The Coffee Market in Japan

This publication presents information on Japan in the world coffee market. It includes distribution channels in Japan and consumer profiles and perceptions

Reproducibility of Non-X-ray Background for the X-ray Imaging Spectrometer aboard Suzaku

One of the advantages of the X-ray Imaging Spectrometer (XIS) system on board Suzaku is its low and stable non-X-ray background (NXB). In order to make the best use of this advantage, modeling the NXB spectra with high accuracy is important to subtract them from the spectra of on-source observations. We construct an NXB database by collecting XIS events when the dark Earth covers the XIS FOV. The total exposure time of the NXB data is about 785 ks for each XIS. It is found that the count rate of the NXB anti-correlates with the cut-off-rigidity and correlates with the count rate of the PIN upper discriminator (PIN-UD) in Hard X-ray Detector on board Suzaku. We thus model the NXB spectrum for a given on-source observation by employing either of these parameters and obtain a better reproducibility of the NXB for the model with PIN-UD than that with the cut-off-rigidity. The reproducibility of the NXB model with PIN-UD is 4.55-5.63% for each XIS NXB in the 1-7 keV band and 2.79-4.36% for each XIS NXB in the 5-12 keV band for each 5 ks exposure of the NXB data. This NXB reproducibility is much smaller than the spatial fluctuation of the cosmic X-ray background in the 1-7 keV band, and is almost comparable to that in the 5-12 keV band.Comment: 25 pages, 13 figures, accepted for publication in PASJ (Suzaku Special Issue

Comparison of TGSE-BLADE DWI, RESOLVE DWI, and SS-EPI DWI in healthy volunteers and patients after cerebral aneurysm clipping

Diffusion-weighted magnetic resonance imaging is prone to have susceptibility artifacts in an inhomogeneous magnetic field. We compared distortion and artifacts among three diffusion acquisition techniques (single-shot echo-planar imaging [SS-EPI DWI], readout-segmented EPI [RESOLVE DWI], and 2D turbo gradient- and spin-echo diffusion-weighted imaging with non-Cartesian BLADE trajectory [TGSE-BLADE DWI]) in healthy volunteers and in patients with a cerebral aneurysm clip. Seventeen healthy volunteers and 20 patients who had undergone surgical cerebral aneurysm clipping were prospectively enrolled. SS-EPI DWI, RESOLVE DWI, and TGSE-BLADE DWI of the brain were performed using 3 T scanners. Distortion was the least in TGSE-BLADE DWI, and lower in RESOLVE DWI than SS-EPI DWI near air–bone interfaces in healthy volunteers (P < 0.001). Length of clip-induced artifact and distortion near the metal clip were the least in TGSE-BLADE DWI, and lower in RESOLVE DWI than SS-EPI DWI (P < 0.01). Image quality scores for geometric distortion, susceptibility artifacts, and overall image quality in both healthy volunteers and patients were the best in TGSE-BLADE DWI, and better in RESOLVE DWI than SS-EPI DWI (P < 0.001). Among the three DWI sequences, image quality was the best in TGSE-BLADE DWI in terms of distortion and artifacts, in both healthy volunteers and patients with an aneurysm clip

Randomized, Phase II Study Comparing Interferon Combined with Hepatic Arterial Infusion of Fluorouracil plus Cisplatin and Fluorouracil Alone in Patients with Advanced Hepatocellular Carcinoma

Objective: This randomized phase II trial compared the response rates to treatment with interferon (IFN) combined with hepatic arterial infusion of fluorouracil (FU) plus cisplatin (CDDP) or FU alone in patients with advanced hepatocellular carcinoma (HCC). Methods: A total of 114 patients with measurable advanced HCC were enrolled and randomized into 2 groups. FU (300 mg/m2, days 1–5, days 8–12) with or without CDDP (20 mg/m2, days 1 and 8) was administered via the hepatic artery. IFNα-2b was administered 3 times per week for 4 weeks. Results: The response rates were 45.6% for the IFN/FU + CDDP group and 24.6% for the IFN/FU group. The response rate was significantly higher in the IFN/FU + CDDP group (p = 0.030). The median overall survival period was 17.6 months in the IFN/FU + CDDP group versus 10.5 months in the IFN/FU group (p = 0.522). The median progression-free survival period was 6.5 months in the IFN/FU + CDDP group versus 3.3 months in the IFN/FU group (p = 0.0048). Hematological toxicity was common, but no toxicity-related deaths were observed. Conclusion: These results show the clinical efficacy of adding CDDP to the hepatic arterial infusion of FU in combined chemotherapy regimens with IFN

UV Background-Induced Bifurcation of the Galactic Morphology

Based upon a novel paradigm of the galaxy formation under UV background, the evolutionary bifurcation of pregalactic clouds is confronted with observations on elliptical and spiral galaxies. The theory predicts that the dichotomy between the dissipational and dissipationless galaxy formation stems from the degree of self-shielding from the UV background radiation. This is demonstrated on a bifurcation diagram of collapse epochs versus masses of pregalactic clouds. Using the observed properties, the collapse epochs are assessed for each type of galaxies with attentive mass estimation. By the direct comparison of the theory with the observations, it turns out that the theoretical bifurcation branch successfully discriminates between elliptical and spiral galaxies. This suggests that the UV background radiation could play a profound role for the differentiation of the galactic morphology into the Hubble sequence.Comment: Accepted for publication in MNRA

Cosmological Radiative Transfer Codes Comparison Project I: The Static Density Field Tests

Radiative transfer simulations are now at the forefront of numerical astrophysics. They are becoming crucial for an increasing number of astrophysical and cosmological problems; at the same time their computational cost has come to the reach of currently available computational power. Further progress is retarded by the considerable number of different algorithms (including various flavours of ray-tracing and moment schemes) developed, which makes the selection of the most suitable technique for a given problem a non-trivial task. Assessing the validity ranges, accuracy and performances of these schemes is the main aim of this paper, for which we have compared 11 independent RT codes on 5 test problems: (0) basic physics, (1) isothermal H II region expansion and (2) H II region expansion with evolving temperature, (3) I-front trapping and shadowing by a dense clump, (4) multiple sources in a cosmological density field. The outputs of these tests have been compared and differences analyzed. The agreement between the various codes is satisfactory although not perfect. The main source of discrepancy appears to reside in the multi-frequency treatment approach, resulting in different thicknesses of the ionized-neutral transition regions and different temperature structure. The present results and tests represent the most complete benchmark available for the development of new codes and improvement of existing ones. To this aim all test inputs and outputs are made publicly available in digital form.Comment: 32 pages, 39 figures (all color), comments welcom

Primordial germ cells in an oligochaete annelid are specified according to the birth rank order in the mesodermal teloblast lineage

The primordial germ cells (PGCs) in the oligochaete annelid Tubifex tubifex are descentants of the mesodermal (M) teloblast and are located in the two midbody segments X and XI in which they serve as germline precursors forming the testicular gonad and the ovarian gonad, respectively. During embryogenesis, vasa-expressing cells (termed presumptive PGCs or pre-PGCs) emerge in a variable set of midbody segments including the genital segments (X and XI); at the end of embryogenesis, pre-PGCs are confined to the genital segments, where they become PGCs in the juvenile. Here, using live imaging of pre-PGCs, we have demonstrated that during Tubifex embryogenesis, pre-PGCs (defined by Vasa expression) stay in segments where they have emerged, suggesting that it is unlikely that pre-PGCs move intersegmentally during embryogenesis. Thus, it is apparent that pre-PGCs derived from the 10th and 11th M teloblast-derived primary m blast cells (designated m10 and m11) that give rise, respectively, to segments X and XI are specified in situ as PGCs and that those born in other segments become undetectable at the end of embryogenesis. To address the mechanisms for this segment-specific development of PGCs, we have performed a set of cell-transplantation experiments as well as cell-ablation experiments. When m10 and m11 that are normally located in the mid region of the embryo were placed in positions near the anterior end of the host embryo, these cells formed two consecutive segments, which exhibited Vasa-positive PGC-like cells at early juvenile stage. This suggests that in terms of PGC generation, the fates of m10 and m11 remain unchanged even if they are placed in ectopic positions along the anteroposterior axis. Nor was the fate of m10 and m11 changed even if mesodermal blast cell chains preceding or succeeding m10 and m11 were absent. In a previous study, it was shown that PGC development in segments X and XI occurs normally in the absence of the overlying ectoderm. All this strongly suggests that irrespective of their surrounding cellular environments, m10 and m11 autonomously generate PGCs. We propose that m10 and m11 are exclusively specified as precursors of PGCs at the time of their birth from the M teloblast and that the M teloblast possesses a developmental program through which the sequence of mesodermal blast cell identities is determined. (c) 2013 Elsevier Inc. All rights reserved