The Intersection of Utility Coordination and SUE

ASCE recently released two new SUE standards—ASCE 38-22 is the updated SUE standard commonly used during the utility coordination process during design, and ASCE 75-22 is the new utility as-built standard that is essential for the accurate location of newly relocated facilities in construction. This presentation will illustrate the interaction and relationship between SUE and utility coordination to enhance project deliverables and reduce risk during construction

Francis Bacon: a psychobiographical study

The study consists of a psychobiography of the British artist, Francis Bacon (1909-1992). Psychobiography employs a qualitative approach to understanding the life story of an individual through the lens of psychological theory. It is typically dedicated to the lives of well-known or enigmatic people and covers the person’s entire lifespan. For this study the analytical theory of Carl Gustav Jung (1875-1961) is used to explore and describe Bacon’s life and personality through concepts relating to personality functioning, history, mythology, anthropology, symbology and religion. Francis Bacon has captured the imagination of the art world for many years - especially where it is felt that the figure-subject is still the highest form of art - and his reputation among the foremost of English painters is assured. Coupled with his artistic output is a life full of curiosity, eccentricity and controversy. This alone would qualify him as a suitable subject for a study such as this, but his extraordinary oeuvre of painting hugely adds to his attractiveness to the psychological researcher. To ensure an accurate description of Bacon’s life, extensive data is examined using Alexander’s (1988) model of identifying salient themes. The study considers the nature and methodology of psychobiography, the theories of Jung, the life of Francis Bacon and then sythesises relevant material in a psychological profile. The findings of this study indicate that Bacon’s intense, creative and unorthodox life of genius fully justifies the research and provides an example of how a theory that is flexible can be an appropriate means of understanding complicated personalities. Jung’s description of the evolution of the personality allows for applicability and coherence, while at the same time accomodating even the most maverick of non-conventional lives

Assessment of the reliability of a simplified matrix sentence test in noise.

The current study aimed to evaluate the reliability of a simplified matrix sentence test in assessing older hearing-impaired adults who may also have some mild cognitive impairment in their perception of speech in noise. The simplified matrix sentence test, known as the simplified University of Canterbury Auditory Matrix Sentence Test-Paediatric (UCAMST-P) is a shorter and less cognitively demanding test that was originally designed to test paediatric listeners. We hypothesise that the shorter and simpler format of the test may make it more suitable for testing older hearing-impaired subjects that may also have cognitive impairment. A large cohort of 64 adults that were recruited through the University of Canterbury speech and hearing clinic were tested with the simplified UCAMST to determining their speech recognition threshold (SRT) in noise. Additionally, their speech recognition in noise was assessed with a clinically available test, the Quick speech in noise (QuickSIN™) test for comparison studies. Participants pure tone hearing thresholds and cognitive status were also assessed. Results showed that the simplified UCAMST gave consistent and reliable results over two trials. When different response formats were used in the simplified UCAMST, open-set and closed-set, it was found that the open-set was more reliable and had a smaller measurement error compared to the closed-set response condition. However, the participants attained better SRTs in the closed-set condition over the open-set condition. It is hypothesised this is due the cognitive advantage of being able to see the word matrix in the closed-set condition which is less cognitively demanding and offers visual cues to the possible word presented when speech intelligibility may not be optimal. Overall, it was found that the two different response conditions could not be used interchangeably. The reliability of the simplified UCAMST was found to be robust against the effect of increasing hearing loss, age and cognitive status of the listener in the closed-set condition. The largest effect found was the effect of older age and mild cognitive impairment on the measurement error in the open-set response condition. The results from the simplified UCAMST positively correlated with the results from the currently clinically used QuickSIN™ test proving the validity of the simplified UCAMST. Moreover, the SRTs derived from the simplified UCAMST had a lower measurement error compared to those found with the QuickSIN™. This study provides important evidence that the simplified UCASMT is a valid, reliable and accurate test for assessing the performance in speech in noise of older adults with a hearing impairment

Co-design for Curriculum Planning: A Model for Professional Development for High School Teachers

This paper describes a model for teacher professional development as co-design for curriculum planning in which facilitators with design and pedagogical expertise iteratively work with groups of secondary school teachers, one school at a time, to plan whole terms of work, as a form of teacher professional development. It contains preliminary results from a design-based research study involving co-design with digital technologies teachers in two Australian secondary schools. It describes two phases of design involving workshops, strategies and instruments that work to facilitate effective co-design with teachers. Results from this pilot study suggest that the co-design for curriculum planning model leads to high quality teacher professional development for 21st century learning

Using statistics to design and estimate vital rates in matrix population models for a perennial herb

Matrix population models are widely used to assess population status and to inform management decisions. Despite existing theories for building such models, model construction is often partially based on expert opinion. So far, model structure has received relatively little attention, although it may affect estimates of population dynamics. Here, we assessed the consequences of two published matrix structures (a 4 × 4 matrix based on expert opinion and a 10 × 10 matrix based on statistical modeling) for estimates of vital rates and stochastic population dynamics of the long‐lived herb Astragalus scaphoides. We explored the ways in which choice of model structure alters the accuracy (i.e., mean) and precision (i.e., variance) of predicted population dynamics. We found that model structure had a negligible effect on the accuracy and precision of vital rates and stochastic stage distribution. However, the 10 × 10 matrix produced lower estimates of stochastic population growth rates than the 4 × 4 matrix, and more accurately predicted the observed trends in population abundance for three out of four study populations. Moreover, estimates of realized variation in population growth rate due to fluctuations in population stage structure over time were occasionally sensitive to matrix structure, suggesting differential roles of transient dynamics. Our study indicates that statistical modeling for choosing categories in matrix models might be preferable over expert opinion to accurately predict population trends and can provide a more objective way for model construction when the biological knowledge of the species is limited.</p

Enhancing effective healthcare communication in Australia and Aotearoa New Zealand: Considerations for research, teaching, policy, and practice.

OBJECTIVE In this article we present a conceptual framework for enhancing effective healthcare communication in Australia and Aotearoa New Zealand. METHODS Through an iterative, deliberative dialogue approach, we, as experts from a variety of health professions and academic disciplines, worked together to identify core values and considerations for healthcare communication across numerous health professions and disciplines and within research, teaching, policy, and practice contexts. RESULTS The framework developed includes five core values at its centre: equitable, inclusive, evidence-based, collaborative, reflective. Around this are concentric circles showing key elements of collaborators, modality, context, and purpose. Each of these is explored. CONCLUSION This work may support benchmarking for healthcare providers, researchers, policymakers, and educators across a breadth of professions to help improve communication in clinical practice. The framework will also help to identify areas across disciplines that are shared and potentially idiosyncratic for various professions to promote interprofessional recognition, education, and collaboration. INNOVATION This framework is designed to start conversations, to form the foundation of a dialogue about the priorities and key considerations for developing teaching curricula, professional development, and research programs related to healthcare communication, providing a set of values specifically for the unique contexts of Australia and Aotearoa New Zealand. It can also be used to guide interdisciplinary healthcare professionals in advancing research, teaching, policy, and practice related to healthcare communication

Identification of residues in ABCG2 affecting protein trafficking and drug transport, using co-evolutionary analysis of ABCG sequences

ABCG2 is an ABC (ATP-binding cassette) transporter with a physiological role in urate transport in the kidney and is also implicated in multi-drug efflux from a number of organs in the body. The trafficking of the protein and the mechanism by which it recognizes and transports diverse drugs are important areas of research. In the current study, we have made a series of single amino acid mutations in ABCG2 on the basis of sequence analysis. Mutant isoforms were characterized for cell surface expression and function. One mutant (I573A) showed disrupted glycosylation and reduced trafficking kinetics. In contrast with many ABC transporter folding mutations which appear to be ‘rescued’ by chemical chaperones or low temperature incubation, the I573A mutation was not enriched at the cell surface by either treatment, with the majority of the protein being retained in the endoplasmic reticulum (ER). Two other mutations (P485A and M549A) showed distinct effects on transport of ABCG2 substrates reinforcing the role of TM helix 3 in drug recognition and transport and indicating the presence of intracellular coupling regions in ABCG2

Evaluation of pragmatic oxygenation measurement as a proxy for Covid-19 severity

Choosing optimal outcome measures maximizes statistical power, accelerates discovery and improves reliability in early-phase trials. We devised and evaluated a modification to a pragmatic measure of oxygenation function, the [Formula: see text] ratio. Because of the ceiling effect in oxyhaemoglobin saturation, [Formula: see text] ratio ceases to reflect pulmonary oxygenation function at high [Formula: see text] values. We found that the correlation of [Formula: see text] with the reference standard ([Formula: see text]/[Formula: see text] ratio) improves substantially when excluding [Formula: see text] and refer to this measure as [Formula: see text]. Using observational data from 39,765 hospitalised COVID-19 patients, we demonstrate that [Formula: see text] is predictive of mortality, and compare the sample sizes required for trials using four different outcome measures. We show that a significant difference in outcome could be detected with the smallest sample size using [Formula: see text]. We demonstrate that [Formula: see text] is an effective intermediate outcome measure in COVID-19. It is a non-invasive measurement, representative of disease severity and provides greater statistical power

Evaluation of pragmatic oxygenation measurement as a proxy for Covid-19 severity

Choosing optimal outcome measures maximizes statistical power, accelerates discovery and improves reliability in early-phase trials. We devised and evaluated a modification to a pragmatic measure of oxygenation function, the [Formula: see text] ratio. Because of the ceiling effect in oxyhaemoglobin saturation, [Formula: see text] ratio ceases to reflect pulmonary oxygenation function at high [Formula: see text] values. We found that the correlation of [Formula: see text] with the reference standard ([Formula: see text]/[Formula: see text] ratio) improves substantially when excluding [Formula: see text] and refer to this measure as [Formula: see text]. Using observational data from 39,765 hospitalised COVID-19 patients, we demonstrate that [Formula: see text] is predictive of mortality, and compare the sample sizes required for trials using four different outcome measures. We show that a significant difference in outcome could be detected with the smallest sample size using [Formula: see text]. We demonstrate that [Formula: see text] is an effective intermediate outcome measure in COVID-19. It is a non-invasive measurement, representative of disease severity and provides greater statistical power

A population of gamma-ray emitting globular clusters seen with the Fermi Large Area Telescope

Globular clusters with their large populations of millisecond pulsars (MSPs) are believed to be potential emitters of high-energy gamma-ray emission. Our goal is to constrain the millisecond pulsar populations in globular clusters from analysis of gamma-ray observations. We use 546 days of continuous sky-survey observations obtained with the Large Area Telescope aboard the Fermi Gamma-ray Space Telescope to study the gamma-ray emission towards 13 globular clusters. Steady point-like high-energy gamma-ray emission has been significantly detected towards 8 globular clusters. Five of them (47 Tucanae, Omega Cen, NGC 6388, Terzan 5, and M 28) show hard spectral power indices $(0.7 < \Gamma <1.4)$ and clear evidence for an exponential cut-off in the range 1.0-2.6 GeV, which is the characteristic signature of magnetospheric emission from MSPs. Three of them (M 62, NGC 6440 and NGC 6652) also show hard spectral indices $(1.0 < \Gamma < 1.7)$, however the presence of an exponential cut-off can not be unambiguously established. Three of them (Omega Cen, NGC 6388, NGC 6652) have no known radio or X-ray MSPs yet still exhibit MSP spectral properties. From the observed gamma-ray luminosities, we estimate the total number of MSPs that is expected to be present in these globular clusters. We show that our estimates of the MSP population correlate with the stellar encounter rate and we estimate 2600-4700 MSPs in Galactic globular clusters, commensurate with previous estimates. The observation of high-energy gamma-ray emission from a globular cluster thus provides a reliable independent method to assess their millisecond pulsar populations that can be used to make constraints on the original neutron star X-ray binary population, essential for understanding the importance of binary systems in slowing the inevitable core collapse of globular clusters.Comment: Accepted for publication in A&A. Corresponding authors: J. Kn\"odlseder, N. Webb, B. Pancraz