA1 cistrome caused by the acquisition of resistance to endocrine therapy. RNA sequencing demonstrated that these changes altered estrogen-driven patterns of gene expression, the expression of ER transcription-complex members, and 6 genes known to be involved in driving the acquisition of endocrine resistance. Using rapid immunoprecipitation mass spectrometry of endogenous proteins, and proximity ligation assays, we found that ELF5 interacted physically with members of the ER transcription complex, such as DNA-PKcs. We found 2 cases of endocrine-resistant brain metastases where ELF5 levels were greatly increased and ELF5 patterns of gene expression were enriched, compared to the matched primary tumour. Thus ELF5 alters ER-driven gene expression by modulating the ER/FOXA1 cistrome, by interacting with it, and by modulating the expression of members of the ER transcriptional complex, providing multiple mechanisms by which ELF5 can drive endocrine resistance

Multi-epoch Spectroscopy of IY UMa: Quiescence, Rise, Normal Outburst & Superoutburst

We exploit rare observations covering the time before and during a normal outburst in the deeply-eclipsing SU UMa system IY UMa to study the dramatic changes in the accretion flow and emission at the onset of outburst. Through Doppler tomography we study the emission distribution, revealing classic accretion flow behaviour in quiescence, with the stream-disc impact ionizing the nearby accretion disc. We observe a delay of hours to a couple of days between the rise in continuum and the rise in the emission lines at the onset of the outburst. From line profiles and Doppler maps during normal and superoutburst we conclude that reprocessing of boundary layer radiation is the dominant emission line mechanism in outburst, and that the normal outburst began in the outer disc. The stream-disc impact feature (the `orbital hump') in the H alpha line flux light curve disappears before the onset of the normal outburst, and may be an observable signal heralding an impending outburst.Comment: 14 pages, 12 figures. Accepted for publication in Monthly Notices of the Royal Astronomical Societ

Discovery of potent and selective MRCK inhibitors with therapeutic effect on skin cancer

The myotonic dystrophy-related Cdc42-binding kinases MRCKα and MRCKβ contribute to the regulation of actin-myosin cytoskeleton organization and dynamics, acting in concert with the Rho-associated coiled-coil kinases ROCK1 and ROCK2. The absence of highly potent and selective MRCK inhibitors has resulted in relatively little knowledge of the potential roles of these kinases in cancer. Here we report the discovery of the azaindole compounds BDP8900 and BDP9066 as potent and selective MRCK inhibitors that reduce substrate phosphorylation, leading to morphological changes in cancer cells along with inhibition of their motility and invasive character. In over 750 human cancer cell lines tested, BDP8900 and BDP9066 displayed consistent anti-proliferative effects with greatest activity in hematological cancer cells. Mass spectrometry identified MRCKα S1003 as an autophosphorylation site, enabling development of a phosphorylation-sensitive antibody tool to report on MRCKα status in tumor specimens. In a two-stage chemical carcinogenesis model of murine squamous cell carcinoma, topical treatments reduced MRCKα S1003 autophosphorylation and skin papilloma outgrowth. In parallel work, we validated a phospho-selective antibody with the capability to monitor drug pharmacodynamics. Taken together, our findings establish an important oncogenic role for MRCK in cancer, and they offer an initial preclinical proof of concept for MRCK inhibition as a valid therapeutic strategy