10 research outputs found
Cytometric and Cytochemical Study of Peritoneal and Alveolar Macrophages from Yersinia pseudotuberculosis Infected Ground Squirrels (Citellus Citellus)
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Polyamine Depletion Following Exposure to DL-α-Difluoromethylornithine Both In Vivo and In Vitro Initiates Morphological Alterations and Mitochondrial Activation in a Monomorphic Strain of Trypanosoma brucei brucei
- Author
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Balloon Dilation of the Eustachian Tube: 12-Month Follow-up of the Randomized Controlled Trial Treatment Group
- Author
- Publication venue
- 'SAGE Publications'
- Publication date
- 01/04/2019
- Field of study
Objective: Obstructive eustachian tube dysfunction (OETD) affects up to 5% of adults; however, available treatment strategies have limitations. It was previously reported that balloon dilation of the eustachian tube (BDET) with the eustachian tube balloon catheter + medical management (MM) results in a significantly higher proportion of subjects with normalized tympanograms versus MM alone at 6- and 24-week follow-up. The current analysis extends these initial findings by investigating the durability of BDET + MM treatment outcomes through 52 weeks. Study Design: Prospective cohort follow-up study from the treatment group in a previously reported multicenter randomized controlled trial. Setting: Twenty-one investigational sites across the United States. Subjects and Methods: Here we report on secondary and exploratory endpoints for patients with OETD who previously failed MM and were randomized to the BDET + MM cohort. Analyses of tympanogram outcomes are reported by ear, unless specified otherwise, as a more accurate measure of durability of the procedure over time. Results: Among subjects randomized to BDET + MM, the overall number with normalized tympanograms and ETDQ-7 scores (Eustachian Tube Dysfunction Questionnaire–7) remained comparable to those reported at 6- versus 52-week follow-up: tympanograms, 73 of 143 (51.0%) versus 71 of 128 (55.5%); ETDQ-7, 79 of 142 (55.6%) versus 71 of 124 (57.3%). The overall number of ears with normalized tympanograms also remained comparable, with 117 of 204 (57%) versus 119 of 187 (63.6%). Conclusions: The present study suggests that the beneficial effects of BDET + MM on tympanogram normalization and symptoms of subjects with refractory OETD demonstrate significant durability that is clinically relevant through 52 weeks
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Targeted Hypoglossal Nerve Stimulation for Patients With Obstructive Sleep Apnea
- Author
- Publication venue
- eScholarship, University of California
- Publication date
- 01/06/2023
- Field of study
ImportanceEvidence is lacking from randomized clinical trials of hypoglossal nerve stimulation in obstructive sleep apnea (OSA).ObjectiveTo evaluate the safety and effectiveness of targeted hypoglossal nerve stimulation (THN) of the proximal hypoglossal nerve in patients with OSA.Design, setting, and participantsThis randomized clinical trial (THN3) was conducted at 20 centers and included 138 patients with moderate to severe OSA with an apnea-hypopnea index (AHI) of 20 to 65 events per hour and body mass index (calculated as weight in kilograms divided by height in meters squared) of 35 or less. The trial was conducted from May 2015 through June 2018. Data were analyzed from January 2022 through January 2023.InterventionImplant with THN system; randomized 2:1 to activation at month 1 (treatment) or month 4 (control). All received 11 months of THN with follow-up at months 12 and 15, respectively.Main outcomes and measuresPrimary effectiveness end points comprised AHI and oxygen desaturation index (ODI) responder rates (RRs). Treatment responses at months 4 and 12/15 were defined as a 50% or greater reduction in AHI to 20 or less per hour and an ODI decrease of 25% or greater. Coprimary end points comprised (1) month 4 AHI and ODI RR in the treatment greater than the control group and (2) month 12/15 AHI and ODI RR in the entire cohort exceeding 50%. Secondary end points included sleep apnea severity (AHI and ODI) and patient-reported outcomes (Epworth Sleepiness Scale, Functional Outcomes of Sleep Questionnaire, and EQ-5D visual analog scale).ResultsAmong 138 participants, the mean (SD) age was 56 (9) years, and 19 (13.8%) were women. Month 4 THN RRs were substantially greater in those in the treatment vs control group (AHI, 52.3% vs 19.6%; ODI, 62.5% vs 41.3%, respectively) with treatment-control standardized mean differences of 0.725 (95% CI, 0.360-1.163) and 0.434 (95% CI, 0.070-0.843) for AHI and ODI RRs, respectively. Months 12/15 RRs were 42.5% and 60.4% for AHI and ODI, respectively. Improvements in AHI, ODI, Epworth Sleepiness Scale, Functional Outcomes of Sleep Questionnaire, and EQ-5D visual analog scale scores were all clinically meaningful (medium to large effect size). Two serious adverse events and 100 nonserious related adverse events were observed from the implant procedure or study protocol.Conclusions and relevanceThis randomized clinical trial found that THN demonstrated improvements in sleep apnea, sleepiness, and quality of life in patients with OSAs over an extended AHI and body mass index range without prior knowledge of pharyngeal collapse pattern. Clinically meaningful improvements in AHI and patient-reported responses compared favorably with those of distal hypoglossal nerve stimulation trials, although clinically meaningful differences were not definitive for ODI.Trial registrationClinicalTrials.gov Identifier: NCT02263859
Balloon dilation of the eustachian tube for dilatory dysfunction: A randomized controlled trial.
- Author
- Publication venue
- Health Sciences Research Commons
- Publication date
- 01/05/2018
- Field of study
Balloon Dilation of the Eustachian Tube for Dilatory Dysfunction: A Randomized Controlled Trial.
- Author
- Publication venue
- 'Wiley'
- Publication date
- 20/09/2017
- Field of study
Changing Metabolism in Differentiating Cardiac Progenitor Cells—Can Stem Cells Become Metabolically Flexible Cardiomyocytes?
- Author
- Abdel-Latif
- Abdelmagid
- Alaynick
- Amano
- AszĂłdi
- Attardi
- Bailey
- Balsam
- Bar-Even
- Barile
- Barr
- Bearzi
- Belke
- Beltrami
- Bergmann
- Besser
- Biala
- Bian
- Bing
- Birket
- Board
- Bolli
- Brand
- Breckenridge
- Breymann
- Brito-Martins
- Bruyneel
- Burridge
- Bursac
- Bushdid
- Cai
- Cai
- Cao
- Carpenter
- Carr
- Carrier
- Carubelli
- Casademont
- Chan
- Chan
- Chang
- Chen
- Chen
- Cho
- Choi
- Chong
- Christman
- Chung
- Cole
- Correia
- Crespo
- Cross
- Da Rocha
- Dai
- Daley
- De Coppi
- Denning
- Dodd
- Don
- Dos Santos
- Drawnel
- Ellen Kreipke
- Ellison
- Eschenhagen
- Evans
- Fang
- Fazel
- Fernandes
- Fisher
- Folmes
- Folmes
- Fragasso
- Freund
- Fukuda
- Fuster
- Fynes
- Gaber
- Gersh
- Gimble
- Go
- Goldfinger
- Gong
- Goumans
- Graichen
- Gude
- Gustafsson
- Hamidouche
- Hansen
- Hatzistergos
- Hazeltine
- Heather
- Heather
- Hedeskov
- Hosios
- Hue
- Huebsch
- Inoue
- Issa
- Jacot
- Jaiswal
- Jang
- Jesty
- Johnson
- Kadota
- Karakikes
- Kattman
- Kaur
- Kawatou
- Kehat
- Kehat
- Khademhosseini
- Kim
- Kim
- Kirklin
- Kofidis
- Kolwicz
- Kondoh
- Kumar
- Kumar
- Kuppusamy
- Kwon
- Laflamme
- Laflamme
- Laflamme
- Lai
- Lai
- Lalit
- Lan
- Larsson
- Lee
- Lee
- Lehman
- Leong
- Leor
- Lesnefsky
- Li
- Li
- Li
- Li
- Li
- Lian
- Lian
- Lian
- Liang
- Lieu
- Lim
- Lin
- Lin
- Linke
- Liu
- Loffredo
- Lopaschuk
- Lopaschuk
- Lopaschuk
- Lopaschuk
- Lundy
- Lunt
- Madeira
- Mahmoud
- Majmundar
- Makino
- Malliaras
- Marazzi
- Marin-Garcia
- Mathieu
- Matsuura
- Mayor
- McCulloch
- Medley
- Menendez-Montes
- Messina
- Mills
- Molkentin
- Moussaieff
- Mummery
- Munyon
- Murry
- Murry
- Nachlas
- Naeem
- Nathan
- Neely
- Neubauer
- Ng
- Noseda
- Oh
- Orlic
- Ott
- Oyama
- Ozawa
- Paige
- Paltauf-Doburzynska
- Panopoulos
- Passier
- Pattappa
- Perbellini
- Perricone
- Prieto
- Puente
- Qian
- Quigley
- Radisic
- Rana
- Randle
- Rangappa
- Ruan
- Sandstedt
- Sandstedt
- Satin
- Sauer
- Schaaf
- Semenza
- Sharov
- Sharov
- Shiba
- Shimizu
- Simsek
- Smart
- Smith
- Smith
- Smits
- Steinmetz
- Stresemann
- Sultana
- Sun
- Taegtmeyer
- Taegtmeyer
- Takahashi
- Takahashi
- Tallini
- Tan
- Tanaka
- Thomson
- Tomita
- Toyoda
- Tzahor
- Uchida
- Ueno
- Ulmer
- Valina
- van
- van der Vusse
- Van Luyn
- van Vliet
- Vander Heiden
- Veerman
- Velagaleti
- Vicinanza
- Vincent
- Virbasius
- Wan Safwani
- Wang
- Wang
- Wang
- Wang
- Wang
- Warburg
- Weinberger
- Wende
- Wolfensohn
- Wu
- Xu
- Xu
- Xu
- Xue
- Yang
- Yang
- Ye
- Yu
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhou
- Zhu
- Zimmermann
- Zimmermann
- Zimmermann
- Zimmermann
- Zong
- Zorzano
- Publication venue
- 'Frontiers Media SA'
- Publication date
- Field of study
Biochemical Effects of Drugs Acting on the Central Nervous System
- Author
- A Abrams
- A Andrejew
- A Andrejew
- A Andrejew
- A Andrejew
- A Andrejew
- A Balestrieri
- A Bazemore
- A Bernmeier
- A Bertelli
- A Bertler
- A Bertler
- A Bertler
- A Bertler
- A Bonsignore
- A Bruni
- A Cannava
- A Carlsson
- A Carlsson
- A Carlsson
- A Casu
- A Chari-Bitron
- A Chesler
- A Chesler
- A Cruz Da
- A Fleckenstein
- A Geiger
- A Geiger
- A Geiger
- A Geiger
- A Geiger
- A Geiger
- A Georgy
- A Giachetti
- A Giachetti
- A Giuditta
- A Golajacomo
- A Goldberg
- A Hamberger
- A Hoffer
- A Hoffer
- A Horita
- A Horita
- A Horita
- A Horita
- A Horita
- A Horita
- A Jori
- A Jorl
- A Kleinzeller
- A Koch
- A Kovarikova
- A Lajtha
- A Lajtha
- A Lajtha
- A Lasslo
- A Leaf
- A Mccoubrey
- A Mori
- A Nadrejew
- A Narayanaswami
- A Nerayanaswani
- A Pletcher
- A Pletcher
- A Pletcher
- A Pletscher
- A Pletscher
- A Pletscher
- A Pletscher
- A Pletscher
- A Pletscher
- A Pletscher
- A Polini
- A Pusztai
- A Rabassini
- A Rabassini
- A Remmer
- A Schaepdryver De
- A Schwartz
- A Schwartzt
- A Segre
- A Sjoerdsma
- A Stolk
- A Todrick
- A Valsecchi
- A Wolleberg
- A Wollenberg
- A Wollenberg
- A Wolpert
- A Yuwiller
- A Zeleny
- AA Smirnov
- AB Rothballer
- AB Roy
- AC Forbes
- AD Freedman
- AE Kornmuller
- AE Takemori
- AF Schaepdryver De
- AH Amin
- AH Conney
- AH Conney
- AH Mehler
- AI Miller
- AI Yakovleva
- AJ Eisenman
- AJ Glazko
- AJ Hudson
- AJ Plummer
- AJ Rosenberg
- AK Pfeifer
- AK Pfeifer
- AK Pfeifer
- AK Weiss
- AL Bartlet
- AL Kovarikova
- AL Lehninger
- AL Lehninger
- AL Lehninger
- AL Lehninger
- AL Lehninger
- AM Aleksejeva
- AM Nemeth
- AM Pumphrey
- AN Davison
- AN Davison
- AN Davison
- AN Davison
- AN Davison
- AP Meiklejohn
- AR Antonelli
- AS Moraczewski
- ASV Burgen
- ASV Burges
- AV Golubzova
- AV Marton
- AV Palladin
- AV Palladin
- AV Palladin
- AV Palladin
- AV Palladin
- AV Palladin
- AV Palladin
- AV Palladin
- AV Palladin
- AV Palladin
- AW Lessin
- AW Lessin
- AW Linnane
- AW Wase
- AW Wase
- B Ashby
- B Bergeret
- B Callieri
- B Century
- B Chance
- B Chance
- B Chance
- B Chance
- B Chance
- B Chance
- B Chance
- B Chance
- B Dubnick
- B Dubnick
- B Elstein
- B Etsen
- B Exer
- B Fischetti
- B Gouzon
- B Hoimstedt
- B Holmstedt
- B Jakoubek
- B Liber
- B Libet
- B Manzini
- B Metz
- B Murelli
- B Pernow
- B Pullman
- B Pullman
- B Sachtor
- BA Callingham
- BA Westfall
- BB Brodie
- BB Brodie
- BB Brodie
- BB Brodiem
- BC Bose
- BC Bose
- BC Bose
- BC Bose
- BE Abreu
- BE Kessler
- BE Ryman
- BG Benfey
- BH Marks
- BH Marks
- BJ Chajkina
- BJ Chajkina
- BJ Chajkina
- BJ Chajkina
- BJ Chejkina
- BM Bollard
- BM Breckenridge
- BN Manuhia
- BN Manuhin
- BP Setchell
- BP Setchell
- BS Cohen
- BT Chadwick
- BT Chadwick
- C August
- C Biddulph
- C Biddulph
- C Carpi
- C Carpi
- C Chin
- C Cohen
- C Cooper
- C Cooper
- C Cooper
- C Cooper
- C Cooper
- C Czaja
- C Duve De
- C Edwards
- C Edwards
- C Evans
- C Fernandez
- C Hadnagy
- C Kennedy
- C Long
- C Lutwak-Mann
- C Lutwak-Mann
- C Manso
- C Pepeu
- C Raulni De
- CA Ashford
- CC Kratzing
- CF Baxter
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- CH Gallagher
- CH Hine
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- D Bellamy
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- D Benitez
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- D Maio De
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- E Bumm
- E Costa
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- E Moklos
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- EAC Elliott
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- EC Bose
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- EJ Conway
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- G Stille
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- G Zettler
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- H Low
- H Low
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- H Martin
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- H Mcilwain
- H Mcilwain
- H Mcilwain
- H Mcilwain
- H Mcilwain
- H Mcilwain
- H Mcilwain
- H Mcilwain
- H Mcilwain
- H Mcilwain
- H Mcilwain
- H Mcilwain
- H Mcilwain
- H Mcilwain
- H Mcilwain
- H Mcilwain
- H Mcilwain
- H Mcilwain
- H Mcilwain
- H Mcilwain
- H Mcilwain
- H Mcilwain
- H Mcilwain
- H Mcilwain
- H Mclennan
- H Mclennan
- H Naruse
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- H Remmer
- H Remmer
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- H Sheppard
- H Takahashi
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- H Waelsche
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- H Weil-Halherbe
- H Weil-Malherbe
- H Weil-Malherbe
- H Weil-Malherbe
- H Weil-Malherbe
- H Weil-Malherbe
- H Weil-Malherbe
- H Weil-Malherbe
- H Weisbach
- H Weisbach
- H Weissbach
- H. Sheppard
- H. Weil-Malherbe
- HA Campos
- HA Krebs
- HA Krebs
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- M Bassi
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- M Goldstein
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- M Jowett
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- M Wollemann
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- MA Grillo
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- N Canal
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- Rindi
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- S Balakrishan
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- S Varon
- SAP Price
- SB Barker
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- SC Harvey
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- SE Kerr
- SE Kerr
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- SE Kerr
- SE Kerr
- SE Kerr
- SG Genes
- SH Carter
- SK Bisset
- SL Bonting
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- SM Greenberg
- SM Hess
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- SM Kirpekar
- SM Kirpekar
- SP Bessman
- SR Guha
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- SR Korey
- SS Barkulis
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- SS Kety
- SS Kety
- SS Kety
- SS Kety
- SS Kety
- SS Kety
- SS Kety
- SS Korey
- SV Gasteva
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- SW Jeffrey
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- T Aizava
- T Berti
- T Braun
- T Masurat
- T Masurat
- T Miura
- T. E. Mansour
- TA Mahowald
- TC Butler
- TE Conover
- TE Mansour
- TE Mansour
- THC Butler
- THL Sourkes
- TL Sourkes
- TM Brody
- TM Brody
- TM Brody
- TM Brody
- TM Brody
- TN Burbridge
- TN Burnbridge
- TN Pattabiraman
- US Euler Von
- US Euler Von
- US Ruler Von
- V Bocci
- V Bonavita
- V Bonavita
- V Bonavita
- V Ersparmer
- V Ersparmer
- V Ersparmer
- V Ersparmer
- V Ersparmer
- V Ferrari
- V Lindaur
- V Nair
- V Pertzoff
- V Spricak
- V Usdin
- VA Engelhardt
- VA Omarova
- VB Mitbander
- VC Sutherland
- VE Sokolova
- VG Borisov
- VH Cohn Jr.
- VH Parker
- VN Goncarova
- VP Skulachev
- VP Skulachev
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- VP Whittaker
- VS Iljin
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- VV Brand
- W Block
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- W Mayer-Gross
- W Munick
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- W Romanowski
- W Sacks
- W Sacks
- W Schaumann
- W Schaumann
- W Schaumann
- W Schiure
- W Sharples
- W Singer
- W Taterka-Seiler
- W Thorn
- W Traczyk
- W Wilbrandt
- W Wirth
- WA Himwich
- WA Krivoy
- WC Starbock
- WC Ullrich
- WD Gray
- WD Gray
- WD Gray
- WD Mcelroy
- WD Mcelroy
- WD Wosilait
- WDM Paton
- WE Glover
- WE Stern
- WE Stone
- WE Stone
- WE Stone
- WE Stone
- WE Stone
- WE Stone
- WE Stone
- WE Stone
- WE Stone
- WE Stone
- WE Stone
- WE Stone
- WE Stone
- WE Stone
- WE Wilson
- WG Schafer
- WG Schäfer
- WH Macmillan
- WJ Johnson
- WJ Johnson
- WK Jordan
- WL Magee
- WL Nelson
- WM Govier
- WM Mcisaac
- WN Aldridge
- WN Aldridge
- WN Alridge
- WP Burkard
- WR Drucker
- WR Soroka
- WR Williams
- WT Jenkins
- Y Hatefi
- Y Hatefi
- Y Hatefi
- Y Takahashi
- Y Tsukada
- Z Suzuki
- ZA Raiko
- ZC Bronowizkaya
- ZS Gerschenovitsch
- ZS Gersenovic
- ZS Gershenovich
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1965
- Field of study
Cardiovascular Activity
- Author
- A Baartscheer
- A Baartscheer
- A Baartscheer
- A Bachmann
- A Bauer
- A Bergdahl
- A Bezold von
- A Biedl
- A Bomzon
- A Bonnacrossi
- A Braillon
- A Brkovic
- A Brueggemann
- A BrĂĽggemann
- A Bucchi
- A Capri
- A Carmeliet
- A Carotenuto
- A Cavalié
- A Cavalli
- A Chatelier
- A Chu
- A Claing
- A Daugherty
- A Daugherty
- A Daugherty
- A Ezzaher
- A Fabiato
- A Fleckenstein
- A Fleckenstein
- A Fleckenstein
- A Fleckenstein
- A Fleckenstein
- A Fleckenstein
- A Gagliardi
- A Genao
- A Genovese
- A Gibson
- A Gibson
- A Gibson
- A Goll
- A Grassegger
- A Graziani
- A Grollman
- A Haugan
- A Hedberg
- A Helman
- A Hilditch
- A Hilditch
- A Hilditch
- A Hislop
- A Hislop
- A Hutchaleelaha
- A Inoue
- A Inoue
- A Inoue
- A Jarisch
- A Jarisch
- A Jarisch
- A Karlin
- A Kasai
- A Kochhar
- A Lerman
- A Lopez de Leon
- A Luchner
- A Luchner
- A LĂĽckhoff
- A LĂĽckhoff
- A Malhotra
- A Marchese
- A Marjamäki
- A Marmarou
- A Mattes
- A McRae
- A Menargues
- A Miwa
- A Molteni
- A Molteni
- A Molteni
- A Molteni
- A Monopoli
- A Morita
- A MĂĽlsch
- A Nygren
- A Osajima
- A Reaux
- A Reaux
- A Rudolph
- A Rutledge
- A Salimbeni
- A Sanbe
- A Sattin
- A Schuster
- A Schömig
- A Sculptoreanu
- A Sgoifo
- A Shiroshita-Takeshita
- A Stirrat
- A Sunami
- A Tajima
- A Tamura
- A Terzic
- A Tzanidis
- A Vacca
- A Vacca
- A Vaille
- A Vegh
- A Vegh
- A Verma
- A Volovsek
- A Wahhab
- A Ward
- A Wollenberger
- A Woppmann
- A Wright
- A Yu
- AA Andreadis
- AA Kochegarow
- AA Owji
- AA Pieper
- AB Fawzi
- AB Schreiber
- AB Schreiber
- AB Steffens
- AC Chiou
- AC Dolphin
- AC MacKinnon
- AC MacKinnon
- AC Sulpizio
- ACG Uprichard
- ACG Uprichard
- AD Medhurst
- AD Michel
- AD Michel
- AD Muskett
- AD Muskett
- AE Busch
- AE Busch
- AE Freedlender
- AE RiberoMO
- AEFH Meijer
- AF Green
- AF Green
- AF Green
- AF Green
- AF Green
- AF Odell
- AF Prigent
- AF Prigent
- AG Ciplea
- AGB Kovâch
- AH Cohen
- AH Gradman
- AH Nielsen
- AH Werber
- AH Weston
- AI Faden
- AI Faden
- AI Khan
- AIM Al-Shafei
- AIM Al-Shafei
- AJ Balmforth
- AJ Bold De
- AJ Carter
- AJ Carter
- AJ D’Alonzo
- AJ Gower
- AJ Gower
- AJ Hutchinson
- AJ Kaumann
- AJ Kielblock
- AJ King
- AJ Newell
- AJ Nichols
- AJ Pijl
- AJ Rice
- AJ Susswein
- AJ SzentmiklĂłsi
- AJ Trapani
- AJ Turner
- AK Fouda
- AK Ommaya
- AK Salyers
- AL Blatz
- AL Boura
- AL Golding
- AL Hudson
- AL Hyman
- AL Kwan
- AL Leoni
- AL Perraud
- AL Pichard
- AL Rothaul
- ALA Boura
- AM Al-Obaid
- AM Al-Obaid
- AM Babic
- AM Babic
- AM Beaufort
- AM Broadhurst
- AM Doherty
- AM Duncan
- AM Ehrly
- AM Feldman
- AM Feldman
- AM Gomez
- AM Hackett
- AM Joussen
- AM Lands
- AM Lands
- AM Lands
- AM Lands
- AM Oliveira
- AM Peier
- AM Peier
- AM Romanic
- AM Vineberg
- AM Watson
- AMB Bilate
- AMD Watson
- AN Santos
- AP Albert
- AP Davenport
- AP Ijzerman
- AP Moreno
- AR Dehpour
- AR Hosseini
- AR Liss
- AR Renzetti
- AR Renzetti
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2007
- Field of study