Generalized Species Sampling Priors with Latent Beta reinforcements

Many popular Bayesian nonparametric priors can be characterized in terms of exchangeable species sampling sequences. However, in some applications, exchangeability may not be appropriate. We introduce a {novel and probabilistically coherent family of non-exchangeable species sampling sequences characterized by a tractable predictive probability function with weights driven by a sequence of independent Beta random variables. We compare their theoretical clustering properties with those of the Dirichlet Process and the two parameters Poisson-Dirichlet process. The proposed construction provides a complete characterization of the joint process, differently from existing work. We then propose the use of such process as prior distribution in a hierarchical Bayes modeling framework, and we describe a Markov Chain Monte Carlo sampler for posterior inference. We evaluate the performance of the prior and the robustness of the resulting inference in a simulation study, providing a comparison with popular Dirichlet Processes mixtures and Hidden Markov Models. Finally, we develop an application to the detection of chromosomal aberrations in breast cancer by leveraging array CGH data.Comment: For correspondence purposes, Edoardo M. Airoldi's email is [email protected]; Federico Bassetti's email is [email protected]; Michele Guindani's email is [email protected] ; Fabrizo Leisen's email is [email protected]. To appear in the Journal of the American Statistical Associatio

Controle de Linepithema micans (Hymenoptera: Formicidae) com iscas tóxicas de hidrogel na cultura da videira.

Linepithema micans (Forel, 1908) (Hymenoptera: Formicidae) é a principal formiga associada à dispersão da pérola-da-terra Eurhizococcus brasiliensis (Wille, 1922) (Hemiptera: Margarodidae) na cultura da videira. Uma alternativa para reduzir a infestação da cochonilha nos vinhedos seria o controle da formiga através do emprego de iscas tóxicas. Neste trabalho, foi avaliado o efeito de uma formulação de isca tóxica de hidrogel para o controle de L. micans em laboratório e em vinhedo comercial.(Embrapa Uva e Vinho. Documentos 99)

Controle de Linepithema micans (Hymenoptera:Formicidae) com iscas tóxicas de hidrogel à base de alginato de cálcio.

Linepithema micans (Forel, 1908) é a principal formiga associada à dispersão da pérola-da-terra Eurhizococcus brasiliensis (Wille, 1922) (Hemiptera: Margarodidae) na cultura da videira. Uma alternativa para reduzir a infestação da cochonilha nos vinhedos é o controle da formiga por meio de isca tóxica de thiametoxam (70mg/1000mL) imobilizado em 20g de polímero de poliacrilamida

O ensino do cuidar na Graduação em Enfermagem sob a perspectiva da complexidade

Trata-se de estudo que destaca o ensino do cuidar na Graduação em Enfermagem sob a perspectiva da Complexidade, defendida e pesquisada por Edgar Morin. Optou-se pela pesquisa qualitativa, utilizando a Análise de Conteúdo Temática. Realizaram-se doze entrevistas individuais semiestruturadas, tendo como cenário uma universidade particular da cidade de São Paulo, Brasil. Os dados foram coletados entre 2004 e 2005, a partir da questão norteadora. A análise dos dados conduziu para as seguintes categorias, aqui denominadas de Sinalizadores Pedagógicos Complexos, que deram sentido ao significado de cuidar complexo. Os resultados evidenciaram que os entrevistados perceberam e expressaram o cuidar sensível em enfermagem, relacionando e inter-relacionando as partes ao todo e o todo às partes, aproximando-se de um cuidar complexo.Se trata de un estudio que destaca la enseñanza del cuidar en la Graduación en Enfermería bajo la perspectiva de la Integralidad, defendida e investigada por Edgar Morin. Se optó por la investigación cualitativa, utilizándose el Análisis de Contenido, modalidad Temática. Se realizaron doce entrevistas individuales semiestructuradas, con escenario en una Universidad privada de la ciudad de San Pablo, Brasil. Los datos fueron recolectados entre 2004 y 2005, a partir de una pregunta orientadora. El análisis de los datos derivó en las siguientes categorías, aquí denominadas como Señalizadores Pedagógicos, que dieron sentido al significado del cuidar integral. Los resultados evidenciaron que los entrevistados percibían o expresaban el cuidar sensible en enfermería, relacionando e interrelacionando las partes al todo y el todo a las partes, aproximándose de tal modo al cuidar integralizado.This study highlights the teaching of care in Nursing Graduation according to the Complexity Theory, supported by Edgar Morin. This is a qualitative study using Thematic Content Analysis. Twelve individual semi-structured interviews were performed at a private university in the city of São Paulo, Brazil. Data collection was performed between 2004 and 2005, using a guiding question. Data analysis revealed categories, herein referred to as Complex Pedagogical Indicators, which assigned meanings to complex care. Results showed that the interviewees realized and expressed sensitive care in nursing, making relations and interrelations of the parts with the whole and the whole with the parts, thus approaching complex care

A Network Biology Approach Identifies Molecular Cross-Talk between Normal Prostate Epithelial and Prostate Carcinoma Cells

© 2016 The Authors. Published by Public Library of Science. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1371/journal.pcbi.1004884The advent of functional genomics has enabled the genome-wide characterization of the molecular state of cells and tissues, virtually at every level of biological organization. The difficulty in organizing and mining this unprecedented amount of information has stimulated the development of computational methods designed to infer the underlying structure of regulatory networks from observational data. These important developments had a profound impact in biological sciences since they triggered the development of a novel data-driven investigative approach. In cancer research, this strategy has been particularly successful. It has contributed to the identification of novel biomarkers, to a better characterization of disease heterogeneity and to a more in depth understanding of cancer pathophysiology. However, so far these approaches have not explicitly addressed the challenge of identifying networks representing the interaction of different cell types in a complex tissue. Since these interactions represent an essential part of the biology of both diseased and healthy tissues, it is of paramount importance that this challenge is addressed. Here we report the definition of a network reverse engineering strategy designed to infer directional signals linking adjacent cell types within a complex tissue. The application of this inference strategy to prostate cancer genome-wide expression profiling data validated the approach and revealed that normal epithelial cells exert an anti-tumour activity on prostate carcinoma cells. Moreover, by using a Bayesian hierarchical model integrating genetics and gene expression data and combining this with survival analysis, we show that the expression of putative cell communication genes related to focal adhesion and secretion is affected by epistatic gene copy number variation and it is predictive of patient survival. Ultimately, this study represents a generalizable approach to the challenge of deciphering cell communication networks in a wide spectrum of biological systems.Cancer research UK, BBSRC, NI