16 research outputs found
Role of chemotherapy in the management of primary rectal lymphoma: a case report and review of the literature
Adult urinary bladder tumors with rabdomyosarcomatous differentiation: Clinical, pathological and immunohistochemical studies
Adult rhabdomyosarcoma (RMS) in the urinary bladder is rare, and is the subject of case reports and small series. It consists of sheets of small round blue cells with high nuclear cytoplasmic ratio, brisk mitosis and apoptosis. In this study, we reported one case of pure rhabdomyosarcoma and two cases of urothelial carcinomas with extensive rhabdomyosarcomatous differentiation. In addition, their immunohistochemical profile was compared to that of small cell carcinoma of the bladder. Our study showed that sufficient sampling was critical for the diagnosis of urothelial carcinoma with extensive rhabdomyosarcomatous differentiation. As adult RMS in the bladder and urothelial carcinoma with rhabdomyosarcomatous differentiation shared morphological features with small cell carcinoma of the bladder, appropriate immunohistochemical stains were necessary in the differential diagnosis. We showed both rhabdomyosarcoma and rhabdomyosarcomatous areas of the urothelial carcinoma were positive for myogenin, negative for cytokeratin and chromogranin stains. In contrast, small cell carcinoma was positive for cytokeratin, and 7 out of 9 cases were also positive for chromogranin. Both rhabdomyosarcoma and small cell carcinoma could be positive for synaptophysin, a potential pitfall to avoid. In addition, all of the tumors with rhabdomyosarcomatous differentiation were negative for FKHR rearrangement
Vergleich eines Prostaglandinanalogon, eines Beta-Blockers und eines Kombinationspräparates von beiden in der Anwendung bei Patienten mit primärem Offenwinkelglaukom
Contrast-enhanced ultrasound of small cell carcinoma in urinary bladder: a case report and review of literature
Pred iction of High Grade Vesicoureteral Reflux in Infants Less than 3 Months with Urinary Tract Infection
Evidence for an ancient BRCA1 pathogenic variant in inherited breast cancer patients from Senegal
Diagnosis and Treatment of Renal and Urinary Tract Malformations in Newborns
Renal and urinary tract malformations in newborns are mostly congenital anomalies with genetic bases. The routine of antenatal ultrasound (US) scans has resulted in the early detection of these conditions and in selected cases has led to the development of prenatal management strategies including fetal intervention and/or the organization of the diagnostic procedures, postnatal surgical intervention, and/or clinical follow-up. In minor cases, where diagnosis is not allowed during prenatal life, it may be obtained after a postnatal routine follow-up or subsequently a clinical complication, generally urinary tract infection (UTI
Iron metabolism in the pathogenesis of iron-induced kidney injury
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118694.pdf (postprint version ) (Open Access)In the past 8 years, there has been renewed interest in the role of iron in both acute kidney injury (AKI) and chronic kidney disease (CKD). In patients with kidney diseases, renal tubules are exposed to a high concentration of iron owing to increased glomerular filtration of iron and iron-containing proteins, including haemoglobin, transferrin and neutrophil gelatinase-associated lipocalin (NGAL). Levels of intracellular catalytic iron may increase when glomerular and renal tubular cells are injured. Reducing the excessive luminal or intracellular levels of iron in the kidney could be a promising approach to treat AKI and CKD. Understanding the role of iron in kidney injury and as a therapeutic target requires insight into the mechanisms of iron metabolism in the kidney, the role of endogenous proteins involved in iron chelation and transport, including hepcidin, NGAL, the NGAL receptor and divalent metal transporter 1, and iron-induced toxic effects. This Review summarizes emerging knowledge, which suggests that complex mechanisms of iron metabolism exist in the kidney, modulated directly or indirectly by cellular iron content, inflammation, ischaemia and oxidative stress. The potential exists for prevention and treatment of iron-induced kidney injury by customized iron removal or relocation, aided by detailed insight into the underlying pathological mechanisms