Interventions based on Mindfulness for Socio-emotional Skill Building in Children on the Autism Spectrum: A Systematic Review

Children on the autism spectrum are characterized by deficits in socioemotional skills. Previous research suggests that mindfulness is effective in improving social, emotional, and behavioural skills in a wide variety of populations. This review systematically investigated the efficacy of mindfulness-based interventions (MBIs) in improving social, emotional, and behavioural functioning in children on the autism spectrum (0-12 years of age). Furthermore, the current review discussed adaptations to traditional MBIs when implemented to children on the autism spectrum. MBIs as a potential evidence-based practice for the target population was also investigated. Eleven studies met inclusion criteria. Results indicated that MBIs led to improvements in social communication, social motivation, externalizing and internalizing behaviors and executive functioning in children on the autism spectrum. MBIs were also assessed to be an established evidence-based practice for children on the autism spectrum. The significance of these findings for clinicians, parents and educators are discussed

engineered bacillus thuringiensis var-israelensis (bti) for the biological control of mosquito-a review

The number of pathogenic microorganisms that are capable of killing insectpests is extremely large. Some bacteria are more attractive to researchersdeveloping microbial biological control agents because their genomes aresimple enabling easier study and manipulation. Several bacterial speciesare already used on a large scale as control agents against some insects.Commercial preparation of these bacteria in theform of insecticidal powdersare available for use in the field. Although these preparations are somewhatmore expensive and also less e/jicient than chemical insecticides, for severalreasons including recent awareness of environmental safety, development ofbiological control agents has recieved increased attention of biologists.Several varieties of Bacillus thuringiensis have been well studied fortheir to:xic effects on insects. These bacteria produce proteinaceous parasporalcrystals during their sporulation. When these crystals are ingestedby insect larvae protein protoxins are solubilised in the alkaline environment ofthe insect midgut releasing polypeptides toxic to the epithelial cells resultingin quick death of the larvae.Toxicity of Bacillus thuringiensis var. israelensis is specific to mosquitoand blackfly larvae. However, large scale use of this bacterium for thecontrol of mosquitoes is limited by its low persistenee in the field afterapplication. Four genes coding for 4 different toxic polypeptides have beenisolated from this bacterium and all these have been cloned in E. coli andstudied. Research is being done to study the posible manipulation of thesegenes in order to obtain potentially much more efficient bacterial strains forthe control of insects

ADAMTS9, a member of the ADAMTS family, in Xenopus development

Extracellular matrix (ECM) remodeling by metalloproteinases is crucial during development. The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin type I motifs) enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that have diverse roles in tissue morphogenesis and patho-physiological remodeling. The human family includes 19 members. In this study we identified the 19 members of the ADAMTS family in Xenopus laevis and Xenopus tropicalis. Gene identification and a phylogenetic study revealed strong conservation of the ADAMTS family and contributed to a better annotation of the Xenopus genomes. Expression of the entire ADAMTS family was studied from early stages to tadpole stages of Xenopus, and detailed analysis of ADAMTS9 revealed expression in many structures during organogenesis such as neural crest (NC) derivative tissues, the pronephros and the pancreas. Versican, a matrix component substrate of ADAMTS9 shows a similar expression pattern suggesting a role of ADAMTS9 in the remodeling of the ECM in these structures by degradation of versican

Ferromagnetic quasi-atomic electrons in two-dimensional electride.

An electride, a generalized form of cavity-trapped interstitial anionic electrons (IAEs) in a positively charged lattice framework, shows exotic properties according to the size and geometry of the cavities. Here, we report that the IAEs in layer structured [Gd2C]2+·2e- electride behave as ferromagnetic elements in two-dimensional interlayer space and possess their own magnetic moments of ~0.52 μB per quasi-atomic IAE, which facilitate the exchange interactions between interlayer gadolinium atoms across IAEs, inducing the ferromagnetism in [Gd2C]2+·2e- electride. The substitution of paramagnetic chlorine atoms for IAEs proves the magnetic nature of quasi-atomic IAEs through a transition from ferromagnetic [Gd2C]2+·2e- to antiferromagnetic Gd2CCl caused by attenuating interatomic exchange interactions, consistent with theoretical calculations. These results confirm that quasi-atomic IAEs act as ferromagnetic elements and trigger ferromagnetic spin alignments within the antiferromagnetic [Gd2C]2+ lattice framework. These results present a broad opportunity to tailor intriguing ferromagnetism originating from quasi-atomic interstitial electrons in low-dimensional materials

Regulation of Classical Cadherin Membrane Expression and F-Actin Assembly by Alpha-Catenins, during Xenopus Embryogenesis

Alpha (α)-E-catenin is a component of the cadherin complex, and has long been thought to provide a link between cell surface cadherins and the actin skeleton. More recently, it has also been implicated in mechano-sensing, and in the control of tissue size. Here we use the early Xenopus embryos to explore functional differences between two α-catenin family members, α-E- and α-N-catenin, and their interactions with the different classical cadherins that appear as tissues of the embryo become segregated from each other. We show that they play both cadherin-specific and context-specific roles in the emerging tissues of the embryo. α-E-catenin interacts with both C- and E-cadherin. It is specifically required for junctional localization of C-cadherin, but not of E-cadherin or N-cadherin at the neurula stage. α-N-cadherin interacts only with, and is specifically required for junctional localization of, N-cadherin. In addition, α -E-catenin is essential for normal tissue size control in the non-neural ectoderm, but not in the neural ectoderm or the blastula. We also show context specificity in cadherin/ α-catenin interactions. E-cadherin requires α-E-catenin for junctional localization in some tissues, but not in others, during early development. These specific functional cadherin/alpha-catenin interactions may explain the basis of cadherin specificity of actin assembly and morphogenetic movements seen previously in the neural and non-neural ectoderm

The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family

The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that have diverse roles in tissue morphogenesis and patho-physiological remodeling, in inflammation and in vascular biology. The human family includes 19 members that can be sub-grouped on the basis of their known substrates, namely the aggrecanases or proteoglycanases (ADAMTS1, 4, 5, 8, 9, 15 and 20), the procollagen N-propeptidases (ADAMTS2, 3 and 14), the cartilage oligomeric matrix protein-cleaving enzymes (ADAMTS7 and 12), the von-Willebrand Factor proteinase (ADAMTS13) and a group of orphan enzymes (ADAMTS6, 10, 16, 17, 18 and 19). Control of the structure and function of the extracellular matrix (ECM) is a central theme of the biology of the ADAMTS, as exemplified by the actions of the procollagen-N-propeptidases in collagen fibril assembly and of the aggrecanases in the cleavage or modification of ECM proteoglycans. Defects in certain family members give rise to inherited genetic disorders, while the aberrant expression or function of others is associated with arthritis, cancer and cardiovascular disease. In particular, ADAMTS4 and 5 have emerged as therapeutic targets in arthritis. Multiple ADAMTSs from different sub-groupings exert either positive or negative effects on tumorigenesis and metastasis, with both metalloproteinase-dependent and -independent actions known to occur. The basic ADAMTS structure comprises a metalloproteinase catalytic domain and a carboxy-terminal ancillary domain, the latter determining substrate specificity and the localization of the protease and its interaction partners; ancillary domains probably also have independent biological functions. Focusing primarily on the aggrecanases and proteoglycanases, this review provides a perspective on the evolution of the ADAMTS family, their links with developmental and disease mechanisms, and key questions for the future

Temporal regulation of Dpp signaling output in the Drosophila wing

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/107377/1/dvdy24122.pd