Common trends in the US state-level crime. What do panel data say?

This paper aims to investigate the long-run relationship between crime, inequality, unemployment and deterrence using state-level data for the US over the period 1978- 2013. The novelty of the paper is to use non-stationary panels with factor structures. The results show that: i) a simple crime model well fits the long run relationship; ii) income inequality and unemployment have a positive impact on crime, whereas deterrence displays a negative sign; iii) the effect of income inequality on crime is large in magnitude; iv) property crime is generally highly sensitive to deterrence measures based upon police activities

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

Infectious and inflammatory diseases have repeatedly shown strong genetic associations within the major histocompatibility complex (MHC); however, the basis for these associations remains elusive. To define host genetic effects on the outcome of a chronic viral infection, we performed genome-wide association analysis in a multiethnic cohort of HIV-1 controllers and progressors, and we analyzed the effects of individual amino acids within the classical human leukocyte antigen (HLA) proteins. We identified >300 genome-wide significant single-nucleotide polymorphisms (SNPs) within the MHC and none elsewhere. Specific amino acids in the HLA-B peptide binding groove, as well as an independent HLA-C effect, explain the SNP associations and reconcile both protective and risk HLA alleles. These results implicate the nature of the HLA-viral peptide interaction as the major factor modulating durable control of HIV infection