Climate change, public health and COP21 – a South African perspective

Current and future climate impacts on public health are a pressing global challenge. Southern Africa is predicted to experience significant changes in climate and by the end of the 21st century, annual average temperatures in the region may warm by up to 4 degrees Celsius. South Africa (SA) is considered to be among one of the most vulnerable countries in the world given the current high incidence of several life-threatening diseases, poverty and inequality. With the 21st session of the Conference of the Parties (COP21) to the United Nations Framework Convention on Climate Change taking place this year, we consider the challenges of and opportunities for SA to accelerate progress towards tackling the adverse impacts of climate change on human health.

An X-ray investigation of the NGC 346 field in the SMC (3): XMM-Newton data

We present new XMM-Newton results on the field around the NGC346 star cluster in the SMC. This continues and extends previously published work on Chandra observations of the same field. The two XMM-Newton observations were obtained, respectively, six months before and six months after the previously published Chandra data. Of the 51 X-ray sources detected with XMM-Newton, 29 were already detected with Chandra. Comparing the properties of these X-ray sources in each of our three datasets has enabled us to investigate their variability on times scales of a year. Changes in the flux levels and/or spectral properties were observed for 21 of these sources. In addition, we discovered long-term variations in the X-ray properties of the peculiar system HD5980, a luminous blue variable star, that is likely to be a colliding wind binary system, which displayed the largest luminosity during the first XMM-Newton observation.Comment: 19 pages, 5 figures (in gif), accepted by ApJ, also available from http://vela.astro.ulg.ac.be/Preprints/P89/index.htm

Effects of Acute Lithium Treatment on Brain Levels of Inflammatory Mediators in Poststroke Rats

Stroke is a leading cause of mortality and morbidity worldwide. Few therapeutic options with proven efficacy are available for the treatment of this disabling disease. Lithium is the gold standard treatment for bipolar disorder. Moreover, lithium has been shown to exhibit neuroprotective effects and therapeutic efficacy as a treatment of other neurological disorders. This study was undertaken to examine the effects of lithium on brain inflammatory mediators levels, fever, and mortality in postischemic stroke rats. Ischemic stroke was induced by occlusion of the mid cerebral artery (MCAO). Pretreatment with a single dose of lithium at 2 hours before MCAO induction significantly reduced the elevation in interleukin- (IL-) 6 and prostaglandin E2 levels in brain of post-MCAO rats, as compared to vehicle-treated animals. On the other hand, lithium did not affect the elevation in IL-1α, IL-10, IL-12, and tumor necrosis factor-α levels in brain of post-MCAO rats. Moreover, pretreatment with lithium did not alter post-MCAO fever and mortality. These results suggest that acute pretreatment with a single dose of lithium did not markedly affect post-MCAO morbidity and mortality in rats

Trunk Refugia : A Simple, Inexpensive Method for Sampling Tree Trunk Arthropods

Trees host a large share of the global arthropod diversity. Several methodologies have been described to sample arthropods from trees, ranging from active sampling techniques (e.g., visual searching, beating, or shaking the branches) to passive sampling devices. The majority of these collection techniques are destructive, and do not specifically target the tree trunk arthropod fauna. Here, we describe an alternative sampling method called trunk refugia (TR). TR are cylindrical shelters made of corrugated cardboard that can be secured to trees using string, and can remain exposed for varying time periods. These refugia are inexpensive, easy to use, and suitable to monitor a diverse array of insects and arachnids. Moreover, TR are nonlethal sampling tools, and allow collecting live individuals for behavioral studies or for rearing.RESUMEN: Los árboles albergan una gran parte de la diversidad global de artrópodos. Varias metodologías han sido descritas para muestrear artrópodos de árboles, desde técnicas activas (e.g., búsqueda visual, red de golpeo) hasta dispositivos de muestreo pasivo. La mayoría de estas técnicas son letales, y no están dirigidas específicamente a los artrópodos de troncos de árboles. Describimos aquí un método alternativo llamado trampas refugio (TR). Las TR son refugios hechos de cartón corrugado que se colocan en los troncos usando cuerda, y pueden permanecer expuestos por períodos variables. Estas trampas son económicas, fáciles de usar, y apropiadas para monitorear una gran variedad de insectos y arácnidos. Además, las TR son no-letales, por lo que permiten la colección de individuos vivos para estudios de comportamiento o crianza.Jacob Blaustein Center for Scientific Cooperation; Israel Nature and Parks Authorities (INPA); Israel's National Nature Assessment Program (HAMAARAG); Israel Ministry of Agriculture (131-1793-14)info:eu-repo/semantics/publishedVersio

Psychiatric Symptomatology, Mood Regulation, and Resting State Functional Connectivity of the Amygdala: Preliminary Findings in Youth With Mood Disorders and Childhood Trauma

Background: As mood dysregulation and hyperarousal are overlapping and prominent features of posttraumatic stress disorder (PTSD), and mood disorders (MD) including bipolar disorder (BD), we aimed to clarify the role of trauma and MD on the resting state functional connectivity (RSFC) of amygdala in MD youth with or without trauma exposure, and healthy controls (HC). Methods: Of 23 subjects, 21 completed the magnetic resonance imaging (MRI) protocol, 5 were excluded for subject motion, leaving final sample size of 16: nine subjects with MD (5/9 with trauma), and 7 HC. Youth were assessed with Schedule for Affective Disorders and Schizophrenia for School Aged Children-Present and Lifetime Version (K-SADS-PL), and other behavioral measures including Young Mania Rating Scale (YMRS). Imaging data were acquired using functional MRI in 3-T scanner. Imaging included T1-weighted structural MRI and 6-min resting state acquisition. Results: In between group analysis, the average correlation coefficients between left anterior cingulate cortex (Acc) and left insula cortex with left amygdala regions were significantly larger in HC compared to the patient population. Connectivity between left amygdala and left cingulate cortex shows a significant negative correlation with YMRS severity. Conclusions: In this preliminary study, MD with trauma youth had more manic symptoms and difficulties regulating anger. While MD youth showed reduced RSFC of left amygdala with left acc and left insula, no significant difference between the subgroups of children with MD was observed. However, when looking at both clinical groups together, we observed a significant correlation of RSFC of left amygdala to left acc, and YMRS scores

Light GUT Triplets and Yukawa Splitting

Triplet-mediated proton decay in Grand Unified Theories (GUTs) is usually suppressed by arranging a large triplet mass. Here we explore instead a mechanism for suppressing the couplings of the triplets to the first and second generations compared to the Yukawa couplings, so that the triplets' mass can be below the GUT scale. This mechanism is based on a ``triplet symmetry'' in the context of product-group GUTs. We study two possibilities. One, which requires the top Yukawa to arise from a non-renormalizable operator at the GUT scale, is that all triplet couplings to matter are negligible, so that the triplets can be at the weak scale. The second is that some triplet couplings, and in particular $T t b$ and $T \bar{t} \bar{l}$, are equal to the corresponding Yukawa couplings. This would give a distinct signature of grand unification if the triplets were sufficiently light. However, we derive a model-independent bound on the triplet mass in this case, which is at least 10$^6$GeV. Finally, we construct a GUT model based on Yukawa splitting, with the triplets at 10$^{14}$GeV, as required for coupling unification to work.Comment: 5 pages, Revtex4, 1 EPS figure. To appear in PRD: Minor changes. Appendix droppe

Formation of Alkanes by Aerobic Carbon–Carbon Bond Coupling Reactions Catalyzed by a Phosphovanadomolybdic Acid

The valorization of alkanes is possible via carbon–carbon coupling reactions. A series of dialkyl cobalt complexes [(RCH_2)_2Co^(III)(bpy)_2]ClO_4 (R = H, Me, Et, and Ph) were reacted with the H_5PV_2Mo_(10)O_(40) polyoxometalate as a catalyst, leading to a selective oxidative carbon–carbon bond coupling reaction. The reaction is initiated by electron transfer from [(RCH_2)_2Co^(III)(bpy)_2]^+ to H_5PV^V_2Mo_(10)O_(40) to yield an intermediate [(RCH_2)_2Co^(IV)(bpy)_2]^(2+)–H_5PV^(IV)V^VMo_(10)O_(40), as identified by a combination of EPR and X-ray photoelectron spectroscopy experiments. The reaction is catalytic with O_2 as terminal oxidant representing an aerobic C–C bond coupling reaction

Juegos serios para el tratamiento o la prevención de la depresión: una revisión sistemática

Serious games (computerised interventions which utilise gaming for serious purposes) have been shown to support improved outcomes in several health conditions. We aimed to review evidence regarding serious games for depression. We undertook electronic searches of PsycInfo, EMBASE and Medline, using terms relevant to computer games and depression. We included fulltext articles published in English in peer-reviewed literature since 2000, where the intervention was designed to treat or prevent depression and which included pre-and post-intervention measurement of depression. Nine studies relating to a total of six interventions met inclusion criteria. Most studies were small and were carried out by the developers of the programs. All were tested with young people (ages between 9 and 25 years). Most reported promising results with some positive impact on depression although one universal program had mixed results. Serious gaming interventions show promise for depression, however evidence is currently very limited.Se ha demostrado que los juegos serios (intervenciones computarizadas que utilizan juegos) mejoran los resultados en diferentes problemas de salud. Pretendemos examinar las evidencias de estos juegos para la depresión. Se realizaron búsquedas electrónicas en PsycINFO, EMBASE y Medline usando términos relacionados con juegos de ordenador y depresión. Se incluyeron artículos publicados desde el año 2000, donde se diseñó la intervención para tratar o prevenir la depresión incluyendo medidas pre- y post-intervención. Nueve estudios sobre un total de seis intervenciones cumplieron los criterios de inclusión. La mayoría de estos fueron pequeños y los llevaron a cabo los desarrolladores de los programas. Todos incluían población joven (9 - 25 años). La mayoría presentan resultados prometedores con un impacto positivo sobre la depresión aunque un programa universal tuvo resultados mixtos. Se concluye que las intervenciones basadas en juegos serios son prometedoras para la depresión, aunque la evidencia es todavía muy limitada