Association between sleep quality and type 2 diabetes at 20-year follow-up in the Southall and Brent REvisited (SABRE) cohort: a triethnic analysis.

BACKGROUND: The risk of developing type 2 diabetes associated with poor sleep quality is comparable to other lifestyle factors (eg, overweight, physical inactivity). In the UK, these risk factors could not explain the two to three-fold excess risks in South-Asian and African-Caribbean men compared with Europeans. This study investigates (1) the association between mid-life sleep quality and later-life type 2 diabetes risk and (2) the potential modifying effect of ethnicity. METHODS: The Southall and Brent REvisited cohort is composed of Europeans, South-Asians and African-Caribbeans (median follow-up 19 years). Complete-case analysis was performed on 2189 participants without diabetes at baseline (age=51.7±7 SD). Competing risks regressions were used to estimate the HRs of developing diabetes associated with self-reported baseline sleep (difficulty falling asleep, early morning waking, waking up tired, snoring and a composite sleep score), adjusting for confounders. Modifying effects of ethnicity were analysed by conducting interaction tests and ethnicity-stratified analyses. RESULTS: There were 484 occurrences of incident type 2 diabetes (22%). Overall, there were no associations between sleep exposures and diabetes risk. Interaction tests suggested a possible modifying effect for South-Asians compared with Europeans for snoring only (p=0.056). The ethnicity-stratified analysis found an association with snoring among South-Asians (HR 1.41, 95% CI 1.08 to 1.85), comparing those who snored often/always versus occasionally/never. There were no elevated risks for the other sleep exposures. CONCLUSION: The association between snoring and type 2 diabetes appeared to be modified by ethnicity, and was strongest in South-Asians

Herschel Far-Infrared and Sub-millimeter Photometry for the KINGFISH Sample of Nearby Galaxies

New far-infrared and sub-millimeter photometry from the Herschel Space Observatory is presented for 61 nearby galaxies from the Key Insights on Nearby Galaxies: A Far-Infrared Survey with Herschel (KINGFISH) sample. The spatially-integrated fluxes are largely consistent with expectations based on Spitzer far-infrared photometry and extrapolations to longer wavelengths using popular dust emission models. Dwarf irregular galaxies are notable exceptions, as already noted by other authors, as their 500um emission shows evidence for a sub-millimeter excess. In addition, the fraction of dust heating attributed to intense radiation fields associated with photo-dissociation regions is found to be (21+/-4)% larger when Herschel data are included in the analysis. Dust masses obtained from the dust emission models of Draine & Li are found to be on average nearly a factor of two higher than those based on single-temperature modified blackbodies, as single blackbody curves do not capture the full range of dust temperatures inherent to any galaxy. The discrepancy is largest for galaxies exhibiting the coolest far-infrared colors.Comment: Accepted for publication in Ap

VVV-WIT-01: highly obscured classical nova or protostellar collision?

© 2020 The Author(s).A search of the first Data Release of the VISTA Variables in the Via Lactea (VVV) Survey discovered the exceptionally red transient VVV-WIT-01 (H-Ks=5.2). It peaked before March 2010, then faded by ~9.5 mag over the following two years. The 1.6-22 µm spectral energy distribution in March 2010 was well fit by a highly obscured black body with T ~ 1000 K and AKs ~ 6.6 mag. The source is projected against the Infrared Dark Cloud (IRDC) SDC G331.062-0.294. The chance projection probability is small for any single event (p ≈ 0.01 to 0.02) which suggests a physical association, e.g. a collision between low mass protostars. However, black body emission at T ~ 1000 K is common in classical novae (especially CO novae) at the infrared peak in the light curve, due to condensation of dust ~30-60 days after the explosion. Radio follow up with the Australia Telescope Compact Array (ATCA) detected a fading continuum source with properties consistent with a classical nova but probably inconsistent with colliding protostars. Considering all VVV transients that could have been projected against a catalogued IRDC raises the probability of a chance association to p=0.13 to 0.24. After weighing several options, it appears likely that VVV-WIT-01 was a classical nova event located behind an IRDC.Peer reviewedFinal Published versio

The Bulk Motion of Flat Edge-On Galaxies Based on 2MASS Photometry

We report the results of applying the 2MASS Tully-Fisher (TF) relations to study the galaxy bulk flows. For 1141 all-sky distributed flat RFGC galaxies we construct J, H, K_s TF relations and find that Kron $J_{fe}$ magnitudes show the smallest dispersion on the TF diagram. For the sample of 971 RFGC galaxies with V_{3K} < 18000 km/s we find a dispersion $\sigma_{TF}=0.42^m$ and an amplitude of bulk flow V= 199 +/-61 km/s, directed towards l=301 degr +/-18 degr, b=-2 degr +/-15 degr. Our determination of low-amplitude coherent flow is in good agreement with a set of recent data derived from EFAR, PSCz, SCI/SCII samples. The resultant two- dimensional smoothed peculiar velocity field traces well the large-scale density variations in the galaxy distributions. The regions of large positive peculiar velocities lie in the direction of the Great Attractor and Shapley concentration. A significant negative peculiar velocity is seen in the direction of Bootes and in the direction of the Local void. A small positive peculiar velocity (100 -- 150 km/s) is seen towards the Pisces-Perseus supercluster, as well as the Hercules - Coma - Corona Borealis supercluster regions.Comment: 10 pages, 5 figures. A&A/2003/3582 accepted 15.05.200

'The Brick' is not a brick : A comprehensive study of the structure and dynamics of the Central Molecular Zone cloud G0.253+0.016

© 2019 The Author(s) Published by Oxford University Press on behalf of the Royal Astronomical Society.In this paper we provide a comprehensive description of the internal dynamics of G0.253+0.016 (a.k.a. 'the Brick'); one of the most massive and dense molecular clouds in the Galaxy to lack signatures of widespread star formation. As a potential host to a future generation of high-mass stars, understanding largely quiescent molecular clouds like G0.253+0.016 is of critical importance. In this paper, we reanalyse Atacama Large Millimeter Array cycle 0 HNCO $J=4(0,4)-3(0,3)$ data at 3 mm, using two new pieces of software which we make available to the community. First, scousepy, a Python implementation of the spectral line fitting algorithm scouse. Secondly, acorns (Agglomerative Clustering for ORganising Nested Structures), a hierarchical n-dimensional clustering algorithm designed for use with discrete spectroscopic data. Together, these tools provide an unbiased measurement of the line of sight velocity dispersion in this cloud, $\sigma_{v_{los}, {\rm 1D}}=4.4\pm2.1$ kms$^{-1}$, which is somewhat larger than predicted by velocity dispersion-size relations for the Central Molecular Zone (CMZ). The dispersion of centroid velocities in the plane of the sky are comparable, yielding $\sigma_{v_{los}, {\rm 1D}}/\sigma_{v_{pos}, {\rm 1D}}\sim1.2\pm0.3$. This isotropy may indicate that the line-of-sight extent of the cloud is approximately equivalent to that in the plane of the sky. Combining our kinematic decomposition with radiative transfer modelling we conclude that G0.253+0.016 is not a single, coherent, and centrally-condensed molecular cloud; 'the Brick' is not a \emph{brick}. Instead, G0.253+0.016 is a dynamically complex and hierarchically-structured molecular cloud whose morphology is consistent with the influence of the orbital dynamics and shear in the CMZ.Peer reviewedFinal Accepted Versio

FXR1 Is an IL-19-Responsive RNA-Binding Protein that Destabilizes Pro-inflammatory Transcripts in Vascular Smooth Muscle Cells

This work identifies the fragile-X-related protein (FXR1) as a reciprocal regulator of HuR target transcripts in vascular smooth muscle cells (VSMCs). FXR1 was identified as an HuR-interacting protein by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The HuR-FXR1 interaction is abrogated in RNase-treated extracts, indicating that their association is tethered by mRNAs. FXR1 expression is induced in diseased but not normal arteries. siRNA knockdown of FXR1 increases the abundance and stability of inflammatory mRNAs, while overexpression of FXR1 reduces their abundance and stability. Conditioned media from FXR1 siRNA-treated VSMCs enhance activation of naive VSMCs. RNA EMSA and RIP demonstrate that FXR1 interacts with an ARE and an element in the 3′ UTR of TNFα. FXR1 expression is increased in VSMCs challenged with the anti-inflammatory cytokine IL-19, and FXR1 is required for IL-19 reduction of HuR. This suggests that FXR1 is an anti-inflammation responsive, HuR counter-regulatory protein that reduces abundance of pro-inflammatory transcripts

A Study of Heating and Cooling of the ISM in NGC 1097 with Herschel-PACS and Spitzer-IRS

NGC 1097 is a nearby Seyfert 1 galaxy with a bright circumnuclear starburst ring, a strong large-scale bar and an active nucleus. We present a detailed study of the spatial variation of the far infrared (FIR) [CII]158um and [OI]63um lines and mid-infrared H2 emission lines as tracers of gas cooling, and of the polycyclic aromatic hydrocarbon (PAH) bands as tracers of the photoelectric heating, using Herschel-PACS, and Spitzer-IRS infrared spectral maps. We focus on the nucleus and the ring, and two star forming regions (Enuc N and Enuc S). We estimated a photoelectric gas heating efficiency ([CII]158um+[OI]63um)/PAH in the ring about 50% lower than in Enuc N and S. The average 11.3/7.7um PAH ratio is also lower in the ring, which may suggest a larger fraction of ionized PAHs, but no clear correlation with [CII]158{\mu}m/PAH(5.5 - 14um) is found. PAHs in the ring are responsible for a factor of two more [CII]158um and [OI]63um emission per unit mass than PAHs in the Enuc S. SED modeling indicates that at most 25% of the FIR power in the ring and Enuc S can come from high intensity photodissociation regions (PDRs), in which case G0 ~ 10^2.3 and nH ~ 10^3.5 cm^-3 in the ring. For these values of G0 and nH PDR models cannot reproduce the observed H2 emission. Much of the the H2 emission in the starburst ring could come from warm regions in the diffuse ISM that are heated by turbulent dissipation or shocks.Comment: 17 pages, 14 figures, 5 tables; accepted for publication in Ap